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Journal Articles

Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation

Yasuhisa Sando, MD, Ken-Ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takumi Kondo, MD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Makoto Nakamura, MD, Miki Iwamoto, Takeru Asano, Takanori Yoshioka, MD, Yoshinobu Maeda, MD PhD

Blood (2018) 132 (Supplement 1): 3400.

https://doi.org/10.1182/blood-2018-99-117548

Published: 2018

Journal Articles

Posttransplant Cyclophosphamide Promote Naïve-Subset Dominant B Cell Recovery Coordinated with Early Treg Expansion; Implication of Reduced Risk of Pathogenesis into Chronic Gvhd

Miki Iwamoto, Yusuke Meguri, MD, Takumi Kondo, MD, Hiroyuki Sugiura, MD, Shuntaro Ikegawa, MD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Yoshinobu Maeda, MD PhD, Ken-Ichi Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 4566.

https://doi.org/10.1182/blood-2018-99-120081

Published: 2018

Journal Articles

Mixed Chimerism and Secondary Engraftment Failure in Allogeneic Transplantation for Aplastic Anemia

Shinichi Kako, MD, Hirohito Yamazaki, MD PhD, Kazuteru Ohashi, MD PhD, Yukiyasu Ozawa, MD PhD, Shuichi Ota, MD, Yoshinobu Kanda, MD PhD, Tetsuo Maeda, MD, Jun Kato, MD, Ken Ishiyama, MD PhD, Ken-Ichi Matsuoka, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Fukuda, MD PhD, Tatsuo Ichinohe, MD PhD, Yoshiko Atsuta, MD PhD, Takehiko Mori, MD PhD

Blood (2018) 132 (Supplement 1): 4631.

https://doi.org/10.1182/blood-2018-99-111175

Published: 2018

Journal Articles

Post-Transplant Cyclophosphamide Ameliorates Lethal Thymic GVHD By Restoring Regulatory and Effector T Cell Homeostasis in Recipients with Prior PD-1 Blockade Therapy

Shuntaro Ikegawa, MD, Yusuke Meguri, MD, Takumi Kondo, MD, Hiroyuki Sugiura, MD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Miki Iwamoto, Yoshinobu Maeda, MD PhD, Ken-Ichi Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 479.

https://doi.org/10.1182/blood-2018-99-111142

Published: 2018

Journal Articles

Efficacy of HLA-Matched PLT Transfusions for Platelet Transfusion Refractoriness in HSCT Patients

Keisuke Seike, Nobuharu Fujii, MD PhD, Keiko Fujii, MD PhD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Kyosuke Saeki, MD, Yusuke Meguri, MD, Noboru Asada, MD PhD, Daisuke Ennishi, MDPhD, Hisakazu Nishimori, MD PhD, Ken-Ichi Matsuoka, MD PhD, Yoshinobu Maeda, MDPhD

Blood (2018) 132 (Supplement 1): 1265.

https://doi.org/10.1182/blood-2018-99-112365

Published: 2018

Journal Articles

Very Early Dynamics of Regulatory T-Cell Chimerism Significantly Varies According to the Donor Sources: Implication for Basic Immune Pathogenesis of Engraftment Phase

Miki Iwamoto, Ken-ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takeru Asano, MD, Takanori Yoshioka, MD, Yuriko Kishi, Makoto Nakamura, MD, Yasuhisa Sando, MD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 4575.

https://doi.org/10.1182/blood.V128.22.4575.4575

Published: 2016

Journal Articles

Comprehensive Analyses of Early Lymphocyte Reconstitution after Haploidentical HSCT with Posttransplant Cyclophosphamide: Coordinated Treg-Dominant T-Cell Reconstitution and Stem Cell-Derived Mature B-Cell with Broad BCR-Repertoir Diversity

Miki Iwamoto, Ken-ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takeru Asano, MD, Takanori Yoshioka, MD, Yuriko Kishi, Makoto Nakamura, MD, Yasuhisa Sando, MD, Ryuji Suzuki, DVM, PhD, Kazutaka Kitaura, DVM, PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 4542.

https://doi.org/10.1182/blood.V128.22.4542.4542

Published: 2016

Journal Articles

Successful Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Mild Renal Dysfunction Calculated By Creatinin Clearance

Shuntaro Ikegawa, MD, Tomoko Inomata, MD, Naoto Ikeda, MD, Hiroyuki Sugiura, MD, Taiga Kuroi, MD, Takeru Asano, MD, Shohei Yoshida, MD, Hisakazu Nishimori, MD PhD, Ken-ichi Matsuoka, MD PhD, Nobuharu Fujii, MD PhD, Eisei Kondo, MD PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 4656.

