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Jane A. Little, MD
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Journal Articles

Thrombin-Induced Endothelial Cell Damage Is Mitigated By Human Anti-Thrombin III in a Microfluidic Device

William Wulftange, Erdem Kucukal, PhD, Yuncheng Man, Ran An, PhD, Karamoja Monchamp, Olabimpe Olayiwola, MS, Jane A. Little, MD, Nigel S. Key, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24–25.
https://doi.org/10.1182/blood-2020-141583
Published: 2020
Journal Articles

Computer Vision and Deep Learning Assisted Microchip Electrophoresis for Integrated Anemia and Sickle Cell Disease Screening

Ran An, PhD, Yuncheng Man, Shamreen Iram, Erdem Kucukal, PhD, Muhammad Noman Hasan, PhD, Ambar Solis-Fuentes, Allison Bode, Ailis Hill, Kevin Cheng, Yuning Huang, Sanjay Ahuja, MD, Jane A. Little, MD, Michael Hinczewski, PhD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–47.
https://doi.org/10.1182/blood-2020-142548
Published: 2020
Journal Articles

Exercise Induced Changes of Vital Signs in Adults with Sickle Cell Disease

Solomon Johnson, MS, Victor R. Gordeuk, MD, Roberto Machado, MD, J Simon R Gibbs, Mariana Hildesheim, MS, Jane A. Little, MD, Gregory J Kato, MD, Mark T Gladwin, MD, Seyed Mehdi Nouraie, PhD MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 59–60.
https://doi.org/10.1182/blood-2020-136393
Published: 2020
Journal Articles

Assessment of Red Blood Cell-Mediated Microvascular Occlusion in Sickle Cell Disease By a Novel Electrical Impedance-Based Microfluidic Device

Yuncheng Man, Debnath Maji, PhD, Ran An, PhD, Sanjay P Ahuja, MD, Jane A. Little, MD, Pedram Mohseni, PhD, Michael A Suster, PhD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-138876
Published: 2020
Journal Articles

Contribution of Red Blood Cell Derived Extracellular Vesicles to Sickle Red Blood Cell Adhesion Discerned Using an Endothelialized Microfluidic Assay

Ran An, PhD, Yuncheng Man, Erdem Kucukal, PhD, Kevin Cheng, William Wulftange, Jane A. Little, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-142176
Published: 2020
Journal Articles

The Grndad Registry: Contemporary Natural History Data and an Analysis of Real-World Patterns of Use and Limitations of Disease Modifying Therapy in Adults with SCD

Alexandra Boye-Doe, Elizabeth Brown, Charu Puri-Sharma, MS, Anjulika Chawla, MD, Joshua J Field, Lynne D. Neumayr, MD, Susan Padrino, MD, Payal Desai, MD, Deepa Manwani, MD, Sophie M. Lanzkron, MD MHS, Jane A. Little, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–36.
https://doi.org/10.1182/blood-2020-138895
Published: 2020
Journal Articles

Chronic Kidney Disease Is Under-Screened in SCD and Mild Albuminuria Is Associated with a Drop in Hemoglobin: A Report from the Grndad Sickle Cell Registry

Elizabeth Williams, BA, Elizabeth Brown, Deepa Manwani, MD, Payal Desai, MD, Joshua J. Field, MD, Lynne D. Neumayr, Susan Padrino, MD, E. Leila Jerome Clay, MD MCTS, FAAP, Ze Cong, PhD, Irene Agodoa, MD, Carolyn Hoppe, MD, Sophie M. Lanzkron, MD, Jane A. Little, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2284.
https://doi.org/10.1182/blood-2019-124933
Published: 2019
Journal Articles

Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia

Santosh L. Saraf, MD, Vimal K. Derebail, MD, Xu Zhang, PhD, Mark T Gladwin, MD, Victor R Gordeuk, MD, Jane A. Little, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2268.
https://doi.org/10.1182/blood-2019-124737
Published: 2019
Journal Articles

