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Journal Articles

The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease

Rowan O. Brothers, Katherine B. Turrentine, Mariam Akbar, Sydney Triplett, Hongting Zhao, Tara M. Urner, Adam Goldman-Yassen, Richard A. Jones, Jack Knight-Scott, Sarah S. Milla, Shasha Bai, Amy Tang, R. Clark Brown, Erin M. Buckley

Blood (2024) 143 (21): 2145–2151.

https://doi.org/10.1182/blood.2023022011

Published: 2024

Includes: Supplemental data

Journal Articles

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Carlton D. Dampier, Marilyn Jo Telen, Ted Wun, R. Clark Brown, Payal Desai, Fuad El Rassi, Beng Fuh, Julie Kanter, Yves Pastore, Jennifer Rothman, James G. Taylor, VI, David Readett, Krupa M. Sivamurthy, Brinda Tammara, Li-Jung Tseng, Jay Nelson Lozier, Helen Thackray, John L. Magnani, Kathryn L. Hassell

Blood (2023) 141 (2): 168–179.

https://doi.org/10.1182/blood.2022015797

Published: 2023

Includes: Supplemental data

Journal Articles

Hydroxyurea Dosing in Very Young Children (HUGKISS): Challenges of Study Design

Meghna Dua, Winfred C. Wang, Timothy McCavit, Suvankar Majumdar, R. Clark Brown, Zora R. Rogers, Jeffrey Gossett, Guolian Kang, Jeremie H. Estepp

Blood (2022) 140 (Supplement 1): 11108–11109.

https://doi.org/10.1182/blood-2022-165760

Published: 2022

Journal Articles

Hydroxyurea Dosing in Very Young Children with Sickle Cell Anemia: A Multicenter, Randomized, Controlled Trial (HUGKISS)

Meghna Dua, Winfred C. Wang, R. Clark Brown, Melissa A. McNaull, Zora R. Rogers, Martha Barton, Jane Hankins, Jeffrey Gossett, Julie Richardson, Jerlym S. Porter, Guolian Kang, Jeremie H. Estepp

Blood (2022) 140 (Supplement 1): 445–446.

https://doi.org/10.1182/blood-2022-160485

Published: 2022

Journal Articles

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

R. Clark Brown, MD PhD, Kimberly Cruz, MD MS, Theodosia A. Kalfa, MD PhD, Frans A. Kuypers, PhD, Santosh L. Saraf, MD, Jeremie H. Estepp, MD, Luke R. Smart, MD, Punam Malik, MD, Mark Lerman, MD, Renae Mayer, MD, Maria D. Ribadeneira, PhD, Sanjeev Forsyth, MS, Patricia Schroeder, PhD, Eric Wu, PhD, Patrick Kelly, MD, Marilyn J. Telen, MD

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-134269

Published: 2020

Journal Articles

Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis

Carlton D. Dampier, MD, Marilyn J. Telen, MD, Ted Wun, MD, Wally R Smith, MD, R. Clark Brown, MD PhD, Payal Desai, MD, Fuad A El Rassi, MD, Julie Kanter, MD, Beng R. Fuh, MD, Yves D. Pastore, MD, Jennifer A. Rothman, MD, James G. Taylor, MD, David Readett, BM, BS, MRCP, Jay N Lozier, MDPhD, John L. Magnani, PhD, Helen M Thackray, MD, Kathryn L. Hassell, MD

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-134803

Published: 2020

Journal Articles

Assessment of Cerebral Blood Flow and Oxygen Extraction in Pediatric Sickle Cell Disease with Non-Invasive Diffuse Optical Spectroscopies

Seung Yup Lee, PhD, Eashani Sathilingam, BS, Kyle R. Cowdrick, MS, Rowan O. Brothers, BS, Wilbur A. Lam, MDPhD, R. Clark Brown, MD PhD, Clinton H. Joiner, MD PhD, Claudia R. Morris, MD, Erin M. Buckley, PhD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-142029

