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Journal Articles

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Sabine Knappe, PhD, Nicolas Fischer, Patrice Robert Douillard, Rudolf Hartmann, PhD, Gerald Schrenk, PhD, Ulla Ravn, Giovanni Magistrelli, Franck Gueneau, Gerard Didelot, Krzysztof Masternak, Marie Kosco-Vilbois, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1083.

https://doi.org/10.1182/blood.V130.Suppl_1.1083.1083

Published: 2017

Journal Articles

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2017) 130 (Supplement 1): 90.

https://doi.org/10.1182/blood.V130.Suppl_1.90.90

Published: 2017

Journal Articles

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Rudolf Hartmann, PhD, Tjerk Feenstra, MSc, Sabine Knappe, PhD, Gerald Schrenk, PhD, Friedrich Scheiflinger, PhD, Michael Dockal, PhD

Blood (2017) 130 (Supplement 1): 1080.

https://doi.org/10.1182/blood.V130.Suppl_1.1080.1080

Published: 2017

Journal Articles

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

Sabine Knappe, Rudolf Hartmann, Brahm Goldstein, MD, Bruce M. Ewenstein, Leonard Valentino, Friedrich Scheiflinger, PhD

Blood (2016) 128 (22): 4952.

https://doi.org/10.1182/blood.V128.22.4952.4952

Published: 2016

Journal Articles

The Application of Thrombin Generation Test Is Compromised By Antithrombin III Deficiency

Sabine Knappe, Susanne Till, Gabriele Gerstenbauer, Friedrich Scheiflinger, PhD, Michael Dockal

Blood (2015) 126 (23): 4663.

https://doi.org/10.1182/blood.V126.23.4663.4663

Published: 2015

Journal Articles

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

Michael Dockal, PhD, Sabine Knappe, PhD, Peter Leidenmuehler, Christina Piskernik, DVM, Sylvia Tippl, Marlene Resch, DVM, Dagmar Verdino, DVM, Alexander Bauer, Werner Hoellriegl, PhD, Friedrich Scheiflinger, PhD

Blood (2013) 122 (21): 2353.

https://doi.org/10.1182/blood.V122.21.2353.2353

Published: 2013

Journal Articles

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Michael Dockal, PhD, Robert Pachlinger, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Benny Sorensen, Wing Yen Wong, Maureen Conlan, Michael Cecerle, Bruce M. Ewenstein, MD PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 1104.

https://doi.org/10.1182/blood.V120.21.1104.1104

Published: 2012

Journal Articles

Structure-Activity Relationship of Pro- and Anticoagulant Effects of Fucus Vesiculosus Fucoidan

Michael Dockal, PhD, Susanne Till, PhD, Zhenqing Zhang, Sabine Knappe, PhD, Sabrina Reutterer, Catherine Quinn, Christoph Redl, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Christina Szabo

Blood (2012) 120 (21): 3353.

https://doi.org/10.1182/blood.V120.21.3353.3353

Published: 2012

Journal Articles

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Michael Dockal, PhD, Rudolf Hartmann, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Willibald Kammlander, PhD, Klara Kunckova, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2012) 120 (21): 2207.

https://doi.org/10.1182/blood.V120.21.2207.2207

Published: 2012

Journal Articles

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Michael Dockal, PhD, Werner Hoellriegl, Zhenqing Zhang, Susanne Till, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Alexandra Schiviz, Hartmut J. Ehrlich, MD, Christina Szabo, Eva-Maria Muchitsch, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 2262.

https://doi.org/10.1182/blood.V118.21.2262.2262

Published: 2011

Journal Articles

Strong Correlation of High Endogenous Plasma Levels of Tissue Factor Pathway Inhibitor (TFPI) with Poor Blood Clotting and Corrective Action of BAX 513 Under FVIII-Inhibited Conditions

Michael Dockal, PhD, Monika Gorczyca, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Bernd Jilma, MD

Blood (2011) 118 (21): 1201.

https://doi.org/10.1182/blood.V118.21.1201.1201

Published: 2011

Journal Articles

Anticoagulant Activity and Mechanism of Non-Anticoagulant Sulfated Polysaccharides

Michael Dockal, PhD, Susanne Till, PhD, Sabine Knappe, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 1208.

