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Journal Articles

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3 , IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group

Blanca Boluda, Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, María Carmen Chillón Santos, Estrella Carrillo-Cruz, Cristina Bilbao, Esther Prados de La Torre, Irene Navarro-Vicente, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, Maria Jose Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3438–3440.
https://doi.org/10.1182/blood-2022-160136
Published: 2022
Journal Articles

Evaluation of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent Low Risk Del(5q) MDS Patients. Final Results of Sintra-REV Phase III International Multicenter Clinical Trial

Félix López Cadenas, Eva Lumbreras, Teresa González, Blanca Xicoy, Joaquín Sánchez-García, Rosa Coll, Bohrane Slama, José Ángel Hernández-Rivas, Sylvain Thepot, Teresa Bernal, Agnès Guerci-Bresler, Guillermo Sanz, Joan Bargay, Maria Luz Amigo, Raquel De Paz Arias, Claude Preudhomme, Aristoteles Giagounidis, Uwe Platzbecker, Stefan Wickenhauser, Katharina S. Goetze, Ali Arar, Jesús M Hernández Rivas, Sofía M Toribio Castelló, Pierre Fenaux, Consuelo Del Cañizo, Maria Diez-Campelo
Journal: Blood
Blood (2022) 140 (Supplement 1): 1109–1111.
https://doi.org/10.1182/blood-2022-168718
Published: 2022
Journal Articles

Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications

Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, Carmen Chillon, Estrella Carrillo, Cristina Bilbao, Esther Prados de La Torre, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martínez Sánchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, María J. Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3422–3424.
https://doi.org/10.1182/blood-2022-166639
Published: 2022
Journal Articles

Indolent Acute Myeloid Leukemia with Long Survival in Patients Treated with Best Supportive Care Only: A Pethema Registry Study

Jorge Labrador, Josefina Serrano, Laura Torres, Evelyn Acuña-Cruz, Jose A. Perez-Simon, Maria Lopez-Pavia, Gabriela Rodriguez Macias, Carmen Botella, Carlos Rodriguez, Pilar Martinez Sanchez, Maria Luz Amigo, Maria Victoria Cuevas, Teresa Bernal del Castillo, María Carmen Montes, Celina Benavente, Juan Ignacio Rodriguez-Gutierrez, Mar Tormo, Raimundo García-Boyero, Aurelio Lopez Martínez, Rafael Lluch Garcia, Jesús Lorenzo Algarra, Esperanza Lavilla, David Martinez-Cuadron, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 8919–8920.
https://doi.org/10.1182/blood-2022-162591
Published: 2022
Journal Articles

Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)

Jorge Labrador, David Martinez-Cuadron, Blanca Boluda, Josefina Serrano, Cristina Gil, Jose A. Perez-Simon, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Joaquín Martínez-López, Carlos Rodriguez, María Belén Vidriales, Raimundo García-Boyero, Jesús Lorenzo Algarra, Marta Polo, Maria Jose Sayas, Mar Tormo, Pilar Herrera, Esperanza Lavilla, Fernando Ramos, Maria Luz Amigo, Susana Vives, Joaquín Sánchez-Garcia, Cristina Bilbao, María Carmen Chillón Santos, Maria Jose Larrayoz, Rosa Ayala, Eva Barragán, Miguel A. Sanz, Pau Montesinos, Juan Manuel Alonso-Dominguez
Journal: Blood
Blood (2022) 140 (Supplement 1): 9100–9102.
https://doi.org/10.1182/blood-2022-163016
Published: 2022
Journal Articles

Nationwide Laboratory Network for AML Cross-Validated NGS Studies: Results from a Real-Life Cohort of the Pethema Group