Published: 2020

Journal Articles

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Matthew M. Heeney, MD, David C. Rees, MD, Mariane de Montalembert, MD PhD, Isaac Odame, MD, R. Clark Brown, MD PhD, Yasser Wali, MD, Thu Thuy Nguyen, Du Lam, MD, Raquel Merino Herranz, Julie Kanter, MD

Blood (2020) 136 (Supplement 1): 22–24.

https://doi.org/10.1182/blood-2020-137081

Published: 2020

Journal Articles

Pharmacokinetics/Pharmacodynamics, Safety and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease and a History of Vaso-Occlusive Crises: Results from the Phase II, Multicenter, Open-Label Solace-Adults Study

Darla Liles, MD, Kim Smith-Whitley, MD, R Clark Brown, MD PhD, Nirmish Shah, MD, Santosh M Nair, MD, Chiaki Tanaka, PhD, Shankaranand Bodla, Gessami Sanchez-Olle, PhD, Urs Albers, PhD, Julie Kanter, MD

Blood (2020) 136 (Supplement 1): 17–19.

https://doi.org/10.1182/blood-2020-137434

Published: 2020

Journal Articles

Efficacy and Safety of Voxelotor in Adolescents and Adults with Sickle Cell Disease: HOPE Trial 72-Week Analysis

Jo Howard, MBBChir, MRCP, FRCPath, Kenneth I. Ataga, MD, R. Clark Brown, MD PhD, Maureen Achebe, MD MPH, Videlis Nduba, MD, Amal El-Beshlawy, MD, Hoda Hassab, MD, Irene Agodoa, MD, Margaret Tonda, PharmD, Sarah Gray, PhD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Elliott Vichinsky, MD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-140553

Published: 2020

Journal Articles

A Quick, Robust Protocol for Liver Iron Quantitation on 3.0 Tesla MRI Scanners

R. Clark Brown, MD PhD, Mitchell Turner, Binjian Sun, PhD, Richard Jones, PhD

Blood (2014) 124 (21): 4069.

https://doi.org/10.1182/blood.V124.21.4069.4069

Published: 2014

Journal Articles

Quantitation of Iron in Brain Structures of Children with Sickle Cell Disease and Transfusion Hemosiderosis

R. Clark Brown, MD PhD, Deqiang Qiu, PhD, Laura Hayes, MD, Vaughn Barry, PhD MPH, Richard Jones, PhD

Blood (2014) 124 (21): 1393.

https://doi.org/10.1182/blood.V124.21.1393.1393

Published: 2014

Journal Articles

Hydroxyurea Treatment of Young Children with Sickle Cell Anemia: Safety and Efficacy of Continued Treatment – the BABY HUG Follow-up Study

Zora R. Rogers, MD, Billie Fish, CCRP, Zhaoyu Luo, PhD, Rathi V. Iyer, MD, Courtney D. Thornburg, MD, MS, Sharada A. Sarnaik, MD, Sohail R. Rana, MD, Lori Luchtman-Jones, MD, Sherron M. Jackson, MD, Thomas H. Howard, MD, James F. Casella, MD, R. Clark Brown, MD, PhD, Ofelia A. Alvarez, MD, Jonathan C. Goldsmith, MD, Scott T. Miller, MD, Winfred C. Wang, MD

Blood (2011) 118 (21): 7.

https://doi.org/10.1182/blood.V118.21.7.7

Published: 2011

Journal Articles

Influence of Hemoglobin Level on Clinical Findings In Infants with Sickle Cell Anemia: Data From BABY HUG

Jeffrey D. Lebensburger, DO, Scott T Miller, MD, Thomas H. Howard, MD, James F. Casella, MD, R. Clark Brown, MD, PhD, Ming Lu, MS, Rathi V. Iyer, MD, Zora R. Rogers, MD, Winfred C. Wang, MD

Blood (2010) 116 (21): 1631.

https://doi.org/10.1182/blood.V116.21.1631.1631

Published: 2010

Journal Articles

Academic Community Standards for Chronic Transfusion Therapy In Children with Sickle Cell Anemia and Abnormal Transcranial Doppler Velocities

