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John M. Ashton, PhD
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Journal Articles

Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy

Shanshan Pei, PhD, Daniel A Pollyea, MD, Annika Gustafson, Mohammad Minhajuddin, PhD, Brett M. Stevens, PhD, Haobin Ye, PhD, Anagha Inguva, BSc, Maria L Amaya, MD PhD, Anna Krug, BS, Courtney L Jones, PhD, Biniam Adane, PhD, Amanda Winters, MD PhD, Nabilah Khan, Jessica Ponder, PhD, Jeffrey Schowinsky, Andrew Hammes, MS, Diana Abbott, PhD, Jason R Myers, MS, John M Ashton, PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Haley E. Ramsey, PhDMSc, Michael R. Savona, MD, Stephen W. Fesik, PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 185.
https://doi.org/10.1182/blood-2019-131390
Published: 2019
Journal Articles

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Thomas J Fountaine, MD, Mark W LaMere, BA, Daniel K Byun, BS, Jason R Myers, MS, John M Ashton, PhD, Jane L. Liesveld, MD, Youmna Kfoury, PhD, David T. Scadden, MD, Michael W. Becker, MD, Laura M. Calvi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1708.
https://doi.org/10.1182/blood-2019-130227
Published: 2019
Journal Articles

Role of RasGRP3 in EPO/EPOR Signaling and Transmigration of Human Hematopoietic CD34+ Cells

Yahui Grace Chiu, PhD, Jacquelyn Lillis, MS, Rakesh Singh, PhD, Jane L. Liesveld, MD, Laura M. Calvi, MD, John M Ashton, PhD, Omar S. Aljitawi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4531.
https://doi.org/10.1182/blood-2018-99-116807
Published: 2018
Journal Articles

Dwjm-Adherence Induces Chemotherapy Resistance in Primary Acute Myeloid Leukemia By Altering Leukemia Cell Metabolism

Brea Lipe, MD, Thomas Conley, Hani Awad, PhD, Jason H. Mendler, MD PhD, Jason R Myers, MS, John M Ashton, PhD, Michael W. Becker, MD, Omar S. Aljitawi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3953.
https://doi.org/10.1182/blood-2018-99-117476
Published: 2018
Journal Articles

Rheumatoid Arthritis Causes Hematopoietic Stem Cell Reprogramming to Maintain Functionality

Taylor Mills, BA, Giovanny Hernandez, BS, Jennifer L Rabe, BS, BA, Susan Kuldanek, MD, James Chavez, BA, Greg Kirkpatrick, PhD, Leila Noetzli, PhD, Widian Jubair, MD, Michelle Zanche, MS, Jason R Myers, MS, Brett M. Stevens, PhD BS, Courtney Fleenor, PhD, Biniam Adane, PhD, John M Ashton, PhD, Craig T Jordan, PhD, James Hagman, Jorge Di Paola, MD, Michael Holers, MD, Kristine Kuhn, Eric Pietras, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2573.
https://doi.org/10.1182/blood-2018-99-120272
Published: 2018
Journal Articles

IQGAP1: A Potential Therapeutic Target in Acute Myelogenous Leukemia (AML)

Deepak Sahasrabudhe, MD, John M Ashton, PhD, Andrew G Evans, MD PhD, McMahon Loralee, Balys Merlene, MS, Jane L. Liesveld, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1391.
https://doi.org/10.1182/blood.V130.Suppl_1.1391.1391
Published: 2017
Journal Articles

Single-Cell Transcriptome Analysis of Embryonic Erythro-Myeloid Progenitor Cells Reveals Lineage Heterogeneity

Jacquelyn Lillis, MS, Kathleen E. McGrath, PhD, Seana C Catherman, BS, Michelle Zanche, MS, Balys Merlene, MS, John M Ashton, PhD, James Palis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3753.
https://doi.org/10.1182/blood.V130.Suppl_1.3753.3753
Published: 2017
Journal Articles

Aging of Hematopoietic Stem Cells Is Driven By Regional Specialization of Marrow Macrophages