Claudia Sargas, Rosa Ayala, Carmen Chillon, Maria Jose Larrayoz, Estrella Carrillo, Cristina Bilbao, Manuel Yébenes, Marta Llop, Inmaculada Rapado, Ramon Garcia-Sanz, Iria Vazquez, Elena Soria, Santiago Sánchez-Sosa, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martinez-Cuadron, Juan-Miguel Bergua, Maria Luz Amigo, Pilar Martinez Sanchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García-Boyero, Lorenzo Algarra, Maria Jose Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan Manuel Alonso Dominguez, Miguel A. Sanz, Joaquín Sánchez, María Teresa Gómez-Casares, Jose A. Perez-Simon, María José Calasanz, Marcos González, Joaquín Martínez-López, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1302.
https://doi.org/10.1182/blood-2021-152353
Published: 2021
Journal Articles

Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome–negative adult lymphoblastic leukemia

Clinical Trials & Observations
Josep-Maria Ribera, Mireia Morgades, Juana Ciudad, Pau Montesinos, Jordi Esteve, Eulàlia Genescà, Pere Barba, Jordi Ribera, Irene García-Cadenas, María José Moreno, Daniel Martínez-Carballeira, Anna Torrent, Pilar Martínez-Sánchez, Silvia Monsalvo, Cristina Gil, Mar Tormo, María Teresa Artola, Marta Cervera, José González-Campos, Carlos Rodríguez, Arancha Bermúdez, Andrés Novo, Beatriz Soria, Rosa Coll, María-Luz Amigo, Aurelio López-Martínez, Rosa Fernández-Martín, Josefina Serrano, Santiago Mercadal, Antònia Cladera, Alberto Giménez-Conca, María-Jesús Peñarrubia, Eugènia Abella, Ferran Vall-llovera, Jesús-María Hernández-Rivas, Antoni Garcia-Guiñon, Juan-Miguel Bergua, Beatriz de Rueda, María-José Sánchez-Sánchez, Alfons Serrano, María Calbacho, Natalia Alonso, Jose-Ángel Méndez-Sánchez, Raimundo García-Boyero, Matxalen Olivares, Susana Barrena, Lurdes Zamora, Isabel Granada, Ludovic Lhermitte, Evarist Feliu, Alberto Orfao
Journal: Blood
Blood (2021) 137 (14): 1879–1894.
https://doi.org/10.1182/blood.2020007311
Published: 2021
Includes: Supplemental data
Journal Articles

Impact of Measurable Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC): A Real-World Study in 1,076 Patients with Acute Myeloid Leukemia (AML)

Bruno Paiva, PhD, María Belén Vidriales, Maria Desamparados Sampere Talens, Fabian Tarin, Enrique Colado, Celina Benavente, María Teresa Cedena, MD, Joaquin Sanchez, MD, Teresa Caballero-Velázquez, MD PhD, Lourdes Cordon, David Martínez-Cuadron, MD, Teresa Bernal del Castillo, MD PhD, Carmen Botella, Sofia Grille, MDPhD, Josefina Serrano, MD, Carlos Rodriguez, Jesús Lorenzo Algarra, Juan Manuel Alonso Dominguez, MD PhD MSc, Maria Luz Amigo, MD, Manuel BARRIOS García, MDPhD, Raimundo García-Boyero, MD, Mercedes Colorado, MD, Jaime Perez De Oteyza, MDPhD, Manuel Perez Encinas, MD, Lissette Del Pilar Costilla, MD, Maria Jose Sayas, Olga Pérez-López, Marcos González, Jose A. Perez-Simon, MD PhD, Joaquin Martinez-Lopez, MD PhD, Claudia Lucia Sossa, Alberto Orfao, MD PhD, Jesús F. San-Miguel, Miguel Sanz, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-134349
Published: 2020
Journal Articles

Phase 3 Study of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients - Interim Analysis of the European Sintra-REV Trial

Félix López Cadenas, MD, Eva Lumbreras, Blanca Xicoy, MD, Joaquín Sánchez, MD, Rosa Coll, MD, Bohrane Slama, MD, Jose Angel Hernandez-Rivas, MD PhD, Sylvain Thepot, MD, Teresa Bernal, MD PhD, Beatriz Arrizabalaga, MD PhD, Agnès Guerci-Bresler, MD PhD, Guillermo F Sanz, MD PhD, Joan Bargay, MD, Maria Luz Amigo, MD, Raquel de Paz, MD, Benet Nomdedeu, MD, Aristoteles Giagounidis, Uwe Platzbecker, Stefan Wickenhauser, Katharina S. Götze, Ali Arar, Jesus María Hernández Rivas, MD PhD, Pierre Fenaux, MD PhD, Consuelo Del Cañizo, MDPhD, Maria Diez-Campelo, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-140339
Published: 2020
Journal Articles

