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Rüdiger Hehlmann, MD
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Journal Articles

Absolute BCR-ABL Transcript Levels At 3 Months but Not At Diagnosis Predict Survival of Chronic Myeloid Leukemia (CML) Patients On Imatinib Therapy

Benjamin Hanfstein, MD, Valeria Shlyakhto, Michael Lauseker, Philipp Erben, MD, Susanne Saussele, MD, Alice Fabarius, PhD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, Joerg Schubert, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Gabriela M. Baerlocher, MD, Markus Pfirrmann, Joerg Hasford, Wolf-Karsten Hofmann, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD
Journal: Blood
Blood (2012) 120 (21): 3761.
https://doi.org/10.1182/blood.V120.21.3761.3761
Published: 2012
Journal Articles

Secondary Malignancies in CML Patients – Data From the German CML Study IV

Manuel Barreto Miranda, MD, Michael Lauseker, Ulrike Proetel, MD, Annette Schreiber, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hermann Einsele, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf-Karsten Hofmann, Martin C. Müller, MD, Markus Pfirrmann, Andreas Hochhaus, MD, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 3746.
https://doi.org/10.1182/blood.V120.21.3746.3746
Published: 2012
Journal Articles

Impact of Balanced or Unbalanced Karyotype At Diagnosis On Prognosis of CML: Long-Term Observation From 1346 Patients of the Randomized CML Study IV

Alice Fabarius, PhD, Claudia Haferlach, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, Martine Jotterrand, MD, Ulrike Proetel, MD, Wolf-Karsten Hofmann, Stefan W. Krause, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, PhD, Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Rüdiger Hehlmann, MD, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 913.
https://doi.org/10.1182/blood.V120.21.913.913
Published: 2012
Journal Articles

Complete Molecular Remission (CMR 4.5) of CML Is Induced Faster by Dose – Optimized Imatinib and Predicts Better Survival - Results From the Randomized CML-Study IV

Rüdiger Hehlmann, MD, Michael Lauseker, Benjamin Hanfstein, MD, Martin C. Müller, MD, Annette Schreiber, MD, Ulrike Proetel, MD, Markus Pfirrmann, Claudia Haferlach, MD, Susanne Schnittger, PhD, Hermann Einsele, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, PhD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, Dominik Heim, MD, Hermann Heimpel, Christoph Nerl, MD, Stefan W. Krause, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Andreas Hochhaus, MD, Joerg Hasford, Susanne Saussele, MD
Journal: Blood
Blood (2012) 120 (21): 67.
https://doi.org/10.1182/blood.V120.21.67.67
Published: 2012
Journal Articles

Distinct Characteristics of e13a2 versus e14a2 BCR-ABL Chronic Myeloid Leukemia under Upfront Treatment with Imatinib – an Analysis of the German CML Study IV,

Benjamin Hanfstein, MD, Philipp Erben, MD, Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Sven Haag, Susanne Schnittger, PhD, Claudia Haferlach, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Jörg E. A. Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C. Müller, MD, for The German CML Study Group, for The SAKK
Journal: Blood
Blood (2011) 118 (21): 3773.
https://doi.org/10.1182/blood.V118.21.3773.3773
Published: 2011
Journal Articles

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Susanne Saussele, MD, Michael Lauseker, Ulrike Proetel, MD, Martin C. Müller, MD, Benjamin Hanfstein, MD, Annette Schreiber, MD, Florian Nolte, MD, Gabriela M. Baerlocher, MD, Gerhard Ehninger, MD, Dominik Heim, MD, Dieter K. Hossfeld, MD, PhD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Wolf Karsten Hofmann, MD, PhD, Jörg Hasford, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Rüdiger Hehlmann, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 781.
https://doi.org/10.1182/blood.V118.21.781.781
Published: 2011
Journal Articles

Impact of Additional Cytogenetic Alterations At Diagnosis on Prognosis of CML: Long-Term Observation From 1151 Patients of the Randomized CML Study IV

