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Journal Articles

Candidate Gene Associations with Vaso-Occlusive Crisis in Children with Sickle Cell Anemia Enrolled in the Multinational DOVE Trial

Carolyn C Hoppe, MD, Joseph A Jakubowski, PhD, Wendra M Foster, Lori E Heath, Sreekumar Pillai, Bhatnagar Pallav

Blood (2017) 130 (Supplement 1): 962.

https://doi.org/10.1182/blood.V130.Suppl_1.962.962

Published: 2017

Journal Articles

Geographic Differences in Phenotype and Treatment of Children with Sickle Cell Anemia from the Multinational DOVE Study

Baba Inusa, Raffaella Colombatti, MD PhD, David C Rees, MA, FRCP, Matthew M Heeney, MD, Carolyn C Hoppe, MD, Bernhards Ogutu, MD PhD, Hoda M Hassab, MD, Chunmei Zhou, MS, Suqin Yao, PhD, Patricia B Brown, BSN, RN, Lori E Heath, MS, Joseph A. Jakubowski, PhD, Miguel R Abboud, MD

Blood (2016) 128 (22): 3653.

https://doi.org/10.1182/blood.V128.22.3653.3653

Published: 2016

Journal Articles

Regional- and Age-Related Differences in Pain in Children with Sickle Cell Anemia: Results from the Multinational DOVE Study

Julie Kanter, MD, Lori E Heath, MS, Chunmei Zhou, MS, Tsiri Agbenyega, MBChB, PhD, Raffaella Colombatti, MD PhD, Carlton Dampier, MD CPI, Hoda M Hassab, MD, Deepa Manwani, MD, Nancy Robitaille, MD, Patricia B Brown, BSN, RN, Joseph A. Jakubowski, PhD, Suqin Yao, PhD, Jack Knorr, PhD, Carolyn C Hoppe, MD

Blood (2016) 128 (22): 3654.

https://doi.org/10.1182/blood.V128.22.3654.3654

Published: 2016

Journal Articles

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Jennifer O. Nwankwo, BS, Rod R. Warburton, BA, Thomas Gremmel, MD, Anja J. Gerrits, PhD, Lauren J. Richey, DVM, PhD, Nicholas S. Hill, MD, Alicia Rivera, Joseph A. Jakubowski, PhD, Andrew L. Frelinger, III, PhD, Athar H. Chishti, PhD

Blood (2015) 126 (23): 413.

https://doi.org/10.1182/blood.V126.23.413.413

Published: 2015

Journal Articles

Possible Role Of Circulating Adenine Nucleotides and Platelet Activation In The Pathogenesis Of Sickle Cell Disease: Observations In a Murine Model

Kousaku Ohno, PhD, Hisako Tanaka, Naozumi Samata, Tomizawa Atsuyuki, PhD, Makoto Mizuno, Joseph A. Jakubowski, PhD, Atsuhiro Sugidachi, PhD

Blood (2013) 122 (21): 2212.

https://doi.org/10.1182/blood.V122.21.2212.2212

Published: 2013

Journal Articles

Prasugrel in Children with Sickle Cell Disease: Pharmacokinetic and Pharmacodynamic Characteristics from an Open-Label, Adaptive-Design, Dose-Ranging Study

Lori Styles, MD, Joseph A. Jakubowski, PhD, Darell E. Heiselman, MD, Lori E. Heath, MS, Chunmei Zhou, MS, Charles T. Quinn, MD, MS, Matthew M. Heeney, MD, Rupa Redding-Lallinger, MD, David S. Small, PhD, Brian A. Moser, MS, Kenneth J. Winters, MD

Blood (2012) 120 (21): 3213.

https://doi.org/10.1182/blood.V120.21.3213.3213

Published: 2012

Journal Articles

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

Andrew L. Frelinger, III, PhD, Joseph A. Jakubowski, PhD, Julie K. Brooks, MS, Sabrina L. Zayas, BS, Michelle A. Berny-Lang, PhD, Marc R. Barnard, MS, Matthew M. Heeney, MD, Alan D. Michelson, MD

Blood (2012) 120 (21): 5147.

https://doi.org/10.1182/blood.V120.21.5147.5147

Published: 2012

Journal Articles

Biomarkers of Hemostatic Activation in a Randomized, Double-Blind, Phase 2 Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

Ted Wun, Charles L. Knupp, MD, Lillian E. McMahon, MD, John J. Strouse, MD, PhD, Chunmei Zhou, MS, Lori E. Heath, MS, Chuke E. Nwachuku, MA, MPH, DrPH, Joseph A. Jakubowski, PhD, Kenneth J. Winters, MD, Jeffrey S. Riesmeyer, MD

Blood (2011) 118 (21): 2127.

https://doi.org/10.1182/blood.V118.21.2127.2127

Published: 2011

Journal Articles

A Randomized, Double-Blind, Adaptive Phase 2 Multi-Center Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