Outcome of Adults with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL) Included in Minimal Residual Disease (MRD)-Oriented Trials

Josep-Maria Ribera, Eduardo Cerello Chapchap, MD, Mireia Morgades, M.Prob.S, Eulàlia Genescà, PhD, Cristina Gil, Irene García-Cadenas, Pere Barba, MD PhD, José González-Campos, MD, Anna Torrent, Teresa Bernal del Castillo, MD PhD, Maria Paz Queipo De Llano, MD, María-Luz Amigo, MD, Mar Tormo, MD, Rosa Coll, MD, Ferran Vall-Llovera, MD, Jordi Ribera, PhD, Maria Jose Sanchez, MD, Beatriz Soria, MD, Antonia Cladera, María Teresa Artola, MD, Antoni Garcia-Guiñon, MD, Alberto Giménez Conca, MD, Lourdes Amador Barciela, MD, Juana Ciudad, PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-137383
Published: 2020
Journal Articles

Triple-hit lymphoma with hyperbasophilic Burkitt-like morphology and solely bone marrow/leukemic phase presentation

Francisco J. Ortuño, Maria-Luz Amigo
Journal: Blood
Blood (2020) 136 (10): 1212.
https://doi.org/10.1182/blood.2020007134
Published: 2020
Journal Articles

Post-Remission Treatment with Chemotherapy or Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) in Adult Patients with High-Risk (HR) Philadelphia Chromosome-Negative (Ph-neg) Acute Lymphoblastic Leukemia (ALL) According to Their Minimal Residual Disease (MRD). Final Results of the Pethema ALL-HR-11 Trial

Josep-Maria Ribera, MD PhD, Mireia Morgades, M.Prob.S, Juana Ciudad, PhD, Pau Montesinos, MD PhD, Pere Barba, MD PhD, Irene García-Cadenas, María José Moreno, MD, Susana Vives, MD, Jordi Esteve, Cristina Gil, Silvia Monsalvo, MD, María Teresa Artola, MD, Jordi Ribera, PhD, Eulàlia Genescà, PhD, Mar Tormo, MD PhD, Marta Cervera, MD, Daniel Martínez-Carballeira, MD, Andrés Novo, MD, José González-Campos, MD, Beatriz Soria, MD, Arancha Bermúdez, MD, Aurelio López Martínez, MD, Santiago Mercadal, MD, Rosa Fernández-Martín, MD, Rosa Coll, MD, Josefina Serrano, Maria Luz Amigo, MD, Pilar Martínez-Sánchez, Juan-Miguel Bergua, MD, Alfons Serrano-Maestro, MD, Alberto Giménez Conca, MD, Susana Barrena, PhD, Isabel Granada, PhD, Evarist Feliu, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 826.
https://doi.org/10.1182/blood-2019-123613
Published: 2019
Journal Articles

Phase 3 Study of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients with Del(5q) — Preliminary Blinded Analysis of the European Sintra-REV Trial

Félix López Cadenas, MD, Eva Lumbreras, Blanca Xicoy, Joaquin Sanchez-Garcia, MD PhD, Pierre Fenaux, MD PhD, Rosa Coll, Borhane Slama, MD, Jose Angel Hernandez-Rivas, MD, Sylvain Thepot, MD, Teresa Bernal, MD, Beatriz Arrizabalaga, MD PhD, Agnès Guerci, Guillermo Sanz, Joan Bargay, MD PhD, Maria Luz Amigo, Raquel de Paz, Aristoteles Giagounidis, Uwe Platzbecker, Benet Nomdedeu, Eric Jourdan, MD, Katharina S. Götze, MD, Ali Arar, Jesús María Hernández-Rivas, MD PhD, Consuelo Del Cañizo, MDPhD, María Díez-Campelo
Journal: Blood
Blood (2018) 132 (Supplement 1): 468.
https://doi.org/10.1182/blood-2018-99-119430
Published: 2018
Journal Articles

