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Nyla A. Heerema, Ph.D
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Journal Articles

Infant Acute Lymphoblastic Leukemias Are Pan-Sensitive to Obatoclax Across molecular/Cytogenetic Subtypes, Especially MLL - ENL , and gene Expression Profiles Determine Obatoclax IC 50 : A Report on the Children's Oncology Group (COG) P9407 Trial

Karen A. Urtishak, PhD, Li-San Wang, PhD, Richard Harvey, PhD, Susan R Atlas, PhD, I-Ming L. Chen, DVM, MS, Blaine W. Robinson, PhD, Lea Moukarzel, Kajia Cao, PhD, Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, Ph.D., Stephen Hunger, MD, Gregory H. Reaman, MD, Joanne M. Hilden, MD, Bruce Camitta, MD, Naomi Winick, MD, William L. Carroll, MD, Alena Y. Zhang, PhD, Lori Cory, Steven Mc Veigh, Jeffery S. Barrett, PhD, Zoann E. Dreyer, MD, Cheryl L. Willman, MD, Carolyn A. Felix, MD
Journal: Blood
Blood (2010) 116 (21): 2757.
https://doi.org/10.1182/blood.V116.21.2757.2757
Published: 2010
Journal Articles

Children with Down Syndrome (DS) and NCI Standard Risk (SR) Acute Lymphoblastic Leukemia (ALL) Have a Superior Five-Year Event-Free Survival (EFS) When Treated with Escalating Intravenous Methotrexate on the Children's Cancer Group (CCG) Study 1991

Yousif Matloub, MD, Bruce C. Bostrom, MD, Stephen Hunger, MD, Anne Angiolillo, MD, Meenakshi Devidas, PhD, Mei La, Nyla A. Heerema, Ph.D., Naomi Winick, MD, James Nachman, MD, Harland Sather, PhD, William L. Carroll, MD, Paul S Gaynon, MD
Journal: Blood
Blood (2010) 116 (21): 497.
https://doi.org/10.1182/blood.V116.21.497.497
Published: 2010
Journal Articles

Interim Analysis of EFC6663, a Multicenter Phase 2 Study of Alvocidib (flavopiridol), Demonstrates Clinical Responses Among Patients with Fludarabine Refractory CLL

Mark C Lanasa, MD, PhD, Leslie Andritsos, MD, Jennifer R Brown, MD, PhD, Janice Gabrilove, M.D., Federico Caligaris-Cappio, M.D., Richard Larson, M.D., Thomas J. Kipps, MD, PhD, Veronique Leblond, M.D., Donald Milligan, MD, FRCP, FRCPath, Ann Janssens, M.D., Nyla A. Heerema, Ph.D., Stephan Stilgenbauer, M.D., John C. Byrd, MD, Michael R. Grever, M.D.
Journal: Blood
Blood (2010) 116 (21): 58.
https://doi.org/10.1182/blood.V116.21.58.58
Published: 2010
Journal Articles

Genome-Wide Analysis of Genetic Alterations In Hypodiploid Acute Lymphoblastic Leukemia Identifies a High Frequency of Mutations Targeting the IKAROS Gene Family and Ras Signaling

Linda Holmfeldt, PhD, Jinghui Zhang, Ph.D., Jing Ma, Ph.D., Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, Ph.D., Julie M. Gastier-Foster, PhD, Susana C. Raimondi, PhD, Mignon L. Loh, M.D., Stephen Hunger, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2010) 116 (21): 411.
https://doi.org/10.1182/blood.V116.21.411.411
Published: 2010
Journal Articles

Interleukin-15 Is a Proto-Oncogene In Acute Large Granular Lymphocyte Leukemia

Anjali Mishra, Ph.D., Shujun Liu, Ph.D., Gregory H Sams, Douglas P Curphey, Ramasamy Santhanam, PhD, Laura J Rush, DVM, PhD, Deanna Schaefer, DVM, Lauren G Falkenberg, Laura Sullivan, Laura Jaroncyk, Xunchang Zou, MS, Harold Fisk, PhD, Jadwiga Labanowska, MS, Enrico Caserta, PhD, Lai-Chu Wu, MD, PhD, Heiko Becker, MD, Sebastian Schwind, MD, Jason C. Chandler, MD, Yue-Zhong Wu, MS, Nyla A. Heerema, Ph.D., Pierluigi Porcu, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2010) 116 (21): 704.
https://doi.org/10.1182/blood.V116.21.704.704
Published: 2010
Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/ MLL -Rearranged AML: Results from an International Retrospective Study

