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Journal Articles

Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism

Lauren Marsh Shevell, MD MPH, Eun-Ju Lee, MD, Rahul Dhodapkar, MBBS, Daniel Dykas, BS, MBA, Andreea Popa, MD PhD, Deqiong Ma, MD PhD, Noffar Bar, MD, Audrey Baluha, RN, Adrienne J. Burns, MMS, PA-C, Cassius Ilya Ochoa Chaar, MD, Anne Dupont, RN, Sean Gu, MD PhD, Stephanie Halene, MD, Randy Luciano, MD PhD, Rebecca Marien, RN, Natalia Neparidze, MD, Terri L Parker, MD, Xiaopan Yao, PhD, Rodney M. Camire, PhD, Eduard Ebberink, PhD, Pablo Garcia de Frutos, Kavitha Gnanasambandan, PhD, Peter P. Sayeski, PhD, James A. Huntington, PhD, Steven R. Lentz, MD PhD, Koen Mertens, PhD, Christopher Parish, PhD, Ray Rezaie, PhD, Jean M. Connors, BA, MD, Andrew Leavitt, MD, Allen Bale, MD, Alfred Ian Lee, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2506.
https://doi.org/10.1182/blood-2018-99-115529
Published: 2018
Journal Articles

Cell-Surface Proteomics to Unravel Cytokine-Induced Endothelial Activation

Eelke Béguin, Bart van den Eshof, Koen Mertens, PhD, Alexander Meijer, PhD, Maartje van den Biggelaar
Journal: Blood
Blood (2015) 126 (23): 1039.
https://doi.org/10.1182/blood.V126.23.1039.1039
Published: 2015
Journal Articles

Von Willebrand Factor Protects Factor VIII from Rapid Endocytosis Via LDL Receptor-Related Protein By Blocking the Initial Rate-Limiting Cell Surface Binding Step of Factor VIII

Henriet Meems, PhD, Carmen van der Zwaan, Koen Mertens, PhD, Alexander Meijer, PhD
Journal: Blood
Blood (2015) 126 (23): 214.
https://doi.org/10.1182/blood.V126.23.214.214
Published: 2015
Journal Articles

Factor VIII Region 1811–1818 Is Involved in Factor IXa Binding and Factor VIIIa Stability

Esther Bloem, Msc, Henriet Meems, PhD, Maartje van den Biggelaar, PhD, Koen Mertens, PhD, Alexander B Meijer, PhD
Journal: Blood
Blood (2012) 120 (21): 3357.
https://doi.org/10.1182/blood.V120.21.3357.3357
Published: 2012
Journal Articles

The N-Terminal Amino Acid Residues Ser764 and Lys773 of the D' Domain of Von Willebrand Factor Contribute to Factor VIII Binding

Lydia Castro-Núñez, Esther Bloem, Carmen van der Zwaan, Koen Mertens, PhD, Alexander B Meijer
Journal: Blood
Blood (2011) 118 (21): 2248.
https://doi.org/10.1182/blood.V118.21.2248.2248
Published: 2011
Journal Articles

Modification of An Interactive Surface in the C1 Domain Reduces Immune Responses to FVIII in a Mouse Model of Hemophilia A

Aleksandra Wroblewska, Simon D van Haren, Eszter Herczenik, Aleksandra Rusiecka, Paul H Kaijen, Anja ten Brinke, Koen Mertens, PhD, Jan Voorberg
Journal: Blood
Blood (2011) 118 (21): 199.
https://doi.org/10.1182/blood.V118.21.199.199
Published: 2011
Journal Articles

The Role of Factor VIII C Domains in Sorting to Weibel-Palade Bodies

Eveline Bouwens, Maartje van den Biggelaar, Jan Voorberg, Koen Mertens, PhD
Journal: Blood
Blood (2011) 118 (21): 2241.
https://doi.org/10.1182/blood.V118.21.2241.2241
Published: 2011
Journal Articles

Co-Trafficking of Coagulation Factor VIII with Von Willebrand Factor Alters the Macromolecular Structure Inside Secretory Weibel-Palade Bodies

Eveline Bouwens, Marjon Mourik, Maartje van den Biggelaar, Jan Voorberg, Karine Valentijn, Koen Mertens, PhD
Journal: Blood
Blood (2010) 116 (21): 325.
https://doi.org/10.1182/blood.V116.21.325.325
Published: 2010
Journal Articles

Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.

Bas De Laat, PhD, Philip G. de Groot, PhD, Ronald H.W.M. Derksen, MD., Rolf T. Urbanus, Koen Mertens, PhD, Frits Rosendaal, MD, PhD, Carine J.M. Doggen, PhD
Journal: Blood
Blood (2008) 112 (11): 1813.
https://doi.org/10.1182/blood.V112.11.1813.1813
Published: 2008
Journal Articles

Factor VIII C1 Domain Residues 2092–2093 Participate in Membrane Binding

Henriet Meems, Alexander B Meijer, Dave Cullinan, Koen Mertens, PhD, Gary E. Gilbert
Journal: Blood
Blood (2008) 112 (11): 587.
https://doi.org/10.1182/blood.V112.11.587.587
Published: 2008
Journal Articles

PEGylation or Polysialylation Reduces FVIII Binding to LRP Resulting in Prolonged Half-Life in Murine Models.

Hanspeter Rottensteiner, Peter L. Turecek, PhD, Rona Pendu, Alexander B. Meijer, Peter Lenting, Koen Mertens, PhD, Eva-Maria Muchitsch, DVM, Hartmut Ehrlich, MD, Hans Peter Schwarz, MD
Journal: Blood
Blood (2007) 110 (11): 3150.
https://doi.org/10.1182/blood.V110.11.3150.3150
Published: 2007
Journal Articles

Antiphospholipid Antibodies with LAC Activity That Bind beta2-Glycoprotein I Cause Increased Resistance Against Activated Protein C.

Bas de Laat, PhD, Sander B. Meijer, PhD, Carel M. Eckmann, M. van Schagen, Koen Mertens, PhD, Jan A. van Mourik, PhD
Journal: Blood
Blood (2007) 110 (11): 3622.
https://doi.org/10.1182/blood.V110.11.3622.3622
Published: 2007
Journal Articles

Somatic Mutations in Factor VIII Inhibitors Determine Their Factor VIII Binding and Inhibitory Properties.

Koen Mertens, PhD, David Gestel, Gunny van Stempvoort, Vincent Limburg, Ed E. Moret, PhD, Alexander B. Meijer, PhD
Journal: Blood
Blood (2007) 110 (11): 1762.
https://doi.org/10.1182/blood.V110.11.1762.1762
Published: 2007
Journal Articles

The Effect of von Willebrand Factor Normandy Mutations on Intracellular Co-Trafficking of Factor VIII to Storage Organelles.

Maartje van den Biggelaar, Birgit Ruhdorfer, Jan Voorberg, PhD, Koen Mertens, PhD
Journal: Blood
Blood (2007) 110 (11): 765.
https://doi.org/10.1182/blood.V110.11.765.765
Published: 2007