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Mahadeo A Sukhai, PhD
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Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 2527.
https://doi.org/10.1182/blood.V122.21.2527.2527
Published: 2013
Journal Articles

A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis

Rashmi S. Goswami, MD, FRCPC, Yali Xuan, Levi Waldron, Ph.D., Mahadeo A. Sukhai, PhD, Patricia P Reis, Ph.D., Thomas Sun, Alessandro Datti, PhD, Wei Xu, Ph.D., John Kuruvilla, MD, FRCPC, David Good, MD, FRCPC, Raymond Lai, MD, Ph.D., Wilson Lam, Alanna Church, MD, David LeBrun, MD, Laurie H. Sehn, MD, Pedro Farinha, MD, Igor Jurisica, Ph.D., Denis Bailey, MD, Randy D. Gascoyne, MD, Michael Crump, MD, FRCPC, Suzanne Kamel-Reid, PhD
Journal: Blood
Blood (2012) 120 (21): 1586.
https://doi.org/10.1182/blood.V120.21.1586.1586
Published: 2012
Journal Articles

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Jhas Bozhena, BSc, Shrivani Sriskanthadevan, PhD, Marko Skrtic, PhD, Mahadeo A. Sukhai, PhD, Veronique Voisin, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Rob C. Laister, PhD, Gary D. Bader, Ph.D., Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD
Journal: Blood
Blood (2012) 120 (21): 1364.
https://doi.org/10.1182/blood.V120.21.1364.1364
Published: 2012
Journal Articles

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Rose Hurren, BSc, Fengshu Lin, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Methvin Isaac, PhD, Elisa Leung, BSc., Mohan Babu, PhD, Mahadeo A. Sukhai, PhD, Walid A. Houry, PhD, Aaron D. Schimmer, MD
Journal: Blood
Blood (2012) 120 (21): 3603.
https://doi.org/10.1182/blood.V120.21.3603.3603
Published: 2012
Journal Articles

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Shrivani Sriskanthadevan, PhD, Timothy E Chung, Marko Skrtic, PhD, Bozhena Jhas, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Xiao Ming Wang, Yulia Jitkova, PhD, Mahadeo A. Sukhai, PhD, Feng-Hsu Lin, PhD, Neil Maclean, BSc, Rob C. Laister, PhD, Peter Mullen, PhD, Stephanie Xie, Linda Penn, PhD, Ian M. Rogers, PhD, John E. Dick, PhD $, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2581.
https://doi.org/10.1182/blood.V120.21.2581.2581
Published: 2012
Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Mahadeo A. Sukhai, PhD, Rose Hurren, BSc, Angela Rutledge, PhD, Bozena Livak, Xiaoming Wang, Ayesh Seneviratne, Maria Christine Cusimano, Marinella Gebbia, PhD, Marko Skrtic, Hong Sun, Marcela Gronda, MSc, Paul A. Spagnuolo, PhD, Malene Urbanus, PhD, Kolja Eppert, PhD, Dilan Dissanayake, Xiaoming Li, PhD, Thomas Sun, Frederick Vizeacoumar, Alessandro Datti, PhD, Pamela Ohashi, PhD, FRSC, Jeff L. Wrana, PhD, Ian M. Rogers, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Seth J. Corey, MD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 61.
https://doi.org/10.1182/blood.V118.21.61.61
Published: 2011
Journal Articles

The Anti-Malarial Mefloquine Demonstrates Preclinical Activity In Leukemia and Myeloma, and Is Dependent Upon Toll-Like Receptor Signaling for Its Cytotoxicity

Mahadeo A. Sukhai, PhD, Xiaoming Li, PhD, Rose Hurren, Xiaoming Wang, Skrtic Marko, B.Sc., Hong Sun, Marcela Gronda, Ayesh Seneviratne, Dilan Dissanayake, Sue Chow, Rod Bremner, PhD, David Hedley, MD, Mark D. Minden, MD, PhD, Ohashi Pamela, PhD, FRSC, Aaron Schimmer, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 290.
https://doi.org/10.1182/blood.V116.21.290.290
Published: 2010
Journal Articles

Assessment of Microrna Expression in Mantle Cell Lymphoma Using High Throughput Techniques

Rashmi S Goswami, MD, FRCPC, Nilva de Karla Cervigne, MSc, Patricia Pintor dos Reis, PhD, Mahadeo A Sukhai, PhD, John Kuruvilla, MD, FRCPC, Michael Crump, MD, FRCPC, Denis Bailey, MD, FRCPC, Suzanne Kamel-Reid, PhD, FACMG
Journal: Blood
Blood (2008) 112 (11): 2824.
https://doi.org/10.1182/blood.V112.11.2824.2824
Published: 2008