https://doi.org/10.1182/blood.V128.22.4656.4656

Published: 2016

Journal Articles

Impact of Incomplete Blood Count Recovery Prior to Allogeneic Hematopoietic Stem Cell Transplantation on Engraftment and Early Infection in Patients with Acute Myeloid Leukemia

Takeru Asano, MD, Shuntaro Ikegawa, MD, Tomoko Inomata, MD, Naoto Ikeda, MD, Hiroyuki Sugiura, MD, Taiga Kuroi, MD, Shohei Yoshida, MD, Hisakazu Nishimori, MD PhD, Ken-ichi Matsuoka, MD PhD, Nobuharu Fujii, MD PhD, Eisei Kondo, MD PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 3408.

https://doi.org/10.1182/blood.V128.22.3408.3408

Published: 2016

Journal Articles

Enhanced Expression of PD-1 Modulates CD4+Foxp3+ Regulatory T Cell Homeostasis during Low-Dose IL-2 Therapy in Patients with Chronic Graft-Versus-Host Disease

Takeru Asano, MD, Haesook T. Kim, PhD, John Koreth, MBBS, DPhil, Robert J Soiffer, MD, Yusuke Meguri, MD, Takanori Yoshioka, MD, Hideo Yagita, PhD, Mitsune Tanimoto, MD PhD, Jerome Ritz, MD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 662.

https://doi.org/10.1182/blood.V124.21.662.662

Published: 2014

Journal Articles

Host Immune Status Determines the Effects of Therapeutic Interleukin-2 Administration: Enhancement of GVL or Induction of Tolerance?

Yusuke Meguri, Takeru Asano, MD, Takanori Yoshioka, MD, Haruka Izumi, Yuriko Kishi, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 2431.

https://doi.org/10.1182/blood.V124.21.2431.2431

Published: 2014

Journal Articles

Early Homeostatic Expansion of Regulatory T Cells with the Predominant Effector/Memory Phenotype May Stabilize Immune Recovery in the First Month after HSCT

Takanori Yoshioka, MD, Yusuke Meguri, MD, Takeru Asano, MD, Taro Masunari, MD PhD, Kumiko Kagawa, MD PhD, Koichi Nakase, MD PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 2501.

https://doi.org/10.1182/blood.V124.21.2501.2501

Published: 2014

Journal Articles

Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, SM, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Kristen Cowens, Suzan Lazo-Kallanian, John Daley, PhD, John Koreth, MBBS, DPhil, Robert J. Soiffer, MD, Anthony Letai, MD, PhD, Jerome Ritz, MD

Blood (2013) 122 (21): 3475.

https://doi.org/10.1182/blood.V122.21.3475.3475

Published: 2013

Journal Articles

Host Tissue PD-1 Pathway Contribute To Murine Chronic Graft-Versus-Host Disease Via Th1+Th17+ Cells

Hideaki Fujiwara, Yoshinobu Maeda, M.D., Ph.D., Koichiro Kobayashi, Hisakazu Nishimori, Ken-ichi Matsuoka, MD, PhD, Miyuki Azuma, MD, PhD, Hideo Yagita, PhD, Lieping Chen, MD, PhD, Mitsune Tanimoto, MD, PhD

Blood (2013) 122 (21): 3244.

https://doi.org/10.1182/blood.V122.21.3244.3244

Published: 2013

Journal Articles

Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Suzan Lazo-Kallanian, John Daley, PhD, Matthew S. Davids, MD, Anthony G. Letai, MD, PhD, Jerome Ritz, MD

Blood (2012) 120 (21): 3280.

https://doi.org/10.1182/blood.V120.21.3280.3280

Published: 2012

Journal Articles

Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Suzan Lazo-Kallanian, John Daley, PhD, John Koreth, MBBS, DPhil, Robert J. Soiffer, MD, Anthony G. Letai, MD, PhD, Jerome Ritz, MD

Blood (2012) 120 (21): 225.

https://doi.org/10.1182/blood.V120.21.225.225

Published: 2012

Journal Articles

Ex Vivo Expansion of Donor-Derived Anti-Tumor T Cells for CLL-Specific Adoptive Immunotherapy

Masayasu Naito, MD, PhD, Ursula Hainz, PhD, Kristen Stevenson, Anselmo Alonso, Ken-ichi Matsuoka, MD, PhD, Tesuro Sasada, MD, PhD, Donna Neuberg, ScD, Jerome Ritz, MD, Gordon J. Freeman, PhD, Catherine J Wu, MD

Blood (2011) 118 (21): 978.

