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Journal Articles

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Yun Liu, MS, Rosa Catera, PhD, Chao Gao, PhD, Xiao J. Yan, MDPhD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Charles C Chu, PhD, Ten Feizi, MD, Kostas Stamatopoulos, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 58.

https://doi.org/10.1182/blood.V130.Suppl_1.58.58

Published: 2017

Journal Articles

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Shih-Shih Chen, PhD, Priyadarshini Ravichandran, Gerardo Ferrer, PhD, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Michael Ibrahim, Yasmine Kieso, Jacqueline C. Barrientos, MD, Edward Clark, PhD, Barbara Sherry, PhD, Jan A. Burger, MD PhD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 387.

https://doi.org/10.1182/blood.V130.Suppl_1.387.387

Published: 2017

Journal Articles

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Eric Sturgill, BA, Xiao J. Yan, MDPhD, Florencia Palacios, PhD, Kanti Rai, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4287.

https://doi.org/10.1182/blood.V130.Suppl_1.4287.4287

Published: 2017

Journal Articles

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

Gerardo Ferrer, PhD, Brendan Franca, BS, Pui Yan Chiu, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shihshih Chen, PhD, Davide Bagnara, PhD, Sophia Yancopoulos, Yun Liu, MS, Aliki Xochelli, MD, Xiao J. Yan, MDPhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kostas Stamatopoulos, Kanti Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4294.

https://doi.org/10.1182/blood.V130.Suppl_1.4294.4294

Published: 2017

Journal Articles

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Marcus Dühren-von Minden, PhD, Palash Chandra Maity, PhD, Gentner Eva, PhD, Stefano Vergani, PhD, Gerardo Ferrer, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD, Kanti Rai, MD, Hassan Jumaa, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 1716.

https://doi.org/10.1182/blood.V130.Suppl_1.1716.1716

Published: 2017

Journal Articles

B Cells of the Proliferative Fraction of CLL Clones Exhibit Activated B-Cell and Myeloid-Cell Signatures Suggesting Enhanced Antigen-Presentation, Integrin Responsiveness, and IL-4 Receptiveness: Additional Targets for CLL Therapy

Xiao-Jie Yan, MD PhD, Florencia Palacios, PhD, Wentian Li, PhD, Sophia Yancopoulos, PhD, Carlo Calissano, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 302.

https://doi.org/10.1182/blood.V128.22.302.302

Published: 2016

Journal Articles

Fcgammariib Expression As a Prognostic Marker in Chronic Lymphocytic Leukemia

Rosa Bosch, Gerardo Ferrer, Eva Puy Vicente, Alba Mora, Rajendra N. Damle, Sergey Gorlatov, Kanti Rai, Emili Montserrat, Jorge Sierra, Nicholas Chiorazzi, Carol Moreno

Blood (2015) 126 (23): 1727.

https://doi.org/10.1182/blood.V126.23.1727.1727

Published: 2015

Journal Articles

The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia

Jennifer R. Brown, Jacqueline C. Barrientos, Paul M. Barr, Ian W. Flinn, Jan A. Burger, Anh Tran, Fong Clow, Danelle F. James, Thorsten Graef, Jonathan W. Friedberg, Kanti Rai, Susan O’Brien

Blood (2015) 125 (19): 2915–2922.

https://doi.org/10.1182/blood-2014-09-585869

Published: 2015

Includes: Supplemental data

Journal Articles

Efficiency of BCR: Anti-BCR Interaction Dictates Cellular Outcomes of Signaling in Chronic Lymphocytic Leukemia Cells

Rajendra Damle, Sonal Temburni, Tara Schaaf, Santanu Paul, Patricia Mongini, Steven L. Allen, Matthew Kaufman, Kanti Rai, Nicholas Chiorazzi

Blood (2008) 112 (11): 3122.

https://doi.org/10.1182/blood.V112.11.3122.3122

Published: 2008

Journal Articles

p53 and COX-2 Inhibitors Control the Replication and Viability of Non-Transformed and CLL B Lymphocytes

Patricia Mongini, Ph.D., Matthew Kaufman, M.D., Jonathan E. Kolitz, MD, Steven L. Allen, M.D., Joshua Trott, Kanti Rai, M.D., Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 3146.