Banu Aygun, MD, Lisa Wruck, PhD, William Herbert Schultz, PA-C, Isaac Odame, R. Clark Brown, William C. Owen, MD, Brian W. Berman, MD, Hamayun Imran, MD, Courtney Thornburg, MD, MS, Michelle Neier, MD, Kamar Godder, MD, MPH, Stephen Nelson, MD, Cynthia A. Gauger, MD, Russell E. Ware, MD, PhD, The TWITCH Investigators

Blood (2010) 116 (21): 2643.

https://doi.org/10.1182/blood.V116.21.2643.2643

Published: 2010

Journal Articles

Neurodevelopment in Infants with Sickle Cell Anemia: Baseline Data from the Baby HUG Trial

F. Daniel Armstrong, Ph.D., T. David Elkin, Ph.D., R. Clark Brown, MD, PhD, Penny Glass, Ph.D., Renee C. Rees, PhD, Winfred C. Wang, M.D., The Baby HUG Investigators

Blood (2008) 112 (11): 713.

https://doi.org/10.1182/blood.V112.11.713.713

Published: 2008

Journal Articles

Pulmonary Function in Children with Sickle Cell Anemia Following Treatment with Hydroxyurea.

Elizabeth Record, MSN, DNP, Tamara New, MD, Randall Brown, MD, MPH, LeRoy Graham, MD, R. Clark Brown, MD, PhD

Blood (2008) 112 (11): 1435.

https://doi.org/10.1182/blood.V112.11.1435.1435

Published: 2008

Journal Articles

Transcranial Doppler (TCD) Ultrasonography in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial.

Winfred Wang, MD, Renee C Rees, PhD, Scott T. Miller, MD, R. Clark Brown, MD, PhD, James F. Casella, MD, Rathi V. Iyer, MD, Ram V. Kalpathi, M.D., Judy Luden, Zora R. Rogers, MD, Courtney Thornberg, M.D., Robert J. Adams, MD, Steven Pavlakis, MD, the BABY HUG Investigators

Blood (2008) 112 (11): 1436.

https://doi.org/10.1182/blood.V112.11.1436.1436

Published: 2008

NARROW

The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease

A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis

Hydroxyurea Dosing in Very Young Children (HUGKISS): Challenges of Study Design

Hydroxyurea Dosing in Very Young Children with Sickle Cell Anemia: A Multicenter, Randomized, Controlled Trial (HUGKISS)

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

Early Initiation of Treatment with Rivipansel for Acute Vaso-Occlusive Crisis in Sickle Cell Disease (SCD) Achieves Earlier Discontinuation of IV Opioids and Shorter Hospital Stay: Reset Clinical Trial Analysis

Assessment of Cerebral Blood Flow and Oxygen Extraction in Pediatric Sickle Cell Disease with Non-Invasive Diffuse Optical Spectroscopies

Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease

Pharmacokinetics/Pharmacodynamics, Safety and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease and a History of Vaso-Occlusive Crises: Results from the Phase II, Multicenter, Open-Label Solace-Adults Study

Efficacy and Safety of Voxelotor in Adolescents and Adults with Sickle Cell Disease: HOPE Trial 72-Week Analysis

A Quick, Robust Protocol for Liver Iron Quantitation on 3.0 Tesla MRI Scanners

Quantitation of Iron in Brain Structures of Children with Sickle Cell Disease and Transfusion Hemosiderosis

Hydroxyurea Treatment of Young Children with Sickle Cell Anemia: Safety and Efficacy of Continued Treatment – the BABY HUG Follow-up Study

Influence of Hemoglobin Level on Clinical Findings In Infants with Sickle Cell Anemia: Data From BABY HUG

Academic Community Standards for Chronic Transfusion Therapy In Children with Sickle Cell Anemia and Abnormal Transcranial Doppler Velocities

Neurodevelopment in Infants with Sickle Cell Anemia: Baseline Data from the Baby HUG Trial

Pulmonary Function in Children with Sickle Cell Anemia Following Treatment with Hydroxyurea.

Transcranial Doppler (TCD) Ultrasonography in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial.

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American Society of Hematology

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American Society of Hematology

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