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Ryo Kurita, PhD
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Journal Articles

Ex vivo Engineering of Red Blood Cells

Jan Frayne, BsC, PhD, Deborah E Daniels, Jan Frayne, BsC PhD, Timothy J Satchwell, PhD, Joseph Hawksworth, BSc PhD, Belinda K Singleton, Tatyana N Andrienko, PhD, Marieangela C Wilson, Sabine Kupzig, Marjolein Meinders, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Ivan Ferrer Vicens, PhD MSc, BSc, Rebecca Griffiths, PhD, Nicola Cogan, Kongtana Trakarnsanga, MD PhD, David J. Anstee, PhD FRCPath, Ashley Mark Toye, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-5.
https://doi.org/10.1182/blood-2019-121117
Published: 2019
Journal Articles

Knockdown of HNF4A Gene Increases Fetal Hemoglobin Synthesis in Hudep-2

Ingrid Grazielle Sousa, BSc, MSc, Priscila Keiko Matsumoto Martin, PhD, Dulcinéia Martins de Albuquerque, BSc, PhD, Carolina Lanaro, BSc, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Fernando Ferreira Costa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 968.
https://doi.org/10.1182/blood-2019-130920
Published: 2019
Journal Articles

Identification of Potential Chemical Compounds Able to Trigger Enucleation of Immortalized Human Erythroid Cell Lines

Svetlana Soboleva, Ryo Kurita, PhD, Fredrik Ek, PhD, Rita Alves, Roger Olsson, PhD, Yukio Nakamura, MD PhD, Kenichi Miharada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 951.
https://doi.org/10.1182/blood-2019-128427
Published: 2019
Journal Articles

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Hanyia Zaidi, Silvia Pires Lourenco, MSc, Carla Casu, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD, Vanessa Carrion, RN, CPN, Virginia Guzikowski, RN, MSN, CRNP, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3477.
https://doi.org/10.1182/blood-2018-99-111319
Published: 2018
Journal Articles

A Single -195 C < G HBG1 Promoter Mediated By CRISPR/Cas9 Genome Editing Induces Fetal Hemoglobin Synthesis in Hudep-2

Priscila Keiko Matsumoto Martin, PhD, Dulcinéia Martins de Albuquerque, PhD, Carolina Lanaro, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Fernando F. Costa, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3481.
https://doi.org/10.1182/blood-2018-99-118534
Published: 2018
Journal Articles

Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations

Yuxuan Wu, PhD, Mitchel A. Cole, BS, Abdou Mousas, Jing Zeng, MD, Qiuming Yao, PhD, Divya Vinjamur, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Guillame Lettre, PhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 532.
https://doi.org/10.1182/blood-2018-99-120229
Published: 2018
Journal Articles

High-Level Setd8 Expression Is Important for Establishment of Normal Patterns of Erythroid Gene Expression and Is Essential for Stress Erythropoiesis

Tyler A Couch, BS, Zachary C. Murphy, PhD, Jacquelyn Lillis, MS, Michael Getman, MS, Paul D. Kingsley, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Laurie A. Steiner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 499.
https://doi.org/10.1182/blood-2018-99-116609
Published: 2018
Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2018-99-117043
Published: 2018
Journal Articles

HMGB1 Causes Anemia of Inflammation By Modulating Erythropoietin Signal Transduction

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Huan Yang, PhD, Ronak H Shah, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Lily Huang, PhD, Betty Diamond, MD, Jeffrey M Lipton, MD PhD, Mohandas Narla, DSc, Ulf Andersson, MDPhD, Kevin Tracey, MD, Lionel Blanc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 628.
https://doi.org/10.1182/blood-2018-99-119553
Published: 2018
Journal Articles

Human Erythroblasts with c-Kit Activating Mutations Have Reduced Cell Culture Costs and Remain Capable of Terminal Maturation and Enucleation

Tyler A Couch, BS, Zachary C. Murphy, PhD, Michael Getman, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Laurie A. Steiner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2315.
https://doi.org/10.1182/blood-2018-99-117157
Published: 2018
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

SIRT1 Increases the Expression of Fetal Hemoglobin Genes in Human Adult and Cord Blood Erythroblasts

Yan Dai, PhD, Tyngwei Chen, Heba Ijaz, Elizabeth Cho, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Martin H. Steinberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 287.
https://doi.org/10.1182/blood.V130.Suppl_1.287.287
Published: 2017
Journal Articles

A Long Noncoding RNA from the HBS1L-MYB Intergenic Region on Chr6q23 Regulates Human Fetal Hemoglobin Expression

