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Journal Articles

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Erica Sparkenbaugh, PhD, John H. Griffin, PhD, Laurent O Mosnier, Rafal Pawlinski, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139862

Published: 2020

Journal Articles

Procoagulant Activity of Skeletal Muscle Myosin Is Not Caused By Contaminating Phosphatidylserine-Vesicles

Shravan Morla, Hiroshi Deguchi, MD PhD, Rolf Brekken, PhD, John H. Griffin, PhD

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-139574

Published: 2020

Journal Articles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Vijay Kumar Reddy Kondreddy, MSc,PhD, Usha R. Pendurthi, PhD, Xiao Xu, John H. Griffin, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 481.

https://doi.org/10.1182/blood-2019-124976

Published: 2019

Journal Articles

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Hiroshi Deguchi, MD PhD, Zihan Guo, Mohammed Hayat, Elsa Pflimlin, Weijun Shen, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3622.

https://doi.org/10.1182/blood-2019-129161

Published: 2019

Journal Articles

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, MD PhD, Mohammed Hayat, Meenal Shukla, PhD, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, PhD, Laurent O Mosnier, Owen J T McCarty, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3632.

https://doi.org/10.1182/blood-2019-129312

Published: 2019

Journal Articles

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Ranjeet Kumar Sinha, PhD MSc, Yaoming Wang, PhD, Zhen Zhao, PhD, Jose A. Fernandez, MD PhD, Naveen Gupta, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, Laurent O Mosnier, PhD, Berislav Zlokovic, PhD, John H. Griffin, PhD

Blood (2016) 128 (22): 13.

https://doi.org/10.1182/blood.V128.22.13.13

Published: 2016

Journal Articles

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Ranjeet Kumar Sinha, PhD MSc, Ryan P Flynn, PhD, Jose A. Fernandez, MD PhD, Xiao Xu, MSc, Greg Martin, MSc, Sergey Kupriyanov, PhD MSc, John H. Griffin, PhD, Bruce R. Blazar, MD

Blood (2016) 128 (22): 808.

https://doi.org/10.1182/blood.V128.22.808.808

Published: 2016

Journal Articles

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Luca Bologna, PhDstudent, Raja Prince, PhDstudent, Mirko Manetti, PhD, Daniela Melchiorre, MD, Irene Rosa, PhDstudent, Natacha Dewarrat, Poorya Amini, PhDstudent, Jose A Fernandez, Claudia Quarroz, Yasuhiro Matsumura, MD PhD, Johanna A Kremer Hovinga, MD PhD, Shida Yousefi, PhD, John H. Griffin, PhD, Simon Hans-Uwe, MD PhD, Lidia Ibba Manneschi, Francois Saller, PhD, Sara Calzavarini, PhD, Anne Angelillo-Scherrer, MD

Blood (2016) 128 (22): 79.

https://doi.org/10.1182/blood.V128.22.79.79

Published: 2016

Journal Articles

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Hartmut Weiler, Hai-Po Liang, PhD, Edward J Kerschen, PhD, Alireza Rezaie, PhD, Jose A. Fernandez, MD PhD, Rodney M. Camire, PhD, Wolfram Ruf, MD, John H. Griffin, PhD, Raffaele Toso, PhD

Blood (2015) 126 (23): 216.

https://doi.org/10.1182/blood.V126.23.216.216

Published: 2015

Journal Articles

Role of Protein S and Gas6 in the Development of Purpura Fulminans

Raja Prince, PhDstudent, Anne Angelillo-Scherrer, MD, John H. Griffin, PhD, Sara Calzavarini, PhD, Yasuhiro Matsumura, MD PhD, Francois Saller, PhD

Blood (2015) 126 (23): 1042.

https://doi.org/10.1182/blood.V126.23.1042.1042

Published: 2015

Journal Articles

Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors

Hiroshi Deguchi, MD PhD, Ranjeet Kumar Sinha, PhD MSc, Darlene J. Elias, MD, John H. Griffin, PhD

Blood (2015) 126 (23): 763.

https://doi.org/10.1182/blood.V126.23.763.763

Published: 2015

Journal Articles

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

John H. Griffin, PhD, Jose A. Fernandez, MD PhD, Ranjeet Kumar Sinha, PhD MSc, Darlene J. Elias, MD, Hiroshi Deguchi, MD PhD

Blood (2015) 126 (23): 3486.

https://doi.org/10.1182/blood.V126.23.3486.3486

Published: 2015

Journal Articles

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Hiroshi Deguchi, MD PhD, Yajnavalka Banerjee, PhD, Gary Siuzdak, PhD, Sunia Trauger, PhD, Ewa Kalisiak, PhD, Jose A. Fernandez, MD PhD, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, PhD, Darlene J Elias, MD, John H. Griffin, PhD