https://doi.org/10.1182/blood.V118.21.978.978

Published: 2011

Journal Articles

Decreased Telomerase Activity In CD4 Regulatory T Cells Is Associated with Severity of Chronic Graft-Versus-Host Disease (cGVHD) After Hematopoietic Stem Cell Transplantation (HSCT)

Yutaka Kawano, MD, PhD, Haesook Kim, PhD, Ken-ichi Matsuoka, MD, PhD, Suzan Lazo-Kallanian, John Daley, Joseph H. Antin, MD, Robert Soiffer, MD, Jerome Ritz, MD

Blood (2010) 116 (21): 1257.

https://doi.org/10.1182/blood.V116.21.1257.1257

Published: 2010

Journal Articles

Effects of Daily Low Dose IL-2 Therapy on Homeostatic Regulation of CD4+Foxp3+ Regulatory T Cells In Patients with Chronic Graft-Versus-Host Disease

Ken-ichi Matsuoka, MD, PhD, John Koreth, MBBS, DPhil, Haesook T. Kim, PhD, O. Gregory Bascug, Sean McDonough, MS, Joseph H. Antin, MD, Robert Soiffer, MD, Jerome Ritz, MD

Blood (2010) 116 (21): 895.

https://doi.org/10.1182/blood.V116.21.895.895

Published: 2010

Journal Articles

Increased Proliferation of FoxP3 Regulatory T Cells after Allogeneic Hematopoietic Stem Cell Transplantation Is Counterbalanced by Increased Susceptibility to Apoptosis

Ken-ichi Matsuoka, MD, PhD, Corey Cutler, MD, MPH, John Koreth, MD, Joseph H Antin, MD, Robert J Soiffer, MD, Jerome Ritz, MD

Blood (2008) 112 (11): 720.

https://doi.org/10.1182/blood.V112.11.720.720

Published: 2008

NARROW

Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation

Posttransplant Cyclophosphamide Promote Naïve-Subset Dominant B Cell Recovery Coordinated with Early Treg Expansion; Implication of Reduced Risk of Pathogenesis into Chronic Gvhd

Mixed Chimerism and Secondary Engraftment Failure in Allogeneic Transplantation for Aplastic Anemia

Post-Transplant Cyclophosphamide Ameliorates Lethal Thymic GVHD By Restoring Regulatory and Effector T Cell Homeostasis in Recipients with Prior PD-1 Blockade Therapy

Efficacy of HLA-Matched PLT Transfusions for Platelet Transfusion Refractoriness in HSCT Patients

Very Early Dynamics of Regulatory T-Cell Chimerism Significantly Varies According to the Donor Sources: Implication for Basic Immune Pathogenesis of Engraftment Phase

Comprehensive Analyses of Early Lymphocyte Reconstitution after Haploidentical HSCT with Posttransplant Cyclophosphamide: Coordinated Treg-Dominant T-Cell Reconstitution and Stem Cell-Derived Mature B-Cell with Broad BCR-Repertoir Diversity

Successful Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Mild Renal Dysfunction Calculated By Creatinin Clearance

Impact of Incomplete Blood Count Recovery Prior to Allogeneic Hematopoietic Stem Cell Transplantation on Engraftment and Early Infection in Patients with Acute Myeloid Leukemia

Enhanced Expression of PD-1 Modulates CD4+Foxp3+ Regulatory T Cell Homeostasis during Low-Dose IL-2 Therapy in Patients with Chronic Graft-Versus-Host Disease

Host Immune Status Determines the Effects of Therapeutic Interleukin-2 Administration: Enhancement of GVL or Induction of Tolerance?

Early Homeostatic Expansion of Regulatory T Cells with the Predominant Effector/Memory Phenotype May Stabilize Immune Recovery in the First Month after HSCT

Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

Host Tissue PD-1 Pathway Contribute To Murine Chronic Graft-Versus-Host Disease Via Th1+Th17+ Cells

Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells

Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Ex Vivo Expansion of Donor-Derived Anti-Tumor T Cells for CLL-Specific Adoptive Immunotherapy

Decreased Telomerase Activity In CD4 Regulatory T Cells Is Associated with Severity of Chronic Graft-Versus-Host Disease (cGVHD) After Hematopoietic Stem Cell Transplantation (HSCT)

Effects of Daily Low Dose IL-2 Therapy on Homeostatic Regulation of CD4+Foxp3+ Regulatory T Cells In Patients with Chronic Graft-Versus-Host Disease

Increased Proliferation of FoxP3 Regulatory T Cells after Allogeneic Hematopoietic Stem Cell Transplantation Is Counterbalanced by Increased Susceptibility to Apoptosis

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American Society of Hematology

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American Society of Hematology

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