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Journal Articles

A Phase 1 Study Evaluating Safety and Tolerability of Navitoclax Monotherapy in Japanese Patients with Myeloproliferative Neoplasms

Hirohiko Shibayama, MD PhD, Hirokazu Tanaka, MD PhD, Su-Peng Yeh, MD, Hui-Hua Hsiao, MD, Silpa Nuthalapati, PhD, Kota Ono, PhD, Kotaro Uehara, MS, Sumiko Okubo, MD PhD, Norio Komatsu, MD PhD

Blood (2020) 136 (Supplement 1): 15–16.

https://doi.org/10.1182/blood-2020-137068

Published: 2020

Journal Articles

Identification of a Patients-Derived CD34+ Myeloma Cell Population with Tumor-Propagating Capacity and Resistance to Anticancer Drugs

Kentaro Serizawa, Hirokazu Tanaka, MD PhD, Ayano Fukui, MD, Ryosuke Fujiwara, MD, Keigo Sano, MD, Hiroaki Inoue, MD, Takahiro Kumode, MD, Yasuhiro Taniguchi, MD, Yasuyoshi Morita, MD, Luis Espinoza, MDPhD, Itaru Matsumura, MDPhD

Blood (2017) 130 (Supplement 1): 1774.

https://doi.org/10.1182/blood.V130.Suppl_1.1774.1774

Published: 2017

Journal Articles

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias

Tomohiko Ishibashi, MD, Takafumi Yokota, MD PhD, Hirokazu Tanaka, MD PhD, Michiko Ichii, MD PhD, Takao Sudo, MD PhD, Yusuke Satoh, MD PhD, Yukiko Doi, MD, Akira Tanimura, MD PhD, Yuri Hamanaka, MD, Sachiko Ezoe, MD PhD, Hirohiko Shibayama, MDPhD, Kenji Oritani, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2015) 126 (23): 1154.

https://doi.org/10.1182/blood.V126.23.1154.1154

Published: 2015

Journal Articles

Chlorpromazine, an Inhibitor of Intracellular Trafficking of FLT3-ITD and KIT D816V, Shows Prominent Anti-Leukemic Activities Against AML Cells and AML Stem Cells in Vitro and in Vivo.

Shinya Rai, MD, Hirokazu Tanaka, MD, PhD, Mai Suzuki, PhD, Akira Tanimura, Keiko Matsui, MD, PhD, Toshio Watanabe, PhD, Yuzuru Kanakura, MD PhD, Itaru Matsumura

Blood (2014) 124 (21): 269.

https://doi.org/10.1182/blood.V124.21.269.269

Published: 2014

Journal Articles

Retrospective Analysis Of The Recent Treatment Strategies For The Patients With Myeloma-Related Diseases Registered In Kansai Myeloma Forum

Blood (2013) 122 (21): 3385.

https://doi.org/10.1182/blood.V122.21.3385.3385

Published: 2013

Journal Articles

Satb1 Determines Hematopoietic Stem Cell Differentiation Toward the Lymphoid Lineages

Yusuke Satoh, MD, PhD, Takafumi Yokota, MD, PhD, Motonari Kondo, MD, PhD, Paul W. Kincade, PhD, Taku Kouro, PhD, Ryuji Iida, PhD, Koichi Kokame, PhD, Toshiyuki Miyata, PhD, Takao Sudo, MD, Hirokazu Tanaka, MD, PhD, Itaru Matsumura, MD, PhD, Kenji Oritani, MD, PhD, Terumi Kohwi-Shigematsu, PhD, Yuzuru Kanakura, MD, PhD

Blood (2011) 118 (21): 388.

https://doi.org/10.1182/blood.V118.21.388.388

Published: 2011

Journal Articles

An Anti-Apoptotic Molecule, Anamorsin, Functions in Both Iron-Sulfur Protein Assembly and Cellular Iron Homeostasis

Akira Tanimura, MD, PhD, Yuri Kondo, MD, Hirokazu Tanaka, MD, PhD, Itaru Matsumura, MD, PhD, Tomohiko Ishibashi, MD, Takao Sudo, MD, Yusuke Satoh, MD, PhD, Takafumi Yokota, MD, PhD, Sachiko Ezoe, Kenji Oritani, MD, PhD, Hirohiko Shibayama, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2011) 118 (21): 2106.

https://doi.org/10.1182/blood.V118.21.2106.2106

Published: 2011

Journal Articles

A Cell-Death-Defying Factor, Anamorsin, Contributes Cell Growth through Binding with PICOT and Inactivation of PKCs and p38MAPK.

