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Journal Articles

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

Upasana Sunil Arvindam, MSc, BSc, Paulien van Hauten, MSc-MD, Caroline Hallstrom, BS, Daniel A. Vallera, PhD, Harry Dolstra, PhD, Jeffrey S. Miller, MD, Martin Felices, PhD

Blood (2018) 132 (Supplement 1): 1454.

https://doi.org/10.1182/blood-2018-99-117150

Published: 2018

Journal Articles

A Phase I Study of Allogeneic Natural Killer Cell Therapy Generated from Cord Blood Hematopoietic Stem and Progenitor Cells in Elderly Acute Myeloid Leukemia Patients

Blood (2015) 126 (23): 1357.

https://doi.org/10.1182/blood.V126.23.1357.1357

Published: 2015

Journal Articles

Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML

Pieter Fokko Van Loo, PhD, Robert Doornbos, PhD, Harry Dolstra, PhD, Setareh Shamsili, MD PhD, Lex Bakker, PhD

Blood (2015) 126 (23): 325.

https://doi.org/10.1182/blood.V126.23.325.325

Published: 2015

Journal Articles

The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1 Stimulates Expression of NK Cell Related Transcription Factors, Thereby It Facilitates Generation of Highly Functional NK Cells in Vitro

Mieke WH Roeven, MD, Jeanette Cany, PhD, Frans Maas, Arwa Kohela, Jansen Joop, PhD, Nicole MA Blijlevens, MD PhD, Nicolaas PM Schaap, MD PhD, Harry Dolstra, PhD

Blood (2014) 124 (21): 3833.

https://doi.org/10.1182/blood.V124.21.3833.3833

Published: 2014

Journal Articles

Influence Of DNA Methyltransferese Inhibitors On The Anti-Leukemic Effect Of Umbilical Cord Blood Derived NK Cells Against Acute Myeloid Leukemia

Harry Dolstra, PhD, Jeannette Cany, PhD, Anniek B. van der Waart, MSc, Marleen Tordoir, BSc, Basav Nagaraj Hangalapura, PhD, Jan Spanholtz, PhD, Robbert van der Voort, PhD, Nicolaas PM Schaap, MD, PhD

Blood (2013) 122 (21): 4496.

https://doi.org/10.1182/blood.V122.21.4496.4496

Published: 2013

Journal Articles

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Margot J Pont, Willemijn Hobo, PhD, M. Willy Honders, Simone A.P. van Luxemburg-Heijs, Michel G.D. Kester, Cornelis A.M. van Bergen, Harry Dolstra, PhD, J.H. Frederik Falkenburg, MD, PhD, Marieke Griffioen, PhD

Blood (2013) 122 (21): 4465.

https://doi.org/10.1182/blood.V122.21.4465.4465

Published: 2013

Journal Articles

Akt Signalling Inhibition Promotes The Ex Vivo generation Of Minor Histocompatibility Antigen-Specific CD8+ Memory Stem T Cells

Anniek B. van der Waart, MSc, Noortje van der Weem, Luca Gattinoni, MD, Nicolaas PM Schaap, MD, PhD, Robbert van der Voort, PhD, Willemijn Hobo, PhD, Harry Dolstra, PhD

Blood (2013) 122 (21): 3269.

https://doi.org/10.1182/blood.V122.21.3269.3269

Published: 2013

Journal Articles

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

Soley Thordardottir, MSc, Hangalapura Basav N., PhD, Tim Hutten, MSc, Marta Cossu, MSc, Jan Spanholtz, PhD, Nicolaas PM Schaap, MD, PhD, Timothy Radstake, MD, PhD, Robbert van der Voort, PhD, Harry Dolstra, PhD

Blood (2013) 122 (21): 2025.

https://doi.org/10.1182/blood.V122.21.2025.2025

Published: 2013

Journal Articles

CXCR3 Is Required for the Efficient Recruitment of Bone Marrow-Resident Memory T Cells to Inflamed Tissues,

