1-9 of 9
Milena Mazan, PhD
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD -Mutant AMLs

Suruchi Pacharne, Oliver M. Dovey, PhD, Jonathan L Cooper, Muxin Gu, Vijay Baskar, PhD, Mathias J Friedrich, Malgorzata Gozdecka, PhD, Sandeep S Rajan, PhD, Etienne De Braekeleer, PhD MSc, Maxim Barenboim, Grace Collord, Hannes Postingl, PhD, Ruben Bautista, Milena Mazan, PhD, Roland Rad, Prof., MD, Konstantinos Tzelepis, Penny Wright, George S. Vassiliou, MD PhD FRCPath, MRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-141743
Published: 2020
Journal Articles

SEL24/MEN1703 Provides PIM/FLT3 Downstream Pathway Inhibition in Acute Myeloid Leukemia (AML) Blast Cells: Results of the Pharmacodynamics (PD) Assay in the Dose Escalation Part of First-in-Human Diamond Trial

Andrea Massimiliano Tomirotti, PhD, Daniela Bellarosa, Scott R. Solomon, MD, Aziz Nazha, MD, Stephen A Strickland, MD MSCI, Roland P Walter, MDPhD, Farhad Ravandi, MBBS, Krzysztof Brzózka, PhD, Milena Mazan, PhD, Simone Baldini, MD, Massimiliano Salerno, Monica Binaschi, PhD, Dirk Laurent, MD, Andrea Pellacani, PhD MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136936
Published: 2020
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

Identification of a Pharmacodynamic Biomarker for SEL24/MEN1703, a First-in-Class Dual PIM/FLT3 Kinase Inhibitor for Acute Myeloid Leukemia, and Its Implementation in the First-in-Human Study CLI24-001

Andrea Tomirotti, PhD, Giuseppe Merlino, Alessio Fiascarelli, PhD, Simone Baldini, MD, Alessia Tagliavini, Elisa Borella, Milena Mazan, PhD, Krzysztof Brzózka, PhD, Alessandro Bressan, Andrea Pellacani, PhD MD, Massimiliano Salerno, Monica Binaschi, PhD, Daniela Bellarosa
Journal: Blood
Blood (2019) 134 (Supplement_1): 5087.
https://doi.org/10.1182/blood-2019-124800
Published: 2019
Journal Articles

CDK8 Inhibitors Induce Transcriptional Reprogramming of AML Cells Associated with Differentiation

Milena Mazan, PhD, Marion Chapellier, PhD, Marcus Järås, PhD, Michal Mikula, MD PhD, Eliza Majewska, PhD, Katarzyna Wiklik, PhD, Michal Combik, PhD, Aniela Golas, PhD, Magdalena Masiejczyk, MSc, Elzbieta Fiedor, MSc, Federico Malusa, MSc, Przemyslaw Juszczynski, Prof., MD PhD, Magdalena Cybulska, DVM, Maciej Mikulski, PhD, Jerzy Ostrowski, Prof., MD PhD, Pawel Chrom, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3774.
https://doi.org/10.1182/blood-2019-128073
Published: 2019
Journal Articles

SEL120 - a First-in-Class CDK8/19 Inhibitor As a Novel Option for the Treatment of Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome - Data from Preclinical Studies and Introduction to a Phase Ib Clinical Trial

Gautam M. Borthakur, MD, William B. Donnellan, MD, Scott R. Solomon, MD, Camille Abboud, MD, Aziz Nazha, MD, Milena Mazan, PhD, Michal Mikula, MD PhD, Eliza Majewska, PhD, Katarzyna Wiklik, PhD, Aniela Golas, PhD, Marcus Järås, PhD, Marion Chapellier, PhD, Anna Polak, PhD, Arkadiusz Bialas, PhD, Renata Windak, PhD, Jerzy Ostrowski, Prof., MD PhD, Przemyslaw Juszczynski, Prof., MD PhD, Pawel Chrom, MD PhD, Tomasz Rzymski, PhD, Krzysztof Brzózka, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2651.
https://doi.org/10.1182/blood-2019-127835
Published: 2019
Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Marion Chapellier, PhD, Jun Chen, MD PhD, Carl Sandén, PhD, Milena Mazan, PhD, Eliza Majewska, Katarzyna Wiklik, PhD, Michal Combik, PhD, Magdalena Masiejczyk, MSc, Elzbieta Fiedor, Marta Obacz, Anna Polak, Arkadiusz Bialas, Paulina Chesy, Ewelina Gabor-Worwa, Przemyslaw Juszczynski, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD, Thoas Fioretos, MD PhD, Johan Flygare, MD PhD, Marcus Jaras, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1520.
https://doi.org/10.1182/blood-2018-99-111859
Published: 2018
Journal Articles

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Jun Chen, MD PhD, Kavitha Siva, PhD, Tomasz Rzymski, PhD, Lars Johansson, Thomas Lundbäck, Lorena Nunez Villacis, Fredrik Ek, PhD, Bingrui Wang, Amee J George, PhD, Yang Wan, Lihong Shi, Melissa IIsley, Agatheeswaran Subramaniam, PhD, Mayur Jain, PhD, Shubhranshu Debnath, PhD, Abdul Ghani Alattar, Hanna Axelsson, Milena Mazan, PhD, Eliza Majewska, Ulf R. Tedgard, MD PhD, Marcin W. Wlodarski, MD PhD, Anna-Lena Gustavsson, Roger Olsson, Michal Mikula, Xiaofan Zhu, PhD, Krzysztof Brzózka, PhD, Ross Hannan, PhD, Johan Flygare, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 753.
https://doi.org/10.1182/blood-2018-99-114570
Published: 2018
Journal Articles

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Faisal Basheer, MBBChir, MA, George Giotopoulos, PhD, Eshwar Meduri, PhD, Haiyang Yun, PhD, Milena Mazan, PhD, Olivia Sheppard, Daniel Sasca, MD, Malgorzata Gozdecka, PhD, George S. Vassiliou, MD PhD, Brian J.P Huntly
Journal: Blood
Blood (2017) 130 (Supplement 1): 1215.
https://doi.org/10.1182/blood.V130.Suppl_1.1215.1215
Published: 2017