https://doi.org/10.1182/blood.V112.11.3146.3146

Published: 2008

Journal Articles

Induction of Apoptosis in CLL by Peptides Binding the B-Cell Antigen Receptor in Vitro

Manuela Woelfle, Till Seiler, Rosa Catera, Hartmut Dohner, Stephan Stilgenbauer, MD, PhD, Steven L. Allen, Kanti Rai, Charles Chu, PhD, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 3151.

https://doi.org/10.1182/blood.V112.11.3151.3151

Published: 2008

Journal Articles

Improved Prognosis of Chronic Lymphocytic Leukemia (CLL) Patients with Increased IgVH Mutations May Reflect Greater Alteration of the B-Cell Receptor (BCR) Binding Site

Matthew Kaufman, MD, Xiao Yan, MD, PhD, Rajendra Damle, PhD, Nina Kohn, MS, Martin Lesser, PhD, Nancy Driscoll, R-PA, Christina Johnson, R-PA, Jahan Aghalar, Yehuda Lebowicz, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 3152.

https://doi.org/10.1182/blood.V112.11.3152.3152

Published: 2008

Journal Articles

In Vivo Labeling of Dividing Chronic Lymphocytic Leukemia B Cells Suggests That CXCR4 and CD5 Define the Clonal Subfraction That Recently Proliferatead and Emigrated from a Solid Tissue

Carlo calissano, MD, Rajendra Damle, PhD, Gregory Hayes, PhD, Elisabeth J Murphy, MD, PhD, Marc Hellerstein, MD, PhD, Barbara Sherry, PhD, Matthew S Kaufman, MD, Steven L Allen, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 358.

https://doi.org/10.1182/blood.V112.11.358.358

Published: 2008

Journal Articles

A Human Hematopoietic Environment and Autologous T-Cell Growth Support Proliferation of Chronic Lymphocytic Leukemia B Cells in Immune-Deficient Mice

Davide Bagnara, Matthew Kaufman, Xiao J. Yan, MD, PhD, Kanti Rai, Nicholas Chiorazzi, MD

Blood (2008) 112 (11): 26.

https://doi.org/10.1182/blood.V112.11.26.26

Published: 2008

Journal Articles

Surprising Lack of Correlation between CD38 and Time to First Treatment in Chronic Lympocytic Leukemia.

Matthew S. Kaufman, MD, Rajendra Damle, PhD, Nina Kohn, MA, Christina Johnson, RPA-C, Nancy Driscoll, RPA-C, Angelica Caramanica, RPA-C, Yehuda Lebowicz, MD, Kai Tsao, MD, Nicholas Chiorazzi, MD, Kanti Rai, MD

Blood (2007) 110 (11): 2058.

https://doi.org/10.1182/blood.V110.11.2058.2058

Published: 2007

Journal Articles

Expression of CD38 and High Levels of CD5 Identifies Members of CLL Clones That Have Progressed beyond G1 and Proliferated.

Carlo Calissano, MD, Rajendra N. Damle, PhD, Marc Hellerstein, MD, Elisabeth J. Murphy, MD, Gregory M. Hayes, PhD, Kaufman Matthew, MD, Steven Allen, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2007) 110 (11): 1114.

https://doi.org/10.1182/blood.V110.11.1114.1114

Published: 2007

Journal Articles

Addition of Oblimersen (Bcl-2 Antisense) to Fludarabine/Cyclophosphamide for Relapsed/Refractory Chronic Lymphocytic Leukemia Extends Survival in Patients Who Achieve CR/nPR: Results from a Randomized Phase 3 Study.

Susan O’Brien, Joseph Moore, Lily Ding, Steven Novick, Kanti Rai

Blood (2007) 110 (11): 751.

https://doi.org/10.1182/blood.V110.11.751.751

Published: 2007

Journal Articles

Response to Rituximab, Cyclophosphamide and Dexamethasone as Initial or Salvage Therapy in Low Grade Lymphoma and Immune Hemolytic Anemia.

