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George Giotopoulos, PhD
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Journal Articles

Transcriptional Heterogeneity Governs Cell Fate Diversification during Pre-Leukemia to Leukemia Progression

Shikha Gupta, MS, Ana Filipa Domingues, Oliwia Cyran, George Giotopoulos, PhD, Sudhakaran Prabakaran, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, Oliver M. Dovey, PhD, George S. Vassiliou, MD PhD FRCPath, MRCP, Cristina Pina, MDDPhil
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-136504
Published: 2020
Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 278.
https://doi.org/10.1182/blood-2019-122413
Published: 2019
Journal Articles

Contrasting Stage Dependent Requirements for the Histone Methyltransferase EZH2 during the Evolution of Acute Myeloid Leukemia

Faisal Basheer, MBBChir, MA, George Giotopoulos, PhD, Eshwar Meduri, PhD, Haiyang Yun, PhD, Milena Mazan, PhD, Olivia Sheppard, Daniel Sasca, MD, Malgorzata Gozdecka, PhD, George S. Vassiliou, MD PhD, Brian J.P Huntly
Journal: Blood
Blood (2017) 130 (Supplement 1): 1215.
https://doi.org/10.1182/blood.V130.Suppl_1.1215.1215
Published: 2017
Journal Articles

Histone Acetyl-Transferase Kat2a Regulates Transcriptional Heterogeneity and Impacts Self-Renewal of Acute Myeloid Leukemia Cells in a Disease-Specific Manner

Ana Filipa Domingues, MSc, Rashmi Kulkarni, PhD, George Giotopoulos, PhD, Brian J.P Huntly, Sudhakaran Prabakaran, PhD, Cristina Pina, MDDPhil
Journal: Blood
Blood (2017) 130 (Supplement 1): 2486.
https://doi.org/10.1182/blood.V130.Suppl_1.2486.2486
Published: 2017
Journal Articles

Modelling Resistance to Emerging Epigenetic Therapies

Chun Yew Fong, MBBS FRACP FRCPA, Omer Gilan, PhD, Enid Lam, PhD, Alan Rubin, PhD, Jessica Morison, PhD, George Giotopoulos, PhD, Kym Stanley, Ftouni Sarah, MSc, Dean Tyler, Dave Lugo, Philip Jeffrey, Richard Gregory, Jaring Schreuder, Shalin Naik, PhD, Tony Kouzarides, PhD, Brian Huntly, MD PhD, Ricky W Johnstone, PhD, Rab K Prinjha, Anthony Papenfuss, PhD, Mark A Dawson, MBBS FRACP FRCPA PhD
Journal: Blood
Blood (2014) 124 (21): 3546.
https://doi.org/10.1182/blood.V124.21.3546.3546
Published: 2014
Journal Articles

Mll-AF4 Induction during Ontogeny Reveals Early Changes in Myeloid and Lymphoid potential and Results in Hematopoietic Malignancies in Adult Mice

Neil A Barrett, MB BCh, Chrysa Kapeni, MSc, Camille Malouf, PhD, George Giotopoulos, PhD, Simon Fitch, PhD, Wendi A. Bacon, BSc, Brian Huntly, MD PhD, Katrin Ottersbach, PhD
Journal: Blood
Blood (2014) 124 (21): 892.
https://doi.org/10.1182/blood.V124.21.892.892
Published: 2014