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Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 3557.

https://doi.org/10.1182/blood-2019-125664

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

Journal Articles

Interrogating RNA Binding Proteins as Novel Regulators of Fetal Hemoglobin Expression

Aoi Wakabayashi, BS, Jeremy D. Grevet, PhD, Xianjiang Lan, PhD, Malini Sharma, BS, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 966.

https://doi.org/10.1182/blood-2019-125901

Published: 2019

Journal Articles

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Belinda Giardine, Zhe Zhang, PhD, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 981.

https://doi.org/10.1182/blood-2019-124099

Published: 2019

Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Jeremy D. Grevet, BA, Scott A. Peslak, MD, Saurabh Bhardwaj, PhD, Cheryl A. Keller, PhD, Belinda Giardine, Ben A. Garcia, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2018) 132 (Supplement 1): 414.

https://doi.org/10.1182/blood-2018-99-119518

Published: 2018

Journal Articles

Heme-Regulated Inhibitor (HRI) Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD, Jeremy D. Grevet, BA, Xianjiang Lan, PhD, Osheiza Abdulmalik, DVM, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2018) 132 (Supplement 1): 721.

https://doi.org/10.1182/blood-2018-99-117436

Published: 2018

Journal Articles

Fetal Hemoglobin Induction with Forced Chromatin Looping in Gene-Modified Erythroid Cells Differentiated from Rhesus Hematopoietic Progenitor Cells

Selami Demirci, PhD, Saurabh Bhardwaj, PhD, Naoya Uchida, MD PhD, Juan J. Haro Mora, PhD, Byoung Y. Ryu, PhD, Gerd A. Blobel, MD PhD, John F Tisdale, MD

Blood (2017) 130 (Supplement 1): 4617.

https://doi.org/10.1182/blood.V130.Suppl_1.4617.4617

Published: 2017

Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells

Jeremy D. Grevet, Nicole Hamagami, Xianjiang Lan, PhD, Laavanya Sankaranarayanan, MS, Saurabh Bhardwaj, PhD, Carolyne Face, David Posocco, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Simone Sidoli, PhD, Ben Garcia, PhD, Stella T Chou, MD, Ross C Hardison, PhD, Chris Vakoc, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2017) 130 (Supplement 1): 536.

https://doi.org/10.1182/blood.V130.Suppl_1.536.536

Published: 2017

Journal Articles

The BET Protein BRD2 Cooperates with CTCF to Enforce a Transcriptional Boundary in Erythroid Cells

Sarah C. Hsu, Caroline Bartman, Aaron J Stonestrom, MD PhD, Christopher R Edwards, PhD, Thomas Gilgenast, Daniel Emerson, Peng Huang, PhD, Michael T. Werner, Kristen Jahn, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD, Jennifer E. Phillips-Cremins, PhD, Gerd A. Blobel, MD PhD

Blood (2016) 128 (22): 1034.

https://doi.org/10.1182/blood.V128.22.1034.1034

Published: 2016

Journal Articles

Deep Mining of Natural Genetic Variation in Erythroid Cells Reveals New Insights about In Vivo Transcription Factor Binding and Chromatin Accessibility

Vivek Behera, B.S., Perry Evans, PhD, Carolyne J Face, B.A., Laavanya Sankaranarayanan, M.B., Gerd A. Blobel, MD PhD

Blood (2016) 128 (22): 3879.

https://doi.org/10.1182/blood.V128.22.3879.3879

Published: 2016

Journal Articles

Genome Editing Recreates Hereditary Persistence of Fetal Hemoglobin in Primary Human Erythroblasts

Elizabeth Traxler, Yu Yao, MD, Chunliang Li, Jeremy Grevet, Peng Huang, PhD, Shaela Wright, Gerd A. Blobel, MD PhD, Mitchell J. Weiss, MD PhD

Blood (2015) 126 (23): 640.

https://doi.org/10.1182/blood.V126.23.640.640

Published: 2015

Journal Articles

A Novel Regulatory Region of the p27 Locus Is Required for Normal Erythroid p27 Expression, and Produces a Long Noncoding RNA with No Detectable Function

Vikram R Paralkar, MD, Cristian Taborda, Yu Yao, MD, Rishi Prasad, Jing Luan, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD, Mitchell J Weiss, MD PhD

Blood (2015) 126 (23): 1175.

https://doi.org/10.1182/blood.V126.23.1175.1175

Published: 2015

Journal Articles

A Dynamic Intron Retention Program in the Mammalian Megakaryocyte and Erythrocyte Lineages

Christopher R Edwards, PhD, Rob Middleton, Xiuli An, MD PhD, Tejaswini Mishra, PhD, Narla Mohandas, DSc, Ross C. Hardison, PhD, John Rasko, MBBS, PhD, Gerd A. Blobel, MD PhD

Blood (2015) 126 (23): 2380.

