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Journal Articles

Syk Plays an Essential Role in Phagosome-Lysosome Fusion By Facilitating Actin-Remodeling in Complement-Mediated Phagocytosis

Yumi Tohyama, PhD, Hiroyuki Tabata, PhD, Kaoru Tohyama, MD PhD

Blood (2019) 134 (Supplement_1): 2315.

https://doi.org/10.1182/blood-2019-125061

Published: 2019

Journal Articles

Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes

Kensuke Kayamori, Cheng Zhong, Daisuke Shinoda, MD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Naoya Mimura, MD PhD, Ryoji Ito, Kaoru Tohyama, MD PhD, William Lennox, Marla Weetall, PhD, Josephine Sheedy, BS, MSc, Emiko Sakaida, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2019) 134 (Supplement_1): 5407.

https://doi.org/10.1182/blood-2019-125200

Published: 2019

Journal Articles

TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome

Jie Sun, MS, Yinghui Zhu, PhD, Zonghui Ding, PhD, Haojie Dong, PhD, Yimei Feng, PhD MD, Qiang Chen, PhD, Xiaochun Yu, PhD MD, Dandan Zhao, MD, Herman Wu, BS, Lifeng Feng, PhD, Kaoru Tohyama, MD PhD, Philipp Oberdoerffer, PhD, Bin Zhang, PhD, Ya-Huei Kuo, PhD, Ravi Bhatia, MD, Hongchuan Jin, PhD MD, Guido Marcucci, MD, Ling Li, PhD

Blood (2016) 128 (22): 1053.

https://doi.org/10.1182/blood.V128.22.1053.1053

Published: 2016

Journal Articles

Association of Increased Ring Ssideroblasts with Inferior Survival in Patients with Myelodysplastic Syndrome with Multi-Lineage Dysplasia

Hiroshi Kawabata, MD PhD, Kaoru Tohyama, MD PhD, Akira Matsuda, MD PhD, Kayano Araseki, MD PhD, Tomoko Hata, MD PhD, Takahiro Suzuki, MD, PhD, Hidekazu Kayano, MD PhD, Kei Shinbo, MT, Kensuke Usuki, MD PhD, Akira Hangaishi, MD PhD, Shigeru Chiba, MD, PhD, Nogawa Masaharu, MD PhD, Nobuyoshi Arima, MD PhD, Takayuki Ishikawa, MD PhD, Keiya Ozawa, MD PhD, Shunya Arai, MD, PhD, Mineo Kurokawa, MD, PhD, Akifumi Takaori-Kondo, MD PhD

Blood (2016) 128 (22): 5530.

https://doi.org/10.1182/blood.V128.22.5530.5530

Published: 2016

Journal Articles

Targeting the Hedgehog Signaling Pathway By PF-04449913 Limits the Self-Renewal of MDS-Derived Induced Potent Stem Cells (iPSC): Molecular Mechanisms

Tetsuzo Tauchi, MDPhD, Seiichi Okabe, MD PhD, Seiichiro Katagiri, MD, Yuko Tanaka, MDPhD, Kaoru Tohyama, MD PhD, Kazuma Ohyashiki, MD PhD

Blood (2015) 126 (23): 791.

https://doi.org/10.1182/blood.V126.23.791.791

Published: 2015

Journal Articles

Decitabine Induced the Cell Differentiation, Decreased Malignant Potential, and Increased Susceptibility to Apoptosis Via a Death Receptor Pathway with Hypomethylation of MS4A3, PAR-4, APITD1, LOX in Myelodysplastic Syndrome Cell Line, MDS-L

Rie Nishi, Takahiro Yamauchi, MD PhD, Miyuki Ookura, MD, Yasufumi Matsuda, MD, Toshiki Tasaki, MD, Kaoru Tohyama, MD PhD, Takanori Ueda, MD PhD

Blood (2014) 124 (21): 4599.

https://doi.org/10.1182/blood.V124.21.4599.4599

Published: 2014

Journal Articles

A Novel Simulation Method for Mapping Dysregulated Pathways and Predicting Effective Therapeutics in the Myelodysplastic Syndromes

Christopher R. Cogle, MD, Kaoru Tohyama, MD PhD, Shireen Vali, PhD, Ansu Kumar, Neeraj Kumar Singh, Krishna Kumar Tiwari, Anuj Tyagi, Taher Abbasi, MS, Peter P. Sayeski, PhD

Blood (2014) 124 (21): 5595.

https://doi.org/10.1182/blood.V124.21.5595.5595

Published: 2014

Journal Articles

WT-1 Expression Level In BM Is The Great Prognostic Marker In Three Of Classification IPSS, WPSS, and Latest Revised IPSS(IPSS-R)

Sumiko Kobayashi, MD, PhD, Yasunori Ueda, MD, PhD, Mineo Kurokawa, MD, PhD, Kiyoyuki Ogata, MD, PhD, Hirohiko Shibayama, Nobuhiko Emi, MD, PhD, Kensuke Usuki, MD, PhD, Kazuma Ohyashiki, MD, PhD, Keiya Ozawa, MD, PhD, Yasushi Miyazaki, MD, PhD, Akira Matsuda, MD, PhD, Kaoru Tohyama, MD, PhD, Kinuko Mitani, M.D., Ph.D., Tomoki Naoe, MD, PhD, Haruo Sugiyama, MD, PhD

Blood (2013) 122 (21): 2795.

