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Journal Articles

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD, PhD, BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 41.

https://doi.org/10.1182/blood-2020-140642

Published: 2020

Journal Articles

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Kouhei Yamamoto, Takeo Fujiwara, MD, Emiko Sakaida, MDPhD, Yoko Edahiro, MD PhD, Misa Imai, PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139162

Published: 2020

Journal Articles

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

Satoru Aoyama, MD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Osamu Miura, MD, PhD, Norihiko Kawamata, MD, PhD

Blood (2019) 134 (Supplement_1): 1941.

https://doi.org/10.1182/blood-2019-121973

Published: 2019

Journal Articles

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Satoru Aoyama, MD MMSc, Toshikage Nagao, MD PhD, Shunichiro Yasuda, MD, Daisuke Watanabe, MD, Hiroki Akiyama, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Yoshihiro Umezawa, MD, Ken Watanabe, MD PhD, Masahide Yamamoto, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata, MD

Blood (2018) 132 (Supplement 1): 5493.

https://doi.org/10.1182/blood-2018-99-114457

Published: 2018

Journal Articles

Genome Editing of the Murine Calreticulin Gene Using the CRISPR/Cas9 and CPF1 System

Daisuke Watanabe, MD, Shunichiro Yasuda, MD, Norihiko Kawamata, MD

Blood (2017) 130 (Supplement 1): 4966.

https://doi.org/10.1182/blood.V130.Suppl_1.4966.4966

Published: 2017

Journal Articles

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

Daniel Nowak, MD, Norihiko Kawamata, MD, PhD, Birte Niebuhr, PhD, Verena Nowak, Maximilian Mossner, Rahul R Nahar, Nils Heinrich Thoennissen, MD, Gabriela B. Iwanski, MD, Carol Stocking, PhD, Martin Dugas, MD, PhD, Wolf Karsten Hofmann, MD, PhD, Markus Müschen, MD, PhD, Phillip H Koeffler, MD, PhD

Blood (2009) 114 (22): 1284.

https://doi.org/10.1182/blood.V114.22.1284.1284

Published: 2009

Journal Articles

PAX5/TEL Exhibits a Dominant-Negative Role by Inhibiting the Expression of Genes Involved in BCR Signalling and Suppressing the Binding of Wild Type PAX5 to Its Direct Target Gene CD79A (mb-1) in a human Pre-B ALL Cell Line.

Gabriela B. Iwanski, MD, Nils Heinrich Thoennissen, MD, PohYeen Lor, Norihiko Kawamata, MD, PhD, Daniel Nowak, MD, Grazia Fazio, PhD, Andrea Biondi, MD, Giovanni Gazzaniga, PhD, H. Phillip Koeffler, MD

Blood (2009) 114 (22): 3455.

https://doi.org/10.1182/blood.V114.22.3455.3455

Published: 2009

Journal Articles

Genomic Changes Associated with Leukemic Transformation of Myeloproliferative Disorders.

Nils Heinrich Thoennissen, Norihiko Kawamata, MD, Terra L Lasho, MT(ASCP), Tamara Weiss, Daniel Nowak, Motohiro Kato, Junko Takita, MD, Masashi Sanada, Torsten Haferlach, MD, Ruben A. Mesa, MD, FACP, Ayalew Tefferi, MD, C. Müller-Tidow, MD, Seishi Ogawa, MD, PhD, Phillip H Koeffler

Blood (2008) 112 (11): 3371.

https://doi.org/10.1182/blood.V112.11.3371.3371

Published: 2008

Journal Articles

ChIP-on-Chip Analysis Using Dominant Negative Form of PAX5 Fusion Gene Revealed Genes Associated with Tumorigenesis Were Directly Regulated by PAX5 in a Human B Cell Line, NALM6

Norihiko Kawamata, MD, Fabienne Isken, Stefanie Goellner, C. Müller-Tidow, MD, H. Phillip Koeffler, MD

Blood (2008) 112 (11): 3585.

