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Samantha J. Shupe
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Journal Articles

Clonal Evolution during Dual B Cell Receptor Pathway Inhibitor Therapy with Acalabrutinib and Umbralisib in CLL Patients

Saurabh Yadav, Sumbul Jawed Khan, Binu Kandathilparambil Sasi, Elizabeth F. Cohen, Kiyomi Mashima, Hannah Cormier, Stacey M. Fernandes, Samantha J. Shupe, Roberta Santos Azevedo, Mariia Mikhaleva, Philippe Armand, David C. Fisher, Matthew S. Davids, Inhye E. Ahn, Michael Y. Tolstorukov, Mark A. Murakami, Jennifer R. Brown
Journal: Blood
Blood (2024) 144 (Supplement 1): 4611.
https://doi.org/10.1182/blood-2024-207527
Published: 2024
Journal Articles

Low Variant Allele Frequency (VAF) TP53 Mutation (mut) Is Not a Poor Prognostic Marker in CLL Patients Treated with Targeted Therapy

Daniel Sungchul Choi, Yue Ren, Svitlana Tyekucheva, Stacey M. Fernandes, Mariia Mikhaleva, Kiyomi Mashima, Rayan Fardoun, Samantha J. Shupe, Stephen Martindale, Matthew S. Davids, Jennifer R. Brown, Inhye E. Ahn
Journal: Blood
Blood (2024) 144 (Supplement 1): 587.
https://doi.org/10.1182/blood-2024-208951
Published: 2024
Journal Articles

Novel Pi3kδ Inhibitor Roginolisib Synergizes with the Bcl-2 Inhibitor Venetoclax in Hematological Malignancies

Binu Kandathilparambil Sasi, Chiara Tarantelli, Elisa Civanelli, Eleonora Cannas, Stacey M Fernandes, Samantha J. Shupe, Michael Lahn, Lars van der Veen, Giusy Di Conza, Francesco Bertoni, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 4179.
https://doi.org/10.1182/blood-2023-180073
Published: 2023
Journal Articles

Defining the Drivers of Idelalisib-Related Early Autoimmune Toxicity in Chronic Lymphocytic Leukemia

Saurabh Yadav, Suraj Singh, Binu Kandathilparambil Sasi, Mandovi Chatterjee, Victor Barrera, Shannan Ho Sui, Stacey M Fernandes, Samantha J. Shupe, John-Hanson Machado, Mano Joseph Mathew, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 6511.
https://doi.org/10.1182/blood-2023-186136
Published: 2023
Journal Articles

Investigating the Influence of Germline ATM Variants on Susceptibility to Chronic Lymphocytic Leukemia and Other Malignancies

Roberta Santos Azevedo, Francesca Morelli, Kiyomi Mashima, Rayan Fardoun, Svitlana Tyekucheva, Stacey M Fernandes, Samantha J. Shupe, Marissa Terra, Anisha Patel, Joseph Yu, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 3266.
https://doi.org/10.1182/blood-2023-180136
Published: 2023
Journal Articles

Understanding Resistance Mechanisms and Growth Kinetics of CLL Treated with Covalent and Non-Covalent BTK Inhibitors

Aishath Naeem, Liang Li, Filippo Utro, Justin Cha, Junko Tsuji, Stacey M Fernandes, Roberta Santos Azevedo, Francesca Morelli, Zunqiu Wang, Samantha J. Shupe, Kahn Rhrissorrakrai, Chaya Levovitz, Brian P Danysh, Alexandria Kluge, Matthew S Davids, Ignaty Leshchiner, Laxmi Parida, Gad Getz, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 4623.
https://doi.org/10.1182/blood-2023-186052
Published: 2023
Journal Articles

Characterizing ATM Aberrations in Chronic Lymphocytic Leukemia (CLL): Prognostic Implications and Sensitivity to PARP Inhibition

Kiyomi Mashima, Mariia Mikhaleva, Stacey M Fernandes, Samantha J. Shupe, Svitlana Tyekucheva, Matthew S. Davids, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 6507.
https://doi.org/10.1182/blood-2023-187406
Published: 2023
Journal Articles

Updated Results from a Multicenter, Phase 2 Study of Acalabrutinib, Venetoclax, Obinutuzumab (AVO) in a Population of Previously Untreated Patients with CLL Enriched for High-Risk Disease

Christine E. Ryan, Benjamin L. Lampson, Svitlana Tyekucheva, Liam R. Hackett, Yue Ren, Samantha J. Shupe, Stacey M. Fernandes, Jennifer L. Crombie, Samuel Ng, Austin I. Kim, Inhye E. Ahn, Matthew J Weinstock, Samantha Pazienza, Josie S. Montegaard, Victoria Patterson, Caron A. Jacobson, Ann S. LaCasce, Philippe Armand, David C. Fisher, Jon E. Arnason, Steve Lo, Adam Olszewski, Jennifer R. Brown, Matthew S. Davids
Journal: Blood
Blood (2022) 140 (Supplement 1): 837–838.
https://doi.org/10.1182/blood-2022-168003
Published: 2022
Journal Articles

Mechanistic Insights into Immune Related Toxicities in Subjects with Relapsed/ Refractory Follicular Lymphoma Treated with Zandelisib

Binu Kandathilparambil Sasi, Stephen P. Martindale, Samantha J. Shupe, Stacey M. Fernandes, Saurabh Yadav, John-Hanson Machado, Tycel Phillips, Andrew D. Zelenetz, Jennifer R. Brown
Journal: Blood
Blood (2022) 140 (Supplement 1): 3575–3576.
https://doi.org/10.1182/blood-2022-159167
Published: 2022
Journal Articles

Characteristics of Rare Germline ATM Variants in Chronic Lymphocytic Leukemia (CLL)

Kiyomi Mashima, Benjamin L. Lampson, Aditi Gupta, Nicholas Moore, Anna Petrackova, Samantha J. Shupe, Stacey M. Fernandes, Amaro Taylor-Weiner, Riaz Gillani, Hoyin Chu, Seunghun Han, Sabrina Camp, Eric Kofman, Gad Getz, Catherine J. Wu, Eliezer Van Allen, Saud H AlDubayan, Jennifer R. Brown
Journal: Blood
Blood (2022) 140 (Supplement 1): 9853–9854.
https://doi.org/10.1182/blood-2022-167009
Published: 2022