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Journal Articles

Sensing of Liver Iron Content Requires Cell-Cell Communication between Hepatocytes and Liver Sinusoidal Endothelial Cells

Silvia Colucci, Sandro Altamura, PhD, Matthias Hentze, Prof., Martina U. Muckenthaler, PhD

Blood (2019) 134 (Supplement_1): 432.

https://doi.org/10.1182/blood-2019-125586

Published: 2019

Journal Articles

Hepcidin-Mediated Ferroportin Control in the Bone Marrow Is Dispensable

Katja Muedder, Bonadonna Michael, Bruno Galy, PhD, Martina U. Muckenthaler, PhD, Sandro Altamura, PhD

Blood (2019) 134 (Supplement_1): 3531.

https://doi.org/10.1182/blood-2019-126655

Published: 2019

Journal Articles

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Francesca Vinchi, PhD, Annalisa Castagna, B.S., PhD, Milene Costa da Silva, Fabiana Busti, MD PhD, Giacomo Marchi, MD, Richard Sparla, Martina U. Muckenthaler, PhD, Domenico Girelli, MD, PhD

Blood (2019) 134 (Supplement_1): 957.

https://doi.org/10.1182/blood-2019-132235

Published: 2019

Journal Articles

Exploring the Mechanisms of Thalassemic Erythropoiesis Improvement Caused By Bone Marrow Tfr2 Deletion

Antonella Nai, PhD, Irene Artuso, MSc, Maria Rosa Lidonnici, PhD, Sandro Altamura, PhD, Giacomo Mandelli, PhD, Mariateresa Pettinato, MSc, Martina U. Muckenthaler, PhD, Laura Silvestri, PhD, Giuliana Ferrari, PhD, Clara Camaschella, MD

Blood (2018) 132 (Supplement 1): 3624.

https://doi.org/10.1182/blood-2018-99-115835

Published: 2018

Journal Articles

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

Francesca Vinchi, PhD, Richard Sparla, Sara Passos, PhD, Heike Weidner, Martina Rauner, PhD, Uwe Platzbecker, Martina U. Muckenthaler, PhD

Blood (2018) 132 (Supplement 1): 3625.

https://doi.org/10.1182/blood-2018-99-113016

Published: 2018

Journal Articles

Hepatocyte Iron Content Controls BMP6-Dependent Hepcidin Regulation

Sandro Altamura, PhD, Silvia Colucci, MSc, Julia Schmidt, Katja Muedder, Joana Neves, Matthias Hentze, Prof., Martina U. Muckenthaler, PhD

Blood (2018) 132 (Supplement 1): 3626.

https://doi.org/10.1182/blood-2018-99-116109

Published: 2018

Journal Articles

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Sandro Altamura, PhD, Sandro Altamura, PhD, Martina U. Muckenthaler, PhD, Sibylle Dames, MSc, Christian Frauendorf, PhD, Steffen Schubert, PhD, Manuela Aleku, MSc, Jim Vadolas, PhD, George Grigoriadis, MBBS PhD FRACP FRCPA, Ulrich Zügel, PhD

Blood (2018) 132 (Supplement 1): 2340.

https://doi.org/10.1182/blood-2018-99-110163

Published: 2018

Journal Articles

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Blood (2018) 132 (Supplement 1): 1545.

https://doi.org/10.1182/blood-2018-99-118255

Published: 2018

Journal Articles

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Blood (2018) 132 (Supplement 1): 2826.

https://doi.org/10.1182/blood-2018-99-117978

Published: 2018

Journal Articles

Identification of an Ultra High-Risk and Targetable Molecular Signature in Relapsed Pediatric T-ALL

Paulina Richter-Pechanska, PhD, Joachim B. Kunz, MD, Jana Hof, Martin Zimmermann, PhD, Tobias Rausch, PhD, Obul Reddy Bandapalli, PhD, Elena Orlova, Greta Scapinello, Judit Sagi, Martin Stanulla, MD, Martin Schrappe, MD PhD, Renate Kirschner-Schwabe, PhD, Cornelia Eckert, PhD, Vladimir Benes, PhD, Jan O. Korbel, PhD, Martina U. Muckenthaler, PhD, Andreas E Kulozik, MD PhD