Prevalence and Monitoring of Diabetes Among Adults with Sickle Cell Disease: A Single Institution Experience

Ashley McLean, MS2, Laura Young, MD PhD, Marcella H. Boynton, PhD, Samuel Wilson, MD, Jane A. Little, MD, Marcus A. Carden, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4832.
https://doi.org/10.1182/blood-2019-128843
Published: 2019
Journal Articles

International Multi-Site Clinical Validation of Point-of-Care Microchip Electrophoresis Test for Hemoglobin Variant Identification

Arwa Fraiwan, PhD, Muhammad Noman Hasan, MS, Ran An, PhD, Julia Z. Xu, MD MSc, Amy J. Rezac, Nicholas J. Kocmich, Tolulope Oginni, BS, Grace Mfon Olanipekun, Fatimah Hassan-Hanga, MD, Binta W. Jibir, MBBS MPH, Safiya Gambo, MBBS, Anil K. Verma, Praveen K. Bharti, Suchada Riolueang, MSc, Takdanai Ngimhung, Thidarat Suksangpleng, PhD, Priyaleela Thota, MD, Rajasubramaniam Shanmugam, PhD, Aparup Das, PhD, Vip Viprakasit, MD DPhil, Connie M. Piccone, MD, Jane A. Little, MD, Stephen K. Obaro, MD PhD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3373.
https://doi.org/10.1182/blood-2019-129336
Published: 2019
Journal Articles

Venous Thromboembolism (VTE) in Sickle Cell Disease (SCD) Is Associated with Neutrophilia

Jahnavi Gollamudi, MD, Shashank Sarvepalli, MD, Tara Alin, APRN-CNP, Animesh Vadaparti, M.Binf, Jane A. Little, MD, Lalitha V. Nayak, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 791.
https://doi.org/10.1182/blood-2019-128855
Published: 2019
Journal Articles

Longitudinal Monitoring of RBC Adhesion in Patients with SCD Is Heterogeneous and Clinically informative

Erdem Kucukal, MS, Erina Quinn, Charlotte Yuan, Constance Fung, Jane A. Little, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 953.
https://doi.org/10.1182/blood.V130.Suppl_1.953.953
Published: 2017
Journal Articles

Adhesion of Sickle RBCs to Heme-Activated Endothelial Cells Correlates with Patient Clinical Phenotypes

Erdem Kucukal, MS, Anton Ilich, MD, Nigel S. Key, MBChB, FRCP, Jane A. Little, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 959.
https://doi.org/10.1182/blood.V130.Suppl_1.959.959
Published: 2017
Journal Articles

Patient-Specific Adhesion of Sickle Red Blood Cells in Shear-Gradient Microscale Flow

Erdem Kucukal, MS, Jane A. Little, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 964.
https://doi.org/10.1182/blood.V130.Suppl_1.964.964
Published: 2017
Journal Articles

A Phase 1 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib (MLN9708) for Relapsed/ Refractory Acute Myeloid Leukemia (AML): Final Results

Anjali S. Advani, MD, Brenda W. Cooper, MD, Valeria Visconte, PhD, Paul Elson, PhD, E. Ricky Chan, PhD, Jennifer Carew, PhD, Sudipto Mukherjee, MD PhD MPH, Aaron T. Gerds, MDMS, Hetty E. Carraway, MD MBA, Aziz Nazha, MD, Betty K. Hamilton, MD, Ronald Sobecks, MD, Paolo Caimi, MD, Benjamin Tomlinson, MD, Ehsan Malek, MD, Jane A. Little, MD, Jaime Fensterl, Allison Unger, Cassie Zimmerman, Christopher Goebel, Nita Hoxha, Caitlin Siebenaller, Jenna Thomas, Mary Lynn Rush, RN, Samjhana Bogati, RN, Eric Parsons, RN, Rachael Diligente, RN, Donna Kane, RN, MSN, Alek Nielsen, BS, Cassandra M. Hirsch, BS, Simone Edelheit, Alexander Miron, PhD, John Pink, PhD, Jaroslaw P. Maciejewski, PhD MD FACP, Matt Kalaycio, MD, Marcos De Lima, MD, Mikkael A. Sekeres, MD MS
Journal: Blood
Blood (2017) 130 (Supplement 1): 150.
https://doi.org/10.1182/blood.V130.Suppl_1.150.150
Published: 2017
Journal Articles

