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Journal Articles

Engineering Superaffinity Antibody Dependent Cellular Cytotoxcity Receptors into iPSC-Derived NK Cells As Next-Generation Immunotherapies for Cancer

Spencer Goodman, Kenyon Lyon, Katelin Hartwig, Suping Peng, Qin Li, David Murray, Davide Bernareggi, Caryn Gonsalves, Max Schabla, Guoxin Zhang, Terri Harder, Baohu Ji, Leah Mitchell, Dan S Kaufman, Robert Hollingsworth, Huang Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 2060.
https://doi.org/10.1182/blood-2023-181261
Published: 2023
Journal Articles

A Novel Method for Efficient cGMP Production of Natural Killer Cells from Clonal Master Induced Pluripotent Stem Cells for Next Generation, Off-the-Shelf Cancer Immunotherapy

Davide Bernareggi, Caryn Gonsalves, Max Schabla, Alejandra Garate-Carrilo, Mohammad El-Kalay, Dan S Kaufman, Robert Hollingsworth, Huang Zhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 1613–1614.
https://doi.org/10.1182/blood-2022-163871
Published: 2022
Journal Articles

Development of Next-Generation NK Cell Optimized Chimeric Antigen Receptors (CARs) for iPSC-Derived NK Cell Therapies Targeting Both Solid and Liquid Tumors

Lee Swanson, Kenyon Lyon, Wael Tadros, Mafalda Loreti, Tammy Babin, Benjamin Blair, Max Schabla, Paschalis Sideras, Dan S Kaufman, Robert Hollingsworth, Huang Zhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 4540–4541.
https://doi.org/10.1182/blood-2022-163884
Published: 2022
Journal Articles

Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Huang Zhu, Robert H. Blum, Ryan Bjordahl, Svetlana Gaidarova, Paul Rogers, Tom Tong Lee, Ramzey Abujarour, Gregory B. Bonello, Jianming Wu, Pei-Fang Tsai, Jeffrey S. Miller, Bruce Walcheck, Bahram Valamehr, Dan S. Kaufman
Journal: Blood
Blood (2020) 135 (6): 399–410.
https://doi.org/10.1182/blood.2019000621
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Deletion of CISH in Human Pluripotent Stem Cell-Derived Natural Killer Cells Enhances Anti-Tumor Activity Via Metabolic Reprogramming

Huang Zhu, PhD, Robert Blum, Zhengming Wu, Zhipeng Meng, PhD, Kun-Liang Guan, PhD, Dan S Kaufman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 619.
https://doi.org/10.1182/blood-2019-124446
Published: 2019
Journal Articles

FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Jode P Goodridge, PhD, Sajid Mahmood, PhD, Huang Zhu, PhD, Svetlana Gaidarova, MS, Robert Blum, Ryan Bjordahl, PhD, Frank Cichocki, PhD, Hui-yi Chu, PhD, Greg Bonello, PhD, Tom Lee, PhD, Brian Groff, Miguel Meza, BS, Bruce Walcheck, PhD, Karl-Johan Malmberg, MD PhD, Jeffrey S. Miller, MD, Dan S Kaufman, MD PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 301.
https://doi.org/10.1182/blood-2019-129319
Published: 2019
Journal Articles

KIR Expression on in Vitro -Derived Natural Killer Cells Does Not Regulate Killing of Allogeneic Targets

Yunzu Michele Wang, MD, Huang Zhu, PhD, Alessa Ruiz-Cisneros, Naveen Heragu, BS, Eivind Heggernes Ask, Hanna Julie Hoel, Karl-Johan Malmberg, MD PhD, Dan S Kaufman, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3705.
https://doi.org/10.1182/blood-2018-99-117151
Published: 2018
Journal Articles

Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity

Dan S Kaufman, MD PhD, Ryan Bjordahl, PhD, Huang Zhu, PhD, Robert Blum, Andres Bahena, Sajid Mahmood, PhD, Greg Bonello, PhD, Tom Lee, PhD, Bruce Walcheck, PhD, Frank Cichocki, PhD, Jeffrey S. Miller, MD, Bahram Valamehr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4541.
https://doi.org/10.1182/blood-2018-99-113701
Published: 2018
Journal Articles

Notch Activation Rescues Exhaustion in CISH -Deleted Human iPSC-Derived Natural Killer Cells to Promote In Vivo Persistence and Enhance Anti-Tumor Activity

Huang Zhu, PhD, Robert Blum, Zhengming Wu, Andres Bahena, Hanna Julie Hoel, Eivind Heggernes Ask, Kun-Liang Guan, PhD, Karl-Johan Malmberg, MD PhD, Dan S Kaufman, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1279.
https://doi.org/10.1182/blood-2018-99-112791
Published: 2018
Journal Articles

Genetically Engineered Pluripotent Cell-Derived Natural Killer Cell Therapy Provides Enhanced Antibody Dependent Cellular Cytotoxicity Against Hematologic Malignancies and Solid Tumors in Combination with Monoclonal Antibody Therapy

Huang Zhu, PhD, Ryan Bjordahl, PhD, Svetlana Gaidarova, Paul Rogers, Robert Blum, Dan Kaufman, MD, Bruce Walcheck, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4452.
https://doi.org/10.1182/blood.V130.Suppl_1.4452.4452
Published: 2017