https://doi.org/10.1182/blood.V126.23.2380.2380

Published: 2015

Journal Articles

A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

Gerd A. Blobel, MD PhD, Chris C.S. Hsiung, B.A., Peng Huang, PhD, Cheryl Keller, PhD, Paul Ginart, Kristen Jahn, Caroline Bartman, Aaron James Stonestrom, BS, Perry Evans, Belinda Giardine, Ross C. Hardison, PhD, Arjun Raj, PhD

Blood (2015) 126 (23): 48.

https://doi.org/10.1182/blood.V126.23.48.48

Published: 2015

Journal Articles

Mechanistic Insights into Forced Chromatin Looping Mediated Activation of Fetal Globin Gene Expression

Caroline Bartman, Gerd A. Blobel, MD PhD, Jeremy Grevet, Chris C.S. Hsiung, B.A., Jeremy W. Rupon, MD PhD, Arjun Raj, PhD

Blood (2014) 124 (21): 331.

https://doi.org/10.1182/blood.V124.21.331.331

Published: 2014

Journal Articles

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

Laura Breda, PhD, Jeremy W. Rupon, MD PhD, Irene Motta, MD, Wulan Deng, Gerd A. Blobel, MD PhD, Stefano Rivella, PhD

Blood (2014) 124 (21): 333.

https://doi.org/10.1182/blood.V124.21.333.333

Published: 2014

Journal Articles

Dissection of BET Protein Function in a Hematopoietic Differentiation Model

Aaron J Stonestrom, Sarah C Hsu, Kristen S Jahn, Chris CS Hsuing, Peng Huang, PhD, Ross C Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2014) 124 (21): 1574.

https://doi.org/10.1182/blood.V124.21.1574.1574

Published: 2014

Journal Articles

Hematopoietic Transcriptional Regulation At The Mitosis-G1 Transition

Chris C.S. Hsiung, B.A., Arjun Raj, PhD, Gerd A. Blobel, MD, PhD

Blood (2013) 122 (21): 2440.

https://doi.org/10.1182/blood.V122.21.2440.2440

Published: 2013

Journal Articles

Using Forced Chromatin Looping To Overcome Developmental Silencing Of Embryonic and Fetal β-Type Globin Genes In Adult Erythroid Cells

Jeremy W Rupon, MD, PHD, Wulan Deng, PhD, Hongxin Wang, Philip D Gregory, PhD, Andreas Reik, PhD, Ann Dean, PhD, Gerd A. Blobel, MD, PhD

Blood (2013) 122 (21): 433.

https://doi.org/10.1182/blood.V122.21.433.433

Published: 2013

Journal Articles

Dissecting the Molecular Pathways That Underlie Disease-Causing GATA1 Mutations

Amy E Campbell, Lorna Wilkinson-White, PhD, Joel P Mackay, PhD, Jacqueline M Matthews, PhD, Gerd A Blobel, MD, PhD

Blood (2012) 120 (21): 3439.

https://doi.org/10.1182/blood.V120.21.3439.3439

Published: 2012

NARROW

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Interrogating RNA Binding Proteins as Novel Regulators of Fetal Hemoglobin Expression

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Heme-Regulated Inhibitor (HRI) Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Fetal Hemoglobin Induction with Forced Chromatin Looping in Gene-Modified Erythroid Cells Differentiated from Rhesus Hematopoietic Progenitor Cells

Domain-Focused CRISPR-Cas9 Screen Identifies Hri Kinase As a Regulator of Fetal Hemoglobin in Adult Human Erythroid Cells

The BET Protein BRD2 Cooperates with CTCF to Enforce a Transcriptional Boundary in Erythroid Cells

Deep Mining of Natural Genetic Variation in Erythroid Cells Reveals New Insights about In Vivo Transcription Factor Binding and Chromatin Accessibility

Genome Editing Recreates Hereditary Persistence of Fetal Hemoglobin in Primary Human Erythroblasts

A Novel Regulatory Region of the p27 Locus Is Required for Normal Erythroid p27 Expression, and Produces a Long Noncoding RNA with No Detectable Function

A Dynamic Intron Retention Program in the Mammalian Megakaryocyte and Erythrocyte Lineages

A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit

Mechanistic Insights into Forced Chromatin Looping Mediated Activation of Fetal Globin Gene Expression

Comparing Strategies to Reactivate Fetal Globin Expression for the Treatment of Beta-Globinopathies

Dissection of BET Protein Function in a Hematopoietic Differentiation Model

Hematopoietic Transcriptional Regulation At The Mitosis-G1 Transition

Using Forced Chromatin Looping To Overcome Developmental Silencing Of Embryonic and Fetal β-Type Globin Genes In Adult Erythroid Cells

Dissecting the Molecular Pathways That Underlie Disease-Causing GATA1 Mutations

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American Society of Hematology

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American Society of Hematology

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