Characteristics and Outcome of Early T Cell Precursor ALL (ETP-ALL) Patients Treated with High-Risk Spanish Pethema Protocols

Eulalia Genesca, PhD, Mireia Morgades, M.Prob.S, Pau Montesinos, MD PhD, Pere Barba, MD, Cristina Gil, MD PhD, Ramon Guàrdia, MD, Maria Jose Moreno, MD, Daniel Martínez-Carballeira, MD, Irene García-Cadenas, Susana Vives, MD, Jordi Ribera, José González-Campos, MD, Marina Diaz-Beyá, MD, Santiago Mercadal, MD, Maria Teresa Artola, MD, Antonia Cladera, MD, Mar Tormo, MD PhD, Arancha Bermudez, MD, Ferran Vall-Llovera, MD, Pilar Martinez, MD, María-Luz Amigo, MD, Juan-Miguel Bergua, MD, María Calbacho, MD, Jesús-María Hernández-Rivas, MD PhD, Silvia Monsalvo, Andrés Novo, MD, Marta Cervera, MD, Antonio Garcia-Guiñon, MD, Jordi Junca, MD, Juana Ciudad, PhD, Alberto Orfao, MD PhD, Josep-Maria Ribera, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1553.
https://doi.org/10.1182/blood-2018-99-114559
Published: 2018
Journal Articles

Transcriptome of DNA Repair Genes in CMML: Rationale for Targeting ERCC1 and CDKN1A As a Synthetic Lethality Approach

Ana M Hurtado, Ginés Luengo-Gil, Tzu Hua Chen-Liang, Fabio Amaral, Laura Palomo, MSc, Eva Lumbreras, Bartlomiej Przychodzen, Eva Caparrós, Maria Luz Amigo, Maria Díez-Campelo, Lurdes Zamora, PhD, Eduardo José Salido, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Francisco José Ortuño, Vicente Vicente, Consuelo Del Cañizo, MDPhD, Francesc Sole, PhD, Francisca Ferrer Marin, Daniel Wiseman, MB, ChB, Andres Jerez
Journal: Blood
Blood (2017) 130 (Supplement 1): 1679.
https://doi.org/10.1182/blood.V130.Suppl_1.1679.1679
Published: 2017
Journal Articles

Results of the Full Pediatric, Minimal Residual Disease (MRD)-Oriented Trial LAL-RI/2008 for Adolescents and Young Adults (AYA) with Standard Risk (SR), Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL)

Josep-Maria Ribera, MD, Mireia Morgades, M.Prob.S, Pau Montesinos, MD PhD, Daniel Martínez-Carballeira, MD, Cristina Gil, MD, Pere Barba, MD, Mar Tormo, MD PhD, Raimundo García-Boyero, MD, Ramon Guàrdia, MD, María Pedreño, MD, Santiago Mercadal, MD, Andrés Novo, MD, Jesús-María Hernández-Rivas, MD PhD, Juan Bergua, MD, José González-Campos, MD, María-Luz Amigo, MD, Marta Cervera, MD, Pilar Martínez-Sánchez, MD, Rodrigo Martino, MD PhD, María Calbacho, MD, Antoni Garcia-Guiñon, MD, Susana Vives, MD, Evarist Feliu, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1273.
https://doi.org/10.1182/blood.V130.Suppl_1.1273.1273
Published: 2017
Journal Articles

Is the Outcome of Patients with High Risk T-Cell Acute Lymphoblastic Leukemia Improving in the Era of Pediatric—Inspired Protocols? a Comparison of 2 Consecutive Pethema Trials

