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John D Crispino, PhD
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Journal Articles

Loss of LKB1/ STK11 Facilitates Leukemic Progression of the Myeloproliferative Neoplasms

Christian Marinaccio, MSc, Praveen K Suraneni, PhD, Hamza Celik, PhD, Andrew Volk, PhD, Jeremy Q. Wen, MD PhD, Te Ling, PhD, Terra Lasho, PhD, Richard P. Koche, PhD, Christopher Famulare, MS, Brady L. Stein, MD, Sandeep Gurbuxani, MBBS, PhD, Ronald Hoffman, MD, Naseema Gangat, MBBS, Navdeep Chandel, Ross L. Levine, MD, Raajit K. Rampal, MD PhD, Grant Challen, Ayalew Tefferi, MD, John D. Crispino, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140557
Published: 2020
Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-141258
Published: 2020
Journal Articles

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, Anne Lehman, Grace Jeschke, PhD, John D. Crispino, PhD MBA, Thierry Besson, PhD, Sarah K. Tasian, MD, Martin Carroll, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2742.
https://doi.org/10.1182/blood-2019-123475
Published: 2019
Journal Articles

FBXO11 Is a Candidate Tumor Suppressor in the Transformation of MDS to Secondary AML

Michael Schieber, MD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2019) 134 (Supplement_1): 4217.
https://doi.org/10.1182/blood-2019-124007
Published: 2019
Journal Articles

The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL

Rahul S. Bhansali, Malini Rammohan, MS, Ji Heon Paul Lee, MD PhD, Sebastien Malinge, PhD, Yi-Chien Tsai, Nobuko Hijiya, MD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Corinne Fruit, Thierry Besson, PhD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 548.
https://doi.org/10.1182/blood-2018-99-119854
Published: 2018
Journal Articles

Alisertib (MLN8237), an Oral Selective Inhibitor of Aurora Kinase a, Has Clinical Activity and Restores GATA1 Expression in Patients with Myelofibrosis

Naseema Gangat, MBBS, Brady Lee Stein, MD, Christian Marinaccio, Ronan Swords, MD PhD, Justin M. Watts, MD, Sandeep Gurbuxani, Olga Frankfurt, MD, Jessica K. Altman, MD, Jeremy Q. Wen, MD PhD, Noushin Farnoud, PhD, Christopher Famulare, MS, Akshar Patel, BA, Roberto Tapia, BS, Amy Handlogten, Yvonne Trang Dinh, BS, Kristen Englund, Shradha Patel, Juan Carlos Nobrega, Dalissa Tejera, MSN, Amber Thomassen, Harald Stein, MD PhD Dr. h.c., Juehua Gao, MD PhD, Peng Ji, MDPhD, Raajit K. Rampal, MD PhD, Francis J. Giles, MD FRCPI, FRCPath, Ayalew Tefferi, MD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 688.
https://doi.org/10.1182/blood-2018-99-110381
Published: 2018
Journal Articles

STAT3 Is Activated By DYRK1A and Is a Potential Therapeutic Target in B-ALL

Malini Rammohan, MS, Rahul S. Bhansali, Yi-Chien Tsai, Alexander Dong, Sebastien Malinge, PhD, Jean-Pierre Bourquin, MD PhD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 3898.
https://doi.org/10.1182/blood-2018-99-115429
Published: 2018
Journal Articles

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Maurice Labuhn, MSc, Kelly Perkins, PhD, Elli Papaemmanuil, PhD, Catherine Garnett, Soeren Matzk, Vyacheslav Amstislavskiy, Marlen Metzner, Alison Kennedy, Carina Scheer, Kenichi Yoshida, MD PhD, Adrian Schwarzer, MD PhD, John D. Crispino, PhD MBA, Jeffrey W. Taub, MD, Mitchell J. Weiss, MD PhD, Etsuro Ito, MDPhD, Seishi Ogawa, MD PhD, Dirk Reinhardt, Marie-Laure Yaspo, PhD, Peter J. Campbell, PhD, Dirk Heckl, PhD, Jan-Henning Klusmann, Paresh Vyas
Journal: Blood
Blood (2018) 132 (Supplement 1): 543.
https://doi.org/10.1182/blood-2018-99-116661
Published: 2018
Journal Articles

Global Chromatin Occupancy and Epigenetic Signature Analysis Reveal New Insights into the Function of GATA1 N-Terminus in Erythropoiesis

Te Ling, PhD, Yehudit Birger, PhD, Monika Stankiewicz, PhD, Nissim Ben-Haim, Itamar Kanter, Tomer Kalisky, Avigail Rein Gil, MD, Neil L Kelleher, PhD, Lihua Zou, PhD, Shai Izraeli, MD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 533.
https://doi.org/10.1182/blood-2018-99-115338
Published: 2018
Journal Articles

Dynamins 2 and 3 Are Required for Human Megakaryocytes Directional Migration

Praveen K Suraneni, PhD, Seth J. Corey, MD, Michael Hession, BS, Rameez Ishaq, Arinola Awomolo, Shirin Hasan, PhD, Najet Debili, PhD, John D. Crispino, PhD MBA, Elizabeth A. Eklund, MD, Yolande Chen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2429.
https://doi.org/10.1182/blood-2018-99-118782
Published: 2018
Journal Articles