Alice Fabarius, PhD, Armin Leitner, MD, Andreas Hochhaus, MD, Martin C Müller, MD, Claudia Haferlach, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD, Martine Jotterand, MD, Andreas Reiter, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Juliana Schwaab, MD, Wolf-Karsten Hofmann, Joerg E. A. Schubert, MD, Hermann Einsele, Anthony D. Ho, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Wolfgang Hiddemann, PhD, Gabriela M. Baerlocher, MD, Michael Lauseker, Markus Pfirrmann, PhD, Susanne Saussele, MD, Rüdiger Hehlmann, MD, Joerg Hasford, MD
Journal: Blood
Blood (2011) 118 (21): 782.
https://doi.org/10.1182/blood.V118.21.782.782
Published: 2011
Journal Articles

Molecular and Cytogenetic Response After 3 Months of Imatinib Treatment Is Predictive for the Risk of Disease Progression and Death in Newly Diagnosed Chronic Myeloid Leukemia Patients – a Follow-up Analysis of the German CML Study IV

Benjamin Hanfstein, MD, Martin C. Müller, MD, Philipp Erben, MD, Michael Lauseker, Susanne Saussele, MD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Claudia Haferlach, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Jörg E. A. Schubert, MD, Hermann Einsele, MD, Mathias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 783.
https://doi.org/10.1182/blood.V118.21.783.783
Published: 2011
Journal Articles

Prediction of Molecular Response of Chronic Phase CML Patients by the EUTOS Score: Results of the Randomized CML-Study IV,

Susanne Saussele, MD, Michael Lauseker, Verena Hoffmann, MA., Ulrike Proetel, MD, Benjamin Hanfstein, MD, Gabriela M. Baerlocher, MD, Dominik Heim, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Anthony D. Ho, MD, PhD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Karsten Spiekermann, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Andreas Hochhaus, MD, Jörg Hasford, MD, Rüdiger Hehlmann, MD, Martin C Müller, MD, for The SAKK, The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 3762.
https://doi.org/10.1182/blood.V118.21.3762.3762
Published: 2011
Journal Articles

Time-Related Interpretation of Molecular Response Levels According to Long Term Overall and Progression-Free Survival of CML Patients on First-Line Imatinib Treatment

Martin C. Müller, MD, Benjamin Hanfstein, MD, Michael Lauseker, Philipp Erben, MD, Ulrike Proetel, MD, Susanne Schnittger, PhD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Joerg E. A. Schubert, MD, Hermann Einsele, MD, Matthias Hänel, MD, Jolanta Dengler, MD, Christiane Falge, MD, Lothar Kanz, MD, Andreas Neubauer, MD, Michael Kneba, MD, Frank Stegelmann, MD, Michael Pfreundschuh, MD, Cornelius F. Waller, MD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Susanne Saussele, MD, Andreas Hochhaus, MD, for The SAKK, for The German CML Study Group
Journal: Blood
Blood (2011) 118 (21): 1681.
https://doi.org/10.1182/blood.V118.21.1681.1681
Published: 2011
Journal Articles

Outcome of Patients with Chronic Myeloid Leukemia After Allogeneic Stem Cell Transplantation in Europe; Data From the EUTOS for CML Registry

Susanne Saussele, MD, Verena Hoffmann, MA., Doris Lindörfer, Andreas Hochhaus, MD, Francisco Cervantes, MD, Gert Ossenkoppele, MD, PhD, Henrik Hjorth-Hansen, MD, Steve O'Brien, PhD, Jiri Mayer, MD, Karel Indrak, Andrzej Hellmann, MD, Adriana Colita, MD, Anna Turkina, MD, PhD, Andrey Zaritskey, Juan Luis Steegmann, MD, PhD, David Marin, Markus Pfirrmann, PhD, Michele Baccarani, MD, Joelle Guilhot, Joerg Hasford, MD, Carmen Piccolo, MD, Bengt Simonsson, MD, PhD, Rüdiger Hehlmann, MD, Gianantonio Rosti, MD
Journal: Blood
Blood (2011) 118 (21): 1688.
https://doi.org/10.1182/blood.V118.21.1688.1688
Published: 2011
Journal Articles

Therapy with Imatinib In Elderly CML Patients (>65years): Results of the German CML-Study IV.

