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Rossana Trotta, PhD
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Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Giovannino Silvestri, PhD, Rossana Trotta, PhD, Lorenzo Stramucci, PhD, Shuzhen Wang, PhD, Ann-Kathrin Eisfeld, MD, Bin Zhang, PhD, Klara Srutova, PhD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Fabio Stagno, MD, Paolo Vigneri, MD PhD, Georgios Nteliopoulos, PhD, Martin Guimond, PhD, Peter Hokland, MD DMSc, Michael W. Deininger, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, MD, Jane Apperley, MB, ChB, MD, Guido Marcucci, MD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Bruno Calabretta, MD PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4141.
https://doi.org/10.1182/blood-2019-131113
Published: 2019
Journal Articles

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Justin Ellis, Jason Harb, PhD, Paolo Neviani, PhD, Bin Zhang, PhD, Klara Srutova, PhD, Carlo Gambacorti-Passerini, MD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Bruno Calabretta, MD PhD, Fabio Stagno, MD PhD, Paolo Vigneri, MD PhD, G. Nteliopoulos, Philippa May, Alistair Reid, BSc, PhD, Ramiro Garzon, MD, Denis-Claude Roy, MD, Martin Guimond, PhD, Peter Hokland, MD, Michael W. Deininger, MD PhD, Garrett Fitzgerald, MD, Chris Harman, MD, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, PhD, Jane F. Apperley, FRCP, FRCPath, MD MBChB, Guido Marcucci, MD, Jianfei Qi, PhD, Kateřina Machová Poláková, PhD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 45.
https://doi.org/10.1182/blood.V130.Suppl_1.45.45
Published: 2017
Journal Articles

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Patrick R. Baldwin, PhD, Shivani Kapoor, B.S., Karthika Natarajan, PhD, Rossana Trotta, PhD, Adriana Tron, PhD, Dennis Huszar, PhD, Eduardo Davila, PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Journal: Blood
Blood (2016) 128 (22): 35.
https://doi.org/10.1182/blood.V128.22.35.35
Published: 2016
Journal Articles

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Justine Yu, B.S., Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Masashi Sanada, MD PhD, Tomoyuki Yamaguchi, PhD, Yang Du, PhD, Jukka Westermarck, MD PhD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, Dragana Milojkovic, MD, Jane F. Apperley, MD, Denis-Claude Roy, MD, Guido Marcucci, MD, Bruno Calabretta, MD PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2909.
https://doi.org/10.1182/blood.V128.22.2909.2909
Published: 2016
Journal Articles

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML

Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Justin Ellis, Justine Yu, Jason Harb, PhD, Paolo Neviani, PhD, Guido Marcucci, MD, Klara Srutova, Katerina Machova Polakova, Denis-Claude Roy, MD, Peter Hokland, MD, Michael W. Deininger, Ravi Bhatia, MD, Carlo Gambacorti-Passerini, Dragana Milojkovic, Alistair G Reid, BSc, PhD, Jane F. Apperley, MD, Ferenc Livak, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2015) 126 (23): 53.
https://doi.org/10.1182/blood.V126.23.53.53
Published: 2015
Journal Articles

MiR-300 Acts As a Tumor Supressor in Ph+ Progenitors By Modulating the JAK2-SET/PP2A/β-Catenin Interplay

Giovannino Silvestri, PhD, Justin Ellis, Lorenzo Stramucci, PhD, Jason G Harb, PhD, Paolo Neviani, PhD, Guido Marcucci, MD, Denis-Claude Roy, MD, Peter Hokland, MD DMSc, Dragana Milojkovic, Alistair Reid, Jane F. Apperley, Ferenc M Livak, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4529.
https://doi.org/10.1182/blood.V124.21.4529.4529
Published: 2014
Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Apoptosis Induction By Clinically Active FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and in Vivo through Synergistic Downregulation of Mcl-1 and of Bcl-xL

Karthika Natarajan, PhD, Trevor J Mathias, MS, Kshama A Doshi, MS, Adriana E Tron, PhD, Manfred Kraus, PhD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD, Dennis Huszar, PhD, Maria R Baer, MD
Journal: Blood
Blood (2014) 124 (21): 3601.
https://doi.org/10.1182/blood.V124.21.3601.3601
Published: 2014
Journal Articles

CD19 Targeting of Lymphoid Malignancies by Novel Fc-Domain Engineered Monoclonal Antibody.

Farrukh Awan, MD, MS, Rosa Lapalombella, PhD, Rossana Trotta, PhD, Jonathan P Butchar, Ph.D., Bo Yu, Don Benson, MD, PhD, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Alan Jones, MD, MPH, Joseph M Flynn, David Jarjoura, Robert A. Baiocchi, MD, PhD, John Desjarlais, Susheela Tridandapani, Ph.D., Michael A. Caligiuri, M.D., Natarajan Muthusamy, PhD, John C. Byrd
Journal: Blood
Blood (2009) 114 (22): 3725.
https://doi.org/10.1182/blood.V114.22.3725.3725
Published: 2009
Journal Articles

In Vitro and In Vivo Evidence That the PP2A Inhibitor SET Regulates IFN-γ Production in Monokine-Stimulated Natural Killer Cells.

Rossana Trotta, PhD, Jessica Dal Col, PhD, Jeffrey Allard, II, BS, Paolo Neviani, PhD, Ramasamy Santhanam, PhD, Hsiaoyin Mao, MS, Brian Becknell, PhD, Jianhua Yu, PhD, Aalok Modi, BS, Bradley W. Blaser, PhD, Danilo Perrotti, MD PhD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2006) 108 (11): 928.
https://doi.org/10.1182/blood.V108.11.928.928
Published: 2006
Journal Articles

In Vitro and In Vivo Evidence That TSC-22 Is a Putative Tumor Suppressor Gene in Primary Murine and Human Leukemia.

Jianhua Yu, PhD, Li Yu, PhD, Bjoern Hackanson, MD, Min Wei, BS, Zachary Boyd, BS, Akihiko Yokohama, PhD, Chunhui Liu, BS, Rossana Trotta, PhD, Hsiaoyin C. Mao, MS, Brian Becknell, PhD, Michael S. Jaung, Shujun Liu, PhD, John C. Byrd, MD, Guido Marcucci, MD, Christoph Plass, PhD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2006) 108 (11): 2211.
https://doi.org/10.1182/blood.V108.11.2211.2211
Published: 2006