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Journal Articles

CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Shih-Shih Chen, PhD, Constantine S. Tam, MBBS (Hons), MD, Alan G. Ramsay, BSc,MSc,PhD, Priyadarshini Ravichandran, Natalia C. Couto-Francisco, Michael Ibrahim, Gerardo Ferrer, PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, He Zhou, Jacqueline C Barrientos, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2019) 134 (Supplement_1): 477.

https://doi.org/10.1182/blood-2019-127255

Published: 2019

Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3027.

https://doi.org/10.1182/blood-2019-122038

Published: 2019

Journal Articles

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Xavier Calvo, MD PhD, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3029.

https://doi.org/10.1182/blood-2019-122061

Published: 2019

Journal Articles

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Shih-Shih Chen, PhD, Jeffery Lorne Kutok, MD PhD, Gerardo Ferrer, PhD, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, MSCR, Jacqueline C Barrientos, MD MS, David T. Weaver, PhD, Jonathan A Pachter, PhD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4420.

https://doi.org/10.1182/blood-2018-99-109853

Published: 2018

Journal Articles

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

Byeongho Jung, BS, Gerardo Ferrer, PhD, Pui Yan Chiu, Rukhsana Aslam, MD, Florencia Palacios, PhD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4402.

https://doi.org/10.1182/blood-2018-99-116505

Published: 2018

Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 4409.

https://doi.org/10.1182/blood-2018-99-118562

Published: 2018

Journal Articles

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Rukhsana Aslam, MD, Jacqueline C Barrientos, MD MS, Gerardo Ferrer, PhD, Pui Yan Chiu, Kanti R Rai, MD, Nicholas Chiorazzi, MD, Barbara Sherry, PhD

Blood (2018) 132 (Supplement 1): 1848.

https://doi.org/10.1182/blood-2018-99-116910

Published: 2018

Journal Articles

Association of CXCR4 with IgM and IgD BCR Isotypes: Role in B Cell Malignancies

Eva Gentner, BSc,MSc,PhD, Andrea Nicola Mazzarello, PhD, Martin Becker, PhD, Antonella Nicolò, M.Sc; B.Sc., Valerio Renna, M.Sc.; B.Sc., Nicholas Chiorazzi, MD, Michael Reth, Prof. Dr., Hassan Jumaa, Prof. Dr., Palash Chandra Maity, PhD

Blood (2018) 132 (Supplement 1): 1852.

https://doi.org/10.1182/blood-2018-99-116585

Published: 2018

Journal Articles

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Shih-Shih Chen, PhD, Xiao J. Yan, MD PhD, Thomas M. Herndon, MD, Clare C. Sun, MD, Priyadarshini Ravichandran, Michael Ibrahim, Barbara Sherry, PhD, Adrian Wiestner, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1836.

https://doi.org/10.1182/blood-2018-99-119843

Published: 2018

Journal Articles

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

Florencia Palacios, PhD, Xiao-Jie Yan, MD PhD, Gerardo Ferrer, PhD, Jacqueline C Barrientos, MD MS, Jonathan E. Kolitz, MD, Steven L. Allen, Rai Kanti R., MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1837.

https://doi.org/10.1182/blood-2018-99-115060

Published: 2018

Journal Articles

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Sophia Yancopoulos, PhD, Wentian Li, PhD, Xiao J. Yan, MD PhD, Andreas Agathangelidis, PhD, Anastasia Hadzidimitriou, PhD, Frederic Davi, MD PhD, Richard Rosenquist, MD PhD, Paolo Ghia, MD PhD, Kostas Stamatopoulos, MD PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1841.

https://doi.org/10.1182/blood-2018-99-119803

Published: 2018

Journal Articles

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Gerardo Ferrer, PhD, Byeongho Jung, BS, Aslam Rukhsana, MD, Pui Yan Chiu, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shih-Shih Chen, PhD, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD MS, Jan A. Burger, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 239.

https://doi.org/10.1182/blood-2018-99-114799

Published: 2018

Journal Articles

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Eva Gentner, BSc, MSc, PhD, Palash Chandra Maity, PhD, Gerardo Ferrer, PhD, Tatyana Tarasenko, Stefano Vergani, PhD, Jacqueline C Barrientos, MD MS, Kanti R Rai, MD, Peter McGuire, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 3124.

https://doi.org/10.1182/blood-2018-99-119989

Published: 2018

Journal Articles

IGHV-D-J Repertoire Analysis Obtained By High-Throughput Sequencing of CD5+ B-Cells in CLL Patients: Prognostic Markers and Disease Development Implications

Davide Bagnara, PhD, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Gerardo Ferrer, PhD, Franco Fais, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 54.

https://doi.org/10.1182/blood.V130.Suppl_1.54.54

Published: 2017

Journal Articles

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Yun Liu, MS, Rosa Catera, PhD, Chao Gao, PhD, Xiao J. Yan, MDPhD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Charles C Chu, PhD, Ten Feizi, MD, Kostas Stamatopoulos, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 58.

https://doi.org/10.1182/blood.V130.Suppl_1.58.58

Published: 2017

Journal Articles

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Shih-Shih Chen, PhD, Priyadarshini Ravichandran, Gerardo Ferrer, PhD, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Michael Ibrahim, Yasmine Kieso, Jacqueline C. Barrientos, MD, Edward Clark, PhD, Barbara Sherry, PhD, Jan A. Burger, MD PhD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 387.

https://doi.org/10.1182/blood.V130.Suppl_1.387.387

Published: 2017

Journal Articles

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Eric Sturgill, BA, Xiao J. Yan, MDPhD, Florencia Palacios, PhD, Kanti Rai, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4287.

https://doi.org/10.1182/blood.V130.Suppl_1.4287.4287

Published: 2017

Journal Articles

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

Xiao J. Yan, MDPhD, Pablo Morande, PhD, Mei Qi, Ezra B Kolitz, Crystal D Grant, Gautam Nayyar, Pablo Oppezzo, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4293.

https://doi.org/10.1182/blood.V130.Suppl_1.4293.4293

Published: 2017

Journal Articles

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

Gerardo Ferrer, PhD, Brendan Franca, BS, Pui Yan Chiu, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shihshih Chen, PhD, Davide Bagnara, PhD, Sophia Yancopoulos, Yun Liu, MS, Aliki Xochelli, MD, Xiao J. Yan, MDPhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kostas Stamatopoulos, Kanti Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4294.

https://doi.org/10.1182/blood.V130.Suppl_1.4294.4294

Published: 2017

Journal Articles

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Palash Chandra Maity, PhD, Gentner Eva, PhD, Stefano Vergani, PhD, Gerardo Ferrer, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD, Kanti Rai, MD, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 1716.

https://doi.org/10.1182/blood.V130.Suppl_1.1716.1716

Published: 2017

NARROW

CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Dual Inhibition of PI3K-δ and PI3K-γ By Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Patient-Derived Xenograft Model

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Association of CXCR4 with IgM and IgD BCR Isotypes: Role in B Cell Malignancies

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia B Cells Display IgM and IgD Isotype-Restricted Features That Affect Association with Co-Receptors, BCR Signaling, and Leukemic B-Cell Growth In Vivo

IGHV-D-J Repertoire Analysis Obtained By High-Throughput Sequencing of CD5+ B-Cells in CLL Patients: Prognostic Markers and Disease Development Implications

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Over-Expression of Activation-Induced Cytidine Deaminase in TCL1 Mice Leads to the Development of IGHV-Mutated CLL Clones That Associate with More Aggressive Disease

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

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American Society of Hematology

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American Society of Hematology

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