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Lenka Besse, PhD
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Journal Articles

Carfilzomib Induces Cardiotoxicity Via ß5/ß2-Specific Proteasome Subunit Inhibition Pattern

Max A Mendez-Lopez, MD, Andrej Besse, PhD, Bogdan Florea, PhD, Christian Zuppinger, PhD, Herman Overkleeft, PhD, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3110.
https://doi.org/10.1182/blood-2019-127987
Published: 2019
Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3193.
https://doi.org/10.1182/blood-2018-99-116939
Published: 2018
Journal Articles

The First in Class, Alkylator-Histone-Deacetylase-Inhibitor Fusion Molecule Edo-S101 in Combination with Proteasome Inhibitors Induces Highly Synergistic Pro-Apoptotic Signaling through UPR Activation and Suppression of c-Myc and BCL2 in Multiple Myeloma

Lenka Besse, PhD, Marianne Kraus, PhD, Andrej Besse, Juergen Bader, Thomas Mehrling, MD PhD, Christoph Driessen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4466.
https://doi.org/10.1182/blood.V128.22.4466.4466
Published: 2016
Journal Articles

Neural Stem Cell Marker Nestin As a Novel Unfavorable Prognostic Biomarker for Multiple Myeloma

Hana Svachova, MD PhD, Lucie Rihova, MSc, PhD, Lenka Besse, PhD, Fedor Kryukov, MD PhD, Lenka Zahradova, MD PhD, Tomas Jelinek, MD, Katerina Gracova, MD, Jiri Jarkovsky, MSc, PhD, Roman Hájek
Journal: Blood
Blood (2016) 128 (22): 5608.
https://doi.org/10.1182/blood.V128.22.5608.5608
Published: 2016
Journal Articles

Proteasome Inhibitor-Adapted Myeloma Cells That Lack Proteasome Gene Mutations Resist Highly Efficient Proteasome Inhibition and Show Proteomic Alterations That Suggest Complex Metabolic Changes

Lenka Besse, PhD, Guillem Soriano, Nan Li, Andrej Besse, Marianne Kraus, Juergen Bader, Tobias Christian Silzle, MD, Nico Meeuwenoord, Hans den Dulk, Herman S Overkleeft, Bogdan Florea, Christoph Driessen, MD
Journal: Blood
Blood (2015) 126 (23): 1278.
https://doi.org/10.1182/blood.V126.23.1278.1278
Published: 2015