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From in silico to in Vitro to In Vivo : Increasing Megakaryocytes to Treat Thrombocytopenia

Alejandra Macias, Mauricio Cortes, Na An, Na Li, Timothy Fulton, Allison Simpson, Samuel Miller, Sunny Sun, Doris Fu, Juan Garcia, Satya Medicherla, Scott Steelman, Atli Thorarensen, Matthew Goddeeris, Sriram Krishnamoorthy
Journal: Blood
Blood (2023) 142 (Supplement 1): 5580.
https://doi.org/10.1182/blood-2023-190250
Published: 2023
Journal Articles

Identification of Small Molecules That Induce Therapeutic Levels of Fetal Hemoglobin for Treatment of Sickle Cell Disease By Pairing Machine Learning with High-Resolution Single Cell RNA Sequencing Maps of Adult and Fetal Human Erythropoiesis

Mauricio Cortes, Anthony J Monti, Sunny Sun, Orna Lynch, Youli Xia, Sarah Lin, Michael Malamas, Scott Steelman, Sriram Krishnamoorthy, Morag Stewart, Effie Tozzo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2022.
https://doi.org/10.1182/blood-2021-152728
Published: 2021
Journal Articles

Remission in Patients with Acute Promyelocytic Leukemia Treated with Arsenic Trioxide (varitrinox) As the First Line in Colombia

Gustavo Milone, MD, Samuel Sarmiento Doncel, MSc Epidemiology, Carol Agudelo Rico, MSc Epidemiology, Fabiola Vizcarra Reyes, Hematology-oncology, Gina Alejandra Diaz Mosquera, MSc, Juan Guillermo Duque Ortega, Hematologist Internist, Javier Mauricio Cortes Bernal, Pediatric Oncohematology, Francisco Javier Meza Cadavid, Hematology
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-137143
Published: 2020
Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Hypoxic Stress-Induced Serotonergic Stimulation Controls Hematopoietic Stem Cell Production Via the Hypothalamic-Pituitary-Interrenal Axis and Glucocorticoid Signaling

Wanda Kwan, PhD, Mauricio Cortes, PhD, Sarah Liu, BSc, Isaura Frost, BSc, Wolfram Goessling, MD PhD, Trista North, PhD
Journal: Blood
Blood (2015) 126 (23): 895.
https://doi.org/10.1182/blood.V126.23.895.895
Published: 2015
Journal Articles

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

James M. Harris, Virginie Esain, Gregory M. Frechette, Lauren J. Harris, Andrew G. Cox, Mauricio Cortes, Maija K. Garnaas, Kelli J. Carroll, Claire C. Cutting, Tahsin Khan, Philip M. Elks, Stephen A. Renshaw, Bryan C. Dickinson, Christopher J. Chang, Michael P. Murphy, Barry H. Paw, Matthew G. Vander Heiden, Wolfram Goessling, Trista E. North
Journal: Blood
Blood (2013) 121 (13): 2483–2493.
https://doi.org/10.1182/blood-2012-12-471201
Published: 2013
Includes: Supplemental data
Journal Articles

Vitamin D3 Modulates Definitive Hematopoiesis by Two Distinct Mechanisms in the Developing Zebrafish Embryo

Mauricio Cortes, Ph.D., Kelsey Natsuhara, Wolfram Goessling, MD, PhD, Trista E. North, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 763.
https://doi.org/10.1182/blood.V120.21.763.763
Published: 2012
Journal Articles

Metabolism-Induced Reactive Oxygen Species and Hif1α-Mediated Gene Regulation Control the Timing and Magnitude of Hematopoietic Stem Cell Induction

James M Harris, Lauren J. Harris, Andrew G Cox, Maija K Garnaas, Gregory M Frechette, Mauricio Cortes, Claire C Cutting, Michael C Dovey, PhD, Barry H. Paw, M.D., Ph.D., Matthew Vander Heiden, MD, PhD, Wolfram Goessling, MD, PhD, Trista E. North, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 1266.
https://doi.org/10.1182/blood.V118.21.1266.1266
Published: 2011