Susanne Saussele, MD, Nadine Pletsch, MD, Michael Lauseker, Armin Leitner, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Martin C. Müller, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, PhD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Stefan W. Krause, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Anthony D. Ho, MD, FRCPC, Christiane Falge, MD, Matthias Hänel, MD, M. Pfreundschuh, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, MD, Karsten Spiekermann, MD, Steffen Koschmieder, MD, Cornelius F. Waller, MD, Martin Bentz, MD, Markus Pfirrmann, PhD, Andreas Hochhaus, Jörg Hasford, MD, Rüdiger Hehlmann, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 3411.
https://doi.org/10.1182/blood.V116.21.3411.3411
Published: 2010
Journal Articles

Impact of Variant t(9;22) and Additional Cytogenetic Aberrations at Diagnosis on Prognosis of CML

Armin Leitner, MD, Susanne Saussele, MD, Claudia Haferlach, MD, Brigitte Schlegelberger, MD, PhD, Gudrun Göhring, MD, Susanne Jung-Munkwitz, MD, Ulrike Proetel, MD, Michael Lauseker, Markus Pfirrmann, PhD, Jörg Hasford, MD, Andreas Hochhaus, Rüdiger Hehlmann, MD, The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 355.
https://doi.org/10.1182/blood.V116.21.355.355
Published: 2010
Journal Articles

Superior CMR-Rates with Tolerability-Adapted Imatinib 800 Mg Vs. 400 Mg Vs. 400 Mg + IFN In CML: The Randomized German CML-Study IV

Rüdiger Hehlmann, MD, Susanne Jung-Munkwitz, MD, Michael Lauseker, Martin C. Müller, MD, Armin Leitner, MD, Nadine Pletsch, MD, Ulrike Proetel, MD, Alois Gratwohl, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Christoph Nerl, MD, PhD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Leopold Balleisen, MD, Hermann Einsele, MD, Christiane Falge, MD, Anthony D. Ho, MD, FRCPC, Matthias Hänel, MD, Michael Pfreundschuh, MD, Lothar Kanz, MD, Frank Stegelmann, MD, Claus-Henning Köhne, MD, Stephan Kremers, CA, MD, Karsten Spiekermann, MD, Steffen Koschmieder, Cornelius F. Waller, MD, Martin Bentz, MD, Stefan W. Krause, MD, Benjamin Hanfstein, MD, Susanne Schnittger, PhD, Markus Pfirrmann, PhD, Jörg Hasford, MD, Andreas Hochhaus, Susanne Saussele, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 357.
https://doi.org/10.1182/blood.V116.21.357.357
Published: 2010
Journal Articles

Molecular Response After 3 Months of 1st Line Imatinib Therapy Is Predictive for Treatment Failure and Disease Progression In Patients with Chronic Phase Chronic Myeloid Leukemia - a Follow-up Analysis of the German CML Study IV

Benjamin Hanfstein, MD, Martin C. Müller, MD, Philipp Erben, MD, Susanne Schnittger, PhD, Susanne Saussele, MD, Armin Leitner, MD, Ulrike Proetel, MD, Gerhard Ehninger, MD, Dieter K. Hossfeld, MD, Hans-Jochem Kolb, MD, Stefan W. Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M. Baerlocher, MD, Hermann Heimpel, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 360.
https://doi.org/10.1182/blood.V116.21.360.360
Published: 2010
Journal Articles

Molecular Response <1% BCR-ABL IS at 12 Months Is Associated with Improved Overall and Progression-Free Survival. the Randomized German CML-Study IV

Martin C. Müller, MD, Andreas Hochhaus, MD, Michael Lauseker, Susanne Jung-Munkwitz, MD, Markus Pfirrmann, PhD, Armin Leitner, MD, Stefan W. Krause, MD, Nadine Pletsch, MD, Benjamin Hanfstein, MD, Susanne Schnittger, PhD, Alois Gratwohl, MD, Jörg Hasford, MD, Susanne Saussele, MD, Rüdiger Hehlmann, MD, for The German CML-Study Group
Journal: Blood
Blood (2010) 116 (21): 669.
https://doi.org/10.1182/blood.V116.21.669.669
Published: 2010
Journal Articles

Pretreatment Expression Levels of MDR1 and OCT-1 Predict Response to First Line Imatinib Treatment In Chronic Phase CML Patients

Philipp Erben, MD, Benjamin Hanfstein, MD, Umang Munjal, PhD, Hannah Daikeler, MD, Mridul Agrawal, Jr., Juliana Popa, MD, Daniel Nowak, MD, Armin Leitner, MD, Dieter K Hossfeld, MD, Hans J Kolb, MD, Stefan W Krause, MD, Christoph Nerl, MD, Hans Pralle, MD, Dominik Heim, MD, Gabriela M Baerlocher, MD, Jörg Hasford, MD, Hermann Heimpel, MD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Martin C Mueller, MD
Journal: Blood
Blood (2010) 116 (21): 671.
https://doi.org/10.1182/blood.V116.21.671.671
Published: 2010
Journal Articles

