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Puja Sapra
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Journal Articles

AZD4512: A novel CD22-directed antibody-drug conjugate for the treatment of b-cell malignancies

Free
Huiying Han, Morgann Klink, Kalyani Daita, Rebecca Filippi, Marcello Marelli, Jin Niu, Ryan Fleming, Andrea Christmas, Steve Arbitman, Francesca Casano, Shraddha Kale, Mark Hutchinson, Qun Du, Reena Varkey, Karyn Folliot, Chandrika Kannadka, Harini Shandilya, Jaqueline Picache, Stefanie Meyer, Rebecca Sargeant, Nicolas Damond, John Meekin, Christina Vasalou, Jennifer Wheeler, Thomas Linke, Ekaterina Jahn, Connor Hall, Balakumar Vijayakrishnan, Maximillian Lee, Ali Saleh, Kimberly Cook, Benedicte Recolin, Jay Harper, John Bullen, Krista Kinneer, Edward Rosfjord, Arthur Shaffer, Elaine Hurt, Ken Wood, Puja Sapra
Journal: Blood
Blood (2025) 146 (Supplement 1): 3296.
https://doi.org/10.1182/blood-2025-3296
Published: 2025
Journal Articles

First Disclosure of AZD9829, a TOP1i-ADC Targeting CD123: Promising Preclinical Activity in AML Models with Minimal Effect on Healthy Progenitors

Free
Dipannita Dutta, Pan Pan, Ryan Fleming, Marcio Andrade-Campos, Elena Belova, Jennifer Wheeler, Patricia Cheung, Paul Santacroce, Casey Daniels, Darrin Sabol, Brad Jakubison, Benedicte Recolin, Andrew Dippel, Margaret Wey, Arthur Shaffer, Edward Rosfjord, Elaine Hurt, Gullu Gorgun, Anas Younes, Puja Sapra
Journal: Blood
Blood (2023) 142 (Supplement 1): 5957.
https://doi.org/10.1182/blood-2023-187642
Published: 2023
Journal Articles

Novel DNA-Damaging Linker Payloads Are Active in Models of Acquired Resistance to Calicheamicin and Standard of Care

Free
Jennifer Kahler, Maureen Dougher, Jia Lu, MS, Jane Xu, MS, Tasneem Kausar, PhD, Luanna Lemon, Wenyan Zhong, PhD, Judy Lucas, Matthew Sung, PhD, Puja Sapra, PhD
Journal: Blood
Blood (2016) 128 (22): 3522.
https://doi.org/10.1182/blood.V128.22.3522.3522
Published: 2016
Journal Articles

Marked Therapeutic Efficacy of a Novel Polyethyleneglycol-SN38 Conjugate, EZN-2208, in Xenograft Models of Non-Hodgkin’s Lymphoma.

Free
Puja Sapra, PhD, Mary Mehlig, BS, Jennifer Malaby, BS, Patricia Kraft, MS, Clifford Longley, MS, Hong Zhao, PhD, Lee M. Greenberger, PhD, Ivan D. Horak, MD
Journal: Blood
Blood (2007) 110 (11): 1397.
https://doi.org/10.1182/blood.V110.11.1397.1397
Published: 2007
Journal Articles

Recombinant Human Mannose-Binding Lectin (rhMBL) Binds to Human and Mouse Cancer Cells and Elicits Antitumor Activity in a MBL Knockout Mouse Model of Murine Cancer.

Free
Puja Sapra, PhD, Patricia Kraft, MS, Mary Mehlig, BS, Zhihua Zhang, MD,PhD, Lee M. Greenberger, PhD, Ivan D. Horak, MD
Journal: Blood
Blood (2006) 108 (11): 1259.
https://doi.org/10.1182/blood.V108.11.1259.1259
Published: 2006
Journal Articles

Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG 4 antibody immunotoxin

Free
Chien-Hsing Chang, Puja Sapra, Sailaja S. Vanama, Hans J. Hansen, Ivan D. Horak, David M. Goldenberg
Journal: Blood
Blood (2005) 106 (13): 4308–4314.
https://doi.org/10.1182/blood-2005-03-1033
Published: 2005
Journal Articles

Preclinical Pharmacology and Toxicology of Humanized Anti-B-Cell Antibodies (Anti-CD22 and Anti-CD20) in Cynomolgus Monkeys (CM).

Free
Puja Sapra, PhD, Gary Kikuchi, Ph.D, Ashwini Venkatasamy, BS, Marianne K. Hayes, Ph.D, Christina M. Satterwhite, Ph.D, Darren Warren, Ph.D, Mark D. Walker, DVM, David M. Goldenberg, M.D, Ivan D. Horak, M.D
Journal: Blood
Blood (2005) 106 (11): 1471.
https://doi.org/10.1182/blood.V106.11.1471.1471
Published: 2005
Journal Articles

Preclinical Safety and Efficacy of Two Novel Immunotoxins Consisting of Ranpirnase (Rap) Fused to an Internalizing Anti-CD74 Humanized IgG4 Antibody in Human Non-Hodgkin’s Lymphoma Xenografts.

Free
Puja Sapra, PhD, Chien-Hsing Chang, Ph.D, Sailaja Vanama, Ph.D, Sharon Singh, BA, Hans J. Hansen, Ph.D, Ivan D. Horak, M.D, David M. Goldenberg, M.D
Journal: Blood
Blood (2005) 106 (11): 346.
https://doi.org/10.1182/blood.V106.11.346.346
Published: 2005
Journal Articles

Initial Safety and Efficacy Results of a Second-Generation Humanized Anti-CD20 Antibody, IMMU-106 (hA20), in Non-Hodgkin’s Lymphoma.

Free
Franck Morschhauser, John P. Leonard, Bertrand Coiffier, Marie-Odile Petillon, Morton Coleman, Amina Bahkti, Puja Sapra, Nick Teoh, William A. Wegener, Ivan D. Horak, David M. Goldenberg
Journal: Blood
Blood (2005) 106 (11): 2428.
https://doi.org/10.1182/blood.V106.11.2428.2428
Published: 2005
Journal Articles

In Vitro and In Vivo Targeting and Therapy of an Antibody-Drug Conjugate (IMMU-110) in B-Cell Malignancies.

Free
Puja Sapra, PhD, Rhona Stein, PhD, Jennifer Pickett, PhD, Serengulam V. Govindan, PhD, Thomas M. Cardillo, PhD, Christopher Damoci, BS, Agatha Sheerin, BS, Hans J. Hansen, PhD, Ivan D. Horak, MD, Gary L. Griffiths, PhD, David M. Goldenberg, ScD, MD
Journal: Blood
Blood (2004) 104 (11): 3287.
https://doi.org/10.1182/blood.V104.11.3287.3287
Published: 2004
Journal Articles

Construction and Characterization of a Novel Ribonuclease Immunotoxin Consisting of Two Ranpirnase (Rap) Molecules Fused to an Internalizing Anti-CD74 Humanized IgG4 Antibody.

Free
Sailaja S. Vanama, PhD, Puja Sapra, PhD, Hans J. Hansen, PhD, Ivan D. Horak, MD, David M. Goldenberg, ScD, MD, Chien-Hsing Chang, PhD
Journal: Blood
Blood (2004) 104 (11): 3289.
https://doi.org/10.1182/blood.V104.11.3289.3289
Published: 2004