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Michael G. Kharas, PhD
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Journal Articles

Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia

Diu T.T. Nguyen, DPhil, Camila Prieto, PhD, Zhaoqi Liu, PhD, Justin Wheat, Alexendar Perez, Saroj Gourkanti, BA, Timothy Chou, BS, Ersilia Barin, Arthur Chow, BS, James Taggart, BA, Katerina Hoskova, Meera Dhodapkar, Alexandra Schurer, BS, Trevor Stephen Barlowe, BA, Ly Vu, PhD, Christina Leslie, PhD, Ulrich G. Steidl, MDPhD, Raul Rabadan, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
https://doi.org/10.1182/blood-2020-142229
Published: 2020
Journal Articles

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells

Sun-Mi Park, PhD, Hyunwoo Cho, PhD, Angela Thornton, PhD, Trevor Stephen Barlowe, BA, Timothy Chou, BS, Sagar Chhangawala, PhD, Lauren Fairchild, PhD, Arthur Chow, BA, James Taggart, BA, Alexander Schurer, BA, Antoine Gruet, Matthew Witkin, Jun Hyun Kim, Ethan Shevach, Andrei Krivstov, Scott A. Armstrong, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3881.
https://doi.org/10.1182/blood-2018-99-115034
Published: 2018
Journal Articles

m 6 A Maintains Hematopoietic Stem and Progenitor Cell Identity

Yuanming Cheng, PhD, Hanzhi Luo, PhD, Franco Izzo, PhD, Brian F Pickering, PhD, Ly P Vu, PhD, Alexandra Schurer, BS, Saroj Gourkanti, BA, Samie R. Jaffrey, MD PhD, Dan A. Landau, MD PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 327.
https://doi.org/10.1182/blood-2018-99-117191
Published: 2018
Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 883.
https://doi.org/10.1182/blood-2018-99-112543
Published: 2018
Journal Articles

The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells

Diu Nguyen, PhD, Yuheng Lu, PhD, Zi-ning Choo, Christopher Chin, Camila Prieto, BA, Saroj Gourkanti, BA, Christina Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 884.
https://doi.org/10.1182/blood-2018-99-118949
Published: 2018
Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Gerard Minuesa Dinares, PhD, Steven K. Albanese, BS, Arthur Chow, BA, Alexandra Schurer, BS, Sun Mi Park, PhD, Christina Z. Rotsides, PhD, James Taggart, BS, Andrea Rizzi, BS, Levi N. Naden, PhD, Timothy Chou, BS, Saroj Gourkanti, BA, Daniel Cappel, PhD, Maria C. Passarelli, BS, Lauren Fairchild, PhD, Carolina Adura, PhD, Joseph Fraser Glickman, MSPH, PhD, Jessica Schulman, Christopher Famulare, MS, Minal Patel, BA, Joseph K. Eibl, PhD, Gregory M. Ross, PhD, Derek Tan, PhD, Christina Leslie, PhD, Thijs Beuming, PhD, Yehuda Goldgur, PhD, John D. Chodera, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 428.
https://doi.org/10.1182/blood-2018-99-118745
Published: 2018
Journal Articles

Therapeutic Disassembly of Leukemogenic Enhancer Complexes

Lauren Forbes, BS, MS, Krasnopolsky Isaac, BA, Gerard Minuesa Dinares, PhD, Michael G. Kharas, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1352.
https://doi.org/10.1182/blood-2018-99-118807
Published: 2018
Journal Articles

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells

Josephine Wesely, PhD MSc, BSc, Andriana G. Kotini, PhD, Maria Georgomanoli, PhD, Hanzhi Luo, PhD, Han Yuan, Franco Izzo, PhD, Dan A. Landau, MD PhD, Christina Leslie, PhD, Michael G. Kharas, PhD, Eirini P. Papapetrou, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 772.
https://doi.org/10.1182/blood-2018-99-111506
Published: 2018
Journal Articles

