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Hao Huang, PhD
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Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N 6 -Methyladenosine RNA Demethylase

Rui Su, PhD, Zejuan Li, MD PhD, Hengyou Weng, PhD, Xiaocheng Weng, PhD, Zhixiang Zuo, Chenying Li, Huilin Huang, PhD, Chao Hu, PhD, Xi Qin, Lichuan Tang, PhD, Yungui Wang, PhD, Gia-Ming Hong, PhD, Hao Huang, PhD, Xiao Wang, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Yuanyuan Li, Shenglai Li, Jennifer Strong, Mary Elizabeth Neilly, Richard A. Larson, Xi Jiang, PhD, Pumin Zhang, Jie Jin, MD PhD, Chuan He, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2706.
https://doi.org/10.1182/blood.V128.22.2706.2706
Published: 2016
Journal Articles

TET1 Regulates DNA Replication through Targeting of Minichromosome Maintenance Genes

Hengyou Weng, PhD, Huilin Huang, PhD, Xi Qin, He Huang, PhD, Okwang Kwon, Ping Chen, Xi Jiang, PhD, Chao Hu, PhD, Hao Huang, PhD, Yungui Wang, PhD, Stephen Arnovitz, Shenglai Li, Jennifer Strong, Kyle Ferchen, Rui Su, PhD, Lei Dong, Chenying Li, Mary Beth Neilly, Zejuan Li, MD PhD, Jason Stewart, PhD, Carolyn Price, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2016) 128 (22): 2687.
https://doi.org/10.1182/blood.V128.22.2687.2687
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia

Takayuki Hoshii, PhD, Paolo Cifani, PhD, Tomoyoshi Nakadai, PhD, Zhaohui Feng, BM, BS, Chun-Hao Huang, PhD, Richard Koche, PhD, Christopher D Delaney, Chun-Wei David Chen, PhD, Scott W. Lowe, PhD, Robert Roeder, PhD, Alex Kentsis, MD PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 434.
https://doi.org/10.1182/blood.V128.22.434.434
Published: 2016
Journal Articles

Uncover TET1 Targets in MLL -Rearranged Leukemia

Hengyou Weng, PhD, Huilin Huang, PhD, He Huang, PhD, Okwang Kwon, Ping Chen, Xi Jiang, PhD, Chao Hu, Hao Huang, PhD, Yungui Wang, PhD, Xi Qin, Stephen Arnovitz, Shenglai Li, Jennifer Strong, Rui Su, PhD, Mary Beth Neilly, Zejuan Li, MD PhD, Yingming Zhao, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3632.
https://doi.org/10.1182/blood.V126.23.3632.3632
Published: 2015
Journal Articles

Targeted Treatment of FLT3 -Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand Peptides

Xi Jiang, PhD, Jason Bugno, Chao Hu, Yang Yang, PhD, Tobias Herold, MD, Jun Qi, PhD, Ping Chen, Sandeep Gurbuxani, MBBS, PhD, Stephen Arnovitz, Bryan Ulrich, Hengyou Weng, PhD, Yungui Wang, PhD, Hao Huang, PhD, Shenglai Li, Jennifer Strong, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Stefan K. Bohlander, MD, Jie Jin, MD PhD, Zejuan Li, MD PhD, James E. Bradner, MD, Seungpyo Hong, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2015) 126 (23): 3784.
https://doi.org/10.1182/blood.V126.23.3784.3784
Published: 2015
Journal Articles

Identification of TET1⊣miR-22⊣CREB-MYC Signaling Reveals Potent Tumor-Suppressor Role of Mir-22 in Acute Myeloid Leukemia

Xi Jiang, PhD, Ping Chen, Stephen Arnovitz, Hao Huang, PhD, Jason Bugno, Zhixiang Zuo, PhD, Hengyou Weng, PhD, Bryan Ulrich, Chao Hu, Sandeep Gurbuxani, MBBS, PhD, Yuanyuan Li, Justin Salat, Shenglai Li, Yang Yang, PhD, Yungui Wang, Mary Elizabeth Neilly, Richard A. Larson, Michelle M. Le Beau, PhD, Tobias Herold, MD, Stefan K. Bohlander, MD, Jiwang Zhang, MD PhD, Jie Jin, MD, Seungpyo Hong, PhD, Zejuan Li, MD PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2014) 124 (21): 886.
https://doi.org/10.1182/blood.V124.21.886.886
Published: 2014
Journal Articles

Identification of MLL-Fusion/Myc⊣miR-26a/Mir-29a⊣Tet1 Signaling Circuit in MLL -Rearranged Leukemia

Hao Huang, PhD, Xi Jiang, PhD, Jinhua Wang, Yuanyuan Li, Ping Chen, Stephen Arnovitz, Shenglai Li, Yungui Wang, Hengyou Weng, PhD, Mary Elizabeth Neilly, Zejuan Li, MD PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2014) 124 (21): 1011.
https://doi.org/10.1182/blood.V124.21.1011.1011
Published: 2014
Journal Articles

Polycomb Group Member Rybp Is a Functional Tumor Suppressor Repressed By Mir-9 in MLL-Rearranged AML

Colles Price, Ping Chen, Shenglai Li, Zejuan Li, MD PhD, Yuanyuan Li, Xi Jiang, PhD, Hao Huang, PhD, Hengyou Weng, PhD, Bryan Ulrich, Stephen Arnovitz, Mary Beth Neilly, Jianjun Chen, PhD
Journal: Blood
Blood (2014) 124 (21): 871.
https://doi.org/10.1182/blood.V124.21.871.871
Published: 2014
Journal Articles