Robbert van der Voort, PhD, Claudia Brandao, MSc, Thomas J. Volman, PhD, Viviènne Verweij, Klaas van Gisbergen, PhD, Bao Lu, MD, Craig Gerard, MD, PhD, Martijn A. Nolte, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 3242.

https://doi.org/10.1182/blood.V118.21.3242.3242

Published: 2011

Journal Articles

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation,

Willemijn Hobo, Kelly Broen, Walter J.F.M. van der Velden, MD, PhD, Annelies Greupink-Draaisma, Niken Adisty, Yannick Wouters, Michel G.D. Kester, Hanny Fredrix, Joop H. Jansen, PhD, Bert A. van der Reijden, PhD, J.H. Frederik Falkenburg, Theo de Witte, MD, PhD, Frank W.M.B. Preijers, PhD, Anton Schattenberg, MD, PhD, Ton Feuth, Nicole N.A. Blijlevens, MD, PhD, Nicolaas Schaap, MD, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 4136.

https://doi.org/10.1182/blood.V118.21.4136.4136

Published: 2011

Journal Articles

Anti-CTLA-4 Antibody Is Not Able to Trigger Apoptosis in CTLA-4 Expressing Myeloid Tumor Cells

Sandra van Bijnen, MD, Maria Rogkoti, Marian Withaar, Theo de Witte, MD, PhD, Petra Muus, MD, PhD, Harry Dolstra, PhD

Blood (2011) 118 (21): 5054.

https://doi.org/10.1182/blood.V118.21.5054.5054

Published: 2011

Journal Articles

T Cells Expressing the Activating NK Cell Receptors KIR2DS4, NKG2C and NKG2D Are Elevated In Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Cytotoxic towards Hematopoietic Progenitor Cell Lines

Sandra van Bijnen, MD, Marian Withaar, Frank Preijers, PhD, Arnold van der Meer, PhD, Theo de Witte, MD, PhD, Petra Muus, MD, PhD, Harry Dolstra, PhD

Blood (2010) 116 (21): 2235.

https://doi.org/10.1182/blood.V116.21.2235.2235

Published: 2010

Journal Articles

Aberrant Expression in Human Epithelial Cancers of the P2X5-Encoded Minor Histocompatibility Antigen LRH-1: Implications for Graft-Versus-Tumor Immunity Against Solid Tumors.

Harry Dolstra, PhD, Henriette Levenga, MD, Ingrid Overes, MSc, Johanna C.M. Vos, BSc, Agnes van Horssen-Zoetbrood, BSc, Robbert van der Voort, PhD, Pieter de Mulder, MD, PhD, T.M. de Witte, MD, PhD

Blood (2007) 110 (11): 1795.

https://doi.org/10.1182/blood.V110.11.1795.1795

Published: 2007

Journal Articles

A Single Nucleotide Polymorphism in CD19 Defines a Novel Target for Immunotherapy of B Cell Malignancies with CD4 + Cytotoxic T Cells.

Robbert M. Spaapen, MSc, Henk M. Lokhorst, MD PhD, Kelly van den Oudenalder, Brith Otterud, PhD, Harry Dolstra, PhD, Mark Leppert, PhD, Monique C. Minnema, MD PhD, Andries C. Bloem, PhD, Tuna Mutis, MD PhD

Blood (2007) 110 (11): 1798.

https://doi.org/10.1182/blood.V110.11.1798.1798

Published: 2007

Journal Articles

Human CD34+ Myeloid Leukemic Progenitor Cells Are Susceptible to Lysis by Minor Histocompatibility Antigen LRH-1-Specific Cytotoxic T Lymphocytes.

Harry Dolstra, PhD, Ingrid Overes, Inge Jedema, PhD, Annemieke Vos, Agnes van Horssen-Zoetbrood, Wieger Norde, Robbert van der Voort, PhD, J.H. Frederik Falkenburg, MD, PhD, Anton V. Schattenberg, MD, PhD, T.M. de Witte, MD, PhD

Blood (2006) 108 (11): 134.

https://doi.org/10.1182/blood.V108.11.134.134

Published: 2006

Journal Articles

Vaccination with Host Dendritic Cells Induces Graft-Versus-Leukemia Responses without Severe Graft-Versus-Host Disease in a Preclinical Mouse Model for Allogeneic Stem Cell Transplantation.

