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Rukhsana Aslam, PhD
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Journal Articles

CD4+CD25+Foxp3+ T Regulatory Cells Protect Against Murine Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2342.
https://doi.org/10.1182/blood.V126.23.2342.2342
Published: 2015
Journal Articles

Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michael Kim, BSc, Anne Zufferey, PhD, Heyu Ni, MD PhD, Michelle Catalina, PhD, Richard Francovitch, PhD
Journal: Blood
Blood (2015) 126 (23): 1045.
https://doi.org/10.1182/blood.V126.23.1045.1045
Published: 2015
Journal Articles

Thymic-Derived Tolerizing Dendritic Cells Are up-Regulated upon Treatment with Intravenous Immunoglobulin or Splenectomy in a Murine Model of Immune Thrombocytopenia

Rick Kapur, MD PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, Michael Kim, BSc, Anne Zufferey, PhD, Li Guo, MD, George B. Segel, MD, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 2251.
https://doi.org/10.1182/blood.V126.23.2251.2251
Published: 2015
Journal Articles

Murine Bone Marrow-Derived Megakaryocytes Are Capable of Antigen Cross-Presentation on Major Histocompatibility Class (MHC) I Molecules

Anne Zufferey, PhD, Edwin R. Speck, BRT, Li Guo, MD, Rukhsana Aslam, PhD, Rick Kapur, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3465.
https://doi.org/10.1182/blood.V126.23.3465.3465
Published: 2015
Journal Articles

C-Reactive Protein (CRP) Enhances Murine Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Rick Kapur, MD PhD, Michael Kim, BSc, Shanjee Shanmugabhavananthan, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Li Guo, MD, Anne Zufferey, PhD, John W. Semple, PhD
Journal: Blood
Blood (2015) 126 (23): 3561.
https://doi.org/10.1182/blood.V126.23.3561.3561
Published: 2015
Journal Articles

CD20 B Cell Depleting Therapy Is Associated with up-Regulation of CD8 + CD25 high Foxp3 + T Regulatory Cells in a Murine Model of Immune Thrombocytopenia (ITP)

Li Guo, MD, Rukhsana Aslam, PhD, Yajing Zhao, Edwin R. Speck, BRT, Heyu Ni, MD PhD, John W. Semple, PhD
Journal: Blood
Blood (2014) 124 (21): 2785.
https://doi.org/10.1182/blood.V124.21.2785.2785
Published: 2014
Journal Articles

Megakaryocyte Abnormalities Occur In The Absence Of Cell-Mediated Immunity In a Murine Model Of Passive Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Kristin Hunt, Yu Hou, Rukhsana Aslam, PhD, Edwin R. Speck, Heyu Ni, MD, PhD, Alan H Lazarus, PhD
Journal: Blood
Blood (2013) 122 (21): 3537.
https://doi.org/10.1182/blood.V122.21.3537.3537
Published: 2013
Journal Articles

Human and Murine Immune Thrombocytopenia (ITP) Is Associated with a Peripheral Deficiency of CD4- T Regulatory Cells (Tc-regs)

John W. Semple, PhD, Daoxin Ma, PhD, Rukhsana Aslam, PhD, Ming Hou, Heyu Ni, MD, PhD, Yu Hu
Journal: Blood
Blood (2012) 120 (21): 3333.
https://doi.org/10.1182/blood.V120.21.3333.3333
Published: 2012
Journal Articles

Thrombopoietin Can Induce Tolerogenic Responses Via the Modulation of Thymic and Splenic T Lymphocyte Populations in a Murine Model of Immune Thrombocytopenia (ITP)

John W. Semple, PhD, Xu Zhang, Yu Hu, Li Guo, Edwin R. Speck, Heyu Ni, MD, PhD, Rukhsana Aslam, PhD
Journal: Blood
Blood (2012) 120 (21): 1088.
https://doi.org/10.1182/blood.V120.21.1088.1088
Published: 2012
Journal Articles

The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Yuhan Chen, Michael Kim, Arata Tabuchi, Wolfgang M. Kuebler, MD, PhD, Rukhsana Aslam, PhD, John J. Freedman, MD, FRCPC, John W. Semple, PhD
Journal: Blood
Blood (2010) 116 (21): 3351.
https://doi.org/10.1182/blood.V116.21.3351.3351
Published: 2010
Journal Articles

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Leola Chow, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michelle Lee Webster, MSc, Pingguo Chen, PhD, Heyu Ni, MD, PhD, John Freedman, MD, John W. Semple, PhD
Journal: Blood
Blood (2008) 112 (11): 399.
https://doi.org/10.1182/blood.V112.11.399.399
Published: 2008
Journal Articles

A New Murine Model of Immune Thrombocytopenia: Evidence of Both Antibody- and CD8+ T Cell-Mediated Platelet Destruction.

Leola Chow, PhD, Heyu Ni, MD, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Pingguo Chen, John Freedman, MD, John W. Semple, PhD
Journal: Blood
Blood (2007) 110 (11): 99.
https://doi.org/10.1182/blood.V110.11.99.99
Published: 2007
Journal Articles

Lipopolysaccharide Binds Platelet Toll-Like Receptor 4 and Mediates the Activation of Phagocytes in the Reticuloendothelial System (RES): A Novel Mechanism of Host Immunity.

John W. Semple, PhD, Rukhsana Aslam, PhD, Edwin R. Speck, BRT, John Freedman, MD
Journal: Blood
Blood (2006) 108 (11): 1093.
https://doi.org/10.1182/blood.V108.11.1093.1093
Published: 2006
Journal Articles

The Specificity and Isotype of Monoclonal Anti-D Antibodies Dictates Their Ability To Inhibit Opsonized Platelet Phagocytosis.

John W. Semple, PhD, Rukhsana Aslam, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Donald I.H. Stewart, PhD, Erik Weirsma, PhD, John Freedman, MD, Mimi Kjaersgaard, MD
Journal: Blood
Blood (2006) 108 (11): 21.
https://doi.org/10.1182/blood.V108.11.21.21
Published: 2006