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Martin Hapke
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Journal Articles

Timely Controlled T Cell Receptor Expression of Genetically Engineered Precursor T Cells Requires Early Transgene Induction for Leukemia Control after Hematopoietic Stem Cell Transplantation

Sayed Shahabuddin Hoseini, Martin Hapke, Jessica Herbst, Dirk Wedekind, PhD, Rolf Baumann, PhD, Andreas Krueger, Niels Heinz, Bernhard Schiedlmeier, PhD, Dario Vignali, PhD, Marcel R.M. van den Brink, MD PhD, Axel Schambach, MDPhD, Bruce R. Blazar, MD, Martin G. Sauer, MD
Journal: Blood
Blood (2014) 124 (21): 657.
https://doi.org/10.1182/blood.V124.21.657.657
Published: 2014
Journal Articles

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8 + T cells

Wolfgang Koestner, Martin Hapke, Jessica Herbst, Christoph Klein, Karl Welte, Joerg Fruehauf, Andrew Flatley, Dario A. Vignali, Matthias Hardtke-Wolenski, Elmar Jaeckel, Bruce R. Blazar, Martin G. Sauer
Journal: Blood
Blood (2011) 117 (3): 1030–1041.
https://doi.org/10.1182/blood-2010-04-283119
Published: 2011
Includes: Supplemental data
Journal Articles

Adoptive Transfer of T Cell Receptor (TCR)-Gene Engineered Allogeneic T Cells: Competitive Downregulation of Alloreactive Endogenous TCRs Reduces the Risk of Graft Versus Host Disease and Preserves Strong Graft Versus Leukemia Effects After MHC-Mismatched Hematopoietic Stem Cell Transplantation (HCT).

Wolfgang Koestner, Martin Hapke, Christoph Klein, Karl Welte, Bruce R. Blazar, MD, Martin G. Sauer, MD
Journal: Blood
Blood (2009) 114 (22): 3549.
https://doi.org/10.1182/blood.V114.22.3549.3549
Published: 2009
Journal Articles

Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras

Arnab Ghosh, Wolfgang Koestner, Martin Hapke, Verena Schlaphoff, Florian Länger, Rolf Baumann, Christian Koenecke, Markus Cornberg, Karl Welte, Bruce R. Blazar, Martin G. Sauer
Journal: Blood
Blood (2009) 113 (18): 4440–4448.
https://doi.org/10.1182/blood-2008-09-181677
Published: 2009
Journal Articles

Ex Vivo Generated Cytotoxic T Cells (CTL) for Adoptive Immunotherapy across MHC Barriers Retain Anti-Leukemic Capacity (GVL) without Eliciting Graft Versus Host Disease (GVHD): Crucial Role of Recipient-Derived Antigen Presenting Cells (APC).

Arnab Ghosh, Martin Hapke, Florian Laenger, MD, Ralf Baumann, PhD, Christian Koenecke, MD, Karl Welte, MD, Martin Sauer, MD
Journal: Blood
Blood (2006) 108 (11): 3168.
https://doi.org/10.1182/blood.V108.11.3168.3168
Published: 2006