Robbert van der Voort, PhD, Jurjen Ruben, BSc, Annemieke Vos, BSc, Marielle Philippens, MD, T.M. de Witte, MD, PhD, Harry Dolstra, PhD

Blood (2006) 108 (11): 3239.

https://doi.org/10.1182/blood.V108.11.3239.3239

Published: 2006

Journal Articles

A Novel Tissue-Restricted Minor Histocompatibility Antigen Resulting from Differential Expression Due to a Deletion/Insertion Polymorphism in the P2X5 Purinergic Receptor Gene.

Harry Dolstra, PhD, Bjorn de Rijke, Agnes van Horssen, Frans Maas, Britt Otterud, PhD, Elly van de Wiel-van Kemenade, PhD, Theo De Witte, MD, PhD

Blood (2004) 104 (11): 3062.

https://doi.org/10.1182/blood.V104.11.3062.3062

Published: 2004

NARROW

CD16-IL15-CLEC12A Trispecific Killer Engager (TriKE) Drives NK Cell Expansion, Activation, and Antigen Specific Killing of Cancer Stem Cells in Acute Myeloid Leukemia

A Phase I Study of Allogeneic Natural Killer Cell Therapy Generated from Cord Blood Hematopoietic Stem and Progenitor Cells in Elderly Acute Myeloid Leukemia Patients

Preclinical Evaluation of MCLA117, a CLEC12AxCD3 Bispecific Antibody Efficiently Targeting a Novel Leukemic Stem Cell Associated Antigen in AML

The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1 Stimulates Expression of NK Cell Related Transcription Factors, Thereby It Facilitates Generation of Highly Functional NK Cells in Vitro

Influence Of DNA Methyltransferese Inhibitors On The Anti-Leukemic Effect Of Umbilical Cord Blood Derived NK Cells Against Acute Myeloid Leukemia

LB-ARHGDIB-1R As Novel Minor Histocompatibility Antigen For Therapeutic Application

Akt Signalling Inhibition Promotes The Ex Vivo generation Of Minor Histocompatibility Antigen-Specific CD8+ Memory Stem T Cells

Ex Vivo Generation Of Functional Plasmacytoid and Myeloid Dendritic Cells Is Strongly Promoted By The Aryl Hydrocarbon Receptor Antagonist Stemregenin 1

CXCR3 Is Required for the Efficient Recruitment of Bone Marrow-Resident Memory T Cells to Inflamed Tissues,

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-Versus-Host-Disease Upon Allogeneic Stem Cell Transplantation,

Anti-CTLA-4 Antibody Is Not Able to Trigger Apoptosis in CTLA-4 Expressing Myeloid Tumor Cells

T Cells Expressing the Activating NK Cell Receptors KIR2DS4, NKG2C and NKG2D Are Elevated In Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Cytotoxic towards Hematopoietic Progenitor Cell Lines

Aberrant Expression in Human Epithelial Cancers of the P2X5-Encoded Minor Histocompatibility Antigen LRH-1: Implications for Graft-Versus-Tumor Immunity Against Solid Tumors.

A Single Nucleotide Polymorphism in CD19 Defines a Novel Target for Immunotherapy of B Cell Malignancies with CD4 + Cytotoxic T Cells.

Human CD34+ Myeloid Leukemic Progenitor Cells Are Susceptible to Lysis by Minor Histocompatibility Antigen LRH-1-Specific Cytotoxic T Lymphocytes.

Vaccination with Host Dendritic Cells Induces Graft-Versus-Leukemia Responses without Severe Graft-Versus-Host Disease in a Preclinical Mouse Model for Allogeneic Stem Cell Transplantation.

A Novel Tissue-Restricted Minor Histocompatibility Antigen Resulting from Differential Expression Due to a Deletion/Insertion Polymorphism in the P2X5 Purinergic Receptor Gene.

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American Society of Hematology

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American Society of Hematology

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