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Kadriye Nehir Cosgun, PhD
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Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Jae-Woong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Chun-Wei Chen, PhD, Raju Pillai, MD, Wing C Chan, MD, Stephen J Forman, Larry W Kwak, MD PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, David M Weinstock, MD, Ari M Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina Luger, MD, Mark R. Litzow, MD, Alexandre Belot, MDPhD, Gulbu Uzel, MD, Michael T McManus, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 776.
https://doi.org/10.1182/blood-2018-99-117553
Published: 2018
Journal Articles

Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies

Teresa Sadras, PhD, Jevon Cutler, Julia Aguade-Gorgorio, PhD, Zhengshan Chen, MD PhD, Kadriye Nehir Cosgun, PhD, Akhilesh Pandey, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3922.
https://doi.org/10.1182/blood-2018-99-116954
Published: 2018
Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 547.
https://doi.org/10.1182/blood-2018-99-116956
Published: 2018
Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 568.
https://doi.org/10.1182/blood-2018-99-115536
Published: 2018
Journal Articles

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation

Jae-Woong Lee, PhD, Huimin Geng, PhD, Derek S Dinson, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Zhengshan Chen, MDPhD, Michael Farzan, MDPhD, Jae U Jung, PhD, Arun P Wiita, MDPhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 552.
https://doi.org/10.1182/blood-2018-99-117472
Published: 2018
Journal Articles

Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia

Kadriye Nehir Cosgun, PhD, Rudi W Hendriks, PhD, Ross A Dickins, PhD, Nora Heisterkamp, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 570.
https://doi.org/10.1182/blood-2018-99-115522
Published: 2018
Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1336.
https://doi.org/10.1182/blood-2018-99-115514
Published: 2018
Journal Articles

Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Gang Xiao, PhD, Zhengshan Chen, MD PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2771.
https://doi.org/10.1182/blood.V128.22.2771.2771
Published: 2016
Journal Articles

IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, PhD, Zhengshan Chen, MD PhD, Eugene Park, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2738.
https://doi.org/10.1182/blood.V128.22.2738.2738
Published: 2016
Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4088.
https://doi.org/10.1182/blood.V128.22.4088.4088
Published: 2016