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Mark Wunderlich, MS
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Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2661.
https://doi.org/10.1182/blood-2019-125455
Published: 2019
Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4647.
https://doi.org/10.1182/blood-2019-130250
Published: 2019
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement

Mark Wunderlich, MS, Jing Chen, Eric O'Brien, BSc, Nicole Manning, Christina Sexton, Luke Byerly, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Journal: Blood
Blood (2019) 134 (Supplement_1): 3766.
https://doi.org/10.1182/blood-2019-129225
Published: 2019
Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Katelyn M. Melgar, PhD, LaQuita M Jones, DO, Mackenzie Walker, Lyndsey C Bolanos, BSc, Kathleen Hueneman, Mark Wunderlich, MS, Jiang-Kang Jiang, Kelli Wilson, Xiaohu Zhang, Patrick Sutter, Xin Xu, Kwangmin Choi, PhD, Gregory Tawa, Donald Lorimer, Jan Abendroth, Eric O'Brien, BSc, Scott Hoyt, Ellin Berman, MD, Christopher Famulare, MS, James C Mulloy, Ross L. Levine, MD, Jan S Rosenbaum, John P Perentesis, Craig J Thomas, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3934.
https://doi.org/10.1182/blood-2019-124178
Published: 2019
Journal Articles

Modeling Effective AML Therapies - Comparative Anti-Leukemic Synergy of BCL2 and MCL1 Inhibition Combined and with Chemotherapy

Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Jackson Alexander, Mitali Basu, MSc, Mark Wunderlich, MS, Mayur Sarangdhar, PhD, Benjamin Mizukawa, John P Perentesis
Journal: Blood
Blood (2019) 134 (Supplement_1): 3370.
https://doi.org/10.1182/blood-2019-131613
Published: 2019
Journal Articles

Proton Sensor GPR68 Is Essential to Maintain Myeloid Malignancies

Xiaofei He, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, MD, James C. Mulloy, PhD, Saran Feng, MD, PhD, Lauren Lawley, B.S., Caleb Hawkins, B.S., Wenxin Fan, B.S., Guokun Zhou, PhD, Xiang-ming Zha, PhD, Jiajia Zhang, PhD, Johnie Hodge, MD,PhD, Daping Fan, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1353.
https://doi.org/10.1182/blood-2018-99-110399
Published: 2018
Journal Articles

In Vitro Approach for the Identification of Exceptional Responders in Acute Myeloid Leukemia

Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Luke Byerly, BSc, Alexander Merk, BSc, Mayur Sarangdhar, PhD, Mark Wunderlich, MS, Mitali Basu, MSc, Benjamin Mizukawa, MD, Erin H. Breese, MD PhD, William Seibel, PhD, John Peter Perentesis, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2212.
https://doi.org/10.1182/blood-2018-99-116650
Published: 2018
Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Xi Jiang, PhD, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, PhD, Liting Cheng, Zhixiang Zuo, PhD, William Seibel, PhD, Chunjiang He, PhD, Yixuan Tang, Jennifer R Skibbe, Mark Wunderlich, MS, William C Reinhold, Lei Dong, PhD, Chao Shen, PhD, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, PhD, Hengyou Weng, PhD, Rui Su, PhD, Huilin Huang, PhD, Yungui Wang, PhD, Chenying Li, MD, Xi Qin, James C. Mulloy, PhD, Yi Zheng, PhD, Jiajie Diao, PhD, Jie Jin, Chong Li, PhD, Paul P Liu, MD, Chuan He, PhD, Yuan Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 857.
https://doi.org/10.1182/blood.V130.Suppl_1.857.857
Published: 2017
Journal Articles

PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of B-Cell Acute Lymphoblastic Leukemia

Mark Wunderlich, MS, Nicole Manning, Christina Sexton, Perentesis P John, MD, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1318.
https://doi.org/10.1182/blood.V130.Suppl_1.1318.1318
Published: 2017
Journal Articles

A Xenograft Model of Lymphocyte-Independent, Effector-Driven Macrophage Activation SyndRome Amenable to Anti-CD33 and Anti-IL-6R Treatment

