1-20 of 26
Roland P. Kuiper, PhD
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

A CRISPR/Cas9 Based Kinome Screen Identifies Bruton Tyrosine Kinase (BTK) As an Important Determinant of Asparaginase Treatment Response in Acute Lymphoblastic Leukemia

Miriam Butler, MSc, Laurens Van Der Meer, PhD, Jiangyan Yu, Silvia Jenni, PhD, Maria Pamela Dobay, PhD, Peter Hoogerbrugge, MD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Roland P. Kuiper, PhD, Frank van Leeuwen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 34.
https://doi.org/10.1182/blood.V130.Suppl_1.34.34
Published: 2017
Journal Articles

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Zeljko Antic, MD, Jiangyan Yu, MSc, Simon V. van Reijmersdal, Renske Kuiper, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2016) 128 (22): 4072.
https://doi.org/10.1182/blood.V128.22.4072.4072
Published: 2016
Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD
Journal: Blood
Blood (2015) 126 (23): 696.
https://doi.org/10.1182/blood.V126.23.696.696
Published: 2015
Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2015) 126 (23): 247.
https://doi.org/10.1182/blood.V126.23.247.247
Published: 2015
Journal Articles

Accurate Detection of Low Mosaic Mutations Associated with Therapy Resistance in Pediatric Acute Lymphoblastic Leukemia Using Single Molecule Tagging and Deep-Sequencing

Jiangyan Yu, MSc, Simon V. van Reijmersdal, Alexander Hoischen, PhD, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2015) 126 (23): 2608.
https://doi.org/10.1182/blood.V126.23.2608.2608
Published: 2015
Journal Articles

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Laurens T Van Der Meer, PhD, Jiangyan Yu, MSc, Miriam Butler, MSc, Jolien M R van der Meer, MSc, Roland P Kuiper, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 2629.
https://doi.org/10.1182/blood.V126.23.2629.2629
Published: 2015
Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2014) 124 (21): 2397.
https://doi.org/10.1182/blood.V124.21.2397.2397
Published: 2014
Journal Articles

Exome Sequencing Identifies Pxdn and DSP As Recurrently Mutated Genes in Infant ALL Patients Carrying a MLL-AF4 Translocation

Eddy HJ van Roon, PhD, Ronald Stam, PhD, Merel Willekes, BSc, Roland P. Kuiper, PhD, Rutger W.W. Brouwer, PhD, van IJcken F. Wilfred, PhD, Rob Pieters, MD PhD
Journal: Blood
Blood (2014) 124 (21): 130.
https://doi.org/10.1182/blood.V124.21.130.130
Published: 2014
Journal Articles

Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study

Judith M. Boer, PhD, Arian van der Veer, MD PhD, Dimitris Rizopoulos, PhD, Marta Fiocco, PhD, Edwin Sonneveld, PhD, Hester A. de Groot-Kruseman, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD PhD, Martin A. Horstmann, MD PhD, Marketa Zaliova, MD PhD, Chiara Palmi, Jan Trka, MD, PhD, Prof., Eva Fronkova, MD, PhD, Mariana Emerenciano, PhD, Maria do Socorro Pombo-de-Oliveira, PhD, Wojciech Mlynarski, MDPhD, Tomasz Szczepanski, MD PhD, Karin Nebral, PhD, Andishe Attarbaschi, MD PhD, Nicola C. Venn, PhD, Rosemary Sutton, PhD, Claire Schwab, BSc, Amir Enshaei, PhD, Ajay J. Vora, Martin Stanulla, MD, Martin Schrappe, MD, Gianni Cazzaniga, PhD, Valentino Conter, MD PhD, Martin Zimmerman, PhD, Anthony V. Moorman, PhD, Rob Pieters, Monique L. Den Boer, MSc, PhD
Journal: Blood
Blood (2014) 124 (21): 368.
https://doi.org/10.1182/blood.V124.21.368.368
Published: 2014
Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Naomi E van der Sligte, Manuela Krumbholz, PhD, Agata Pastorczak, MD, Blanca Scheijen, PhD, Josephine T. Tauer, Christina Nowasz, Edwin Sonneveld, PhD, Truuske H. de Bock, PhD, Tiny G. Meeuwsen - de Boer, BSc, Simon V. van Reijmersdal, BSc, Roland P. Kuiper, PhD, Jutta Bradtke, PhD, Markus Metzler, MD, Meinolf Suttorp, Evelina S. De Bont, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2715.
https://doi.org/10.1182/blood.V122.21.2715.2715
Published: 2013
Journal Articles

