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J. Fraser Wright, PhD
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Journal Articles

Spk-9001: Adeno-Associated Virus Mediated Gene Transfer for Hemophilia B Achieves Sustained Mean Factor IX Activity Levels of >30% without Immunosuppression

Lindsey A. George, MD, Spencer K. Sullivan, MD, Adam Giermasz, MD, PhD, Jonathan M. Ducore, Jerome M. Teitel, MD, Adam Cuker, MD MS, Lisa M. Sullivan, MD, Suvankar Majumdar, MD, Catherine E. McGuinn, MD, Aline M. Galvao, M.S., B.S.N.-R.N., Alvin Y. Luk, PhD, M.B.A., J. Fraser Wright, PhD, Yifeng Chen, MD, Daniel J. Hui, PhD, Katie Wachtel, M.S., Teresa Urich, B.S., Daniel Takefman, PhD, Linda B. Couto, PhD, Marcus E. Carr, MD, PhD, Xavier M. Anguela, PhD, Katherine A. High, MD
Journal: Blood
Blood (2016) 128 (22): 3.
https://doi.org/10.1182/blood.V128.22.3.3
Published: 2016
Journal Articles

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

Harrison C. Brown, BBA, Jordan E Shields, Shangzhen Zhou, MD, J. Fraser Wright, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD
Journal: Blood
Blood (2013) 122 (21): 4210.
https://doi.org/10.1182/blood.V122.21.4210.4210
Published: 2013
Journal Articles

A Novel Strategy to Circumvent Pre-Existing Humoral Immunity to AAV

Federico Mingozzi, PhD, Xavier M Anguela, PhD, Giulia Pavani, MS, Yifeng Chen, MD, Robert J Davidson, Daniel J. Hui, Ph.D., Christian J Hinderer, MS, Armida Faella, Crolann Howard, BS, Alex Tai, MS, Gregory M Podsakoff, Margaret V. Ragni, MD, MPH, Shangzhen Zhou, MD, Etiena Basner-Tschakarjan, J. Fraser Wright, PhD, Katherine A. High, MD
Journal: Blood
Blood (2012) 120 (21): 2050.
https://doi.org/10.1182/blood.V120.21.2050.2050
Published: 2012
Journal Articles

Rabbit Anti-Thymocyte Globulin (rATG) Administrated Concomitantly with Liver Delivery of AAV2-hFIX Can Promote Inhibitor Formation In Rhesus Macaques.

Jonathan D. Finn, PhD, Patricia Favaro, PhD, J. Fraser Wright, PhD, Federico Mingozzi, PhD., Katherine A. High, MD, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3765.
https://doi.org/10.1182/blood.V116.21.3765.3765
Published: 2010
Journal Articles

Assessment of Insertional Mutagenesis Risk Following AAV Vector-Mediated Factor IX Gene Transfer in Mice.

Hojun Li, Nirav Malani, Shari R Hamilton, DVM, Alexander Schlachterman, MD, Jim Z Zhang, PhD, Giulio Bussadori, Shyrie A Edmonson, Federico Mingozzi, PhD, J. Fraser Wright, PhD, Valder R. Arruda, MD, PhD, Frederic D Bushman, PhD, Katherine A. High, MD
Journal: Blood
Blood (2009) 114 (22): 2465.
https://doi.org/10.1182/blood.V114.22.2465.2465
Published: 2009
Journal Articles

Coating of AAV Vectors with Human Albumin Blocks Antibody Binding and Enables Transduction of Human Hepatocytes in the Presence of Neutralizing Antibodies

J. Fraser Wright, PhD
Journal: Blood
Blood (2008) 112 (11): 3542.
https://doi.org/10.1182/blood.V112.11.3542.3542
Published: 2008
Journal Articles

Trace Capsid DNA Impurities in AAV2 Vectors Are Not Transcribed and Are Unlikely To Contribute to Capsid Peptide-MHC Class I Complexes

Bernd Hauck, Ph.D., Samuel Murphy, Ph.D., Xingge Lui, M.D., Olga Zelenaia, Ph.D., Katherine A. High, M.D., J. Fraser Wright, PhD
Journal: Blood
Blood (2007) 110 (11): 3736.
https://doi.org/10.1182/blood.V110.11.3736.3736
Published: 2007