Mark Wunderlich, MS, Courtney Stockman, Mahima Devarajan, Navin Ravishankar, Christina Sexton, Ashish R Kumar, MBBS, PhD, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 3684.
https://doi.org/10.1182/blood.V128.22.3684.3684
Published: 2016
Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2016) 128 (22): 3860.
https://doi.org/10.1182/blood.V128.22.3860.3860
Published: 2016
Journal Articles

Lymphoid Lineage Preference of MLL-AF4 Is Revealed in a Species-Specific Model

Shan Lin, Roger T. Luo, PhD, Mark Wunderlich, MS, Joseph J. Kaberlein, Ahmad Rayes, MDMSc, John Anastasi, MD, Maureen M O'Brien, MD, James C. Mulloy, PhD, Michael J. Thirman, MD
Journal: Blood
Blood (2015) 126 (23): 2454.
https://doi.org/10.1182/blood.V126.23.2454.2454
Published: 2015
Journal Articles

Maintenance Of Bone Marrow Residency and Self-Renewal Of Leukemic Stem Cells By Cdc42 Gtpase

Benjamin Mizukawa, MD, Eric O'Brien, BS, Wei Liu, MD, PhD, Daniel Moriera Ridsdale, MD, Mark Wunderlich, MS, Yi Zheng, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2013) 122 (21): 2889.
https://doi.org/10.1182/blood.V122.21.2889.2889
Published: 2013
Journal Articles

CD3 Antibody Treatment Prevents Gvhd and Allows For Rapid, Long Term, Multilineage Engraftment Of Unfractionated UCB Into Immunodeficient Mice

Mark Wunderlich, MS, Ryan Brooks, Garrett Rhyasen, BSc, James C. Mulloy, PhD
Journal: Blood
Blood (2013) 122 (21): 2018.
https://doi.org/10.1182/blood.V122.21.2018.2018
Published: 2013
Journal Articles

NSGS Mice Develop a Progressive, Myeloid Cell Dependent Aplastic Anemia and Bone Marrow Failure Upon Engraftment With Human Umbilical Cord Blood CD34+ Cells

Mark Wunderlich, MS, Christina Sexton, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2013) 122 (21): 3716.
https://doi.org/10.1182/blood.V122.21.3716.3716
Published: 2013
Journal Articles

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Helena Agerstam, PhD, Maria Askmyr, PhD, Nils Hansen, Marianne Rissler, Gunnar Juliusson, MD, PhD, Johan Richter, MD, PhD, Mark Wunderlich, MS, Marcus Järås, PhD, James C. Mulloy, PhD, Thoas Fioretos, MD PhD
Journal: Blood
Blood (2013) 122 (21): 3954.
https://doi.org/10.1182/blood.V122.21.3954.3954
Published: 2013
Journal Articles

Development and Characterization of a Novel Human Xenograft Model Using an MDS Patient-Derived Cell Line

Garrett Rhyasen, BSc, Mark Wunderlich, MS, James C. Mulloy, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2012) 120 (21): 3814.
https://doi.org/10.1182/blood.V120.21.3814.3814
Published: 2012
Journal Articles

Prenatal Origin of Monosomy 7 in Very Young Children.

Parinda A. Mehta, M.D., Mark Wunderlich, MS, Teresa Smolarek, PhD, Stella M. Davies, MBBS, PhD, Sarah Zimmerman, PhD, Alexandra H. Filipovich, MD, Emmett H. Broxson, Jr., MD, Jose A. Cancelas, M.D. PhD., James C. Mulloy, PhD
Journal: Blood
Blood (2012) 120 (21): 2557.
https://doi.org/10.1182/blood.V120.21.2557.2557
Published: 2012
Journal Articles

Stroma-Free Ex Vivo Expanded, CD34+ Cord Blood-Derived NK Cells Retain Lytic Activity After Long-Term Engraftment in NSGS Mice

Mark Wunderlich, MS, Mahesh Shrestha, MS, Lin Kang, PhD, Eric Law, MS, Vladimir Jankovic, MD, Xiaokui Zhang, PhD, Uri Herzberg, PhD, DVM, Stewart Abbot, PhD, Robert Hariri, MD, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2012) 120 (21): 580.
https://doi.org/10.1182/blood.V120.21.580.580
Published: 2012