Hirohiko Shibayama, MD, PhD, Yuri Saito, Akira Tanimura, MD, PhD, Hirokazu Tanaka, MD, PhD, Itaru Matsumura, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2010) 116 (21): 1552.

https://doi.org/10.1182/blood.V116.21.1552.1552

Published: 2010

Journal Articles

Myeloid Neoplasm-Related Gene Abnormalities Differentially Affect FLT3-Ligand Mediated Dendritic Cell Differentiation From Murine Hematopoietic Stem/Progenitor Cells

Jiro Fujita, Masao Mizuki, Masayasu Otsuka, Sachiko Ezoe, Hirokazu Tanaka, Yusuke Satoh, Kentaro Fukushima, Masahiro Tokunaga, Itaru Matsumura, Yuzuru Kanakura

Blood (2010) 116 (21): 3899.

https://doi.org/10.1182/blood.V116.21.3899.3899

Published: 2010

Journal Articles

A Chromatin Modifier SATB1 Promotes Lymphocyte Production From Primitive Hematopoietic Stem/Progenitor Cells

Yusuke Satoh, MD, PhD, Takafumi Yokota, MD, PhD, Hirokazu Tanaka, MD, PhD, Koichi Kokame, PhD, Toshiyuki Miyata, PhD, Itaru Matsumura, MD, PhD, Kenji Oritani, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2010) 116 (21): 836.

https://doi.org/10.1182/blood.V116.21.836.836

Published: 2010

Journal Articles

C-Terminal Mutation of RUNX1 Deteriorates DNA Damage-Repair Response and Promotes the Development of Acute Myeloid Leukemia.

Yusuke Satoh, MD, PhD, Itaru Matsumura, MD, PhD, Hirokazu Tanaka, MD, PhD, Hironori Harada, MD, PhD, Yuka Harada, MD, Yuzuru Kanakura, MD, PhD

Blood (2009) 114 (22): 183.

https://doi.org/10.1182/blood.V114.22.183.183

Published: 2009

Journal Articles

Wnt/β-Catenin Pathway Affects the Cell-Fate Decisions of Hematopoietic Stem/Progenitor Cells Modulating the Epigenetic States of Various Essential Transcription Factors

Hirokazu Tanaka, M.D., Ph.D., Itaru Matsumura, M.D., Ph.D., Yusuke Satoh, M.D., Ph.D., Sachiko Ezoe, M.D., Ph.D., Tatsutoshi Nakahata, M.D., Ph.D., Yuzuru Kanakura, M.D., Ph.D.

Blood (2008) 112 (11): 2433.

https://doi.org/10.1182/blood.V112.11.2433.2433

Published: 2008

Journal Articles

SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.

Sachiko Ezoe, Itaru Matsumura, Hirokazu Tanaka, Yusuke Satoh, Takafumi Yokota, Kenji Oritani, Yuzuru Kanakura

Blood (2008) 112 (11): 1394.

https://doi.org/10.1182/blood.V112.11.1394.1394

Published: 2008

Journal Articles

Roles for the AML1/RUNX1 Point Mutation in the Pathogenesis of MDS/AML.

Yusuke Satoh, Itaru Matsumura, Hirokazu Tanaka, Takafumi Yokota, Sachiko Ezoe, Kenji Oritani, Yuzuru Kanakura

Blood (2008) 112 (11): 1791.

https://doi.org/10.1182/blood.V112.11.1791.1791

Published: 2008

Journal Articles

FIP1L1/PDGFRα Imposes Commitment towards Eosinophil Lineage on Hematopoietic Stem/Progenitor Cells by Modifying the Expression and Function of Lineage Specific Transcription Factors.

Kentaro Fukushima, Itaru Matsumura, Sachiko Ezoe, Hirohiko Shibayama, Michiko Ichii, Takafumi Yokota, Hirokazu Tanaka, Yuzuru Kanakura

Blood (2007) 110 (11): 988.

https://doi.org/10.1182/blood.V110.11.988.988

Published: 2007

Journal Articles

Canonical NF-κ B Pathway Is Required for Early Mesodermal Differentiation from the Murine Embryonic Stem Cells.

Hirokazu Tanaka, MD, PhD, Itaru Matsumura, M.D., Ph.D., Kazuki Nakao, Ph.D., Takumi Era, M.D., Ph.D., Yuzuru Kanakura, M.D., Ph.D.

