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Peter M. Hoogerbrugge, MD, PhD
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Journal Articles

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Zeljko Antic, MD, Jiangyan Yu, MSc, Simon V. van Reijmersdal, Renske Kuiper, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2016) 128 (22): 4072.
https://doi.org/10.1182/blood.V128.22.4072.4072
Published: 2016
Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2015) 126 (23): 247.
https://doi.org/10.1182/blood.V126.23.247.247
Published: 2015
Journal Articles

Accurate Detection of Low Mosaic Mutations Associated with Therapy Resistance in Pediatric Acute Lymphoblastic Leukemia Using Single Molecule Tagging and Deep-Sequencing

Jiangyan Yu, MSc, Simon V. van Reijmersdal, Alexander Hoischen, PhD, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2015) 126 (23): 2608.
https://doi.org/10.1182/blood.V126.23.2608.2608
Published: 2015
Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 3768.
https://doi.org/10.1182/blood.V126.23.3768.3768
Published: 2015
Journal Articles

Post Induction Minimal Residual Disease Levels Identifies a Group of High Risk Relapsed Childhood Acute Lymphoblastic Leukemia (rALL) with a Favorable Outcome Independent of Induction Therapy

Catriona Anne Parker, PhD, Marie Reeves, MSc, Sharon Love, MSc, Jeremy Hancock, PhD, Peter M Hoogerbrugge, MD PhD, Rosemary Sutton, Tom Revesz, MD, Vaskar Saha, PhD FRCP, FRCPath
Journal: Blood
Blood (2015) 126 (23): 1294.
https://doi.org/10.1182/blood.V126.23.1294.1294
Published: 2015
Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD
Journal: Blood
Blood (2015) 126 (23): 696.
https://doi.org/10.1182/blood.V126.23.696.696
Published: 2015
Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study

Judith M. Boer, PhD, Arian van der Veer, MD PhD, Dimitris Rizopoulos, PhD, Marta Fiocco, PhD, Edwin Sonneveld, PhD, Hester A. de Groot-Kruseman, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD PhD, Martin A. Horstmann, MD PhD, Marketa Zaliova, MD PhD, Chiara Palmi, Jan Trka, MD, PhD, Prof., Eva Fronkova, MD, PhD, Mariana Emerenciano, PhD, Maria do Socorro Pombo-de-Oliveira, PhD, Wojciech Mlynarski, MDPhD, Tomasz Szczepanski, MD PhD, Karin Nebral, PhD, Andishe Attarbaschi, MD PhD, Nicola C. Venn, PhD, Rosemary Sutton, PhD, Claire Schwab, BSc, Amir Enshaei, PhD, Ajay J. Vora, Martin Stanulla, MD, Martin Schrappe, MD, Gianni Cazzaniga, PhD, Valentino Conter, MD PhD, Martin Zimmerman, PhD, Anthony V. Moorman, PhD, Rob Pieters, Monique L. Den Boer, MSc, PhD
Journal: Blood
Blood (2014) 124 (21): 368.
https://doi.org/10.1182/blood.V124.21.368.368
Published: 2014
Journal Articles

Aggravated Bone Density Decline after Symptomatic Osteonecrosis in Children with Acute Lymphoblastic Leukemia

Marissa den Hoed, S.M.F. Pluijm, Mariël L. Te Winkel, Hester A. de Groot-Kruseman, PhD, Marta Fiocco, PhD, Peter M. Hoogerbrugge, MD PhD, J.a. Leeuw, Marrie Bruin, MD PhD, Inge M. van der Sluis, MD PhD, Dorine Bresters, MD PhD, Maarten H. Lequin, MD PhD, Jan C. Roos, A. Veerman, MD PhD, Rob Pieters, Marry M. van den Heuvel-Eibrink
Journal: Blood
Blood (2014) 124 (21): 2260.
https://doi.org/10.1182/blood.V124.21.2260.2260
Published: 2014
Journal Articles

The Negative Impact of Underweight and Weight Loss on Survival of Children with Acute Lymphoblastic Leukemia

Marissa den Hoed, S.M.F. Pluijm, Hester A. de Groot-Kruseman, PhD, Mariël L. Te Winkel, Erica L.T. van den Akker, MD PhD, Peter M. Hoogerbrugge, MD PhD, Henk van den Berg, MD, J.a. Leeuw, Marrie Bruin, MD PhD, Dorine Bresters, MD PhD, A.J.P. Veerman, MD PhD, Marta Fiocco, PhD, Rob Pieters, MD PhD, Marry M. van den Heuvel-Eibrink
Journal: Blood
Blood (2014) 124 (21): 2261.
https://doi.org/10.1182/blood.V124.21.2261.2261
Published: 2014
Journal Articles

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurensia Yuniati, MSc, Jorn Havinga, MSc, Felice Tirone, PhD, Jean-Pierre Rouault, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2014) 124 (21): 4311.
https://doi.org/10.1182/blood.V124.21.4311.4311
Published: 2014
Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 5193.
https://doi.org/10.1182/blood.V124.21.5193.5193
Published: 2014
Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2014) 124 (21): 2397.
https://doi.org/10.1182/blood.V124.21.2397.2397
Published: 2014
Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3587.
https://doi.org/10.1182/blood.V124.21.3587.3587
Published: 2014
Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3630.
https://doi.org/10.1182/blood.V124.21.3630.3630
Published: 2014
Journal Articles

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, BSc, Marc M Hahn, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD
Journal: Blood
Blood (2012) 120 (21): 126.
https://doi.org/10.1182/blood.V120.21.126.126
Published: 2012
Journal Articles

Tumor Suppressors BTG1 and BTG2 Fulfill Both Unique and Overlapping Functions During Normal B Lymphocyte Development

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Jørn Havinga, MSc, Jean-Pierre Rouault, PhD, Felice Tirone, PhD, Peter M. Hoogerbrugge, MD, PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2012) 120 (21): 1303.
https://doi.org/10.1182/blood.V120.21.1303.1303
Published: 2012
Journal Articles

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Laurens T. van der Meer, PhD, Esmé Waanders, PhD, Marloes Levers, BSc, Hanka Venselaar, MSc, Debbie Roeleveld, BSc, Joachim Boos, MD, PhD, Claudia Lanvers-Kaminsky, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD, D. Maroeska W.M. te Loo, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2458.
https://doi.org/10.1182/blood.V120.21.2458.2458
Published: 2012
Journal Articles

Itraconazol Inhibits the P-Glycoprotein Pump and Increases Vincristine Induced Toxicity in Patients with Acute Lymphoblastic Leukemia Carrying a Genetic Variant of the MDR1 Gene

D. Maroeska W.M. te Loo, MD, PhD, Melanie Hagleitner, Peter M. Hoogerbrugge, MD, PhD, Rosalinde Masareeuw, Marieke Coenen
Journal: Blood
Blood (2011) 118 (21): 231.
https://doi.org/10.1182/blood.V118.21.231.231
Published: 2011
Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 399.
https://doi.org/10.1182/blood.V118.21.399.399
Published: 2011