MLL-Rearranged Acute Myeloid Leukemias Drive Expression Of Mir-9, a Critical Oncogene In Leukemogenesis

Colles Price, Ping Chen, MD, Zejuan Li, MD, PhD, Yuanyuan Li, Anissa Wiley, Chunjiang He, PhD, Rejani B. Kunjamma, Hao Huang, PhD, Xi Jiang, PhD, Stephen Arnovitz, Mary Beth Neilly, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2013) 122 (21): 3740.
https://doi.org/10.1182/blood.V122.21.3740.3740
Published: 2013
Journal Articles

The HOXA/PBX3 Pathway Is an Attractive Therapeutic Target in MLL -Rearranged Acute Leukemia

Zejuan Li, MD, PhD, Zhiyu Zhang, Yuanyuan Li, Stephen Arnovitz, Ping Chen, MD, Hao Huang, PhD, Xi Jiang, PhD, Gia-Ming Hong, PhD, Chunjiang He, PhD, Chong-Zhi Wang, Abdel Elkahloun, PhD, Peter J. M. Valk, PhD, Konstanze Dohner, MD, PhD, Mary Beth Neilly, Lars Bullinger, MD, PhD, Ruud Delwel, PhD, Bob Lowenberg, MD, PhD, Pu Paul Liu, MD, PhD, Richard Morgan, Janet D. Rowley, MD, Chun-Su Yuan, Jianjun Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 3522.
https://doi.org/10.1182/blood.V120.21.3522.3522
Published: 2012
Journal Articles

Blockade of Mir-150 Maturation by MLL -Fusion/MYC/Lin-28 Is Required for MLL -Associated Leukemia

Xi Jiang, PhD, Hao Huang, PhD, Zejuan Li, MD, PhD, Yuanyuan Li, Xiao Wang, Sandeep Gurbuxani, MBBS, PhD, Ping Chen, MD, Chunjiang He, PhD, Dewen You, PhD, Shuodan Zhang, Jinhua Wang, Stephen Arnovitz, Abdel Elkahloun, PhD, Colles Price, Gia-Ming Hong, PhD, Haomin Ren, Rejani B. Kunjamma, Mary Beth Neilly, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Robert K. Slany, PhD, Paul P. Liu, MD, PhD, Jun Lu, PhD, Jiwang Zhang, MD, PhD, Chuan He, PhD, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 3499.
https://doi.org/10.1182/blood.V120.21.3499.3499
Published: 2012
Journal Articles

MLL-Associated Leukemias Drive Expression of MiR-9, Required for Tumorigenesis

Colles Price, Ping Chen, MD, Zejuan Li, MD, PhD, Yuanyuan Li, Anissa Wiley, Chunjiang He, PhD, Rejani B. Kunjamma, Hao Huang, PhD, Xi Jiang, PhD, Stephen Arnovitz, Mary Beth Neilly, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 525.
https://doi.org/10.1182/blood.V120.21.525.525
Published: 2012
Journal Articles

Activation of a Mir-181-Targeting HOXA-PBX3 Homeobox Gene Signature Is Associated with Adverse Prognosis of Cytogenetically Abnormal Acute Myeloid Leukemia

Zejuan Li, MD, PhD, Hao Huang, PhD, Yuanyuan Li, Xi Jiang, PhD, Ping Chen, MD, Stephen Arnovitz, Michael D. Radmacher, PhD, Kati Maharry, MAS, Abdel Elkahloun, Xinan Yang, Chunjiang He, PhD, Colles O. Price, Konstanze Dohner, MD, PhD, Zhiyu Zhang, Chen Shen, Mary Beth Neilly, Yves A Lussier, Yanming Zhang, MD, Richard A. Larson, MD, Michelle M. Le Beau, PhD, Michael A Caligiuri, MD, Lars Bullinger, Peter Valk, Ruud Delwel, Ph.D., Bob Lowenberg, MD, PhD, Paul P. Liu, Guido Marcucci, MD, Clara D. Bloomfield, MD, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2011) 118 (21): 236.
https://doi.org/10.1182/blood.V118.21.236.236
Published: 2011
Journal Articles

MLL-Rearrangements Result in Upregulation of Mir-9 and Subsequent Inhibition of the Tumor Suppressor TGFBI

Colles O. Price, Ping Chen, MD, Zejuan Li, MD, PhD, Yuanyuan Li, Anissa Wiley, Chunjiang He, PhD, Hao Huang, PhD, Xi Jiang, PhD, Stephen Arnovitz, Mary Beth Neilly, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2011) 118 (21): 2453.
https://doi.org/10.1182/blood.V118.21.2453.2453
Published: 2011
Journal Articles

Repression of Mir-495, a Microrna Associated with Favorable Outcome of Acute Myeloid Leukemia Patients, Is Required for the MLL -Associated Leukemogenesis,

Xi Jiang, PhD, Hao Huang, PhD, Zejuan Li, MD, PhD, Yuanyuan Li, Ping Chen, MD, Chunjiang He, PhD, Stephen Arnovitz, Mary Beth Neilly, Janet D. Rowley, MD, Jianjun Chen, PhD
Journal: Blood
Blood (2011) 118 (21): 3462.
https://doi.org/10.1182/blood.V118.21.3462.3462
Published: 2011