Pere Barba, MD, Mireia Morgades, M.Prob.S, Pau Montesinos, MD PhD, Cristina Gil, MD, Maria Laura Fox, Juana Ciudad, maria Jose Moreno, José González-Campos, MD, Eulalia Genesca, Daniel Martínez-Carballeira, MD, Rodrigo Martino, MD PhD, Susana Vives, MD, Ramon Guàrdia, MD, Santiago Mercadal, MD, Maria Teresa Artola, Antonia Cladera, Mar Tormo, MD PhD, Jordi Esteve, MD, Juan Bergua, MD, Ferran Vall-Llovera, Jordi Ribera, Pilar Martínez-Sánchez, MD, María-Luz Amigo, MD, Arancha Bermudez, María Calbacho, MD, Jesús-María Hernández-Rivas, MD PhD, Evarist Feliu, MD PhD, Josep-Maria Ribera, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1323.
https://doi.org/10.1182/blood.V130.Suppl_1.1323.1323
Published: 2017
Journal Articles

Frequency and Prognostic Significance of the Presence of Additional Cytogenetic Abnormalitions (ACA) to the Philadelphia (Ph) Chromosome in Young Adults with ACUTE Lymphoblastic Leukemia (ALL) Treated with the ALL Ph08 Trial from the Pethema Group

Cristina Motlló, MD, Josep-Maria Ribera, MD PhD, Mireia Morgades, MProbS, Isabel Granada, Pau Montesinos, MD PhD, Santiago Mercadal, MD, José González-Campos, MD, Maria-José Moreno, MD, Pere Barba, MD PhD, Marta Cervera, MD, Manuel Barrios, MD, Andrés Novo, MD, Teresa Bernal, MD PhD, Jesus María Hernandez-Rivas, MD PhD, Eugenia Abella, MD PhD, Maria Luz Amigo, MD, Mar Tormo, MD, Rodrigo Martino, MD PhD, Esperanza Lavilla, MD, Juan Bergua, MD, Alfons Serrano, MD, Daniel García-Belmonte, MD, Ramon Guàrdia, MD PhD, Javier Grau, Evarist Feliu, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1602.
https://doi.org/10.1182/blood.V128.22.1602.1602
Published: 2016
Journal Articles

Downregulation of BAP1 in Chronic Myelomonocytic Leukemia: Correlated with a Post-Translational Reduction of BRCA1 Levels and Independent of Promoter Methylation

Ana María Hurtado, Gines Luengo-Gil, Laura Palomo, MSc, Eva Lumbreras, Eva Caparrós, Tzu Hua Chen-Liang, Bartlomiej Przychodzen, MSc, Maria Luz Amigo, María Díez-Campelo, MD PhD, Lurdes Zamora, PhD, Francisco José Ortuño, Raul Teruel Montoya, PhD, Jaroslaw P. Maciejewski, MD PhD, Consuelo Del Cañizo, MD PhD, Francesc Sole, PhD, Francisca Ferrer-Marin, Andres Jerez
Journal: Blood
Blood (2015) 126 (23): 1648.
https://doi.org/10.1182/blood.V126.23.1648.1648
Published: 2015
Journal Articles

Prognostic Value of Complex Karyotype and Monosomal Karyotype in Patients with Adult Acute Lymphoblastic Leukemia Treated with Risk-Adapted Protocols

Cristina Motlló, Josep-Maria Ribera, MD, PhD, Mireia Morgades, Isabel Granada, Javier Grau, MD, Pau Montesinos, José González-Campos, Pascual Fernández-Abellán, Mar Tormo, Concha Bethencourt, MD, Salut Brunet, Jesús M Hernández-Rivas, MJ Moreno, Jose Sarra, Eloy Del Potro, MD, Pere Barba, Teresa Bernal, MD, Maria-Luz Amigo, Carlos Grande, Arancha Bermudez, MD, Ramon Guardia, Andrés Llorente, Maria Jesús Peñarrubia, Jesús Arias, Miguel Angel Sanz, Evarist Feliu, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4785.
https://doi.org/10.1182/blood.V120.21.4785.4785
Published: 2012