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Journal Articles

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Kotaro Shide, MD PhD, Takuro Kameda, MD PhD, Ayako Kamiunten, MD, Yoshinori Ozono, MD, Yuki Tahira, MD, Masaaki Sekine, MD, Masaya Ono, MD PhD, Takako Yokomizo, PhD, Sho Kubota, Keiichi Akizuki, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD

Blood (2019) 134 (Supplement_1): 309.

https://doi.org/10.1182/blood-2019-130034

Published: 2019

Journal Articles

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Jie Bai, Sho Kubota, PhD, Takako Yokomizo, PhD, Akinori Kanai, PhD, Yuqi Sun, MD, Mihoko Iimori, CLS, Hironori Harada, MD PhD, Naomi Nakagata, PhD, Atsushi Iwama, MD PhD, Goro Sashida, MD PhD

Blood (2019) 134 (Supplement_1): 3782.

https://doi.org/10.1182/blood-2019-127583

Published: 2019

Journal Articles

Haploinsufficiency of CALR Confers Hematopoietic Stem Cells (HSCs) with a Clonal Advantage over Wild-Type Cells, and, in Setting of Myeloproliferative Neoplasms, Compensates for the Functions of HSCs Impaired By the Calr Mutation

Kotaro Shide, MD PhD, Takuro Kameda, MD, Ayako Kamiunten, MD, Masaaki Sekine, MD, Yoshinori Ozono, MD, Takako Yokomizo, PhD, Keiichi Akizuki, MD, Yuki Tahira, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD

Blood (2018) 132 (Supplement 1): 97.

https://doi.org/10.1182/blood-2018-99-114304

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

Sho Kubota, PhD, Kenji Tokunaga, MD, Tomohiro Umezu, PhD, Takako Yokomizo, PhD, Motohiko Oshima, PhD, Eisaku Iwanaga, MD PhD, Norio Asou, MDPhD, Atsushi Iwama, MD PhD, Kazuma Ohyashiki, MD PhD, Motomi Osato, MD, PhD, Goro Sashida, MD PhD

Blood (2018) 132 (Supplement 1): 761.

https://doi.org/10.1182/blood-2018-99-110333

Published: 2018

Journal Articles

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Takako Yokomizo, PhD, Daiki Tanaka, Sho Kubota, PhD, Motohiko Oshima, PhD, Yuka Harada, MD PhD, Akinori Kanai, PhD, Atsushi Iwama, MD PhD, Hironori Harada, Motomi Osato, MD PhD, Goro Sashida, MD PhD

Blood (2017) 130 (Supplement 1): 2494.

https://doi.org/10.1182/blood.V130.Suppl_1.2494.2494

Published: 2017

Journal Articles

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

Kazumasa Aoyama, PhD, Makiko Mochizuki-Kashio, PhD, Motohiko Oshima, PhD, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Mitsutaka Maeda, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2016) 128 (22): 1968.

https://doi.org/10.1182/blood.V128.22.1968.1968

Published: 2016

Journal Articles

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Atsunori Saraya, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 712.

https://doi.org/10.1182/blood.V126.23.712.712

Published: 2015

Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Blood (2015) 126 (23): 303.

https://doi.org/10.1182/blood.V126.23.303.303

Published: 2015

Journal Articles

Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation

Goro Sashida, MD PhD, Changshan Wang, MD PhD, Daisuke Sato, MS, Motohiko Oshima, PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 308.

https://doi.org/10.1182/blood.V126.23.308.308

Published: 2015

Journal Articles

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Kotaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 4596.

https://doi.org/10.1182/blood.V124.21.4596.4596

Published: 2014

Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2014) 124 (21): 362.

https://doi.org/10.1182/blood.V124.21.362.362

Published: 2014

Journal Articles

Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML In Mouse

Yue Zhang, MD, Xiaomei Yan, Aili Chen, Goro Sashida, MD, PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2013) 122 (21): 2746.

https://doi.org/10.1182/blood.V122.21.2746.2746

Published: 2013

Journal Articles

Ezh2 Loss Accelerates JAK2V617F-Driven Primary Myelofibrosis

Takahisa Tomioka, BS, Goro Sashida, MD, PhD, Kotaro Shide, MD, PhD, Kazuya Shimoda, MD, PhD, Naoto Yamaguchi, PhD, Atsushi Iwama, MD, PhD

Blood (2013) 122 (21): 110.

https://doi.org/10.1182/blood.V122.21.110.110

Published: 2013

Journal Articles

Pre-mRNA Splicing Factor Sf3b1 Regulates Proliferation and Survival Of Hematopoietic Stem and Progenitor Cells

Wang Changshan, MD, Goro Sashida, MD, PhD, Saraya Atsunori, MS, Atsushi Iwama, MD, PhD

Blood (2013) 122 (21): 1577.

https://doi.org/10.1182/blood.V122.21.1577.1577

Published: 2013

Journal Articles

Concurrent Loss Of Ezh2 and Tet2 Cooperates In The Pathogenesis Of Myelodysplastic Disorders,

Tomoya Muto, MD, PhD, Goro Sashida, MD, PhD, Motohiko Oshima, PhD, George R Wendt, Makiko Mochizuki-Kashio, PhD, Masashi Sanada, MD, Satoru Miyagi, PhD., Atsunori Saraya, MS, Chiaki Nakaseko, M.D., Ph.D., Koutaro Yokote, MD, PhD, Kazuya Shimoda, MD, PhD, Haruhiko Koseki, MD, PhD, Yutaka Suzuki, PhD, Sumio Sugano, PhD, Seishi Ogawa, MD, PhD, Atsushi Iwama, MD, PhD

Blood (2013) 122 (21): 480.

https://doi.org/10.1182/blood.V122.21.480.480

Published: 2013

Journal Articles

Loss of Ezh2 Promotes the Development of Mutant-RUNX1 Induced MDS

Goro Sashida, MD, PhD, Satomi Tanaka, MD, Makiko Mochizuki-Kashio, PhD, Atsunori Saraya, MS, Tomoya Muto, MD, Atsushi Iwama, MD, PhD

Blood (2012) 120 (21): 402.

https://doi.org/10.1182/blood.V120.21.402.402

Published: 2012

Journal Articles

Long-Term Cell Autonomous Effect of Tet2 Loss in Hematopoietic Cells in Mice.

Tomoya Muto, MD, Goro Sashida, MD, PhD, Motohiko Oshima, PhD, Chiaki Nakaseko, MD, PhD, Kotaro Yokote, M.D., PhD., Kazuya Shimoda, MD, PhD, Atsushi Iwama, MD, PhD

Blood (2012) 120 (21): 2416.

https://doi.org/10.1182/blood.V120.21.2416.2416

Published: 2012

NARROW

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Haploinsufficiency of CALR Confers Hematopoietic Stem Cells (HSCs) with a Clonal Advantage over Wild-Type Cells, and, in Setting of Myeloproliferative Neoplasms, Compensates for the Functions of HSCs Impaired By the Calr Mutation

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML In Mouse

Ezh2 Loss Accelerates JAK2V617F-Driven Primary Myelofibrosis

Pre-mRNA Splicing Factor Sf3b1 Regulates Proliferation and Survival Of Hematopoietic Stem and Progenitor Cells

Concurrent Loss Of Ezh2 and Tet2 Cooperates In The Pathogenesis Of Myelodysplastic Disorders,

Loss of Ezh2 Promotes the Development of Mutant-RUNX1 Induced MDS

Long-Term Cell Autonomous Effect of Tet2 Loss in Hematopoietic Cells in Mice.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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