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Patrick T Gunning
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Journal Articles

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Karoline V Gleixner, MD, Mathias A Schneeweiss, MD, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Daniela Berger, Gregor Eisenwort, MD PhD, Georg Greiner, MD, Konstantin Byrgazov, PhD, Gregor Hoermann, Marina Konopleva, MD PhD, Islam Waliul, Patrick T Gunning, PhD, Hiroshi Maeda, PhD, Richard Moriggl, PhD, Michael W. Deininger, MD PhD, Thomas Lion, PhD, Michael Andreeff, MD PhD, Peter Valent, MD
Journal: Blood
Blood (2016) 128 (22): 4241.
https://doi.org/10.1182/blood.V128.22.4241.4241
Published: 2016
Journal Articles

Design, Optimization, and Pre-Clinical Evaluation of Direct, Mechanism-Based STAT3 Inhibitors for Treating Myeloid Disorders

William L. Heaton, M.S., Anna M. Eiring, PhD, Nadeem A. Vellore, PhD, Diana Resetca, B.S., Sina Haftchenary, PhD, David Rosa, PhD, Ahmed M. Ali, Anna V. Senina, M.S., Anthony D. Pomicter, M.S., Brent D.G. Page, PhD, Ira L. Kraft, B.S., Kimberly R. Reynolds, M.S., Derek J. Wilson, PhD, Riccardo Baron, PhD, Thomas O'Hare, PhD, Patrick T. Gunning, PhD, Michael W. Deininger
Journal: Blood
Blood (2014) 124 (21): 4816.
https://doi.org/10.1182/blood.V124.21.4816.4816
Published: 2014
Journal Articles

A Novel Small Molecule STAT Inhibitor, BP-4-018, Demonstrates Significant Anti-Tumour Activity and Synergism With Bortezomib In Pre-Clinical In Vivo Models Of Multiple Myeloma

Danielle C Croucher, MSc, BSc, Zhihua Li, Brent D.G. Page, PhD, Ellen Nong Wei, Patrick T. Gunning, PhD, Suzanne Trudel, MD, MSC, FRCPC
Journal: Blood
Blood (2013) 122 (21): 4441.
https://doi.org/10.1182/blood.V122.21.4441.4441
Published: 2013
Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 2527.
https://doi.org/10.1182/blood.V122.21.2527.2527
Published: 2013
Journal Articles

BP5-087, a Novel STAT3 Inhibitor, Combines With BCR-ABL1 Inhibition To Overcome Kinase-Independent Resistance In Chronic Myeloid Leukemia

Anna M. Eiring, PhD, Ira L. Kraft, BS, Brent D.G. Page, PhD, Tian Y. Zhang, MD, PhD, Jamshid S. Khorashad, MD, PhD, FRCPath, Nadeem A. Vellore, PhD, Kimberly R. Reynolds, MS, Anthony D. Pomicter, MS, Anna V. Senina, MS, Matthew S. Zabriskie, BS, Shazia Ahmad, Clinton C. Mason, PhD, Richard Moriggl, PhD, Riccardo Baron, PhD, Thomas O'Hare, Patrick T. Gunning, PhD, Michael W. Deininger
Journal: Blood
Blood (2013) 122 (21): 854.
https://doi.org/10.1182/blood.V122.21.854.854
Published: 2013
Journal Articles

STAT3 Inhibition Synergizes with BCR-ABL1 Inhibition to Overcome Kinase-Independent TKI Resistance in Chronic Myeloid Leukemia (CML)

Anna M. Eiring, PhD, Ira L Kraft, BS, Brent DG Page, BS, David J Anderson, BA, Zhimin Gu, PhD, Jamshid S Khorashad, MD, PhD, Anthony D Pomicter, MS, Kimberly R Reynolds, MS, Matthew S Zabriskie, BS, Richard Moriggl, PhD, Patrick T Gunning, PhD, Thomas O'Hare, PhD, Michael W Deininger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 31.
https://doi.org/10.1182/blood.V120.21.31.31
Published: 2012
Journal Articles

BP-2-047, a Novel Small-Molecule Inhibitor of Stat3 Is Active in Myeloma Pre-Clinical Models: Rationale for Treatment of Stat3-Dependent Multiple Myeloma

Victor Hugo Jimenez-Zepeda, MD, Brent DG Page, BS, Li Zhia Hua, Ellen Wei, Leif Bergsagel, M.D., Patrick T Gunning, PhD, Suzanne Trudel, MD, MSC, FRCPC
Journal: Blood
Blood (2012) 120 (21): 576.
https://doi.org/10.1182/blood.V120.21.576.576
Published: 2012
Journal Articles

Next-Generation STAT3 Inhibitors As Targeted Therapeutics in Chronic Myeloid Leukemia.

Ira L Kraft, BS, Anna M. Eiring, PhD, Brent DG Page, BS, Clinton C Mason, PhD, Zhimin Gu, PhD, Jamshid S Khorashad, MD, PhD, David J Anderson, BA, Anthony D Pomicter, MS, Kimberly R Reynolds, MS, Johanna Estrada, Matthew S Zabriskie, BS, Patrick T Gunning, PhD, Thomas O'Hare, PhD, Michael W Deininger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2445.
https://doi.org/10.1182/blood.V120.21.2445.2445
Published: 2012
Journal Articles

The Potent STAT3/5 Inhibitor, BP-1-102 Demonstrates Significant Anti-Tumor Activity Against Waldenström Macroglobulinemia

Danielle C Croucher, Victor H Jimenez-Zepeda, MD, PD, Zhi Hua Li, Ellen Wei, Brent DG Page, James Turkson, Patrick T Gunning, Suzanne Trudel, MD, MSC, FRCPC
Journal: Blood
Blood (2011) 118 (21): 5101.
https://doi.org/10.1182/blood.V118.21.5101.5101
Published: 2011
Journal Articles

Studies of BP-1-102, a Novel Direct Small-Molecule Inhibitor of Stat3 Demonstrates Substantial Anti-Myeloma Pre-Clinical Activity

Victor H Jimenez-Zepeda, MD, PD, Zhi Hua Li, Brent DG Page, Seda Zeng, Ellen Wei, Chungyee Leung-Hagesteijn, James Turkson, Patrick T. Gunning, Suzanne Trudel, MD, MSC, FRCPC
Journal: Blood
Blood (2010) 116 (21): 138.
https://doi.org/10.1182/blood.V116.21.138.138
Published: 2010