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Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD

Blood (2020) 136 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2020-139312

Published: 2020

Journal Articles

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Raksha Shrestha, MD, DiMM, Maie Koichiro, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Olivier Bernard, Hirotaka Matsui, MD PhD, Yaeko Nakajima-Takagi, PhD, Takayasu Kato, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD, Shigeru Chiba, MD PhD

Blood (2018) 132 (Supplement 1): 1330.

https://doi.org/10.1182/blood-2018-99-112352

Published: 2018

Journal Articles

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Blood (2018) 132 (Supplement 1): 2824.

https://doi.org/10.1182/blood-2018-99-118627

Published: 2018

Journal Articles

Aberrant Repression of GFI1 Super-Enhancer By LSD1 Plays an Important Role in Leukemia Programs in Acute Myeloid Leukemia

Goichi Tatsumi, MD, Masahiro Kawahara, MD PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Ryusuke Yamamoto, MD, Masakatsu Hishizawa, MD PhD, Toshiya Inaba, MD PhD, Takayoshi Suzuki, PhD, Akira Andoh, MD PhD, Akifumi Kondo Takaori, MD PhD

Blood (2017) 130 (Supplement 1): 3797.

https://doi.org/10.1182/blood.V130.Suppl_1.3797.3797

Published: 2017

Journal Articles

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

Hiroko Sakurai, MD, Yuka Harada, MD PhD, Hirotaka Matsui, MD PhD, Hideaki Nakajima, MD PhD, Toshio Kitamura, MD PhD, Norio Komatsu, MD PhD, Hironori Harada, MD PhD

Blood (2015) 126 (23): 4108.

https://doi.org/10.1182/blood.V126.23.4108.4108

Published: 2015

Journal Articles

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Atsunori Saraya, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 712.

https://doi.org/10.1182/blood.V126.23.712.712

Published: 2015

Journal Articles

Low Miki Expression in Myelodysplastic Syndromes Results in Polynuclear Cell Formation through Decondensation of Chromosomes in Prolonged Prometaphase

Akiko Nagamachi, PhD, Yuko Ozaki, PhD, Hirotaka Matsui, MD PhD, Akinori Kanai, PhD, Toshiya Inaba, MD

Blood (2015) 126 (23): 2845.

https://doi.org/10.1182/blood.V126.23.2845.2845

Published: 2015

Journal Articles

Epigenetic Regulation of Hematopoietic Stem and Progenitor Cells By the Eset Histone Methyltranferas

Shuhei Koide, Keiyo Takubo, MD PhD, Motohiko Oshima, PhD, Satoru Miyagi, PhD, Hirotaka Matsui, MD PhD, Hiroshi Kimura, PhD, Changshan Wang, PhD, George R Wendt, Shogo Yabata, Yoichi Shinkai, MD PhD, Toshio Suda, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 765.

https://doi.org/10.1182/blood.V124.21.765.765

Published: 2014

Journal Articles

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Kotaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 4596.

https://doi.org/10.1182/blood.V124.21.4596.4596

Published: 2014

Journal Articles

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Daichi Inoue, MD PhD, Hirotaka Matsui, MD PhD, Hsin-An Hou, MD PhD, Wen-Chien Chou, MD PhD, Akiko Nagamachi, PhD, Jiro Kitaura, MD PhD, Kimihito Cojin Kawabata, MD PhD, Katsuhiro Togami, MD PhD, Reina Nagase, Sayuri Horikawa, Makoto Saika, MD, Jean-Baptiste Micol, MD, Yasutaka Hayashi, MD, Yuka Harada, MD PhD, Hironori Harada, MD PhD, Hwei-Fang Tien, MD PhD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD PhD

Blood (2014) 124 (21): 525.

https://doi.org/10.1182/blood.V124.21.525.525

Published: 2014

Journal Articles

Haploinsufficiency Of SAMD9L , An Endosome Fusion Facilitator, In Mice Induces The Development Of Myeloid Malignancies Mimicking Human Diseases With Monosomy 7

Hirotaka Matsui, MD, PhD, Akiko Nagamachi, Akinori Kanai, PhD, Yuko Ozaki, Hiroaki Honda, MD, PhD, Toshiya Inaba, MD, PhD

Blood (2013) 122 (21): 227.

https://doi.org/10.1182/blood.V122.21.227.227

Published: 2013

Journal Articles

Identification of Integrin β3 L718P Mutation in a Pedigree with Autosomal Dominant Macrothrombocytopenia

Yoshiyuki Kobayashi, MD, Hirotaka Matsui, MD, Akinori Kanai, PhD, Miyuki Tsumura, MSc, Satoshi Okada, MD, PhD, Mizuka Miki, MD, Kazuhiro Nakamura, MD, PhD, Shinji Kunishima, PhD, Toshiya Inaba, MD, PhD, Masao Kobayashi, MD, PhD

Blood (2012) 120 (21): 1081.

https://doi.org/10.1182/blood.V120.21.1081.1081

Published: 2012

Journal Articles

SLIT1 Mutation in Patients with Acquired Aplastic Anemia: Its Relevance in Immune Pathophysiology

Chizuru Saito, MD, Kohei Hosokawa, MD, Takamasa Katagiri, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD, Toshiya Inaba, MD, PhD, Masafumi Taniwaki, MD, PhD, Hirohito Yamazaki, MD, PhD, Shinji Nakao, MD, PhD

Blood (2012) 120 (21): 645.

https://doi.org/10.1182/blood.V120.21.645.645

Published: 2012

Journal Articles

Abnormal Mitosis Due to Impairment of Centrosome Maturation by the Deletion of Candidate 7q- Responsible Genes

Hirotaka Matsui, MD, Yuko Ozaki, Akiko Nagamachi, Toshiya Inaba, MD, PhD

Blood (2012) 120 (21): 1297.

