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Miguel A. Cruz, PhD
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Journal Articles

Vimentin Is a Novel Molecule Required for the Formation of Von Willebrand Factor Strings from the Vascular Endothelium

Titilope Ishola, MD PhD, Qi Da, PhD, Sean P Marrelli, PhD, Miguel A. Cruz, PhD
Journal: Blood
Blood (2015) 126 (23): 2237.
https://doi.org/10.1182/blood.V126.23.2237.2237
Published: 2015
Journal Articles

FAM20c-Mediated Serine 1613 Phosphorylation in the A2 Domain of Von Willebrand Factor Regulates ADAMTS13 Activity and Thrombus Formation

Qi Da, PhD, Jennifer Nolasco, B.S., Tanvir Khatlani, PhD, Fernandez Maria, B,S., Miguel A. Cruz, PhD, K. Vinod Vijayan, PhD
Journal: Blood
Blood (2015) 126 (23): 236.
https://doi.org/10.1182/blood.V126.23.236.236
Published: 2015
Journal Articles

Wdr1-Mediated Actin Reorganization Is Essential for Integrin αIIbβ3 Activation in Platelets

Swapan Kumar Dasgupta, PhD, Qi Da, PhD, Anhquyen Le, Miguel A. Cruz, PhD, Perumal Thiagarajan, MD
Journal: Blood
Blood (2015) 126 (23): 2231.
https://doi.org/10.1182/blood.V126.23.2231.2231
Published: 2015
Journal Articles

Intermediate Filament (IF) Protein Vimentin Regulates T Cell Mediated Immune Response in Gvhd

Dan Li, PhD, Patenia Rebecca, BS, Miguel A. Cruz, PhD, Jeffrey J. Molldrem, MD, Richard E. Champlin, MD, Qing Ma, PhD
Journal: Blood
Blood (2015) 126 (23): 3073.
https://doi.org/10.1182/blood.V126.23.3073.3073
Published: 2015
Journal Articles

A Novel Molecular Mechanism In The Interplay Of Platelet GPIb-VWF-Fibrin In Thrombus Formation

Miguel A. Cruz, PhD, Perumal Thiagarajan, MD, Swapan Kumar Dasgupta, Sameer Thacker
Journal: Blood
Blood (2013) 122 (21): 1065.
https://doi.org/10.1182/blood.V122.21.1065.1065
Published: 2013
Journal Articles

Vimentin Exposed On Platelets Serves As an Adhesive Receptor for Von Willebrand Factor

Miguel A. Cruz, PhD, K. Vinod Vijayan, PhD
Journal: Blood
Blood (2012) 120 (21): 259.
https://doi.org/10.1182/blood.V120.21.259.259
Published: 2012
Journal Articles

The Study of GPIb-VWF Mediated Early-Stage Platelet Activation Triggering On a Single Cell

Lining Ju, Cheng Zhu, Miguel A. Cruz, PhD, Yunfeng Chen
Journal: Blood
Blood (2012) 120 (21): 1069.
https://doi.org/10.1182/blood.V120.21.1069.1069
Published: 2012
Journal Articles

Extracellular Hemoglobin Increases the Binding of the Active Form of Von Willebrand Factor to Glycoprotein Ibα and Platelet Activation Under Shear Stress: Implications for Sickle Cell Disease and Other Hemolytic Disorders

Miguel A. Cruz, PhD,, Prasenjit Guchhait, PhD, Ryanne Ashley Brown
Journal: Blood
Blood (2011) 118 (21): 2095.
https://doi.org/10.1182/blood.V118.21.2095.2095
Published: 2011
Journal Articles

Soluble Monomeric Von Willebrand Factor A1A2A3 (R1450E) Mutant Fragment Enhances Shear-Induced Platelet Aggregation and Platelet Adhesion to Fibrin(ogen) Via αIIbβ3 Under High Shear Stress.

Miguel A. Cruz, PhD, Katie E. Sowa, Scott M. Smith
Journal: Blood
Blood (2009) 114 (22): 4025.
https://doi.org/10.1182/blood.V114.22.4025.4025
Published: 2009
Journal Articles

Hemoglobin Bound Von Willebrand Factor (HbVWF) Multimers Are Hyperactive and More Prevalent in Patients with Sickle Cell Disease.

Zhou Zhou, PhD, Hyojeong Han, Mark M. Udden, MD, Miguel A. Cruz, PhD, Jing-fei Dong, MD, PhD, Prasenjit Guchhait, PhD
Journal: Blood
Blood (2009) 114 (22): 3058.
https://doi.org/10.1182/blood.V114.22.3058.3058
Published: 2009
Journal Articles

Hemoglobin Blocks Von Willebrand Factor Proteolysis by ADAMTS-13: A Mechanism Associated with Acquired ADAMTS-13 Deficiency in Patients with Sickle Cell Disease

Zhou Zhou, Han Hyojeong, Miguel A. Cruz, PhD, Jose A. Lopez, MD, Jing-fei Dong, MD, PhD, Prasenjit Guchhait, PhD
Journal: Blood
Blood (2008) 112 (11): 3919.
https://doi.org/10.1182/blood.V112.11.3919.3919
Published: 2008
Journal Articles

Factor H Binds to Von Willebrand Factor (VWF) and Regulates Its Cleavage by ADAMTS-13

Miguel A. Cruz, PhD, Francisca C. Gushiken, MD, Rolando Rumbaut, Kavita N Patel, Nancy Turner, Leticia Nolasco, Hyojeong Han, Matthew Pickering, Jing-fei Dong, MD, PhD, Joel L. Moake, MD, Vahid Afshar-Kharghan, MD
Journal: Blood
Blood (2008) 112 (11): 3935.
https://doi.org/10.1182/blood.V112.11.3935.3935
Published: 2008
Journal Articles

Single-Molecule Measurements of Force-Induced Cleavage of VWF A1A2A3-Tridomain by ADAMTS13

Tao Wu, Jiangguo Lin, Miguel A. Cruz, PhD, Jing-fei Dong, MD, PhD, Cheng Zhu, PhD
Journal: Blood
Blood (2008) 112 (11): 3936.
https://doi.org/10.1182/blood.V112.11.3936.3936
Published: 2008
Journal Articles

Thermodynamic Analysis of Von Willebrand Disease Type 2B and 2M Mutations on the Structural Stability of the Von Willebrand Factor A1 Domain.

Matthew Auton, BSc, PhD, Erik Sedlák, PhD, Joel L. Moake, MD, Miguel A. Cruz, PhD
Journal: Blood
Blood (2008) 112 (11): 3389.
https://doi.org/10.1182/blood.V112.11.3389.3389
Published: 2008
Journal Articles

The Interaction of Platelet GPIB with the VWF-A1 Domain in Solution or Immobilized Is Regulated by the D3 Domain (A.A. 1238–1260) and the A2A3 Domains

Miguel A. Cruz, PhD, Cecilia Martin, B.S., Tao Wu, Ph.D., Cheng Zu, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 3726.
https://doi.org/10.1182/blood.V110.11.3726.3726
Published: 2007
Journal Articles

Superoxide Inhibits ADAMTS-13 Activity and Regulates Sickle Cell Adhesion.

Prasenjit Guchhait, PhD, Miguel A. Cruz, PhD, Jing-Fei Dong, MD, PhD, José A. López, MD
Journal: Blood
Blood (2005) 106 (11): 2342.
https://doi.org/10.1182/blood.V106.11.2342.2342
Published: 2005