Corey M Hoffman, MS, Sarah E Latchney, PhD, Mark LaMere, BA, Jason R Myers, MS, John M Ashton, PhD, Allison J. Li, MS, Frank Akwaa, MD, Rakhil Rubinova, D.O., Amanda McCabe, PhD, Julianne N. Smith, PhD, Jane L. Liesveld, MD, Benjamin J. Frisch, PhD, Michael Rusty Elliott, PhD, Katherine C MacNamara, PhD, Michael W. Becker, MD, James Palis, MD, Archibald S. Perkins, MD PhD, Laura M. Calvi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 95.
https://doi.org/10.1182/blood.V130.Suppl_1.95.95
Published: 2017
Journal Articles

Bone Marrow Mesenchymal Stem Cells from Acute Myelogenous Leukemia Patients Demonstrate Adipogenic Differentiation Propensity

Mitra Azadniv, PhD, Jason R. Myers, MS, Helene McMurray, PhD, John M. Ashton, PhD, Naxin Guo, PhD, Phil Rock, BS, Myra Coppage, PhD, Laura M. Calvi, MD, Michael W. Becker, MD, Jane L. Liesveld, MD
Journal: Blood
Blood (2016) 128 (22): 5064.
https://doi.org/10.1182/blood.V128.22.5064.5064
Published: 2016
Journal Articles

A Role for IL1RAP in Acute Myelogenous Leukemia Stem Cells Following Treatment and Progression

Tzu-Chieh Ho, PhD, Craig T Jordan, PhD, Mark W. LaMere, BA, John M. Ashton, PhD, Kristen O'Dwyer, MD, Jason H. Mendler, MD PhD, Jane L. Liesveld, MD, Eunice S. Wang, MD, Monica L. Guzman, PhD, Laura M. Calvi, MD, Michael W. Becker, MD
Journal: Blood
Blood (2015) 126 (23): 4266.
https://doi.org/10.1182/blood.V126.23.4266.4266
Published: 2015
Journal Articles

Distinct Properties of Leukemia Stem Cells in Primary Refractory Acute Myeloid Leukemia

Jason H. Mendler, MD PhD, Marlene Balys, Umayal Sivagnanalingam, Allison Eberhardt, Korinne Thorne, Tzu-Chieh Ho, PhD, Mark W. LaMere, BA, Samuel Moore, Helene McMurray, PhD, Jason R. Myers, John M. Ashton, PhD, Kristen O'Dwyer, MD, Jane L. Liesveld, MD, Laura M. Calvi, MD, Michael W. Becker, MD
Journal: Blood
Blood (2015) 126 (23): 685.
https://doi.org/10.1182/blood.V126.23.685.685
Published: 2015
Journal Articles

Adipose Tissue Functions As a Reservoir for Leukemia Stem Cells and Confers Chemo-Resistance

Haobin Ye, Biniam Adane, Nabilah Khan, PhD, John M. Ashton, PhD, Marlene Balys, Brett M Stevens, PhD, Mohammad Minhajuddin, Craig T Jordan, PhD
Journal: Blood
Blood (2015) 126 (23): 845.
https://doi.org/10.1182/blood.V126.23.845.845
Published: 2015
Journal Articles

Leukemia Cells Resident in Adipose Tissue Display a Pro-Inflammatory Phenotype and Induce Lipolysis and Atrophy of Adipose Tissue

Haobin Ye, Nabilah Khan, PhD, Marlene Balys, John M. Ashton, PhD, Biniam Adane, Craig T Jordan, PhD
Journal: Blood
Blood (2015) 126 (23): 2765.
https://doi.org/10.1182/blood.V126.23.2765.2765
Published: 2015
Journal Articles

A Novel Xenograft Model of Cytogenetically Normal Acute Myeloid Leukemia Harboring RUNX1 and ASXL1 Mutations Demonstrates Residual Disease after Anthracycline/Cytarabine-Based Chemotherapy

Umayal Sivagnanalingam, BS, Marlene Balys, Allison Eberhardt, Nancy Wang, PhD, John M. Ashton, PhD, Jason H. Mendler, MD PhD
Journal: Blood
Blood (2014) 124 (21): 9.
https://doi.org/10.1182/blood.V124.21.9.9
Published: 2014