https://doi.org/10.1182/blood.V118.21.1208.1208

Published: 2011

Journal Articles

Procoagulant Activity of Laminaria Japonica Derived Fucoidan (BAX513) Depends on the Interaction with the C-Terminus of Tissue Factor Pathway Inhibitor

Michael Palige, PhD, Christoph Redl, Sabine Knappe, PhD, Hartmut J. Ehrlich, MD, Michael Dockal, PhD, Friedrich Scheiflinger, PhD

Blood (2010) 116 (21): 4417.

https://doi.org/10.1182/blood.V116.21.4417.4417

Published: 2010

Journal Articles

Procoagulant Activity of Sulfated Polysaccharides

Michael Dockal, PhD, Sabine Knappe, PhD, Erwin Panholzer, Michael Palige, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD

Blood (2010) 116 (21): 4419.

https://doi.org/10.1182/blood.V116.21.4419.4419

Published: 2010

Journal Articles

AV513 Promotes Tissue Factor-Mediated Coagulation in Fresh Human Whole Blood from Severe and Moderate Hemophilia a Subjects.

Jerry Sherman Powell, MD, Sabine Knappe, PhD, Janet A Harrison, BS, Susannah Patarroyo-White, BS, Kirk Johnson, PhD, Srinivasa Prasad, PhD

Blood (2008) 112 (11): 1223.

https://doi.org/10.1182/blood.V112.11.1223.1223

Published: 2008

Journal Articles

Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A

Srinivasa Prasad, David Lillicrap, Andrea Labelle, Sabine Knappe, Tracy Keller, Erin Burnett, Sandra Powell, Kirk W. Johnson

Blood (2008) 111 (2): 672–679.

https://doi.org/10.1182/blood-2007-07-098913

Published: 2008

Journal Articles

AV513 Enhances Tissue Factor Activity by Inhibiting TFPI in Hemophilia A Plasma: Potential TFPI Target Sites and Potentiation of Factor VIII Activity.

Sabine Knappe, PhD, Nicholas Kripalani, BS, Susannah Patarroyo-White, BS, Kirk W. Johnson, PhD, Srinivasa Prasad, PhD

Blood (2007) 110 (11): 497.

https://doi.org/10.1182/blood.V110.11.497.497

Published: 2007

NARROW

Bispecific Antibodies with Native Human IgG Structure As Mimetics for FVIII Activity

Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents

A Bispecific Antibody Lacks Measurability in Routine Coagulation Assays and Comparability to Factor VIII

Synergistic Effects of a Procoagulant Bispecific Antibody and Rescue Therapies on Thrombin Generation- a Potential Safety Risk

The Application of Thrombin Generation Test Is Compromised By Antithrombin III Deficiency

Concomitant Administration Of Activated Prothrombin Complex Concentrate and Recombinant Activated Factor VII At Low Doses Are Efficacious and Safe In Hemophilic Mice

Biological Explanation of Clinically Observed Elevation of TFPI Plasma Levels After Treatment with TFPI-Antagonistic Aptamer BAX 499

Structure-Activity Relationship of Pro- and Anticoagulant Effects of Fucus Vesiculosus Fucoidan

Effect of Increased Tissue Factor Pathway Inhibitor (TFPI) Levels On Factor Xa Inhibition and Global Hemostasis in the Presence of TFPI-Antagonistic Aptamer BAX 499.

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Strong Correlation of High Endogenous Plasma Levels of Tissue Factor Pathway Inhibitor (TFPI) with Poor Blood Clotting and Corrective Action of BAX 513 Under FVIII-Inhibited Conditions

Anticoagulant Activity and Mechanism of Non-Anticoagulant Sulfated Polysaccharides

Procoagulant Activity of Laminaria Japonica Derived Fucoidan (BAX513) Depends on the Interaction with the C-Terminus of Tissue Factor Pathway Inhibitor

Procoagulant Activity of Sulfated Polysaccharides

AV513 Promotes Tissue Factor-Mediated Coagulation in Fresh Human Whole Blood from Severe and Moderate Hemophilia a Subjects.

Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A

AV513 Enhances Tissue Factor Activity by Inhibiting TFPI in Hemophilia A Plasma: Potential TFPI Target Sites and Potentiation of Factor VIII Activity.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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