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Ly P Vu, PhD, Brian F Pickering, PhD, Yuanming Cheng, PhD, Zaccara Sara, PhD, Diu Nguyen, PhD, Gerard Minuesa, PhD, Timothy Chou, BS, Arthur Chow, BS, Matthew MacKay, Christopher Famulare, MS, Minal Patel, BA, Francine Garret-Bakelman, MD PhD, Ari Melnick, MD, Martin Carroll, MD, Christopher Mason, PhD, Samie R. Jaffrey, MD PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 791.
https://doi.org/10.1182/blood.V130.Suppl_1.791.791
Published: 2017
Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Ly P. Vu, PhD, Camila Prieto, Elianna Amin, PhD, Gerard Minuesa, PhD, Sagar Chhangawala, Maria J Vidal, PhD, Andrei V. Krivtsov, PhD, Tim Chou, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Raquel P. Deering, Mithat Gonen, PhD, Maria E Figueroa, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Ari Melnick, MD, Ross L. Levine, MD, Fatima Al-Shahrour, PhD, Marcus Järås, Lisa Chu, Ralph Garippa, PhD, Christopher Lengner, PhD, Scott A. Armstrong, MD PhD, Glenn Cowley, PhD, David Root, PhD, John G Doench, PhD, Leandro Cerchietti, MD, Christina Leslie, PhD, Benjamin Ebert, Michael G. Kharas, PhD
Journal: Blood
Blood (2016) 128 (22): 739.
https://doi.org/10.1182/blood.V128.22.739.739
Published: 2016
Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3945.
https://doi.org/10.1182/blood.V128.22.3945.3945
Published: 2016
Journal Articles

IKZF2, a Novel Target of MSI2 RNA-Binding Protein Plays an Oncogenic Role in Myeloid Leukemia

Sun Mi Park, PhD, Angela Thornton, PhD, Ly P. Vu, PhD, Sagar Chhangawala, Gerard Minuesa, PhD, Trevor Barlowe, BA, James Taggart, BS, Patrick Tivnan, BS, Theodore Kim, Ethan Shevach, MD, Christina S Leslie, PhD, Michael G. Kharas, PhD
Journal: Blood
Blood (2015) 126 (23): 440.
https://doi.org/10.1182/blood.V126.23.440.440
Published: 2015
Journal Articles

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

Tzu-Chieh Ho, PhD, James Taggart, BS, Elianna Amin, PhD, Haiming Xu, PhD, Trevor Barlowe, BA, Alexander R Perez, BS, Patrick Tivnan, BS, Rachel Okabe, BS, Christopher Lengner, PhD, Amit Verma, MD, Gail J Roboz, MD, Monica L. Guzman, PhD, Christina S Leslie, PhD, Stephen D. Nimer, MD, Michael G. Kharas, PhD
Journal: Blood
Blood (2015) 126 (23): 714.
https://doi.org/10.1182/blood.V126.23.714.714
Published: 2015
Journal Articles

Integrative Analysis of the Mutational Landscape of Mouse and Human AML Identifies Functionally Relevant Leukemia Disease Alleles

Megan A. Hatlen, PhD, Kanika Arora, MS, Vladimir Vacic, PhD, Ewa A. Grabowska, BS, Willey Liao, BS, Bridget Riley-Gillis, PhD, Dayna M. Oschwald, BS, Lan Wang, PhD, Jacob E. Joergens, Alan H. Shih, MD PhD, Franck Rapaport, PhD, Shengqing Gu, PhD, Francesca Voza, BS, Takashi Asai, MD PhD, Benjamin Neel, MD PhD, Michael G. Kharas, PhD, Mithat Gonen, PhD, Ross L. Levine, MD, Stephen D. Nimer, MD
Journal: Blood
Blood (2015) 126 (23): 1247.
https://doi.org/10.1182/blood.V126.23.1247.1247
Published: 2015
Journal Articles