Neetu Radhakrishnan, MD, Rajasree Roy, MD, Reuven Yakubov, MD, Matthew Kaufman, MD, Kanti Rai, MD, Bhoomi Mehrotra, MD, Dilip Patel, MD

Blood (2006) 108 (11): 4726.

https://doi.org/10.1182/blood.V108.11.4726.4726

Published: 2006

Journal Articles

In Vivo Labeling of Newly Synthesized DNA Suggests That the CD38 + Fraction Is Enriched in Proliferating Cells within a Clone of Chronic Lymphocytic Leukemia B Cells.

Carlo Calissano, MD, Rajendra Damle, PhD, Taraneh Banapour, BS, Denise Cesar, Marc Hellerstein, MD, PhD, Steven Allen, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2006) 108 (11): 27.

https://doi.org/10.1182/blood.V108.11.27.27

Published: 2006

Journal Articles

Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia

Jacques-Louis Binet, Federico Caligaris-Cappio, Daniel Catovsky, Bruce Cheson, Tom Davis, Guillaume Dighiero, Hartmut Döhner, Michael Hallek, Peter Hillmen, Michael Keating, Emili Montserrat, Thomas J. Kipps, Kanti Rai, for the International Workshop on Chronic Lymphocytic Leukemia (IWCLL)-initiated working group on prognostic and diagnostic parameters in CLL

Blood (2006) 107 (3): 859–861.

https://doi.org/10.1182/blood-2005-04-1677

Published: 2006

NARROW

CLL Stereotyped Subset #4 Igs Acquire Binding to Viable B Lymphocyte Surfaces By Somatic Mutations, Isotype Class Switching, and with the Prerequisite of IG Self-Association

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Reactive Oxygen Species and Metabolic Gene Expression Profiling Further Differentiate CXCR4/CD5 Fractions in Chronic Lymphocytic Leukemia

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

IgM and IgD Differential CLL BCRs Organization and Interaction with Co-Receptors before and during Ibrutinib Therapy

B Cells of the Proliferative Fraction of CLL Clones Exhibit Activated B-Cell and Myeloid-Cell Signatures Suggesting Enhanced Antigen-Presentation, Integrin Responsiveness, and IL-4 Receptiveness: Additional Targets for CLL Therapy

Fcgammariib Expression As a Prognostic Marker in Chronic Lymphocytic Leukemia

The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia

Efficiency of BCR: Anti-BCR Interaction Dictates Cellular Outcomes of Signaling in Chronic Lymphocytic Leukemia Cells

p53 and COX-2 Inhibitors Control the Replication and Viability of Non-Transformed and CLL B Lymphocytes

Induction of Apoptosis in CLL by Peptides Binding the B-Cell Antigen Receptor in Vitro

Improved Prognosis of Chronic Lymphocytic Leukemia (CLL) Patients with Increased IgVH Mutations May Reflect Greater Alteration of the B-Cell Receptor (BCR) Binding Site

In Vivo Labeling of Dividing Chronic Lymphocytic Leukemia B Cells Suggests That CXCR4 and CD5 Define the Clonal Subfraction That Recently Proliferatead and Emigrated from a Solid Tissue

A Human Hematopoietic Environment and Autologous T-Cell Growth Support Proliferation of Chronic Lymphocytic Leukemia B Cells in Immune-Deficient Mice

Surprising Lack of Correlation between CD38 and Time to First Treatment in Chronic Lympocytic Leukemia.

Expression of CD38 and High Levels of CD5 Identifies Members of CLL Clones That Have Progressed beyond G1 and Proliferated.

Addition of Oblimersen (Bcl-2 Antisense) to Fludarabine/Cyclophosphamide for Relapsed/Refractory Chronic Lymphocytic Leukemia Extends Survival in Patients Who Achieve CR/nPR: Results from a Randomized Phase 3 Study.

Response to Rituximab, Cyclophosphamide and Dexamethasone as Initial or Salvage Therapy in Low Grade Lymphoma and Immune Hemolytic Anemia.

In Vivo Labeling of Newly Synthesized DNA Suggests That the CD38 + Fraction Is Enriched in Proliferating Cells within a Clone of Chronic Lymphocytic Leukemia B Cells.

Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia

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American Society of Hematology

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