https://doi.org/10.1182/blood.V120.21.1297.1297

Published: 2012

Journal Articles

Samd9L-Deficient Mice Develop Myeloid Malignancies Mimicking Human Diseases with Monosomy 7

Hirotaka Matsui, MD, Akiko Nagamachi, Yuko Ozaki, Hiroya Asou, MD, PhD, Hiroaki Honda, MD, PhD, Toshiya Inaba, MD, PhD

Blood (2011) 118 (21): 869.

https://doi.org/10.1182/blood.V118.21.869.869

Published: 2011

Journal Articles

Titan (Samd9L), a Candidate -7/7q- Responsible Gene Product, Downregulates Cytokine Signals by Facilitating Formation of Early Endosomes

Hirotaka Matsui, MD, Akiko Nagamachi, Yuko Ozaki, Hiroya Asou, MD, Hiroaki Honda, MD, Toshiya Inaba, MD

Blood (2010) 116 (21): 4170.

https://doi.org/10.1182/blood.V116.21.4170.4170

Published: 2010

Journal Articles

Loss of Titan ( Samd9L ), a Candidate -7/7q- Responsible Gene Encoding An Actin Remodeling Regulator, Develops MDS/AML in Cooperation with Evi1 or Fbxl10 .

Hirotaka Matsui, MD, Akiko Nagamachi, Yuko Ozaki, Daisuke Aki, Hiroya Asou, MD, Hiroaki Honda, MD, Toshiya Inaba, MD

Blood (2009) 114 (22): 2963.

https://doi.org/10.1182/blood.V114.22.2963.2963

Published: 2009

Journal Articles

Levels of sIL-2R in Sera Depend On Number of CD25-Positive Lymphoma Cells and MMP-9-Positive Macrophages in DLBCL.

Noriaki Yoshida, MD, Akira Sakai, MD, PhD, Yoshiko Okikawa, MD, Yuta Katayama, MD, PhD, Hideki Asaoku, MD, Hirotaka Matsui, MD, PhD, Koji Arihiro, MD, PhD, Megumu Fujihara, MD, PhD, Takashi Nishisaka, MD, PhD, Naomi Sasaki, MD, PhD, Yoshito Sadahira, MD, PhD, Akiro Kimura, MD, PhD

Blood (2009) 114 (22): 2927.

https://doi.org/10.1182/blood.V114.22.2927.2927

Published: 2009

Journal Articles

Haploinsufficiency and Deficiency of a 7q Gene Titan (Samd9L) Predispose Leukemia Development in Cooperation with Deregulated Expression of a Transcription Factor, Evi1, or a Histone Demethylase, Fbxl10

Akiko Nagamachi, Hiroya Asou, MD, Hirotaka Matsui, MD, Yuko Ozaki, Daisuke Aki, PhD, Kazuko Miyazaki, Norimasa Yamasaki, Masaki Miyazaki, MD, Linda Wolff, PhD, Richard Koller, Hideaki Oda, MD, Toshiya Inaba, MD, Hiroaki Honda, MD

Blood (2008) 112 (11): 197.

https://doi.org/10.1182/blood.V112.11.197.197

Published: 2008

Journal Articles

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

Nozomi Yamakage, MA, Akihiro Takeshita, PhD, MD, Kaori Shinjo, MD, Takaaki Ono, MD, Hirotaka Matsui, MD, Satoki Nakamura, MD, Kazuyuki Shigeno, MD, Masato Maekawa, PhD, MD, Kazunori Ohnishi, PhD, MD, Ryuzo Ohno, PhD, MD

Blood (2007) 110 (11): 2362.

https://doi.org/10.1182/blood.V110.11.2362.2362

Published: 2007

NARROW

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Residual Wild-Type Tet2/Tet3 Allele Is the Savior Preventing Mouse Hematopoietic Progenitor Cells from Leukemia Development

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Aberrant Repression of GFI1 Super-Enhancer By LSD1 Plays an Important Role in Leukemia Programs in Acute Myeloid Leukemia

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Low Miki Expression in Myelodysplastic Syndromes Results in Polynuclear Cell Formation through Decondensation of Chromosomes in Prolonged Prometaphase

Epigenetic Regulation of Hematopoietic Stem and Progenitor Cells By the Eset Histone Methyltranferas

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Haploinsufficiency Of SAMD9L , An Endosome Fusion Facilitator, In Mice Induces The Development Of Myeloid Malignancies Mimicking Human Diseases With Monosomy 7

Identification of Integrin β3 L718P Mutation in a Pedigree with Autosomal Dominant Macrothrombocytopenia

SLIT1 Mutation in Patients with Acquired Aplastic Anemia: Its Relevance in Immune Pathophysiology

Abnormal Mitosis Due to Impairment of Centrosome Maturation by the Deletion of Candidate 7q- Responsible Genes

Samd9L-Deficient Mice Develop Myeloid Malignancies Mimicking Human Diseases with Monosomy 7

Titan (Samd9L), a Candidate -7/7q- Responsible Gene Product, Downregulates Cytokine Signals by Facilitating Formation of Early Endosomes

Loss of Titan ( Samd9L ), a Candidate -7/7q- Responsible Gene Encoding An Actin Remodeling Regulator, Develops MDS/AML in Cooperation with Evi1 or Fbxl10 .

Levels of sIL-2R in Sera Depend On Number of CD25-Positive Lymphoma Cells and MMP-9-Positive Macrophages in DLBCL.

Haploinsufficiency and Deficiency of a 7q Gene Titan (Samd9L) Predispose Leukemia Development in Cooperation with Deregulated Expression of a Transcription Factor, Evi1, or a Histone Demethylase, Fbxl10

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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