Blood (2016) 128 (22): 1084.

https://doi.org/10.1182/blood.V128.22.1084.1084

Published: 2016

Journal Articles

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Francesca Vinchi, PhD, Gregory M Vercellotti, MD, John D. Belcher, PhD, Eitan Fibach, PhD, Hala Zreid, MD, Rushdy Rasras, Hussam Ghoti, MD, Martina U. Muckenthaler, PhD, Eliezer A. Rachmilewitz, MD

Blood (2016) 128 (22): 2469.

https://doi.org/10.1182/blood.V128.22.2469.2469

Published: 2016

Journal Articles

The Combination of MRD and Copy Number Alterations (CNAs) Defines an Ultra-High Risk Group of Children with Primary T-Lymphoblastic Leukemia (T-ALL)

Joachim B. Kunz, MD, Julia Seemann, Martin Zimmermann, PhD, Paulina Richter-Pechanska, Obul Reddy Bandapalli, PhD, Elena Orlova, Gunnar Cario, Martin Stanulla, MD, Martin Schrappe, MD PhD, Marketa Zaliova, Jan Trka, MD PhD, Renate Panzer-Grümayer, MD, Georg Mann, MD, Martina U. Muckenthaler, PhD, Jan O. Korbel, PhD, Andreas E Kulozik, MD PhD

Blood (2016) 128 (22): 2911.

https://doi.org/10.1182/blood.V128.22.2911.2911

Published: 2016

Journal Articles

Low-Iron Diet and Chelation Therapy Rescue Severe Atherosclerosis Associated with High Circulating Iron Levels

Francesca Vinchi, PhD, Andreas Simmelbauer, Master student, Sandro Altamura, PhD, Sebastian Spaich, Richard Sparla, Bruno Galy, PhD, Matthias W. Hentze, MD, Martina U. Muckenthaler, PhD

Blood (2016) 128 (22): 199.

https://doi.org/10.1182/blood.V128.22.199.199

Published: 2016

Journal Articles

The Role of Hepcidin in Health And Disease

Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): SCI-43.

https://doi.org/10.1182/blood.V126.23.SCI-43.SCI-43

Published: 2015

Journal Articles

Gene Panel Sequencing of Primary and Relapsed Pediatric T-ALL Shows That Relapse-Specific Mutations Are Diverse and Mostly Non-Recurrent

Paulina Pechanska, Joachim Kunz, MD, Tobias Rausch, Obul Reddy Bandapalli, PhD, Elena Orlova, Judit Sagi, Martin Stanulla, MD, Martin Schrappe, MD PhD, Renate Kirschner-Schwabe, PhD, Jana Hof, Cornelia Eckert, Rolf Köhler, Martina U. Muckenthaler, PhD, Jan o. Korbel, Andreas E Kulozik, MDPhD

Blood (2015) 126 (23): 1428.

https://doi.org/10.1182/blood.V126.23.1428.1428

Published: 2015

Journal Articles

High Circulating Iron Levels Are a Risk Factor for Cardiovascular Disease: Clinical Implications for Iron-Overload Conditions

Francesca Vinchi, PhD, Andreas Simmelbauer, Master student, Milene Costa da Silva, PhDstudent, Sandro Altamura, PhD, Bruno Galy, PhD, Matthias W. Hentze, MD, Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): 1040.

https://doi.org/10.1182/blood.V126.23.1040.1040

Published: 2015

Journal Articles

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

Francesca Vinchi, PhD, Milene Costa da Silva, PhDstudent, Giada Ingoglia, PhDstudent, Sara Petrillo, PhDstudent, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, PhD, Emanuela Tolosano, PhD, Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): 2205.

https://doi.org/10.1182/blood.V126.23.2205.2205

Published: 2015

Journal Articles

Drug Response Profiling to Identify Selective Pharmacological Activity in Drug Resistant ALL