https://doi.org/10.1182/blood.V112.11.3585.3585

Published: 2008

Journal Articles

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Daniel Nowak, MD, Norihiko Kawamata, MD, Tadayuki Akagi, PhD, Ryoko Okamoto, PhD, Nils Thoennissen, MD, Wolf-Karsten Hofmann, MD, PhD, Motohiro Kato, PhD, Torsten Haferlach, MD, PhD, Seishi Ogawa, MD, PhD, H. Phillip Koeffler, MD, PhD

Blood (2008) 112 (11): 3182.

https://doi.org/10.1182/blood.V112.11.3182.3182

Published: 2008

Journal Articles

Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

Sanada Masashi, MD, Shih Lee Yung, MD, PhD, Takahiro Suzuki, MD, PhD, Motohiro Kato, MD, Mamiko Yanagimoto Sakata, MD, PhD, Keiki Kumano, MD, PhD, Norihiko Kawamata, MD, PhD, Junko Takita, MD, PhD, Hiraku Mori, MD, PhD, Mineo Kurokawa, MD, PhD, Shigeru Chiba, MD, PhD, Mitsuhiro Omine, MD, PhD, H. Phillip Koeffler, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2008) 112 (11): 855.

https://doi.org/10.1182/blood.V112.11.855.855

Published: 2008

Journal Articles

Numerous Genomic Abnormalities in AML with Normal Karyotype.

Tadayuki Akagi, PhD, Seishi Ogawa, MD, Go Yamamoto, MD, Yasuhito Nannya, MD, Masashi Sanada, MD, Norihiko Kawamata, MD, Carl W. Miller, PhD, Martin Dugas, PhD, Susanne Schnittger, PhD, Torsten Haferlach, MD, PhD, Claudia Haferlach, MD, H. Phillip Koeffler, MD

Blood (2007) 110 (11): 1811.

https://doi.org/10.1182/blood.V110.11.1811.1811

Published: 2007

Journal Articles

Rearrangement and Deletion of the PAX5 Gene in Pediatric Acute B-Cell Lineage Lymphoblastic Leukemia.

Norihiko Kawamata, MD, Seishi Ogawa, M.D., Martin Zimmermann, Ph.D., Masashi Sanada, M.D., Kari Hemminki, M.D., Go Yamatomo, M.D., Yasuhito Nannya, M.D., Rolf Koehler, Ph.D., Thomas Flohr, Ph.D., Carl W. Miller, Ph.D., Jochen Harbott, M.D., Wolf-Dieter Ludwig, M.D., Martin Stanulla, M.D., Martin Schrappe, M.D., Claus R. Bartram, M.D., Phillip H. Koeffler, M.D.

Blood (2007) 110 (11): 981.

https://doi.org/10.1182/blood.V110.11.981.981

Published: 2007

Journal Articles

Hidden Abnormalities and Novel Classification of t(15;17) APL Based on Genomic Alterations.

Tadayuki Akagi, PhD, Seishi Ogawa, MD, PhD, Go Yamamoto, MD, Masashi Sanada, MD, Norihiko Kawamata, MD, Carl W. Miller, PhD, Der-Cherng Liang, MD, Lee-Yung Shih, MD, H. Phillip Koeffler, MD

Blood (2007) 110 (11): 4133.

https://doi.org/10.1182/blood.V110.11.4133.4133

Published: 2007

Journal Articles

SNP Chip Analysis of Myelodysplastic Syndromes Disclosed High Frequency of Uniparental Disomy and a Novel Dominant Mutation as the Target of 11q UPD.

Masashi Sanada, MD, Lee-Yung Shih, MD, Takahiro Suzuki, MD, Go Yamamoto, MD, Yasuhito Nannya, MD, Mamiko Y. Sakata, MD, Motohiro Kato, MD, Keiki Kumano, MD, Norihiko Kawamata, MD, Hiraku Mori, MD, Mineo Kurokawa, MD, Shigeru Chiba, MD, Mitsuhiro Omine, MD, Phillip H. Koeffler, MD, Seishi Ogawa, MD

Blood (2007) 110 (11): 119.

https://doi.org/10.1182/blood.V110.11.119.119

Published: 2007

Journal Articles

Genetic Profiling of Myeloproliferative Disorders by Single Nucleotide Polymorphism Oligonucleotide Microarray.

