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John H. Bushweller, PhD
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Journal Articles

Direct Binding of BCOR, but Not CBX8, to MLL-AF9 Is Essential for MLL-AF9 Leukemia Via Regulation of the EYA1/SIX1 Gene Network

John H. Bushweller, PhD, Charles Schmidt, Nicholas Achille, Aravinda Kuntimaddi, Adam Boulton, Benjamin Leach, Shubin Zhang, Nancy J. Zeleznik-Le, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1316.
https://doi.org/10.1182/blood-2018-99-111388
Published: 2018
Journal Articles

Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML

John Anto Pulikkan, PhD, Anuradha Illendula, PhD, Jolanta Grembecka, Liting Xue, Roger Rajewski, Monica L. Guzman, PhD, John H. Bushweller, PhD, Lucio H. Castilla, PhD
Journal: Blood
Blood (2014) 124 (21): 390.
https://doi.org/10.1182/blood.V124.21.390.390
Published: 2014
Journal Articles

Structural and Functional Studies Of The Intrinsically Disordered Protein AF9 In MLL-AF9 Leukemia

Aravinda Kuntimaddi, Alyson Lokken, Shubin Zhang, Jeremy Thorpe, Benjamin Leach, PhD, Bhavna Lumba, PhD, Charles S. Hemenway, MD, PhD, Mazhar Adli, PhD, Nancy J. Zeleznik-Le, PhD, John H. Bushweller, PhD
Journal: Blood
Blood (2013) 122 (21): 3762.
https://doi.org/10.1182/blood.V122.21.3762.3762
Published: 2013
Journal Articles

A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo

John H. Bushweller, PhD, Anuradha Illendula, Ph.D., John Anto Pulikkan, Jolanta Grembecka, PhD, Paul Bradley, Yunpeng Zhou, Ph.D., Liting Xue, Yan Gao, Lucio H. Castilla, PhD
Journal: Blood
Blood (2012) 120 (21): 286.
https://doi.org/10.1182/blood.V120.21.286.286
Published: 2012
Journal Articles

The Role of the Intrinsically Disordered and Multifunctional AF9 C-Terminal Domain in MLL-AF9 Leukemia,

John H. Bushweller, PhD, Benjamin Leach, Ming-jin Chang, Bhavna Lumba, Tomasz Cierpicki, PhD, Nancy J. Zeleznik-Le, PhD, Charles S. Hemenway, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3464.
https://doi.org/10.1182/blood.V118.21.3464.3464
Published: 2011
Journal Articles

DNMT1 Cxxc Domain Can Functionally Substitute In An MLL Fusion Protein

Laurie E. Risner, PhD, Aravinda Kuntimaddi, John H. Bushweller, PhD, Nancy J. Zeleznik-Le, PhD
Journal: Blood
Blood (2010) 116 (21): 4193.
https://doi.org/10.1182/blood.V116.21.4193.4193
Published: 2010
Journal Articles

Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia.

Laurie Risner, Tomasz Cierpicki, PhD, Jolanta Grembecka, PhD, Stephen M Lukasik, PhD, Relja Popovic, PhD, David S Shultis, PhD, Nancy J. Zeleznik-Le, PhD, John H. Bushweller, PhD
Journal: Blood
Blood (2009) 114 (22): 763.
https://doi.org/10.1182/blood.V114.22.763.763
Published: 2009
Journal Articles

Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins.

Jolanta E. Grembecka, PhD, Kristin Graf, Yali Kong, PhD, Michael Douvas, MD, Tomasz Cierpicki, PhD, Anuradha Illendula, PhD, Gwen Baber, Izabela Bielnicka, Liya Roudaia, Nancy A. Speck, PhD, Milton L. Brown, PhD, MD, John H. Bushweller, PhD
Journal: Blood
Blood (2007) 110 (11): 1591.
https://doi.org/10.1182/blood.V110.11.1591.1591
Published: 2007
Journal Articles

Structural and Functional Characterization of the NHR2 and Runt Domains of AML1/ETO.

Matthew D. Cheney, AB, Yizhou Liu, MS, Justin J. Gaudet, BS, Maksymilian Chruszcz, PhD, Stephen M. Lukasik, BS, Daisuke Sugiyama, MD, PhD, Jeff Lary, PhD, James Cole, PhD, Zbyszek Dauter, PhD, Wladek Minor, PhD, Nancy A. Speck, PhD, John H. Bushweller, PhD
Journal: Blood
Blood (2005) 106 (11): 2854.
https://doi.org/10.1182/blood.V106.11.2854.2854
Published: 2005
Journal Articles

The CBFb-SMMHC Oncoprotein Inhibits Binding of the Runx1 Runt Domain to DNA.

John H. Bushweller, PhD, Stephen M. Lukasik, BS, Nancy A. Speck, PhD
Journal: Blood
Blood (2005) 106 (11): 2709.
https://doi.org/10.1182/blood.V106.11.2709.2709
Published: 2005
Journal Articles

Development of Small Molecule Inhibitors of the CBFβ-SMMHC Oncoprotein.

John H. Bushweller, PhD, Michael J. Gorczynski, PhD, Jolanta Grembecka, PhD, Miki Newman, MS, Takeshi Corpora, BA, Yunpeng Zhou, BS, Yali Kong, PhD, Jae-Pil Jeon, PhD, Pu Paul Liu, PhD, Milton L. Brown, PhD
Journal: Blood
Blood (2005) 106 (11): 3359.
https://doi.org/10.1182/blood.V106.11.3359.3359
Published: 2005
Journal Articles

Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein.

Jolanta Grembecka, PhD, Kristin Graf, Miki Newman, Yunpeng Zhou, Mathew Cheney, Nancy A. Speck, PhD, Milton L. Brown, PhD, John H. Bushweller, PhD
Journal: Blood
Blood (2005) 106 (11): 1515.
https://doi.org/10.1182/blood.V106.11.1515.1515
Published: 2005