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Journal Articles

A Novel BCL2-Driven Compound Mutant Mouse Model for In Vivo Research on BH3 Mimetics

Ismini Halmer, Alexandra da Palma Guerreiro, PhD, Laura Beckmann, MD, Christian Reinhardt, MD, Hamid Kashkar, Michael Hallek, Lukas P. Frenzel, MD

Blood (2020) 136 (Supplement 1): 39.

https://doi.org/10.1182/blood-2020-142569

Published: 2020

Journal Articles

BIM Regulation Is BTK Dependent and Can be Targeted By Entospletinib in Ibrutinib Refractory Mutants

Laura Beckmann, MD, Valeska Berg, PhD, Clarissa Dickhut, Gunter Krause, PhD, René Zahedi, PhD, Michael Hallek, Lukas P. Frenzel, MD

Blood (2019) 134 (Supplement_1): 1765.

https://doi.org/10.1182/blood-2019-127148

Published: 2019

Journal Articles

FcmR Shapes BCR Signaling in IgM-Positive Leukemia

Alexandra da Palma Guerreiro, PhD, Cornelia Dorweiler, Ismini Halmer, Olaf Merkel, Elena Maria Hartmann, MD, Valeska Berg, PhD, Nina Reinart, Günter Fingerle-Rowson, MD PhD, Gero Knittel, MSc, Christian Pallasch, MD, Andreas Rosenwald, Christian Reinhardt, MD, Clemens-Martin Wendtner, Michael Hallek, MD, Lukas P. Frenzel, MD

Blood (2018) 132 (Supplement 1): 2620.

https://doi.org/10.1182/blood-2018-99-118352

Published: 2018

Journal Articles

Integrated Proteomic and Phosphoproteomic Analysis Reveal Novel Targets and Suggest Rationale for Ibrutinib Efficacy in UM-CLL

Laura Beckmann, MD, Valeska Berg, PhD, Clarissa Dickhut, Johannes Bloehdorn, MD, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Malte Hülsemann, MD, Stefan Loroch, Olaf Merkel, Kirsten Fischer, MD, Clemens-Martin Wendtner, Stephan Stilgenbauer, Albert Sickmann, PhD, Michael Hallek, René Zahedi, PhD, Lukas P. Frenzel, MD

Blood (2018) 132 (Supplement 1): 583.

https://doi.org/10.1182/blood-2018-99-118235

Published: 2018

Journal Articles

Increased Palmitoylation Modulates Cytoskeletal Regulators to Enhance CXCR4-Mediated Motility of Malignant B Cells

Andrea Haerzschel, PhD, Dunja Baatout, PhD, Valeska Berg, PhD, Manuela Paunovic, Karin Oberascher, PhD, Hubert Kerschbaum, PhD, Richard Greil, MD, Michael J. Hallek, MD, Tanja N. Hartmann, PhD, Lukas P. Frenzel, MD

Blood (2017) 130 (Supplement 1): 3988.

https://doi.org/10.1182/blood.V130.Suppl_1.3988.3988

Published: 2017

Journal Articles

Mechanisms of Venetoclax Resistance in Chronic Lymphocytic Leukemia

Blood (2017) 130 (Supplement 1): 263.

https://doi.org/10.1182/blood.V130.Suppl_1.263.263

Published: 2017

Journal Articles

Loss of TOSO Promotes Richter's Transformation of TCL1A Driven CLL

Alexandra da Palma Guerreiro, PhD, Cornelia Dorweiler, Laurent Kintzelé, Dunja Baatout, M.Sc., Malte Huelsemann, Valeska Berg, PhD, Olaf Merkel, Nina Reinart, PhD, Guenter Fingerle-Rowson, MD PhD, Gero Knittel, Christian Pallasch, MD, Hans Christian Reinhardt, Clemens Martin Wendtner, MD, Michael Hallek, Lukas P. Frenzel, MD

Blood (2016) 128 (22): 354.

https://doi.org/10.1182/blood.V128.22.354.354

Published: 2016

Journal Articles

APT1-Mediated Cross-Talk Between Palmitoylation and Phosphorylation Events of the BCR Pathway Sensitizes CLL Cells Towards BCR-Associated Kinase Inhibitors

