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Markus Müschen, MD PhD
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Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies

Teresa Sadras, PhD, Mickaël Martin, MD PhD, Lauren Kim-Sing, Jevon Cutler, PhD, Gal Lenz, PhD, Anne Marie Knapp, Dana Ghergus, MD PhD, Fabien Delmotte, Cédric Schleiss, Anne-Sophie Korganow, MD PhD, Pauline Soulas-Sprauel, PharmD, PhD, Zhengshan Chen, MD PhD, Akhilesh Pandey, MD PhD, David M. Weinstock, MD, Hassan Jumaa, PhD, Eric Meffre, PhD, Thierry Martin, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 295.
https://doi.org/10.1182/blood-2019-128999
Published: 2019
Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Jaewoong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Liting Chen, PhD, Lai N Chan, PhD, Lars Klemm, MS, Chun-Wei David Chen, PhD, Ning Ma, PhD, Wing C. Chan, MD, Stephen J Forman, MD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina M. Luger, MD FRCPC, Mark Litzow, MD, Michael T McManus, PhD, Nagarajan Vaidehi, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, David M. Weinstock, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 393.
https://doi.org/10.1182/blood-2019-131270
Published: 2019
Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Autonomous Ca 2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Kohei Kume, PhD, Liting Chen, PhD, Jaewoong Lee, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1253.
https://doi.org/10.1182/blood-2019-130708
Published: 2019
Journal Articles

Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL

Gang Xiao, PhD, Kohei Kume, PhD, Huimin Geng, PhD, Than Than Han, MS, Lars Klemm, MS, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3785.
https://doi.org/10.1182/blood-2019-128719
Published: 2019
Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2782.
https://doi.org/10.1182/blood-2019-127615
Published: 2019
Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1465.
https://doi.org/10.1182/blood-2019-129849
Published: 2019
Journal Articles

Paraoxonase 2 Enables Initiation of B-ALL By Subverting Metabolic Gatekeeper Functions

Lili Pan, MD, Chao Hong, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Shaoyuan Wang, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 746.
https://doi.org/10.1182/blood-2019-125171
Published: 2019
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Lai N Chan, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Erica Ballabio, Gang Xiao, PhD, Gauri Deb, MS, PhD, Haytham Khoury, MD PhD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Tom Arthur Milne, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1239.
https://doi.org/10.1182/blood-2019-131565
Published: 2019
Journal Articles

Feedback Regulation of STAT5 Is Critical to Balance MYC and BCL6-Dependent Transcriptional Programs That Regulate Cell Size and Glucose Metabolism

Zhengshan Chen, MD PhD, Huimin Geng, PhD, Lars Klemm, BSc, MSc, Lai N Chan, PhD, Brass Daniel, PhD, Warren S. Alexander, PhD, Cheryl L. Willman, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4069.
https://doi.org/10.1182/blood.V128.22.4069.4069
Published: 2016
Journal Articles

Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments

Susanna Teppo, MSc, Juha Mehtonen, MSc, Samuli Eldfors, MSc, Caroline A Heckman, PhD, Markus Müschen, MD PhD, Merja Heinäniemi, PhD, Olli Lohi
Journal: Blood
Blood (2016) 128 (22): 4077.
https://doi.org/10.1182/blood.V128.22.4077.4077
Published: 2016
Journal Articles

mTOR Kinase Inhibitors Enhance Efficacy of TKIs in Preclinical Models of Ph-like B-ALL

Moran Gotesman, MD, Thanh-Trang T Vo, PhD, Sharmila Mallya, MS, Qi Zhang, MDPhD, Ce Shi, MD PhD, Markus Müschen, MD PhD, David M. Weinstock, MD, Charles Mullighan, MBBS, MSc, MD, Sarah K Tasian, MD, Marina Konopleva, MD PhD, David A. Fruman, PhD
Journal: Blood
Blood (2016) 128 (22): 2763.
https://doi.org/10.1182/blood.V128.22.2763.2763
Published: 2016
Journal Articles

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Gang Xiao, PhD, Zhengshan Chen, MD PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2771.
https://doi.org/10.1182/blood.V128.22.2771.2771
Published: 2016
Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2738.
https://doi.org/10.1182/blood.V128.22.2738.2738
Published: 2016
Journal Articles

PP2A Balances Glucose Metabolism and Foxo Activation to Maintain Cellular Redox Homeostasis in Acute Lymphoblastic Leukemia

Gang Xiao, PhD, Zhengshan Chen, MD PhD, Brass Daniel, PhD, Lai N Chan, PhD, Huimin Geng, PhD, Xiaoyan Jiang, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1056.
https://doi.org/10.1182/blood.V128.22.1056.1056
Published: 2016
Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4088.
https://doi.org/10.1182/blood.V128.22.4088.4088
Published: 2016
Journal Articles

Transcriptional Control of Glucose and Energy Supply Prevents Oncogenic Signaling and B Cell Transformation

Lai N Chan, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Jaewoong Lee, PhD, Huimin Geng, PhD, Hurtz Christian, PhD, Valeria Cazzaniga, PhD, Giovanni Cazzaniga, PhD, Ross A Dickins, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 437.
https://doi.org/10.1182/blood.V128.22.437.437
Published: 2016
Journal Articles

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Lai N Chan, PhD, Christian Hurtz, PhD, Gang Xiao, PhD, Seyedmehdi Shojaee, PhD, Rebecca Caeser, Huimin Geng, PhD, Ari Melnick, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 438.
https://doi.org/10.1182/blood.V128.22.438.438
Published: 2016