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

Jorn Havinga, MSc, Laurensia Yuniati, MSc, Marc Demkes, BSc, Dorette van Ingen Schenau, Msc, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2013) 122 (21): 3865.
https://doi.org/10.1182/blood.V122.21.3865.3865
Published: 2013
Journal Articles

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Blanca Scheijen, PhD, Agata Pastorczak, MD, Simon V. van Reijmersdal, BSc, Deborah A. Thomas, MD, Niangxiang Zhang, PhD, Kevin R. Coombes, PhD, Hagop M. Kantarjian, MD, Elias J. Jabbour, MD, Eveline S.J.M De Bont, MD, PhD, Frank N. van Leeuwen, PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2013) 122 (21): 1313.
https://doi.org/10.1182/blood.V122.21.1313.1313
Published: 2013
Journal Articles

Leukemia Cells with a BCR-ABL1-Like signature and/or IKZF1 deletions, but Not High CRLF2 Expression, Are Predictive of an Unfavorable Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia

Arian Van Der Veer, Esmee Waanders, PhD, Rob Pieters, MD, PhD, Marieke E. Willemse, Simon Reijmersdaal, Lisa J Russell, PhD, Christine J Harrison, PhD, FRCPath, William E. Evans, PharmD, Vincent H.J. van der Velden, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, G. Escherich, Martin Horstman, Leila mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. de Groot-Kruseman, PhD, Edwin Sonneveld, PhD, Roland P. Kuiper, PhD, Monique L. Den Boer, PhD
Journal: Blood
Blood (2012) 120 (21): 880.
https://doi.org/10.1182/blood.V120.21.880.880
Published: 2012
Journal Articles

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, BSc, Marc M Hahn, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD
Journal: Blood
Blood (2012) 120 (21): 126.
https://doi.org/10.1182/blood.V120.21.126.126
Published: 2012
Journal Articles

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Laurens T. van der Meer, PhD, Esmé Waanders, PhD, Marloes Levers, BSc, Hanka Venselaar, MSc, Debbie Roeleveld, BSc, Joachim Boos, MD, PhD, Claudia Lanvers-Kaminsky, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD, D. Maroeska W.M. te Loo, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2458.
https://doi.org/10.1182/blood.V120.21.2458.2458
Published: 2012
Journal Articles

Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

Esmé Waanders, PhD, Vincent H.J. van der Velden, PhD, Tomasz Szczepanski, Lisenka E.L.M. Vissers, PhD, Joep de Ligt, MSc, Christian Gilissen, Anke A.H. van Dijk, BSc, Simon V. van Reijmersdal, BSc, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Jacques J.M. van Dongen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 755.
https://doi.org/10.1182/blood.V118.21.755.755
Published: 2011
Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 399.
https://doi.org/10.1182/blood.V118.21.399.399
Published: 2011
Journal Articles

A Key Role for Tumor Suppressor BTG1 In the Regulation of Metabolic Stress Responses: Implications for Asparaginase Resistance In Pediatric Acute Lymphoblastic Leukemia.

Laurens van der Meer, Marloes Levers, Liesbeth van Emst, Joost C. van Galen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD, Peter Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2010) 116 (21): 1028.
https://doi.org/10.1182/blood.V116.21.1028.1028
Published: 2010
Journal Articles

Integrated Use of Minimal Residual Disease Classification and IKZF1 Alteration Status Accurately Predicts 79% of Relapses In Pediatric Acute Lymphoblastic Leukemia

Esmé Waanders, PhD, Vincent H.J. van der elden, PhD, Ellen van der Schoot, MD, PhD, Frank N. van Leeuwen, PhD, Simon V. van Reijmersdal, BSc, Valerie de Haas, PhD, Anjo J. Veerman, MD, PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Roland P. Kuiper, PhD, Jacques J.M. van Dongen, PhD
Journal: Blood
Blood (2010) 116 (21): 272.
https://doi.org/10.1182/blood.V116.21.272.272
Published: 2010