Valeska Berg, PhD, Dunja Baatout, M.Sc., Clemens Wendtner, MD, Michael Hallek, Lukas P. Frenzel, MD

Blood (2016) 128 (22): 4361.

https://doi.org/10.1182/blood.V128.22.4361.4361

Published: 2016

Journal Articles

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Malte F Huelsemann, Michaela Patz, PhD, Laura Beckmann, Kerstin Brinkmann, Teresa Otto, Joachim Fandrey, MD, Hans Jiro Becker, Sebastian Theurich, MD, Michael S. von Bergwelt-Baildon, MD PhD, Christian P. Pallasch, MD, Réne P. Zahedi, Hamid Kashkar, PhD, Christian Reinhardt, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1947.

https://doi.org/10.1182/blood.V124.21.1947.1947

Published: 2014

Journal Articles

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Valeska Berg, Marion Rusch, PhD, Nachiket Vartak, PhD, Christian Juengst, Astrid Schauss, Herbert Waldmann, PhD, Christian Hedberg, PhD, Christian P. Pallasch, MD, Philippe Bastiaens, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2014) 124 (21): 1953.

https://doi.org/10.1182/blood.V124.21.1953.1953

Published: 2014

Journal Articles

Increased Functional T Cell Defects in Patients with low CD4 Counts after Allogeneic Hematopoietic Stem Cell Transplantation

Udo Holtick, MD PhD, Lukas P. Frenzel, MD, Shimabukuro-Vornhagen Alexander, MD, Sebastian Theurich, MD, Julia Claasen, Christof Scheid, MD, PhD, Michael von-Bergwelt-Baildon, MD PhD, Michael Hallek, MD PhD, Clemens Wendtner, MD, Jens M. Chemnitz, MD

Blood (2013) 122 (21): 4588.

https://doi.org/10.1182/blood.V122.21.4588.4588

Published: 2013

Journal Articles

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Valeska Berg, Nachiket Vartak, PhD, Rainer Claus, MD, Julia Claasen, Marion Rusch, PhD, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Christopher Plass, PhD, Philippe Bastiaens, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens Wendtner, MD, Lukas P. Frenzel, MD

Blood (2013) 122 (21): 4148.

https://doi.org/10.1182/blood.V122.21.4148.4148

Published: 2013

Journal Articles

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Christian P. Pallasch, MD, Leskov Ilya, MD, PhD, Yadira M Soto, Christian J. Braun, MD, Nadine Kutsch, MD, Adam Drake, PhD, Lukas P. Frenzel, MD, Bettina Iliopoulou, PhD, Nico van Rooijen, PhD, Clemens Wendtner, MD, Michael Hallek, MD, Jianzhu Chen, PhD, Michael T Hemann, PhD

Blood (2012) 120 (21): 1335.

https://doi.org/10.1182/blood.V120.21.1335.1335

Published: 2012

Journal Articles

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

Malte Huelsemann, Lukas P. Frenzel, MD, Dunja Baatout, M.Sc., Julia Claasen, Sebastian Theurich, MD, Laurent Kintzelé, Hans Jiro Becker, Michaela Patz, PhD, Christian P. Pallasch, MD, Michael S. von Bergwelt-Baildon, MD, PhD, Michael Hallek, MD, Clemens-Martin Wendtner, MD

Blood (2012) 120 (21): 3918.

https://doi.org/10.1182/blood.V120.21.3918.3918

Published: 2012

Journal Articles

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Alexandra Schulz, PhD, Yoon Jung Park, Ph.D., Rainer Claus, MD, Hamid Kashkar, PhD, Jens Seeger, PhD, Julia Claasen, Christian P. Pallasch, MD, Christoph Plass, PhD, Michael Hallek, MD, Clemens Wendtner, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3898.

https://doi.org/10.1182/blood.V120.21.3898.3898

Published: 2012

Journal Articles

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

Janine Schwamb, MD, Valeska Feldhaus, M.Sc., Michael Baumann, MD, Michaela Patz, PhD, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens-Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2012) 120 (21): 3905.