Men with Sickle Cell Disease Show Significant Concerns over Safety While Being Treated for Vaso-Occlusive Crises: Preliminary Observations from the Escaped Trial

Sophie Lanzkron, MD, Rebecca Seufert, Jane A. Little, MD, Joshua J. Field, MD, Joseph Ryan Shows, MD, Carlton Haywood, PhD, Mustapha Saheed, MD, Ravi Varadhan, PhD, Jodi Segal, Hang Wang, PhD, Jasmine Brooks, BA, Steven Frymark, Brandi Griffin, BSN, RN, Adrienne Kincaid, Lorri Burgess, BS, Derek Robertson, Marc Proudford, Charles Green, Allie Piehet, BS, Shao-Hsuan Wang, PhD, Chiung-Yu Huang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 129.
https://doi.org/10.1182/blood.V130.Suppl_1.129.129
Published: 2017
Journal Articles

A Phase II Study of Midostaurin and 5-Azacitidine for Elderly Patients with Acute Myeloid Leukemia

Molly M Gallogly, MDPhD, Ben K. Tomlinson, MD, Pam Bunner, MT, CCRC, Paolo Caimi, MD, Michael Craig, MD, Marcos de Lima, MD, Stanton L. Gerson, MD, Donna Kane, RN, MSN, Hillard M Lazarus, MD, Mark J. Levis, MD, Ehsan Malek, MD, Jane A. Little, MD, Crystal Street, MT, CCRC, Willem J. van Heeckeren, MD PhD, William Tse, MD, Brenda W. Cooper, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1332.
https://doi.org/10.1182/blood.V130.Suppl_1.1332.1332
Published: 2017
Journal Articles

Pilot Use of a Novel DNA Methytransferase -1 (DNMT1) Flow Cytometric Pharmacodynamic Assay to Evaluate Response to Low-Dose Azacitidine Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Hematopoietic Cell Transplantation

Najla H El Jurdi, MD, Masumi Ueda, MD MA, BA, Philip Woost, PhD, Hillard M Lazarus, MD, Paolo Caimi, MD, Brenda W. Cooper, MD, Richard Creger, PhD, Jane A. Little, MD, Linda Baer, MSN, NP-C, AOCNP, Lauren Brister, MSN, NP-C, AOCNP, Ehsan Malek, MD, Leland Metheny, MD, Folashade Otegbeye, MBBChir, MPH, Ben K. Tomlinson, MD, Basem M. William, MRCP,MD, James Jacobberger, PhD, Marcos De Lima, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5503.
https://doi.org/10.1182/blood.V130.Suppl_1.5503.5503
Published: 2017
Journal Articles

A Prospective Multi-Centered Registry Is Feasible in Sickle Cell Disease: Globin Regional Network for Data and Discovery (GRNDaD)

Matthew Sears, Caroline Ewing, Sophie Lanzkron, MD, Joshua J. Field, MD, Carolyn C Hoppe, MD, Jane A. Little, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3375.
https://doi.org/10.1182/blood.V130.Suppl_1.3375.3375
Published: 2017
Journal Articles

Hemechip: An Automated Portable Microchip Electrophoresis Platform for Point-of-Care Sickle Cell Disease Screening

Muhammad Noman Hasan, MS, Arwa Fraiwan, PhD, Jane A. Little, MD, Umut A. Gurkan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3519.
https://doi.org/10.1182/blood.V130.Suppl_1.3519.3519
Published: 2017