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Journal Articles

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Shizuka Yamano, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Huihui Tang, PhD, Vikas Gupta, MD PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Constantine S. Mitsiades, MD PhD

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-143117

Published: 2020

Journal Articles

Interactions with a "Humanized" Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Olga Dashevsky, Sara Gandolfi, MD, Megan Bariteau, BSc, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Maria Themeli, MD PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Richard W.J. Groen, PhD, Constantine S. Mitsiades, MD PhD

Blood (2020) 136 (Supplement 1): 40.

https://doi.org/10.1182/blood-2020-143151

Published: 2020

Journal Articles

Mechanisms Regulating Myeloma Cell Responsiveness to Antisense Oligonucleotides Targeting IRF4

Ryosuke Shirasaki, MD PhD, Esperanza M Algarín, PhD, Ricardo De Matos Simoes, PhD, Sondra L. Downey-Kopyscinski, PhD, Shizuka Yamano, Xiaolin Luo, Youngsoo Kim, PhD, Robert MacLeod, Constantine S. Mitsiades, MD PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-142518

Published: 2020

Journal Articles

Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights from Studies of Pooled "DNA-Barcoded" Cell Line Panels

Sara Gandolfi, MD, Michal Sheffer, PhD, Olli Dufva, Khalid Saeed, Emily Lowry, Olga Dashevsky, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Jennifer Roth, Rizwan Romee, MD PhD, Satu Mustjoki, MD PhD, Constantine S. Mitsiades, MD PhD

Blood (2019) 134 (Supplement_1): 620.

https://doi.org/10.1182/blood-2019-130793

Published: 2019

Journal Articles

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied "Drivers" of Myeloma

Huihui Tang, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Sara Gandolfi, MD, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD

Blood (2019) 134 (Supplement_1): 313.

https://doi.org/10.1182/blood-2019-128919

Published: 2019

Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Blood (2019) 134 (Supplement_1): 318.

https://doi.org/10.1182/blood-2019-130549

Published: 2019

Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Blood (2019) 134 (Supplement_1): 4407.

https://doi.org/10.1182/blood-2019-130901

Published: 2019

Journal Articles

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Megan Bariteau, BSc, Jonathan D. Licht, MD, Brian Glassner, PhD, Richard WJ Groen, PhD, Joan Levy, PhD, Daniel Auclair, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 189.

https://doi.org/10.1182/blood-2018-189

Published: 2018

Journal Articles

CRISPR Activation Screen for HDAC Inhibitor Resistance

Huihui Tang, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Sondra L. Downey-Kopyscinski, PhD, Sara Gandolfi, MD, Michal Sheffer, PhD, Megan Bariteau, BSc, John G Doench, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 3958.

https://doi.org/10.1182/blood-2018-99-119044

Published: 2018

Journal Articles

CRISPR Activation Screen for Drivers of MM Cell Proliferation

Blood (2018) 132 (Supplement 1): 3197.

https://doi.org/10.1182/blood-2018-99-118712

Published: 2018

Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Blood (2018) 132 (Supplement 1): 1367.

https://doi.org/10.1182/blood-2018-99-116232

Published: 2018

Journal Articles

Identification of Molecular Markers of Tumor Cell Sensitivity and Resistance to Natural Killer Cells through Genome-Wide CRISPR Activation and CRISPR Editing Screens in Multiple Myeloma Cell Lines: Implications for Anti-Myeloma Immunotherapy

Sara Gandolfi, MD, Michal Sheffer, PhD, Emily Lowry, Olga Dashevsky, PhD, Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 1115.

https://doi.org/10.1182/blood-2018-99-118736

Published: 2018

Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Blood (2017) 130 (Supplement 1): 1212.

https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212

Published: 2017

Journal Articles

Long-Term Interactions with Bone Marrow Stromal Cells Alter the Molecular Dependencies of Myeloma Cells: Insights from Genomewide CRISPR-Based Functional Genomic Screens

Sara Gandolfi, MD, Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Michal Sheffer, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 3028.

https://doi.org/10.1182/blood.V130.Suppl_1.3028.3028

Published: 2017

Journal Articles

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

Ricardo De Matos Simoes, PhD, Eugen Dhimolea, PhD, Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Geoffrey Matthews, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 2501.

https://doi.org/10.1182/blood.V130.Suppl_1.2501.2501

Published: 2017

Journal Articles

Hemogenic Endothelium-like Changes Were Derived to an Adult Human Dermal Fibroblast By Electrical Stimulation

Takuji Matsuo, MD, Ryosuke Shirasaki, MD PhD, Oka Yoko, MD, PhD, Tadashi Yamamoto, MD, Jun Ooi, MD, Kennsuke Matsumoto, MD, PhD, Naoki Shirafuji, MDPhD

Blood (2014) 124 (21): 5129.

https://doi.org/10.1182/blood.V124.21.5129.5129

Published: 2014

Journal Articles

T Cell Receptor Vbeta Repertoire Plays An Important Role In Graft-Versus-Leukemia Effect To Acute Lymphocytic Leukemia With TCF3-PBX1

Yoko Oka, MD, PhD, Ryosuke Shirasaki, MD, PhD, Takuji Matsuo, MD, Haruko Tashiro, MD, PhD, Jun Ooi, MD, Naoki Shirafuji, MD, PhD

Blood (2013) 122 (21): 5434.

https://doi.org/10.1182/blood.V122.21.5434.5434

Published: 2013

Journal Articles

Neutralization Of Vascular Endothelial Growth Factor-A Induced CD138-Expression In Bone Marrow Cells From Multiple Myeloma Patients

Ryosuke Shirasaki, MD, PhD, Takuji Matsuo, MD, Yoko Oka, MD, PhD, Jun Ooi, MD, Naoki Shirafuji, MD,PhD

Blood (2013) 122 (21): 5331.

https://doi.org/10.1182/blood.V122.21.5331.5331

Published: 2013

NARROW

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Interactions with a "Humanized" Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

Mechanisms Regulating Myeloma Cell Responsiveness to Antisense Oligonucleotides Targeting IRF4

Heterogeneity of Molecular Mechanisms Determining Blood Cancer Cell Lines Resistance to Natural Killer Cells in the Context of Tumor-Stromal Interactions: Insights from Studies of Pooled "DNA-Barcoded" Cell Line Panels

Functional Characterization of Genes Driving Enhanced Biological Aggressiveness of Myeloma Cells: Identification of Novel and Understudied "Drivers" of Myeloma

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma

CRISPR Activation Screen for HDAC Inhibitor Resistance

CRISPR Activation Screen for Drivers of MM Cell Proliferation

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Identification of Molecular Markers of Tumor Cell Sensitivity and Resistance to Natural Killer Cells through Genome-Wide CRISPR Activation and CRISPR Editing Screens in Multiple Myeloma Cell Lines: Implications for Anti-Myeloma Immunotherapy

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Long-Term Interactions with Bone Marrow Stromal Cells Alter the Molecular Dependencies of Myeloma Cells: Insights from Genomewide CRISPR-Based Functional Genomic Screens

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

Hemogenic Endothelium-like Changes Were Derived to an Adult Human Dermal Fibroblast By Electrical Stimulation

T Cell Receptor Vbeta Repertoire Plays An Important Role In Graft-Versus-Leukemia Effect To Acute Lymphocytic Leukemia With TCF3-PBX1

Neutralization Of Vascular Endothelial Growth Factor-A Induced CD138-Expression In Bone Marrow Cells From Multiple Myeloma Patients

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American Society of Hematology

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