Differential Phosphoproteomics Provides New Insights into Role of DYRK1A in Lymphopoiesis

Rahul S. Bhansali, Malini Rammohan, BS, Ji Heon Paul Lee, MD PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1152.
https://doi.org/10.1182/blood.V130.Suppl_1.1152.1152
Published: 2017
Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 245.
https://doi.org/10.1182/blood.V130.Suppl_1.245.245
Published: 2017
Journal Articles

A Multicenter, Open-Label, Pilot Study of Alisertib (MLN8237), a Novel Inhibitor of Aurora Kinase a, in Myelofibrosis

Naseema Gangat, MBBS, Ronan T. Swords, MD PhD FRCPI, FRCPath, Brady Lee Stein, MDMHS, Christian Marinaccio, Justin M Watts, MD, Olga Frankfurt, MD, Jessica K. Altman, MD, Aref Al-Kali, MD, Darci Zblewski, CNP, Sandeep Gurbuxani, Jeremy Q. Wen, MD PhD, Roberto Tapia, BS, Stephanie Barath, Amy Graf, Amy Handlogten, Yvonne Trang Dinh, BS, Kristen Englund, Shradha Patel, Orlando Bodes, Jillian Ogden, Francis J. Giles, MD MB, FRCPath, Ayalew Tefferi, MD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1631.
https://doi.org/10.1182/blood.V130.Suppl_1.1631.1631
Published: 2017
Journal Articles

Dot1l Reverses the Abnormal Self-Renewal Conferred on HSPCs through Cohesin Haploinsufficiency By Diminishing Expression of Hoxa7 and Hoxa9

Joseph B Fisher, PhD, Cary Stelloh, Emily Kristine Phillips, BS, Katelyn Heimbruch, BS, Alison E Meyer, PhD, Kirthi Pulakanti, Maureen McNulty, BS, Aaron D Viny, MDMS, Ross L. Levine, MD, John D. Crispino, PhD, Sridhar Rao, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 246.
https://doi.org/10.1182/blood.V130.Suppl_1.246.246
Published: 2017
Journal Articles

Defect in Ribosome Biogenesis Contributes to Impaired Megakaryopoiesis in Primary Myelofibrosis

Laure Gilles, PhD, Ahmet Dirim Arslan, PhD, Katerina Konstantinoff, Maureen McNulty, Lasho Terra, PhD, Animesh Pardanani, MBBS, PhD, Brady L Stein, MD, Isabelle Plo, William Vainchenker, MD PhD, Leonidas Platanias, Ayalew Tefferi, MD, John D Crispino, PhD
Journal: Blood
Blood (2014) 124 (21): 4585.
https://doi.org/10.1182/blood.V124.21.4585.4585
Published: 2014
Journal Articles

Stage Selective Requirement For The N-Terminus Of GATA1 During Erythropoiesis

Monika J Stankiewicz, PhD, Timothy M Chlon, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 3670.
https://doi.org/10.1182/blood.V122.21.3670.3670
Published: 2013
Journal Articles

The Chromosome 21 Kinase DYRK1A Controls Cell Cycle Exit and Survival During Lymphoid Development and Is a Novel Therapeutic Target In Acute Lymphoblastic Leukemia

Benjamin J. Thompson, MD, PhD, Lauren Diebold, Sebastien Malinge, PhD, Bertrand Leblond, Anne-Sophie Casagrande, Laurent Désiré, Alicia Foucourt, Thierry Besson, Nobuko Hijiya, MD, John D. Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 814.
https://doi.org/10.1182/blood.V122.21.814.814
Published: 2013
Journal Articles

Aurora A Kinase Is Required For Hematopoiesis and Couples Polyploidization With Terminal Differentiation In Megakaryocytes Through Phosphorylation Of NF-E2

Benjamin Goldenson, BS, Qiang Jeremy Wen, PhD, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 219.
https://doi.org/10.1182/blood.V122.21.219.219
Published: 2013
Journal Articles

Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms

Qiang Jeremy Wen, PhD, MD, Benjamin Goldenson, Sebastien Malinge, PhD, Brady L Stein, MD MHS, Terra L Lasho, MT, (ASCP), Lawrence Breyfogle, Rachael Schultz, Qiong Yang, Laure gilles-Gendre, Priya Koppikar, Omar Abdel-Wahab, MD, Benjamin L. Ebert, MD, PhD, Animesh Pardanani, MBBS, PhD, Sandeep Gurbuxani, MBBS, PhD, Ross L. Levine, MD, Ann Mullally, MD, Ayalew Tefferi, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 109.
https://doi.org/10.1182/blood.V122.21.109.109
Published: 2013
Journal Articles

A Role for Survivin in Enucleation of Erythroid Progenitors.

Ganesan Keerthivasan, MD, Jeong Ah. Kang, PhD, Dwight S. Seferos, PhD, Chad A. Mirkin, PhD, Amittha Wickrema, PhD, John D. Crispino, PhD
Journal: Blood
Blood (2007) 110 (11): 1704.
https://doi.org/10.1182/blood.V110.11.1704.1704
Published: 2007