Eva A Coenen, MD, Susana C. Raimondi, PhD, Jochen Harbott, Zimmermann Martin, Brian V Balgobind, Todd A. Alonzo, PhD, Anne Auvrignon, Berna Beverloo, Myron Chang, Ursula Creutzig, MD, Michael Dworzak, Erik Forestier, Brenda Gibson, Henrik Hasle, MD, PhD, Christine J Harrison, PhD, FRCPath, Nyla A. Heerema, Ph.D., Gertjan J. Kaspers, MD, PhD, Anna Leszl, Nathalia Litvinko, Luca lo Nigro, Akira Morimoto, Christine Perot, Dirk Reinhardt, MD, PhD, Jeffrey Rubnitz, MD, PhD, Franklin O. Smith, MD, Jan Stary, Irina Stasevich, Sabine Strehl, Takashi Taga, MD, PhD, Daisuke Tomizawa, MD, David Webb, Zuzana Zemanova, PhD, Rob Pieters, MD, PhD, C. Michel Zwaan, Marry van den Heuvel-Eibrink
Journal: Blood
Blood (2010) 116 (21): 762.
https://doi.org/10.1182/blood.V116.21.762.762
Published: 2010
Journal Articles

TET2 SNP rs2454206 (I1762V) Correlates with Improved Survival In Pediatric Acute Myelogenous Leukemia, a Report From the Children's Oncology Group

Matthew A. Kutny, MD, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Phoenix A. Ho, MD, Daniel Geraghty, PhD, Beverly Lange, MD, Nyla A. Heerema, Ph.D., Soheil Meshinchi, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 949.
https://doi.org/10.1182/blood.V116.21.949.949
Published: 2010
Journal Articles

The WT1 synonymous SNP rs16754 Is Associated with Higher mRNA Expression and Predicts Significantly Improved Outcome In Favorable-Risk Pediatric AML: a Report From the Children's Oncology Group

Phoenix A. Ho, MD, Julia Kuhn, BA, Robert B. Gerbing, MA, Jessica A. Pollard, MD, Rong Zeng, BS, Kristen L. Miller, BS, Nyla A. Heerema, Ph.D., Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Janet Franklin, MD, MPH, Beverly Lange, MD, Alan S. Gamis, MD, MPH, Todd A. Alonzo, PhD, Soheil Meshinchi, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 950.
https://doi.org/10.1182/blood.V116.21.950.950
Published: 2010
Journal Articles

Gene Expression Profiling Reveals Genes Predictive of Outcome In Infant Acute Lymphoblastic Leukemia (ALL) and Distinctive Age-Related Gene Expression Profiles (< 90 Days vs. > 90 Days): A Children's Oncology Group Study

Huining Kang, PhD, Carla S. Wilson, MD, PhD, Richard C. Harvey, PhD, I-Ming Chen, DVM, MS, Maurice H. Murphy, MS, Susan R. Atlas, PhD, Edward J. Bedrick, PhD, Meenakshi Devidas, PhD, Andrew J. Carroll, PhD, Blaine W. Robinson, PhD, Nyla A. Heerema, Ph.D., Joanne M. Hilden, MD, Zoann E. Dreyer, MD, Bruce Camitta, MD, Naomi Winick, MD, William L. Carroll, MD, Carolyn A. Felix, MD, Gregory H. Reaman, MD, Stephen P. Hunger, MD, Cheryl L. Willman, MD
Journal: Blood
Blood (2010) 116 (21): 412.
https://doi.org/10.1182/blood.V116.21.412.412
Published: 2010
Journal Articles

Early Response to Therapy Is Significantly Associated with Genetic Subtype of Acute Lymphoblastic Leukemia: A Report from the Children’s Oncology Group.

Mignon L. Loh, MD, Elizabeth Raetz, M.D., Meenakshi Devidas, Ph.D., Stephen B. Linda, Ph.D., Michael J. Borowitz, M.D, Andrew J. Carroll, M.D., I.-Ming L. Chen, Julie M. Gastier-Foster, Ph.D., Nyla A. Heerema, Ph.D, Richard C. Harvey, Ph.D, Eric Larsen, M.D., Kelly Maloney, M.D., Cheryl L. Willman, M.D., Naomi Winick, M.D., Brent Wood, M.D., Stephen P. Hunger, M.D., William L. Carroll, M.D.
Journal: Blood
Blood (2007) 110 (11): 758.
https://doi.org/10.1182/blood.V110.11.758.758
Published: 2007