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Le Xuan Truong Nguyen, PhD
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Journal Articles

Venetoclax Synergizes with the RNA-Directed Nucleoside Analog 8-Chloro-Adenosine in Acute Myeloid Leukemia in Vitro and In Vivo

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Corey James Morales, BA, BS, Lisa S Chen, PhD, Timothy Synold, PhD, Dinh Hoa Hoang, BS, Bin Amber Zhang, PhD, Lucy Ghoda, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-143240
Published: 2020
Journal Articles

Microrna-142 Deficiency Promotes Chronic Myeloid Leukemia (CML) Transformation from Chronic Phase (CP) to Blast Crisis (BC)

Bin Amber Zhang, PhD, Dandan Zhao, MD, Huafeng Wang, MD, Chen Liang, MD, Le Xuan Truong Nguyen, PhD, Junjing Qiao, MD PhD, Shanshan Suo, MD, Yasmin Elhajmoussa, Lucy Ghoda, PhD, David Frankhouser, Russell Rockne, PhD, Ling Li, PhD, Ya-Huei Kuo, PhD, Mark Boldin, MD PhD, Guido Marcucci, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-143202
Published: 2020
Journal Articles

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Dinh Hoa Hoang, BS, Dandan Zhao, MD, Sergio Branciamore, Davide Maestrini, PhD, Yu-Lin SU, PhD, Sonia Rodriguez, PhD, Flavia Pichiorri, PhD, Steven Rosen, MD, Michael A. Caligiuri, MD, Stephen J. Forman, MD, Ling Li, PhD, Marcin Kortylewski, PhD, Russell Rockne, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD, Guido Marcucci, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2722.
https://doi.org/10.1182/blood-2019-131871
Published: 2019
Journal Articles

Spred1 Insufficiency in the Hematopoietic and/or Vascular Compartments of the Bone Marrow (BM) Niche Promotes Aggressive Leukemogenesis in Chronic Myelogenous Leukemia (CML)

Junjing Qiao, MD PhD, Dandan Zhao, MD, Le Xuan Truong Nguyen, PhD, Herman Wu, BS, Gang Liu, PhD, Shanshan Suo, MD, Huafeng Wang, Yasmin Elhajmoussa, Chen Liang, MD, David Snyder, MD, Haris Ali, MD, Steven Rosen, MD, Nadia Carlesso, MD, Ling Li, PhD, Ya-Huei Kuo, PhD, Guido Marcucci, MD, Bin Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3791.
https://doi.org/10.1182/blood-2019-127616
Published: 2019
Journal Articles

Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, PhD, Le Xuan Truong Nguyen, PhD, Dijiong Wu, MD, Casey J Brewer, PhD, Xin He, PhD, Man Li, PhD, Dandan Zhao, MD, Guerry Jeanne Cook, PhD, Jing Qi, PhD, Herman Wu, BS, Bin Zhang, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3914.
https://doi.org/10.1182/blood-2019-123468
Published: 2019
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target?

Huafeng Wang, Bin Zhang, PhD, Wei-Le Wang, BS, Dandan Zhao, MD, Ling Li, PhD, Herman Wu, BS, Le Xuan Truong Nguyen, PhD, Weixu Meng, MD PhD, Tinisha McDonald, MS, Flavia Pichiorri, PhD, Ya-Huei Kuo, PhD, Jianjun Chen, PhD, Nadia Carlesso, MD PhD, Ibrahim Aldoss, MD, Vinod A. Pullarkat, MD, Monzr Al Malki, MD, Anthony S. Stein, MD, Mark Boldin, MD PhD, Jie Jin, MD PhD, Guido Marcucci
Journal: Blood
Blood (2018) 132 (Supplement 1): 1338.
https://doi.org/10.1182/blood-2018-99-119599
Published: 2018
Journal Articles

Targeted Delivery of CpG-Mir-146a Mimic Oligonucleotides As a Therapeutic Strategy to Reduce NF-Κb-Mediated Pathogenic Inflammation and Myeloid Leukemia Progression

Yu-Lin SU, PhD, Zhuoran Zhang, PhD, Mati Mann, PhD, Xiuli Wang, PhD, Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Ling Li, PhD, Piotr Swiderski, PhD, Mark Boldin, MD PhD, Stephen J Forman, Guido Marcucci, Marcin Kortylewski, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3501.
https://doi.org/10.1182/blood-2018-99-115637
Published: 2018
Journal Articles

Inhibition of ROS-Induced Nrf2 Antioxidant Pathway Activation May Explain Synergy between Venetoclax and Hypomethylating Agents Against Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Estelle Troadec, PhD, Arjun Kalvala, PhD, Dinh Hoa Hoang, Bachelor, Domenico Viola, BS, Stephen J. Forman, MD FACP, Guido Marcucci, MD, Vinod Pullarkat, MD MRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1367.
https://doi.org/10.1182/blood.V130.Suppl_1.1367.1367
Published: 2017
Journal Articles

MiR-126 Promotes Leukemogenesis in Inv(16) Acute Myeloid Leukemia

Casey J Brewer, PhD, Guerry Jeanne Cook, PhD, Bin Zhang, PhD, Le Xuan Truong Nguyen, PhD, Jing Qi, PhD, Wei-Kai Hua, PhD, Qi Cai, PhD, Emily Carnahan, MS, Ayelet Marom, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 301.
https://doi.org/10.1182/blood.V130.Suppl_1.301.301
Published: 2017
Journal Articles

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Le Xuan Truong Nguyen, PhD, Min Huang, Steven M. Chan, MD, PhD, Ravi Majeti, MD, PhD, Beverly S. Mitchell
Journal: Blood
Blood (2013) 122 (21): 1266.
https://doi.org/10.1182/blood.V122.21.1266.1266
Published: 2013