Norihiko Kawamata, MD, Seishi Ogawa, M.D., Ross L. Levine, M.D, Yana Pikman, M.D., Toshiki Nanya, M.D., Masashi Sanada, M.D., Carl W. Miller, Ph.D, D. Gary Gilliland, M.D., H. Phillip Koeffler, M.D.

Blood (2006) 108 (11): 2688.

https://doi.org/10.1182/blood.V108.11.2688.2688

Published: 2006

Journal Articles

Identification of Marker Genes That Discriminate between Different Myeloproliferative Disorders and Normal Individuals Including RUNX3 (AML2).

Claudia I. Muller, MD, Quang T. Luong, PhD, Letetia C. Jones, PhD, Julian C. Desmond, PhD, Norihiko Kawamata, MD, PhD, Tcherniantchouk Tcherniantchouk, MD, Lee-Yung Shih, MD, Yoshiaki Ito, MD, PhD, Kosei Ito, PhD, Qiang Liu, PhD, Motomi Osato, MD, PhD, Sven de Vos, MD, H. Phillip Koeffler, MD

Blood (2005) 106 (11): 3522.

https://doi.org/10.1182/blood.V106.11.3522.3522

Published: 2005

Journal Articles

Identification of Candidate Tumor Suppressor Genes Silenced Epigenetically in Mantle Cell Lymphoma.

Norihiko Kawamata, MD, Takayuki Saitoh, MD, Sakura Sakajiri, MD, Phillip H. Koeffler, MD

Blood (2005) 106 (11): 3001.

https://doi.org/10.1182/blood.V106.11.3001.3001

Published: 2005

Journal Articles

Methylation Status and Polymorphism of Asparagine Synthetase Gene in Acute Lymphoblastic Leukemia Cells.

Tadayuki Akagi, PhD, Dong Yin, PhD, Norihiko Kawamata, MD, Claus R. Bartram, MD, Carl W. Miller, Ph.D, Phillip H. Koeffler, MD

Blood (2005) 106 (11): 847.

https://doi.org/10.1182/blood.V106.11.847.847

Published: 2005

NARROW

A Protease-Mediated Regulatory Chimeric Antigen Receptor (CAR): "Double Arm" CAR System Improves Tumor-Cell-Specificity of CAR-T Cell Therapy

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

A Novel Protease-Mediated Chimeric Antigen Receptor (CAR): "Double-Arm" CAR-T Cell System Improves Target Specificity of CAR-T Cell Therapy

A Novel Cell Line, Tnet-2, Derived from "Triple-Negative" Essential Thrombocythemia

Genome Editing of the Murine Calreticulin Gene Using the CRISPR/Cas9 and CPF1 System

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

PAX5/TEL Exhibits a Dominant-Negative Role by Inhibiting the Expression of Genes Involved in BCR Signalling and Suppressing the Binding of Wild Type PAX5 to Its Direct Target Gene CD79A (mb-1) in a human Pre-B ALL Cell Line.

Genomic Changes Associated with Leukemic Transformation of Myeloproliferative Disorders.

ChIP-on-Chip Analysis Using Dominant Negative Form of PAX5 Fusion Gene Revealed Genes Associated with Tumorigenesis Were Directly Regulated by PAX5 in a Human B Cell Line, NALM6

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

Numerous Genomic Abnormalities in AML with Normal Karyotype.

Rearrangement and Deletion of the PAX5 Gene in Pediatric Acute B-Cell Lineage Lymphoblastic Leukemia.

Hidden Abnormalities and Novel Classification of t(15;17) APL Based on Genomic Alterations.

SNP Chip Analysis of Myelodysplastic Syndromes Disclosed High Frequency of Uniparental Disomy and a Novel Dominant Mutation as the Target of 11q UPD.

Genetic Profiling of Myeloproliferative Disorders by Single Nucleotide Polymorphism Oligonucleotide Microarray.

Identification of Marker Genes That Discriminate between Different Myeloproliferative Disorders and Normal Individuals Including RUNX3 (AML2).

Identification of Candidate Tumor Suppressor Genes Silenced Epigenetically in Mantle Cell Lymphoma.

Methylation Status and Polymorphism of Asparagine Synthetase Gene in Acute Lymphoblastic Leukemia Cells.

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American Society of Hematology

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American Society of Hematology

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