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Osheiza Abdulmalik, DVM
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Journal Articles

Anti-Inflammatory Activities of Sulfated Non-Anticoagulant Heparin Derivative Beyond Its Anti-Sickling and Anti-Selectin for the Effective Management of Sickle Cell Disease

Noureldien Darwish, MBBCh,PhD, Osheiza Abdulmalik, DVM, Shaker A Mousa, PhDMSc,BPharm,MBA
Journal: Blood
Blood (2020) 136 (Supplement 1): 27.
https://doi.org/10.1182/blood-2020-141632
Published: 2020
Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137646
Published: 2020
Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, PhD, Ren Ren, PhD, Ruopeng Feng, PhD, Lana C Ly, Yemin Lan, PhD, Zhe Zhang, PhD, Nicholas Aboreden, Kunhua Qin, John R Horton, Jeremy D. Grevet, PhD, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Merlin Crossley, PhD, Mitchell J. Weiss, MD PhD, Xiaodong Cheng, PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54.
https://doi.org/10.1182/blood-2020-137564
Published: 2020
Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3557.
https://doi.org/10.1182/blood-2019-125664
Published: 2019
Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 73.
https://doi.org/10.1182/blood-2019-128646
Published: 2019
Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Valentina Ghiaccio, PhD, Alisa Dong, PhD, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Susan M Freier, Andy Watt, Yasuhiro Ikawa, MD PhD, Maxwell Chappell, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, MD, Marina Kleanthous, PhD, Kim Smith-Whitley, MD, Deepa Manwani, MD, Carla Casu, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, Stefano Rivella, PhD, Laura Breda, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2244.
https://doi.org/10.1182/blood-2019-127017
Published: 2019
Journal Articles

Multi-Modal Mechanisms and Anti-Sickling of Novel Sulfated Non-Anticoagulant Low Molecular Weight Heparin in Sickle Cell Disease

Shaker A Mousa, PhD BPharm, MBA, MSc, Noureldien Hassan Elsayed Darwish, MDPhDBS, Vandhana Muralidharan-Chari, PhD, Mohamed Qari, MD, Chen Qiukan, J Eric Russell, MD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2018) 132 (Supplement 1): 265.
https://doi.org/10.1182/blood-2018-99-115121
Published: 2018
Journal Articles

Heme-Regulated Inhibitor (HRI) Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD, Jeremy D. Grevet, BA, Xianjiang Lan, PhD, Osheiza Abdulmalik, DVM, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 721.
https://doi.org/10.1182/blood-2018-99-117436
Published: 2018
Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells

Jeremy D. Grevet, Nicole Hamagami, Xianjiang Lan, PhD, Laavanya Sankaranarayanan, MS, Saurabh Bhardwaj, PhD, Carolyne Face, David Posocco, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Simone Sidoli, PhD, Ben Garcia, PhD, Stella T Chou, MD, Ross C Hardison, PhD, Chris Vakoc, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 536.
https://doi.org/10.1182/blood.V130.Suppl_1.536.536
Published: 2017
Journal Articles

SCD-101: A New Anti-Sickling Drug Reduces Pain and Fatigue and Improves Red Blood Cell Shape in Peripheral Blood of Patients with Sickle Cell Disease

Robert Swift, PhD, Osheiza Abdulmalik, DVM, MS, Qiukan Chen, Toshio Asakura, MD PhD, Kelsey Gustafson, MS, James E Simon, PhD, Virdah Zaman, MS, Kevin Alexis Quiusky, MD, Kathryn L. Hassell, MD, Iuliana Shapira, MD, Gurinder Sidhu, MD, Tracian James-Goulbourne, MD, Kisha Carrington, MD, John Muthu, MD, Peter N Gillette, MD
Journal: Blood
Blood (2016) 128 (22): 121.
https://doi.org/10.1182/blood.V128.22.121.121
Published: 2016
Journal Articles

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Alisa Cheung Dong, Valentina Ghiaccio, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, Marina Kleanthous, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, MS, Laura Breda, PhD, Stefano Rivella, PhD
Journal: Blood
Blood (2016) 128 (22): 1014.
https://doi.org/10.1182/blood.V128.22.1014.1014
Published: 2016
Journal Articles

Development of a Triazolyldisulfide Compound That Increases the Affinity of Hemoglobin for Oxygen and Reduces Hypoxic Sickling of Sickle Cells

