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Journal Articles

Reversal of Apixaban Anticoagulation with Reduced Doses of Andexanet Alfa in a Porcine Polytrauma Model

Oliver Grottke, MD PhD MPH, Necib Akman, MD, Till Braunschweig, MD, Pamela B. Conley, PhD, Rolf Rossaint, MD

Blood (2018) 132 (Supplement 1): 2456.

https://doi.org/10.1182/blood-2018-99-114426

Published: 2018

Journal Articles

Comparison of Second and First Generation of Andexanet Alfa in a Porcine Polytrauma Model with Apixaban Anticoagulation

Oliver Grottke, MD PhD MPH, Necib Akman, MD, Till Braunschweig, MD, Pamela B. Conley, PhD, Rolf Rossaint, MD

Blood (2018) 132 (Supplement 1): 3778.

https://doi.org/10.1182/blood-2018-99-114542

Published: 2018

Journal Articles

Blood Loss in Rivaroxaban Anticoagulated Pigs with Severe Polytrauma Is Significantly Reduced By Early Therapy with Prothrombin Complex Concentrate

Oliver Grottke, MD PhD MPH, Necib Akman, MD, Till Braunschweig, MD, Markus Honickel, MD, Hugo ten Cate, MD PhD

Blood (2017) 130 (Supplement 1): 2392.

https://doi.org/10.1182/blood.V130.Suppl_1.2392.2392

Published: 2017

Journal Articles

Markers of Thromboembolic Risk Were Insignificantly Affected By Either Intraosseous or Intravenous Idarucizumab in a Dabigatran-Anticoagulated Porcine Polytrauma Model

Markus Honickel, MD, Akman Necib, MD, Hugo ten Cate, MD PhD, Rolf Rossaint, MD Prof, Oliver Grottke, MD PhD

Blood (2016) 128 (22): 2623.

https://doi.org/10.1182/blood.V128.22.2623.2623

Published: 2016

Journal Articles

Mechanistic Differences of Prothrombin Complex Concentrate and Idarucizumab in a Trauma Model Under Dabigatran Anticoagulation

Markus Honickel, MD, Joanne van Ryn, PhD, Oliver Grottke, MDPhD

Blood (2015) 126 (23): 1128.

https://doi.org/10.1182/blood.V126.23.1128.1128

Published: 2015

Journal Articles

Prothrombin Complex Concentrate or Idarucizumab in a Multimodal Hemostatic Approach with Tranexamic Acid and Fibrinogen for the Acute Reversal of Dabigatran

Oliver Grottke, MDPhD, Markus Honickel, MD, Rolf Rossaint, MDProf, Till Braunschweig, MD

Blood (2015) 126 (23): 2275.

https://doi.org/10.1182/blood.V126.23.2275.2275

Published: 2015

Journal Articles

Reversal of Trauma-Induced Bleeding and Anticoagulation with a Dabigatran-Specific Antidote (idarucizumab) As Assessed By Shed and Washed Blood Tests in a Pig Model of Supratherapeutic Anticoagulation and Trauma

Oliver Grottke, MD PhD, Markus Honickel, MD, Johanna Schurer, Joanne van Ryn, PhD

Blood (2014) 124 (21): 4268.

https://doi.org/10.1182/blood.V124.21.4268.4268

Published: 2014

Journal Articles

Prothrombin Complex Concentrate in Combination with Fibrinogen Plus Tranexamic Acid Is More Effective Than Mono-Therapy with Prothrombin Complex Concentrate in a Dabigatran Anticoagulation Experimental Polytrauma Model

Oliver Grottke, MD PhD, Markus Honickel, MD, Henri M.H. Spronk, PhD, Hugo ten Cate, Joanne van Ryn, PhD, Rolf Rossaint, MD

Blood (2014) 124 (21): 346.

https://doi.org/10.1182/blood.V124.21.346.346

Published: 2014

Journal Articles

Ex Vivo Prothrombin Complex Concentrates and a Specific Antidote Are Effective In Reversing Dabigatran-Induced Coagulopathy In Pigs

Joanne van Ryn, PhD, Henri M.H. Spronk, PhD, Rolf Rossaint, MD, Oliver Grottke, MD, PhD

Blood (2013) 122 (21): 2387.

https://doi.org/10.1182/blood.V122.21.2387.2387

Published: 2013

Journal Articles

Resuscitation With Different Volume Expanders Does Not Influence Coagulation After Antidoting Dabigatran With Its Specific Fab In a Pig Model Of Hemorrhagic Shock

Henri M.H. Spronk, PhD, Joanne van Ryn, PhD, Christian Zentai, Hugo ten Cate, MD, PhD, Rolf Rossaint, MD, Oliver Grottke, MD, PhD

Blood (2013) 122 (21): 3649.

https://doi.org/10.1182/blood.V122.21.3649.3649

Published: 2013

Journal Articles

Thrombin Generation Capacity of Prothrombin Complex Concentrate in an in Vitro Dilutional Model

Henri M.H. Spronk, PhD, Rolf Rossaint, MD, Henskens M.C. Yvonne, Rene van Oerle, Hugo Ten Cate, MD, PhD, Oliver Grottke, MD

Blood (2012) 120 (21): 4380.

https://doi.org/10.1182/blood.V120.21.4380.4380

Published: 2012

Journal Articles

Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury

Oliver Grottke, Till Braunschweig, Henri M. H. Spronk, Stephanie Esch, Annette D. Rieg, Rene van Oerle, Hugo ten Cate, Christina Fitzner, Rene Tolba, Rolf Rossaint

Blood (2011) 118 (7): 1943–1951.

https://doi.org/10.1182/blood-2011-03-343046

Published: 2011

Includes: Supplemental data

NARROW

Reversal of Apixaban Anticoagulation with Reduced Doses of Andexanet Alfa in a Porcine Polytrauma Model

Comparison of Second and First Generation of Andexanet Alfa in a Porcine Polytrauma Model with Apixaban Anticoagulation

Blood Loss in Rivaroxaban Anticoagulated Pigs with Severe Polytrauma Is Significantly Reduced By Early Therapy with Prothrombin Complex Concentrate

Markers of Thromboembolic Risk Were Insignificantly Affected By Either Intraosseous or Intravenous Idarucizumab in a Dabigatran-Anticoagulated Porcine Polytrauma Model

Mechanistic Differences of Prothrombin Complex Concentrate and Idarucizumab in a Trauma Model Under Dabigatran Anticoagulation

Prothrombin Complex Concentrate or Idarucizumab in a Multimodal Hemostatic Approach with Tranexamic Acid and Fibrinogen for the Acute Reversal of Dabigatran

Reversal of Trauma-Induced Bleeding and Anticoagulation with a Dabigatran-Specific Antidote (idarucizumab) As Assessed By Shed and Washed Blood Tests in a Pig Model of Supratherapeutic Anticoagulation and Trauma

Prothrombin Complex Concentrate in Combination with Fibrinogen Plus Tranexamic Acid Is More Effective Than Mono-Therapy with Prothrombin Complex Concentrate in a Dabigatran Anticoagulation Experimental Polytrauma Model

Ex Vivo Prothrombin Complex Concentrates and a Specific Antidote Are Effective In Reversing Dabigatran-Induced Coagulopathy In Pigs

Resuscitation With Different Volume Expanders Does Not Influence Coagulation After Antidoting Dabigatran With Its Specific Fab In a Pig Model Of Hemorrhagic Shock

Thrombin Generation Capacity of Prothrombin Complex Concentrate in an in Vitro Dilutional Model

Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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