https://doi.org/10.1182/blood.V122.21.2795.2795

Published: 2013

Journal Articles

CD7 Expression On Blasts Of Myelodysplastic Syndromes Is Associated With Apoptosis Resistance With Decreased Expression Of The Proapoptotic Protein Bad and An Independent Unfavorable Prognostic Factor Together With The Revised IPSS Score In Patients

Yasuko Hamada, MD, Hideto Tamura, MD, PhD, Mariko Ishibashi, PhD, Namiko Okuyama, MD, Asaka Kondo, MD, PhD, Keiichi Moriya, MD, PhD, Kiyoyuki Ogata, MD, PhD, Keiji Kakumoto, Yoshihide Miyazaki, Akira Matsuda, MD, PhD, Kaoru Tohyama, MD, PhD, Yasunori Ueda, MD, PhD, Mineo Kurokawa, MD, PhD, Hirohiko Shibayama, Nobuhiko Emi, MD, PhD, Kinuko Mitani, M.D., Ph.D., Tomoki Naoe, MD, PhD, Haruo Sugiyama, MD, PhD, Koiti Inokuchi, MD, PhD

Blood (2013) 122 (21): 2799.

https://doi.org/10.1182/blood.V122.21.2799.2799

Published: 2013

Journal Articles

BH3 Profiling Predicts 5-Azacytidine Response in Malignant Myeloid Cells

James M Bogenberger, PhD, William E. Pierceall, PhD, Ryan Lena, BS, Reinhold Munker, MD, Kaoru Tohyama, MD, PhD, Lisa Sproat, MD, MSW, Pierre Noel, MD, Jose F. Leis, MD, PhD, James L Slack, MD, Ruben A. Mesa, Michael Cardone, PhD, Raoul Tibes, MD, PhD

Blood (2012) 120 (21): 1432.

https://doi.org/10.1182/blood.V120.21.1432.1432

Published: 2012

Journal Articles

TC11, a Novel Phthalimide Derivative, Directly Binds to NPM1 and Induced Apoptosis of High-Risk Myeloma Cells Via Centrosomal Disruption

Saito Sosei, Kana Yoshikawa, Noriko Tabata, PhD, Hiroshi Yanagawa, PhD, Tsukasa Oikawa, PhD, Wenlin Du, MD, PhD, Taketo Yamada, MD, PhD, Maiko Matsushita, MD, PhD, Junya Seki, Kaoru Tohyama, MD, PhD, Yutaka Hattori, MD, PhD

Blood (2012) 120 (21): 1841.

https://doi.org/10.1182/blood.V120.21.1841.1841

Published: 2012

Journal Articles

Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes,

Akira Yoshida, MD, PhD, Kouichi Zokumasu, Takahiro Yamauchi, MD, PhD, Kazutaka Takagi, MD, PhD, Shinji Kishi, MD, PhD, Yoshimasa Urasaki, MD, PhD, Kaoru Tohyama, MD, PhD, Takanori Ueda, MD, PhD

Blood (2011) 118 (21): 3823.

https://doi.org/10.1182/blood.V118.21.3823.3823

Published: 2011

Journal Articles

High-Resolution CGH Analysis of CD34+ Cells from Lower-Risk Myelodysplastic Patients Reveals Cryptic Copy Number Alterations and Predicts Overall and Leukemia-Free Survival.

Daniel T. Starczynowski, PhD, Suzanne Vercauteren, MD, Adele Telenius, Sandy Sung, Kaoru Tohyama, MD, PhD, Angela Brooks-Wilson, PhD, John J. Spinelli, PhD, Connie J. Eaves, PhD, Allen C. Eaves, MD, PhD, Douglas E. Horsman, MD, Wan L. Lam, PhD, Aly Karsan, MD

Blood (2007) 110 (11): 2431.

https://doi.org/10.1182/blood.V110.11.2431.2431

Published: 2007

NARROW

Syk Plays an Essential Role in Phagosome-Lysosome Fusion By Facilitating Actin-Remodeling in Complement-Mediated Phagocytosis

Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes

TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome

Association of Increased Ring Ssideroblasts with Inferior Survival in Patients with Myelodysplastic Syndrome with Multi-Lineage Dysplasia

Targeting the Hedgehog Signaling Pathway By PF-04449913 Limits the Self-Renewal of MDS-Derived Induced Potent Stem Cells (iPSC): Molecular Mechanisms

Decitabine Induced the Cell Differentiation, Decreased Malignant Potential, and Increased Susceptibility to Apoptosis Via a Death Receptor Pathway with Hypomethylation of MS4A3, PAR-4, APITD1, LOX in Myelodysplastic Syndrome Cell Line, MDS-L

A Novel Simulation Method for Mapping Dysregulated Pathways and Predicting Effective Therapeutics in the Myelodysplastic Syndromes

WT-1 Expression Level In BM Is The Great Prognostic Marker In Three Of Classification IPSS, WPSS, and Latest Revised IPSS(IPSS-R)

CD7 Expression On Blasts Of Myelodysplastic Syndromes Is Associated With Apoptosis Resistance With Decreased Expression Of The Proapoptotic Protein Bad and An Independent Unfavorable Prognostic Factor Together With The Revised IPSS Score In Patients

BH3 Profiling Predicts 5-Azacytidine Response in Malignant Myeloid Cells

TC11, a Novel Phthalimide Derivative, Directly Binds to NPM1 and Induced Apoptosis of High-Risk Myeloma Cells Via Centrosomal Disruption

Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes,

High-Resolution CGH Analysis of CD34+ Cells from Lower-Risk Myelodysplastic Patients Reveals Cryptic Copy Number Alterations and Predicts Overall and Leukemia-Free Survival.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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