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Sun Mi Park, PhD, Mithat Gönen, PhD, Ly P. Vu, PhD, Gerard Minuesa, PhD, Patrick Tivnan, Trevor Barlowe, James Taggart, Yuheng Lu, Raquel P Deering, PhD, Nir Hacohen, PhD, Maria Figueroa, MD, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Ari M. Melnick, MD, Ross L. Levine, MD, Christina Leslie, PhD, Christopher J Lengner, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2014) 124 (21): 836.
https://doi.org/10.1182/blood.V124.21.836.836
Published: 2014
Journal Articles

Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells

Sun-Mi Park, Ph.D, Raquel P Deering, Yuheng Lu, Tivnan Patrick, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, Christina Leslie, Benjamin L. Ebert, MD, PhD, Christopher Lengner, George Q Daley, Michael G Kharas, PhD
Journal: Blood
Blood (2013) 122 (21): 468.
https://doi.org/10.1182/blood.V122.21.468.468
Published: 2013
Journal Articles

Casein Kinase 1 Alpha Maintains Normal and Leukemic Stem Cells by Regulating p53 Activity

Marcus Järås, PhD, Peter G. Miller, PhD, Lisa Chu, Rebekka K. Schneider, MD, Rishi V Puram, Fatima Al-Shahrour, PhD, Emma Fink, Kimberly A. Hartwell, PhD, Marie McConkey, Glenn Cowley, PhD, Ann Mullally, MD, Michael G Kharas, PhD, Benjamin L. Ebert
Journal: Blood
Blood (2012) 120 (21): 209.
https://doi.org/10.1182/blood.V120.21.209.209
Published: 2012
Journal Articles

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate.

Sun Mi Park, Ph.D, Raquel Deering, Yuheng Lu, Patrick Tivnan, Varun Shenoy, Steve Lianoglou, Ph.D, Fatima Al-Shahrour, PhD, Christina Leslie, PhD, Benjamin L. Ebert, MD, PhD, Christopher Lengner, Ph.D, George Q. Daley, MD, PhD, Michael G Kharas, PhD
Journal: Blood
Blood (2012) 120 (21): 2324.
https://doi.org/10.1182/blood.V120.21.2324.2324
Published: 2012
Journal Articles

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Peter Miller Graduate Student Brigham and Womens Miller, Fatima Al-Shahrour, PhD, Kimberly A. Hartwell, PhD, Lisa P Chu, Jaras Marcus, Rishi V Puram, Alexandre Puissant, Kevin Callahan, PhD, John M Ashton, Marie Ellen McConkey, BSc, PhD, Luke Poveromo, Glenn Cowley, PhD, Michael G Kharas, PhD, Myriam Labelle, PhD, Sebastian Shterental, Muhammad Al-Hajj, Christopher Shelton, Scott A. Armstrong, MD, PhD, David E. Root, PhD, Richard Hynes, PhD, Siddhartha Mukherjee, MD, PhD, Kimberly Stegmaier, MD, Craig T. Jordan, PhD, Benjamin L. Ebert, MD, D.Phil
Journal: Blood
Blood (2011) 118 (21): 758.
https://doi.org/10.1182/blood.V118.21.758.758
Published: 2011
Journal Articles

Increased MSI2 expression Is Associated with Aggressive CML and AML

Jaspal S Kaeda, PhD, FRCPath, Ken I. Mills, PhD, FRCPath, Michael G Kharas, PhD, Giuseppe Saglio, MD, Michaela Schwarz, MD, Christian Oberender, Bärbel Pawlaczyk-Peter, Antje van Lessen, Seval Türkmen, MD, Claudia D Baldus, MD, Frauke Ringel, PhD, Thomas Pretzsch, Peggy Grille, Anna Serra, PhD, Anne Carson, PhD, Mary Frances McMullin, MD, Jörg Westermann, MD, Peter Daniel, MD, PhD, Bernd Dörken, Philipp D. le Coutre, MD
Journal: Blood
Blood (2011) 118 (21): 2516.
https://doi.org/10.1182/blood.V118.21.2516.2516
Published: 2011