Ted Wun, Denis Soulieres, MD, FRCPC, MSc, Lakshmanan Krishnamurti, MD, Abdullah Kutlar, MD, Kenneth Ataga, MD, Chunmei Zhou, MS, Lori E. Heath, MS, Chuke E. Nwachuku, MA, MPH, DrPH, Joseph A. Jakubowski, PhD, Kenneth J. Winters, MD, Jeffrey S. Riesmeyer, MD

Blood (2011) 118 (21): 847.

https://doi.org/10.1182/blood.V118.21.847.847

Published: 2011

Journal Articles

In Vivo Platelet Activation and Its In Vitro Inhibition by Prasugrel's Active Metabolite In Adolescents with Sickle Cell Disease

Andrew L. Frelinger, III, PhD, Joseph A. Jakubowski, PhD, Julie K. Brooks, MS, Anu Nigam, MS, Michelle A. Berny-Lang, Ph.D., Marc R. Barnard, MS, Matthew M. Heeney, MD, Alan D. Michelson, MD

Blood (2011) 118 (21): 2141.

https://doi.org/10.1182/blood.V118.21.2141.2141

Published: 2011

Journal Articles

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity

Joseph A. Jakubowski, PhD, Chunmei Zhou, MS, David S. Small, PhD, Kenneth J. Winters, MD, D. Richard Lachno, DPhil, Andrew L. Frelinger, III, PhD, Jo Howard, MB, BChir, MRCP, FRCPath, Stipo Jurcevic, MD, Christopher D. Payne, MSc

Blood (2011) 118 (21): 1053.

https://doi.org/10.1182/blood.V118.21.1053.1053

Published: 2011

Journal Articles

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Effects on In Vivo Markers of Platelet Activation and of Coagulation

Blood (2011) 118 (21): 1049.

https://doi.org/10.1182/blood.V118.21.1049.1049

Published: 2011

Journal Articles

Effects of Prasugrel In a Rat Model of Myocardial Infarction Induced by Thrombotic Coronary Artery Occlusion

Atsuhiro Sugidachi, PhD, Shinji Yamaguchi, PhD, Joseph A Jakubowski, PhD, Masami Hashimoto, PhD, Yoichi Niitsu, PhD

Blood (2010) 116 (21): 3317.

https://doi.org/10.1182/blood.V116.21.3317.3317

Published: 2010

Journal Articles

Prasugrel (CS-747, LY640315) Hydrochloride, a Novel Thienopyridine Prodrug, Shows Potent Antiplatelet and Antithrombotic Effects with Rapid Onset of Action in Rats.

Yoichi Niitsu, PhD, Taketoshi Ogawa, PhD, Atsuhiro Sugidachi, PhD, Joseph A. Jakubowski, PhD, Yuki Yokouchi, Mayumi Kakusaka, Michihiro Hasegawa, Fumitoshi Asai, PhD

Blood (2005) 106 (11): 1879.

https://doi.org/10.1182/blood.V106.11.1879.1879

Published: 2005

NARROW

Candidate Gene Associations with Vaso-Occlusive Crisis in Children with Sickle Cell Anemia Enrolled in the Multinational DOVE Trial

Geographic Differences in Phenotype and Treatment of Children with Sickle Cell Anemia from the Multinational DOVE Study

Regional- and Age-Related Differences in Pain in Children with Sickle Cell Anemia: Results from the Multinational DOVE Study

Hypoxia Reoxygenation Treatment Induces Platelet Hyperactivity and Relieves Calpain-1-Mediated Inhibition of Platelet Aggregation in a Mouse Model of Severe Sickle Cell Disease

Possible Role Of Circulating Adenine Nucleotides and Platelet Activation In The Pathogenesis Of Sickle Cell Disease: Observations In a Murine Model

Prasugrel in Children with Sickle Cell Disease: Pharmacokinetic and Pharmacodynamic Characteristics from an Open-Label, Adaptive-Design, Dose-Ranging Study

Platelet Activation and Inhibition in Sickle Cell Disease (PAINS) Study

Biomarkers of Hemostatic Activation in a Randomized, Double-Blind, Phase 2 Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

A Randomized, Double-Blind, Adaptive Phase 2 Multi-Center Study of Prasugrel Compared to Placebo in Adults with Sickle Cell Disease

In Vivo Platelet Activation and Its In Vitro Inhibition by Prasugrel's Active Metabolite In Adolescents with Sickle Cell Disease

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity

A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Effects on In Vivo Markers of Platelet Activation and of Coagulation

Effects of Prasugrel In a Rat Model of Myocardial Infarction Induced by Thrombotic Coronary Artery Occlusion

Prasugrel (CS-747, LY640315) Hydrochloride, a Novel Thienopyridine Prodrug, Shows Potent Antiplatelet and Antithrombotic Effects with Rapid Onset of Action in Rats.

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American Society of Hematology

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American Society of Hematology

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