https://doi.org/10.1182/blood.V120.21.3905.3905

Published: 2012

Journal Articles

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

Alexandra Schulz, Christian P. Pallasch, MD, Michael Hallek, MD, Lukas P. Frenzel, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1779.

https://doi.org/10.1182/blood.V118.21.1779.1779

Published: 2011

Journal Articles

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Janine Schwamb, MD, Valeska Feldhaus, Susanne Brodesser, PhD, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Martin Wendtner, MD, Lukas P. Frenzel, MD

Blood (2011) 118 (21): 1766.

https://doi.org/10.1182/blood.V118.21.1766.1766

Published: 2011

Journal Articles

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Lukas P. Frenzel, MD, Malte Huelsemann, Julia Claasen, Reinhild Brinker, Sebastian Theurich, MD, Hans Jiro Becker, Michael S. von Bergwelt-Baildon, MD, PhD, Christian P. Pallasch, MD, Michael Hallek, MD, Clemens Wendtner, MD

Blood (2011) 118 (21): 1767.

https://doi.org/10.1182/blood.V118.21.1767.1767

Published: 2011

Journal Articles

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

Lukas P. Frenzel, MD, Valeska Feldhaus, Marion Rusch, Reinhild Brinker, Julia Claasen, Christian P. Pallasch, MD, Herbert Waldmann, PhD, Michael Hallek, MD, Christian Hedberg, PhD, Clemens-Martin Wendtner, MD

Blood (2011) 118 (21): 2829.

https://doi.org/10.1182/blood.V118.21.2829.2829

Published: 2011

NARROW

A Novel BCL2-Driven Compound Mutant Mouse Model for In Vivo Research on BH3 Mimetics

BIM Regulation Is BTK Dependent and Can be Targeted By Entospletinib in Ibrutinib Refractory Mutants

FcmR Shapes BCR Signaling in IgM-Positive Leukemia

Integrated Proteomic and Phosphoproteomic Analysis Reveal Novel Targets and Suggest Rationale for Ibrutinib Efficacy in UM-CLL

Increased Palmitoylation Modulates Cytoskeletal Regulators to Enhance CXCR4-Mediated Motility of Malignant B Cells

Mechanisms of Venetoclax Resistance in Chronic Lymphocytic Leukemia

Loss of TOSO Promotes Richter's Transformation of TCL1A Driven CLL

APT1-Mediated Cross-Talk Between Palmitoylation and Phosphorylation Events of the BCR Pathway Sensitizes CLL Cells Towards BCR-Associated Kinase Inhibitors

p38 MAPK Controls Sensitivity Towards BH3 Mimetics By Regulating Mcl-1 Expression of Chronic Lymphocytic Leukemia in Hypoxia and Acquired Resistance

Mirs-138 and -424 Control Palmitoylation-Dependent CD95-Mediated Cell Death By Targeting Acyl Protein Thioesterases 1 and 2 in Chronic Lymphocytic Leukemia

Increased Functional T Cell Defects in Patients with low CD4 Counts after Allogeneic Hematopoietic Stem Cell Transplantation

A Complex Molecular Network Controls Palmitoylation-Dependant CD95 Sensitivity Of CLL Cells

Drug-Induced Cytokine Release Sensitizes Protective Tumor Microenvironments to Antibody- Mediated Therapy

Impact of Hypoxia As Novel Microenvironmental Factor On Drug Susceptibility of Primary CLL Cells

TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo

Novel Tyrosine Kinase Inhibitors Trigger Drug Sensitivity of Primary CLL Cells by Controlling Glucosylation of Ceramides

TOSO-Deficient B Cells Show An Impaired NF-κB and Migration Signaling In Vivo

B-Cell Receptor-Mediated Glucosylceramide Synthesis Protects Primary CLL Cells From Ceramide-Dependent Apoptosis

Primed for Death: Hypoxia Sensitizes Primary CLL Cells towards Compounds Targeting Mitochondrial Integrity

Palmitoylation Controls Death Receptor Function in Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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