Blood (2014) 124 (21): 2797.

https://doi.org/10.1182/blood.V124.21.2797.2797

Published: 2014

Journal Articles

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Ranjeet Kumar Sinha, PhD, Laurent Burnier, PhD, Naveen Gupta, MD, Xiao Xu, MS, Sergey Kupriyanov, PhD, Greg Martin, MS, Laurent O. Mosnier, PhD, John H. Griffin, PhD

Blood (2014) 124 (21): 99.

https://doi.org/10.1182/blood.V124.21.99.99

Published: 2014

Journal Articles

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Vikas Bhat, PhD, Annette von Drygalski, MD PharmD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2014) 124 (21): 692.

https://doi.org/10.1182/blood.V124.21.692.692

Published: 2014

Journal Articles

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

Vikas Bhat, PhD, Andrew J. Gale, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD, Annette von Drygalski, MD PharmD

Blood (2014) 124 (21): 695.

https://doi.org/10.1182/blood.V124.21.695.695

Published: 2014

Journal Articles

Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage

Abdulrahman Alsultan, MD, Andrew J. Gale, PhD, Kadijah Kurban, MD, Mohammed Khalifah, MD, Fahad B. Albadr, MD, John H. Griffin, PhD

Blood (2013) 122 (21): 3587.

https://doi.org/10.1182/blood.V122.21.3587.3587

Published: 2013

Journal Articles

Reduction Of Histone H1 Cytotoxicity By Activated Protein C and Its Exosite Variants

Thomas J. Cramer, PhD, Ranjeet K. Sinha, PhD, John H. Griffin, PhD

Blood (2013) 122 (21): 2334.

https://doi.org/10.1182/blood.V122.21.2334.2334

Published: 2013

Journal Articles

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Annette Von Drygalski, MD, PharmD, Andrew J. Gale, PhD, Laurent Burnier, PhD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Laurent O. Mosnier, PhD

Blood (2013) 122 (21): 203.

https://doi.org/10.1182/blood.V122.21.203.203

Published: 2013

Journal Articles

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

Annette Von Drygalski, MD, PharmD, Thomas J. Cramer, PhD, John H. Griffin, PhD, Andrew J. Gale, PhD, Laurent O. Mosnier, PhD

Blood (2012) 120 (21): 17.

https://doi.org/10.1182/blood.V120.21.17.17

Published: 2012

NARROW

Biased PAR-1 Signaling Regulates Thrombo-Inflammation in a Mouse Model of Sickle Cell Disease

Procoagulant Activity of Skeletal Muscle Myosin Is Not Caused By Contaminating Phosphatidylserine-Vesicles

Factor VIIa Induces Biased Cytoprotective Signaling through the Cleavage of Protease Activated Receptor 1 at Canonical Arg41 Site

Molecular Interaction Site on Procoagulant Skeletal Muscle Myosin for Factor Xa-Dependent Prothrombin Activation

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke

Activated Protein C (APC) Therapy Ameliorates Chronic Graft Versus Host Disease By Cell Signaling Mechanisms That Require Cleavage at Arg46 in PAR1 on T Cells

Blocking Protein S Improves Hemostasis in Hemophilia a and B

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Role of Protein S and Gas6 in the Development of Purpura Fulminans

Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors

Plasma Constitutive Serum Amyloid A4 Is Procoagulant and Is Elevated in Venous Thrombosis Patients

Acylcarnitines Are Novel Anticoagulant Lipids That Target Factor Xa and That Are Reduced in Plasma of Venous Thrombosis Patients Based on Untargeted and Targeted Metabolomics

Novel R41Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for in Vivo Mechanisms of Action for Thrombin (IIa) and Activated Protein C (APC)

Synergistic Effect in Bleed Reduction By super fva and Recombinant Human FVIIa in Vivo Suggests a Novel Bypassing Strategy for Hemophilia Patients with Inhibitors

Reversal of Novel Oral Anticoagulant (NOAC)-Induced Bleeding in Mice By Engineered super factor Va

Activation-Resistant Homozygous Protein C R229W Mutation Causing Familial Perinatal Intracranial Hemorrhage

Reduction Of Histone H1 Cytotoxicity By Activated Protein C and Its Exosite Variants

An Engineered Factor Fva Prevents Bleeding Induced By Anticoagulant Wild Type Activated Protein C

Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice

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American Society of Hematology

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American Society of Hematology

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