Akito Nakagawa, PhD, Ferrari Michele, MD, Chen Liu, PhD, Lorenzo Berra, MD, Elizabeth S. Klings, MD, Martin K. Safo, PhD, Donald B. Bloch, MD, Osheiza Abdulmalik, DVM, MS, Warren M. Zapol, MD
Journal: Blood
Blood (2016) 128 (22): 3642.
https://doi.org/10.1182/blood.V128.22.3642.3642
Published: 2016
Journal Articles

Vzhe-039, a Novel Structurally-Enhanced Allosteric Hemoglobin Effector Inhibits Sickling of SS Erythrocytes In Vitro , and Exhibits Improved Pharmacologic Properties In Vivo

Martin K. Safo, PhD, Guoyan Xu, PhD, Mohini Ghatge, PhD, Qiukan Chen, Carla Casu, PhD, David Tanya, PhD, Yan Zhang, PhD, Jurgen Venitz, MD PhD, Osheiza Abdulmalik, DVM, MS
Journal: Blood
Blood (2016) 128 (22): 3645.
https://doi.org/10.1182/blood.V128.22.3645.3645
Published: 2016
Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Kaiqi Sun, BS, Yang Xia, MD PhD, Angelo D'Alessandro, PhD, Mostafa H Ahmed, PhD, Yujin Zhang, MD, Anren Song, PhD, Tzu-Ping KO, Travis Nemkov, Julie Haines, Hongyu Wu, PhD, Morayo G. Adebiyi, BS, Hong Liu, MD, Aji Huang, BS, MS, Zhangzhe Peng, MD, Yuan Edward Wen, Alexander Wen, Vladimir Berka, PhD, Mikhail Bogdanov, PhD, Osheiza Abdulmalik, DVM, MS, Gregory J Kato, MD, Ah-lim Tsai, Modupe Idowu, MD, Harinder S. Juneja, MD, Rodney E. Kellems, PhD, Kirk C Hansen, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2016) 128 (22): 2474.
https://doi.org/10.1182/blood.V128.22.2474.2474
Published: 2016
Journal Articles

Temporally Distinct Developmental Waves of Erythropoiesis from Human Pluripotent Stem Cells

Orna Steinberg Shemer, MD MSc, Marta Byrska-Bishop, PhD, Jacob C Ulirsch, Osheiza Abdulmalik, DVM, MS, Yu Yao, MD, Ah Ram Kim, PhD, Paul Gadue, PhD, Paul D. Kingsley, PhD, Deborah French, PhD, Ross C. Hardison, PhD, James Palis, MD, Vijay G Sankaran, MD PhD, Mitchell J Weiss, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1170.
https://doi.org/10.1182/blood.V126.23.1170.1170
Published: 2015
Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2014) 124 (21): 218.
https://doi.org/10.1182/blood.V124.21.218.218
Published: 2014
Journal Articles

Methemoglobinemia In Rhesus Monkeys Due To M-Hemoglobinopathy

Osheiza Abdulmalik, DVM, MS, Larry Handt, DVM, MS, Martin Safo, PhD, Mary M Patterson, MS, DVM, Ping Wang, Caitlin A Fitzgerald, BS, Urs Giger, PD Dr. med. vet. MS FVH
Journal: Blood
Blood (2013) 122 (21): 4696.
https://doi.org/10.1182/blood.V122.21.4696.4696
Published: 2013
Journal Articles

Design and Validation of Genes Encoding Hyperstable β-Globin mRNAs.

Osheiza Abdulmalik, DVM, MS, J. Eric Russell, MD
Journal: Blood
Blood (2009) 114 (22): 4059.
https://doi.org/10.1182/blood.V114.22.4059.4059
Published: 2009
Journal Articles

New Approach for Finding Novel Antisickling Agents at the NIH NHLBI Sickle Cell Disease Reference Laboratory.

Toshio Asakura, MD, PhD, Jisheng Yang, Qiukan Chen, MD, Greg Evans, PhD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2006) 108 (11): 1219.
https://doi.org/10.1182/blood.V108.11.1219.1219
Published: 2006
Journal Articles

A Novel High-Throughput Method for Evaluating deoxy-Hb S Solubility.

Osheiza Abdulmalik, DVM, Patrick Lec, Jisheng Yang, Toshio Asakura, MD PhD, Kwaku Ohene-Frempong, MD, J. Eric Russell, MD
Journal: Blood
Blood (2006) 108 (11): 3782.
https://doi.org/10.1182/blood.V108.11.3782.3782
Published: 2006