Tasha A. Morrison, MPH,BA, Ibifiri Wilcox, BS, Hong-Yuan Luo, PhD, John Farrell, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, George J Murphy, PhD, Shuaiying Cui, PhD, Martin H. Steinberg, MD, David H.K. Chui, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 288.
https://doi.org/10.1182/blood.V130.Suppl_1.288.288
Published: 2017
Journal Articles

Screening Fetal Hemoglobin Inducing Compounds in Human Umbilical Cord Blood-Derived Erythroid Progenitor Cells

Yankai Zhang, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Vivien Sheehan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2222.
https://doi.org/10.1182/blood.V130.Suppl_1.2222.2222
Published: 2017
Journal Articles

High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling

Brian M Dulmovits, MS, Julien Papoin, MS, Jian Hua Li, MS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Yousef Al-Abed, MD, Luanne L. Peters, PhD, Betty Diamond, MD, Anupama Narla, MD, Jeffrey M Lipton, MDPhD, Mohandas Narla, DSc, Kevin Tracey, MD, Lionel Blanc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2196.
https://doi.org/10.1182/blood.V130.Suppl_1.2196.2196
Published: 2017
Journal Articles

Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression

Silvia Pires Lourenco, MSc, Amaliris Gonzalez, PhD, Tobias Raabe, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Laura Breda, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5563.
https://doi.org/10.1182/blood.V130.Suppl_1.5563.5563
Published: 2017
Journal Articles

Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing)

Daniel E. Bauer, MD, PhD, Matthew C. Canver, B.S., Elenoe C. Smith, PhD, Falak Sher, PhD, Luca Pinello, PhD, Neville E. Sanjana, PhD, Ophir Shalem, PhD, Diane D. Chen, B.S., Patrick G. Schupp, B.S., Divya S. Vinjamur, PhD, Sara P. Garcia, PhD, Sidinh Luc, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Yuko Fujiwara, PhD, Takahiro Maeda, MD, PhD, Guo-Cheng Yuan, PhD, Guillaume Lettre, PhD, Feng Zhang, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2015) 126 (23): 638.
https://doi.org/10.1182/blood.V126.23.638.638
Published: 2015
Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Takeshi Masuda, PhD, Xin Wang, PhD, Manami Maeda, MD, PhD, Matthew C. Canver, B.S., Falak Sher, PhD, Alister P.W. Funnell, PhD, Chris Fisher, PhD, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Ruijia Zhu, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Jian Xu, PhD, Douglas R. Higgs, FRS, Merlin Crossley, DPhil, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Peter V. Kharchenko, PhD, Takahiro Maeda, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2.
https://doi.org/10.1182/blood.V126.23.2.2
Published: 2015
Journal Articles

Newly Developed Measles Viral Vector Can Efficiently Transduce Multiple Genes into naïve T Cells

Takafumi Hiramoto, PhD, Maino Tahara, PhD, Yoshie Miura, PhD, Yuichiro Nakatsu, PhD, Toru Kubota, MD PhD, Ryo Kurita, PhD, Hiroshi Hamana, PhD, Chika Sakamoto, Megumi Narusawa, PhD, Saori Yamaguchi, Hiroaki Ono, MD, Jiuan Liao, PhD, Takenobu Nii, PhD, Yuto Takishima, Michiyo Okada, Yumiko Matsumura, DVM PhD, Yoshihiro Tanaka, PhD, Kazunari Yamada, MD, PhD, Yasuki Hijikata, MD PhD, Hiroshi Kohara, PhD, Sonoko Ishihara, MD PhD, Toshihisa Tsuruta, MD PhD, Toshihiko Okazaki, MD PhD, Hiroyuki Kishi, MD PhD, Atsushi Muraguchi, MD PhD, Akihide Ryo, MD PhD, Makoto Takeda, MD PhD, Kenzaburo Tani, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4798.
https://doi.org/10.1182/blood.V124.21.4798.4798
Published: 2014
Journal Articles

Efficient Induction of Hematopoietic Progenitor/Stem Cell Differentiation by Lentiviral Gene Transduction of TAL1/SCL Into Human ES Cells.

Ryo Kurita, PhD, Yoshie Miura, PhD, Michiyo Okada, Rui Kageyama, Takafumi Hiramoto, Tomoko Yokoo, Megumi Narusawa, Youko Suehiro, PhD, M.D., Hiroyuki Inoue, PhD, M.D., Tomotoshi Marumoto, PhD, M.D., Atsushi Takahashi, PhD, M.D., Kenzaburo Tani, PhD, M.D.
Journal: Blood
Blood (2009) 114 (22): 1477.
https://doi.org/10.1182/blood.V114.22.1477.1477
Published: 2009