Stability of Conversion Factors for BCR-ABL Monitoring -– Implications for the Frequency of Validation Rounds

Martin C. Müller, MD, Umang Munjal, PhD, Philipp Erben, MD, Thomas Lion, MD, PhD, Gerlinde Mitterbauer-Hohendanner, MD, Hakim El Housni, MD, Nancy Boeckx, Renata Zadro, MD, PhD, Jiri Mayer, MD, PhD, Peter Rohon, MD, Jana Rulcova, PhD, Lykke Grubach, Kadri Raudsepp, MD, Veli Kairisto, MD, PhD, Francois-Xavier Mahon, MD, PhD, Claude Preudhomme, MD, Sandrine Hayette, MD, Jean Gabert, MD, Jean-Michel Cayuela, MD, PhD, Christian Thiede, Lars Galonska, MD, Heike Pfeifer, MD, Carsten Hirt, MD, Philippe Schafhausen, MD, Nils von Neuhoff, PhD, Martin Roskos, MD, Christiane Pott, MD, Thoralf Lange, MD, Georg Hess, MD, Susanne Schnittger, PhD, Annika Dufour, MD, Steffen Koschmieder, MD, Frank Stegelmann, MD, Katerina Zoi, MD, PhD, Kostas Stamatopoulos, Hajnalka Andrikovics, MD, PhD, Tali Tohami, MD, PhD, Giovanni Martinelli, MD, Barbara Izzo, PhD, Enrico Gottardi, MD, Mindaugas Stoskus, Dag Andre Nymoen, MD, Tomasz Sacha, MD, Joana Diamond, MD, PhD, Rodica Talmaci, PhD, Andrey Misyurin, MD, Michael V. Dubina, MD, Tadej Pajic, MD, PhD, Josep F. Nomdedeu, MD, Dolors Colomer, MD, PhD, Gisela Barbany-Bustinza, MD, Hans Ehrencrona, MD, Elisabeth Oppliger Leibundgut, PhD, Jeroen Janssen, MD, Vincent H. J. van der elden, MD, Peter J.M. Valk, MD, PhD, Ugur Ozbek, MD, PhD, Lihui Wang, Gareth Gerrard, PhD, Helen E White, PhD, Thomas Schenk, MD, Thomas Ernst, MD, Rüdiger Hehlmann, MD, Giuseppe Saglio, MD, PhD, Andreas Hochhaus, MD, Nicholas C. P. Cross, PhD
Journal: Blood
Blood (2010) 116 (21): 893.
https://doi.org/10.1182/blood.V116.21.893.893
Published: 2010
Journal Articles

Interferon Alpha 2a (IFN) Maintenance Therapy After Imatinib Plus IFN Induction Therapy in Chronic Myeloid Leukemia (CML) Induces Stable Long-Term Molecular Remissions and Is Associated with Increased Proteinase 3 (PR3) Expression and the Presence of PR1-Specific T-Cells.

Andreas Burchert, MD, Martin C Müller, MD, Philippe Kostrewa, med., Philipp Erben, MD, Tilman Bostel, MD, Simone Liebler, MD, Rüdiger Hehlmann, MD, Andreas Neubauer, MD, Andreas Hochhaus, MD
Journal: Blood
Blood (2009) 114 (22): 647.
https://doi.org/10.1182/blood.V114.22.647.647
Published: 2009
Journal Articles

Complete Hematologic Response to Sunitinib in an Eosinophilia-Associated Chronic Myeloproliferative Disorder with an ETV6-FLT3 Fusion Gene.

Christoph Walz, MD, Michael Ritter, MD, Claudia Haferlach, MD, Susanne Schnittger, PhD, Christoph Schulte, MD, Torsten Haferlach, MD, PhD, Georgia Metzgeroth, MD, Rüdiger Hehlmann, MD, Andreas Hochhaus, MD, Nicholas C.P. Cross, PhD, Andreas Reiter, MD
Journal: Blood
Blood (2007) 110 (11): 3558.
https://doi.org/10.1182/blood.V110.11.3558.3558
Published: 2007