Viktoras Frismantas, MSc, Maria Pamela Dobay, PhD, Anna Rinaldi, PhD, Kunz Joachim, MD, Blerim Marovca, Peter Horvath, PhD, Mauro Delorenzi, PhD, Gunnar Cario, MD, Martin Schrappe, MD, Martin Stanulla, MD, Andreas E. Kulozik, MD PhD, Martina U. Muckenthaler, PhD, Arend Stackelberg, MD, Cornelia Eckert, Thomas Radimerski, PhD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD

Blood (2015) 126 (23): 2532.

https://doi.org/10.1182/blood.V126.23.2532.2532

Published: 2015

Journal Articles

In Vivo Disruption Of The Hepcidin−Ferroportin Regulatory Circuitry Causes Fatal Systemic and Exocrine Pancreatic Iron Overload

Sandro Altamura, PhD, Hermann Josef Gröne, MD, Regina Kessler, Bruno Galy, PhD, Matthias W. Hentze, MD, Martina U. Muckenthaler, PhD

Blood (2013) 122 (21): 175.

https://doi.org/10.1182/blood.V122.21.175.175

Published: 2013

Journal Articles

Whole Exome Sequencing In Relapsed Pediatric T-ALL: Progression Into Relapse Is Characterized By An Increased Number Of Somatic Mutations and a Conservation Of Mutations In Leukemogenic Driver Genes

Joachim Kunz, MD, Tobias Rausch, PhD, Obul R Bandapalli, PhD, Martina U. Muckenthaler, PhD, Adrian M Stuetz, PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Rupert Handgretinger, Smadar Avigad, PhD, Jan Korbel, PhD, Andreas E. Kulozik, MD, PhD

Blood (2013) 122 (21): 228.

https://doi.org/10.1182/blood.V122.21.228.228

Published: 2013

NARROW

Sensing of Liver Iron Content Requires Cell-Cell Communication between Hepatocytes and Liver Sinusoidal Endothelial Cells

Hepcidin-Mediated Ferroportin Control in the Bone Marrow Is Dispensable

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Exploring the Mechanisms of Thalassemic Erythropoiesis Improvement Caused By Bone Marrow Tfr2 Deletion

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

Hepatocyte Iron Content Controls BMP6-Dependent Hepcidin Regulation

SLN124, a Galnac-siRNA Conjugate Targeting TMPRSS6, for the Treatment of Iron Overload and Ineffective Erythropoiesis Such As in Beta-Thalassemia

Pediatric T-ALLs Developing into a Type 2 Relapse Originate from Cells That Carry the Potential of Variable Maturation into Subclones with Distinct Chromatin Landscapes

Longitudinal Multilevel Omic Analysis of Pediatric T-ALL Reveals Distinct Mechanisms for Disease Progression in Type 1 and in Type 2 Relapses

Identification of an Ultra High-Risk and Targetable Molecular Signature in Relapsed Pediatric T-ALL

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

The Combination of MRD and Copy Number Alterations (CNAs) Defines an Ultra-High Risk Group of Children with Primary T-Lymphoblastic Leukemia (T-ALL)

Low-Iron Diet and Chelation Therapy Rescue Severe Atherosclerosis Associated with High Circulating Iron Levels

The Role of Hepcidin in Health And Disease

Gene Panel Sequencing of Primary and Relapsed Pediatric T-ALL Shows That Relapse-Specific Mutations Are Diverse and Mostly Non-Recurrent

High Circulating Iron Levels Are a Risk Factor for Cardiovascular Disease: Clinical Implications for Iron-Overload Conditions

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

Drug Response Profiling to Identify Selective Pharmacological Activity in Drug Resistant ALL

In Vivo Disruption Of The Hepcidin−Ferroportin Regulatory Circuitry Causes Fatal Systemic and Exocrine Pancreatic Iron Overload

Whole Exome Sequencing In Relapsed Pediatric T-ALL: Progression Into Relapse Is Characterized By An Increased Number Of Somatic Mutations and a Conservation Of Mutations In Leukemogenic Driver Genes

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American Society of Hematology

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American Society of Hematology

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