Blood (2006) 108 (11): 1144.

https://doi.org/10.1182/blood.V108.11.1144.1144

Published: 2006

Journal Articles

NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.

Sachiko Ezoe, MD, PhD, Itaru Matsumura, MD.PhD, Hirokazu Tanaka, MD.PhD, Hirohiko Shibayama, MD.PhD, Masao Mizuki, MD.PhD, Yuzuru Kanakura, MD.PhD

Blood (2006) 108 (11): 1320.

https://doi.org/10.1182/blood.V108.11.1320.1320

Published: 2006

Journal Articles

The Function of AML1 (RUNX1) C-Deletion Mutant in Hematopoietic Stem/Progenitor Cells.

Yusuke Satoh, Itaru Matsumura, Sachiko Ezoe, Hirokazu Tanaka, Takafumi Yokota, Jun Ishikawa, Kenji Oritani, Yuzuru Kanakura

Blood (2005) 106 (11): 1738.

https://doi.org/10.1182/blood.V106.11.1738.1738

Published: 2005

Journal Articles

NF-kB Family Proteins Participate in Multiple Steps of Hematopoiesis through Elimination of Reactive Oxygen Species (ROS).

Soichi Nakata, MD, Itaru Matsumura, MD, PhD, Hirokazu Tanaka, MD, PhD, Yusuke Satoh, MD, Takumi Era, MD, PhD, Yzuru Kanakura, MD, PhD

Blood (2004) 104 (11): 1694.

https://doi.org/10.1182/blood.V104.11.1694.1694

Published: 2004

Journal Articles

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

Itaru Matsumura, Akira Kawasaki, Hirokazu Tanaka, Junko Sonoyama, Sachiko Ezoe, Naoko Minegishi, Koichi Nakajima, Masayuki Yamamoto, Yuzuru Kanakura

Blood (2000) 96 (7): 2440–2450.

https://doi.org/10.1182/blood.V96.7.2440

Published: 2000

NARROW

A Phase 1 Study Evaluating Safety and Tolerability of Navitoclax Monotherapy in Japanese Patients with Myeloproliferative Neoplasms

Identification of a Patients-Derived CD34+ Myeloma Cell Population with Tumor-Propagating Capacity and Resistance to Anticancer Drugs

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias

Chlorpromazine, an Inhibitor of Intracellular Trafficking of FLT3-ITD and KIT D816V, Shows Prominent Anti-Leukemic Activities Against AML Cells and AML Stem Cells in Vitro and in Vivo.

Retrospective Analysis Of The Recent Treatment Strategies For The Patients With Myeloma-Related Diseases Registered In Kansai Myeloma Forum

Satb1 Determines Hematopoietic Stem Cell Differentiation Toward the Lymphoid Lineages

An Anti-Apoptotic Molecule, Anamorsin, Functions in Both Iron-Sulfur Protein Assembly and Cellular Iron Homeostasis

A Cell-Death-Defying Factor, Anamorsin, Contributes Cell Growth through Binding with PICOT and Inactivation of PKCs and p38MAPK.

Myeloid Neoplasm-Related Gene Abnormalities Differentially Affect FLT3-Ligand Mediated Dendritic Cell Differentiation From Murine Hematopoietic Stem/Progenitor Cells

A Chromatin Modifier SATB1 Promotes Lymphocyte Production From Primitive Hematopoietic Stem/Progenitor Cells

C-Terminal Mutation of RUNX1 Deteriorates DNA Damage-Repair Response and Promotes the Development of Acute Myeloid Leukemia.

Wnt/β-Catenin Pathway Affects the Cell-Fate Decisions of Hematopoietic Stem/Progenitor Cells Modulating the Epigenetic States of Various Essential Transcription Factors

SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.

Roles for the AML1/RUNX1 Point Mutation in the Pathogenesis of MDS/AML.

FIP1L1/PDGFRα Imposes Commitment towards Eosinophil Lineage on Hematopoietic Stem/Progenitor Cells by Modifying the Expression and Function of Lineage Specific Transcription Factors.

Canonical NF-κ B Pathway Is Required for Early Mesodermal Differentiation from the Murine Embryonic Stem Cells.

NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.

The Function of AML1 (RUNX1) C-Deletion Mutant in Hematopoietic Stem/Progenitor Cells.

NF-kB Family Proteins Participate in Multiple Steps of Hematopoiesis through Elimination of Reactive Oxygen Species (ROS).

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

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American Society of Hematology

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American Society of Hematology

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